Hypertension and Tuberous Xanthomas predict Cardiovascular Disease in Familial Dysbetalipoproteinemia
A.B. received research grants from Merck Frosst, Amgen, Sanofi, Astra Zeneca and the Fondation Leducq. He has participated in clinical research protocols from Pfizer, Regeneron Pharmaceuticals Inc., The Medecines Company, Amgen, Acasti Pharma Inc., Novartis, Sanofi, Ionis Pharmaceuticals, Inc., Astra Zeneca, Akcea and Merck Frosst. He has served on advisory boards and received honoraria for symposia from Amgen, Akcea and Sanofi. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - May 1, 2019 Category: Lipidology Authors: Alexis Baass, Martine Paquette, Sophie Bernard Source Type: research

Prevalence of US Adults With Triglycerides ≥135 mg/dL: NHANES 2007-2014
Employment, ownership interests (Amarin Pharma Inc.). (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - May 1, 2019 Category: Lipidology Authors: Sephy Philip, Wenjun Fan, Craig Granowitz, Peter Toth, Nathan Wong Source Type: research

Safety and Efficacy of Anti-PD-1 Monoclonal Antibodies in Patients With Relapsed or Refractory Lymphoma: A Meta-Analysis of Prospective Clinic Trails
Hui Zhou, Xiaoyan Fu, Qian Li and Ting Niu* Department of Hematology and Research Laboratory of Hematology, West China Hospital, Sichuan University, Chengdu, China Background: Immune checkpoint inhibition therapy with monoclonal antibody against programmed cell death protein 1 (PD-1), including nivolumab and pembrolizumab, has demonstrated powerful clinical efficacy in the treatment of advanced cancers. However, there is no evidence-based systematic review on the safety and efficacy of anti-PD-1 antibody in treating lymphoma. Methods: To evaluate the safety and efficacy of nivolumab/pembrolizumab, we analyzed clin...
Source: Frontiers in Pharmacology - May 1, 2019 Category: Drugs & Pharmacology Source Type: research

Rare Functional Variants in Complement Genes and Anti-FH Autoantibodies-Associated aHUS
In conclusion, we have confirmed in our cohort of patients, the strong association between FHR1 deficiency and aHUS with anti-FH autoantibodies. Through an innovative approach based on the comparison with “supercontrols” carrying the homozygous CFHR1 deletion, identified by screening a large number of healthy adult subjects, we have documented that patients with anti-FHs aHUS are enriched in complement gene LPVs. This observation indicates that the pathogenesis of anti-FHs aHUS is complex and multiple “hits” are required for its clinical manifestation. We also document that the CFH H3 and the CD46GG...
Source: Frontiers in Immunology - May 1, 2019 Category: Allergy & Immunology Source Type: research

Genetic Counseling in Huntington's Disease: Potential New Challenges on Horizon?
Conclusion and Recommendations In this review we attempt to summarize current knowledge about the HD mutation and how information about CAG repeats in the HTT gene can be used to provide sound genetic counseling, which can possibly extend to other neurodegenerative diseases (44). By involving families in observational (i.e., ENROLL-HD platform) and interventional trials, clinicians have an opportunity to include adult patients and their relatives (e.g., partners, symptomatic minors, premanifest adults) in research-based networks that provide current knowledge about developments in genetic testing and novel therapies in HD...
Source: Frontiers in Neurology - April 30, 2019 Category: Neurology Source Type: research

Oligonucleotide Microarrays Identified Potential Regulatory Genes Related to Early Outward Arterial Remodeling Induced by Tissue Plasminogen Activator
Olga Plekhanova1,2*, Yelena Parfyonova1,2, Irina Beloglazova1,2, Bradford C. Berk3 and Vsevolod Tkachuk1,2 1Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia 2National Medical Research Center of Cardiology, Moscow, Russia 3Aab Cardiovascular Research Institute, University of Rochester Medical Center, Rochester, NY, United States Constrictive vascular remodeling limiting blood flow, as well as compensatory outward remodeling, has been observed in many cardiovascular diseases; however, the underlying mechanisms regulating the remodeling response of the vessels remain unclear. Plasminogen acti...
Source: Frontiers in Physiology - April 30, 2019 Category: Physiology Source Type: research

Effect of ultra-short-term treatment of patients with iron deficiency or anaemia undergoing cardiac surgery: a prospective randomised trial
This study assessed whether immediate preoperative treatment could result in reduced perioperative red blood cell (RBC) transfusions and improved outcome.MethodsIn this single-centre, randomised, double-blind, parallel-group controlled study, patients undergoing elective cardiac surgery with anaemia (n=253; haemoglobin concentration (Hb)
Source: The Lancet - April 27, 2019 Category: General Medicine Source Type: research

Powered by Open Innovation: Opportunities and Challenges in the Pharma Sector
AbstractThe value of innovation in medicines is clear. Despite all of the progress in the twenty-first century, there are still many unmet medical needs and opportunities to improve healthcare. The challenges for pharmaceutical companies include ways in which to stay competitive and flexible in an environment of constant knowledge growth and increasingly sophisticated technologies, and ways to generate sufficient revenues to sustain their own growth. To that end, pharmaceutical companies are compelled to adapt different business models in the face of new challenges. The industry is plagued with long research and developmen...
Source: Pharmaceutical Medicine - April 26, 2019 Category: Drugs & Pharmacology Source Type: research

Radiomics Signature on Computed Tomography Imaging: Association With Lymph Node Metastasis in Patients With Gastric Cancer
Conclusions: The newly developed radiomic signature was a powerful predictor of LN metastasis and the radiomics nomogram could facilitate the preoperative individualized prediction of LN status. Introduction Gastric cancer (GC) is one of the most common malignant tumors and the second leading cause of cancer-related deaths worldwide (1). Accurate evaluation of lymph node metastasis (LNM) status in GC patients is vital for prognosis and treatment decisions (2–4). Some histopathologic factors and biomarkers (e.g., lymphatic invasion, matrix metalloproteinase-2) are found to be able to predict LNM in GC, but mos...
Source: Frontiers in Oncology - April 26, 2019 Category: Cancer & Oncology Source Type: research

Endometrial Tumor Microenvironment Alters Human NK Cell Recruitment, and Resident NK Cell Phenotype and Function
Clara Degos1, Mellie Heinemann2, Julien Barrou2, Nicolas Boucherit1, Eric Lambaudie2, Ariel Savina3†, Laurent Gorvel1* and Daniel Olive1* 1Tumor Immunology Team, IBISA Immunomonitoring Platform, Cancer Research Center of Marseillle, INSERM U1068, CNRS U7258, Institut Paoli-Calmettes, Aix-Marseille University, Marseille, France 2Department of Surgical Oncology 2, CNRS, INSERM, Institut Paoli-Calmettes, CRCM, Aix-Marseille University, Marseille, France 3Institut Roche, Boulogne Billancourt, France Endometrial Cancer is the most common cancer in the female genital tract in developed countries, and with its ...
Source: Frontiers in Immunology - April 26, 2019 Category: Allergy & Immunology Source Type: research

BDNF Actions in the Cardiovascular System: Roles in Development, Adulthood and Response to Injury
This study also identified the cardiac myocyte as a significant local source of BDNF, as cardiac myocyte-specific deletion of BDNF induced a similar cardiomyopathy phenotype. While these results do not exclude a role for other neurotrophins, particularly in injury states, they point to the requirement for continued, local synthesis of BDNF to maintain optimal cardiac function. A major, unresolved question relates to how the truncated TrkB isoform (TrkBT1) transduces the inotropic effects of BDNF, which will require additional study. A concurrent study evaluated the potential impact of the BDNF-mediated activation of the k...
Source: Frontiers in Physiology - April 26, 2019 Category: Physiology Source Type: research

A Symphytum officinale Root Extract Exerts Anti-inflammatory Properties by Affecting Two Distinct Steps of NF- κB Signaling
A Symphytum officinale Root Extract Exerts Anti-inflammatory Properties by Affecting Two Distinct Steps of NF-κB Signaling Jacqueline Seigner1, Marc Junker-Samek2, Alberto Plaza2, Gilda D‘Urso3, Milena Masullo3, Sonia Piacente3, Yvonne M. Holper-Schichl4*† and Rainer de Martin1*† 1Department of Vascular Biology, Medical University of Vienna, Vienna, Austria 2R&D, Procter & Gamble Health, Darmstadt, Germany 3Dipartimento di Farmacia, Università degli Studi di Salerno, Salerno, Italy 4Drehm Pharma GmbH, Vienna, Austria Symphytum officinale, commonly known as comfrey, const...
Source: Frontiers in Pharmacology - April 26, 2019 Category: Drugs & Pharmacology Source Type: research

Neoadjuvant Chemotherapy Alters Neuropilin-1, PlGF, and SNAI1 Expression Levels and Predicts Breast Cancer Patients Response
In this report, we are adding an extra finding, in which we show that the levels of circulating NRP-1 were significantly increased in patients who received NAC and had a partial response. Assessing patients who underwent NAC indicated that the levels of NRP-1 measured post-NAC were significantly higher in younger patients and patients with either a low or a medium body mass index (BMI), as well as in patients who remained with larger tumor size and partial response. Previously, we showed that SNAI1 expression in the immune cells collected from the peripheral blood of breast cancer patients was significantly higher in patie...
Source: Frontiers in Oncology - April 25, 2019 Category: Cancer & Oncology Source Type: research

Systemic Lupus Erythematosus With Isolated Psychiatric Symptoms and Antinuclear Antibody Detection in the Cerebrospinal Fluid
Conclusion: Some patients with psychiatric syndromes and increased ANA titers may suffer from psychiatric variants of SLE, even if the American College of Rheumatology criteria for SLE are not met. Whether the psychiatric symptoms in our patient represent a prodromal stage with the later manifestation of full-blown SLE or a subtype of SLE with isolated CNS involvement remains unclear. Regardless, early diagnosis and initiation of immunosuppressive treatment are essential steps in preventing further disease progression and organ damage. Intrathecal ANAs with extractable nuclear antigen differentiation may be a more sensitiv...
Source: Frontiers in Psychiatry - April 25, 2019 Category: Psychiatry Source Type: research

Beta Amyloid Deposition Is Not Associated With Cognitive Impairment in Parkinson's Disease
Beta Amyloid Deposition Is Not Associated With Cognitive Impairment in Parkinson's Disease Tracy R. Melzer1,2,3†, Megan R. Stark1,2†, Ross J. Keenan1,4, Daniel J. Myall1, Michael R. MacAskill1,2, Toni L. Pitcher1,2,3, Leslie Livingston1,2, Sophie Grenfell1, Kyla-Louise Horne1,2, Bob N. Young1, Maddie J. Pascoe1, Mustafa M. Almuqbel1,2,4, Jian Wang5, Steven H. Marsh6, David H. Miller1,2,7, John C. Dalrymple-Alford1,2,3,8 and Tim J. Anderson1,2,3,9* 1New Zealand Brain Research Institute, Christchurch, New Zealand 2Department of Medicine, University of Otago, Christchurch, New Zealand 3Brain Rese...
Source: Frontiers in Neurology - April 24, 2019 Category: Neurology Source Type: research

Ability to Suppress TGF- β-Activated Myofibroblast Differentiation Distinguishes the Anti-pulmonary Fibrosis Efficacy of Two Danshen-Containing Chinese Herbal Medicine Prescriptions
Conclusion: This study suggests that a clinically efficacious cardiovascular Chinese herbal medicine (DLP) can be successfully repurposed to treat a lung disease in pulmonary fibrosis guided by TCM theory. Our comparative study between DLP and DHP demonstrated a critical requirement of suppressing both pro-inflammatory and pro-fibrotic pathways for the treatment of pulmonary fibrosis, supporting that a multi-component prescription capable of “removing both phlegm and blood stasis” will better achieve co-protection of heart and lung in PHD. Introduction Idiopathic pulmonary fibrosis (IPF) is a chronic an...
Source: Frontiers in Pharmacology - April 24, 2019 Category: Drugs & Pharmacology Source Type: research

Oligonucleotides —A Novel Promising Therapeutic Option for IBD
This study showed a good safety and tolerability profile of the studied substance (Monteleone et al., 2012). Since TGFβ has been described to induce the profibrogenetic response of fibroblasts, patients were monitored for 6 months with intestinal ultrasonography, not showing signs of intestinal stenosis. Moreover, half of the patients maintained remission during the 6 months follow up period (Zorzi et al., 2012). Afterwards, a randomized, double-blind, phase 2 study was conducted in CD patients with inflammatory lesions in the terminal ileum and/or right colon, with steroid-dependence/resistance, randomized to three ...
Source: Frontiers in Pharmacology - April 24, 2019 Category: Drugs & Pharmacology Source Type: research

The Analysis of Key Factors Related to ADCs Structural Design
Conclusion and Perspective With in-depth understandings of antibodies, linkers, and payloads, ADCs have also achieved great development. The linkage strategy and target diversity have already improved the delivery of the payloads to tumor tissues and reduced exposure to normal tissues. With the development of payloads, some novel potent payloads are used by ADCs, which allows researchers to exploit novel linkers to attach the antibody and payloads without disturbing their potency (Dragovich et al., 2018). Furthermore, some irrelevant antigen-target ADCs also may exert toxicity to tumor cells due to the vascular gap of tum...
Source: Frontiers in Pharmacology - April 24, 2019 Category: Drugs & Pharmacology Source Type: research

Rescued from a war zone, an Iraqi chemist finds a future in pharma
A scholarship led Firas Jumaah to graduate studies at Lund University, which then saved him and his family from Islamic State militants (Source: Chemical and Engineering News)
Source: Chemical and Engineering News - April 21, 2019 Category: Chemistry Authors: Alla Katsnelson, special to C & amp;EN Source Type: research

The Association of Tacrolimus Formulation Switching with Trough Concentration Variability: A Retrospective Cohort Study of Tacrolimus Use Post-Kidney Transplantation Based on National Drug Code (NDC) Numbers
ConclusionA variable tacrolimus formulation regimen was associated with a higher frequency of trough level measurements and a greater number of excursions in trough levels compared with continuing on a fixed formulation regimen of tacrolimus in this retrospective chart review study.FundingAstellas Pharma Global Development, Inc.Plain Language SummaryPlain language summary available for this article. (Source: Advances in Therapy)
Source: Advances in Therapy - April 19, 2019 Category: Drugs & Pharmacology Source Type: research

Impact of Hepatitis Virus on the Feasibility and Efficacy of Anticancer Agents in Patients With Hepatocellular Carcinoma in Phase I Clinical Trials
This study was approved by the NCCH institutional review board and performed in compliance with our institutional guidelines. Patients positive for anti-HCV antibody or HBV antigen (HBsAg) were considered to have HCC due to chronic viral hepatitis, whereas those without anti-HCV antibody nor HBsAg were considered to have HCC by another etiology (non-B/non-C). All medical records were reviewed to summarize the patients' clinical characteristics, treatments, and outcomes based on the status of chronic viral hepatitis. The baseline clinical characteristics included age, gender, ECOG-performance status (PS), treatmen...
Source: Frontiers in Oncology - April 18, 2019 Category: Cancer & Oncology Source Type: research

The Effect of Resveratrol on the Composition and State of Lipids and the Activity of Phospholipase A2 During the Excitation and Regeneration of Somatic Nerves
Discussion It has been known that lipids participate in the functions of cell membranes that are related to their composition and high exchange rate, and various fatty acids determines the bilayer physical state and the ability to oxidize (Revin et al., 2006). Using layer chromatography, we investigated the change in lipid composition of the rat nerve after stimulation, damage, and resveratrol action. From the studies on the changes in individual phospholipid compositions in the rat nerve, it was eslished that the content of phosphatidylethanolamine (PEA) in the nerve (of the first experimental group) was 236.56 ±...
Source: Frontiers in Physiology - April 18, 2019 Category: Physiology Source Type: research

Mortality and cardiovascular and respiratory morbidity in individuals with impaired FEV1 (PURE): an international, community-based cohort study
Publication date: May 2019Source: The Lancet Global Health, Volume 7, Issue 5Author(s): MyLinh Duong, Shofiqul Islam, Sumathy Rangarajan, Darryl Leong, Om Kurmi, Koon Teo, Kieran Killian, Gilles Dagenais, Scott Lear, Andreas Wielgosz, Sanjeev Nair, Viswanathan Mohan, Prem Mony, Rajeev Gupta, Rajesh Kumar, Omar Rahman, Khalid Yusoff, Johannes Lodewykus du Plessis, Ehimario U Igumbor, Jephat ChifambaSummaryBackgroundThe associations between the extent of forced expiratory volume in 1 s (FEV1) impairment and mortality, incident cardiovascular disease, and respiratory hospitalisations are unclear, and how these associations mi...
Source: The Lancet Global Health - April 17, 2019 Category: International Medicine & Public Health Source Type: research

Assessment of disposal practices of expired and unused medications among community pharmacies in Anambra State southeast Nigeria: a mixed study design
ConclusionPoor compliance with the national guideline for medication disposal increases the potential risk of contamination of our environment and increases the possibility of ingesting toxic pharmaceutical wastes by humans and animals. This underscores the need for improvement on expired drugs management protocols to prevent contaminations and the attendant health hazards. (Source: Journal of Pharmaceutical Policy and Practice)
Source: Journal of Pharmaceutical Policy and Practice - April 16, 2019 Category: Pharmaceuticals Source Type: research

Chemotherapy in Combination With Immune Checkpoint Inhibitors for the First-Line Treatment of Patients With Advanced Non-small Cell Lung Cancer: A Systematic Review and Literature-Based Meta-Analysis
Alfredo Addeo1*, Giuseppe Luigi Banna2, Giulio Metro3 and Massimo Di Maio4 1Department of Oncology, University Hospital of Geneva, Geneva, Switzerland 2Division of Medical Oncology, Cannizzaro Hospital, Catania, Italy 3Medical Oncology, Santa Maria della Misericordia Hospital, Azienda Ospedaliera di Perugia, Perugia, Italy 4Department of Oncology, Ordine Mauriziano Hospital, University of Turin, Turin, Italy Background: Checkpoint inhibitors plus platinum-based chemotherapy have shown superiority compared to chemotherapy alone as first-line therapy in advanced non–small cell lung carcinoma (NSCLC). To ev...
Source: Frontiers in Oncology - April 16, 2019 Category: Cancer & Oncology Source Type: research

Myelodysplastic Syndrome-Associated SRSF2 Mutations Cause Splicing Changes by Altering Binding Motif Sequences
In this study, we characterized MDS-associated SRSF2 mutants (P95H, P95L, and P95R). We found that those mutants and wild-type SRSF2 proteins showed nuclear localization in HeLa cells. In vitro splicing reaction also revealed that mutant proteins associated with both precursor and spliced mRNAs, suggesting that the mutants directly participate in splicing. We established the human myeloid leukemia K562 cell lines that stably expressed myc-tagged wild-type or mutant SRSF2 proteins, and then performed RNA-sequence to analyze the splicing pattern of each cell line. The results revealed that both wild-type and mutants affected...
Source: Frontiers in Genetics - April 16, 2019 Category: Genetics & Stem Cells Source Type: research

Stakeholder driven development of a multi-criteria decision analysis tool for purchasing off-patent pharmaceuticals in Kuwait
ConclusionsA MCDA model was successfully adapted to the Kuwait decision context by a group of Kuwaiti pharmacists from a broad range of institutions. The participants agreed with the approach and considered it suitable to improve the transparency and consistency of decision making for off-patent pharmaceuticals in Kuwait. A pilot implementation project was proposed. (Source: Journal of Pharmaceutical Policy and Practice)
Source: Journal of Pharmaceutical Policy and Practice - April 16, 2019 Category: Pharmaceuticals Source Type: research

Frequency of Hemorrhage on Follow Up Imaging in Stroke Patients Treated With rt-PA Depending on Clinical Course
Johannes Schurig1,2*, Karl Georg Haeusler1,2,3, Ulrike Grittner4,5, Christian H. Nolte1,2, Jochen B. Fiebach1,2, Heinrich J. Audebert1,2, Matthias Endres1,2,5,6 and Andrea Rocco1,2 1Center for Stroke Research Berlin, Charité–Universitätsmedizin Berlin, Berlin, Germany 2Department of Neurology, Charité–Universitätsmedizin Berlin, Berlin, Germany 3Department of Neurology, Universitätsklinikum Würzburg, Würzburg, Germany 4Insitute of Biometry and Clinical Epidemiology, Charité – Universitätsmedizin Berlin, Berlin, Germany 5Berlin Institute of Heal...
Source: Frontiers in Neurology - April 16, 2019 Category: Neurology Source Type: research

Understanding Follicular Output Rate (FORT) and its Implications for POSEIDON Criteria
Michael Grynberg1,2,3,4* and Julie Labrosse2 1AP-HP, Department of Reproductive Medicine & Fertility Preservation, Hôpital Antoine Béclère, Clamart, France 2AP-HP, Department of Reproductive Medicine & Fertility Preservation, Hôpital Jean Verdier, Bondy, France 3INSERM U1185, University Paris-Sud, Le Kremlin-Bicêtre, France 4INSERM U1133, University Paris Diderot, Paris, France The management of low prognosis patients in ART represents a challenge for reproductive specialists. Different profiles and biologic characteristics have been identified among these patients. Inde...
Source: Frontiers in Endocrinology - April 16, 2019 Category: Endocrinology Source Type: research

Initial Trials With Susceptibility-Based and Empiric Anti-H. pylori Therapies in Mongolia
Conclusion: In Mongolia, the prevalence of H. pylori resistance is high requiring bismuth quadruple therapy or susceptibility-based therapy to obtain acceptable cure rates. Introduction As in most developing countries, the prevalence of Helicobacter pylori infection is high in Mongolia (Nyamdavaa, 2013) with reported prevalence ranging of 80% among adults (Matsuhisa et al., 2015; Khasag et al., 2018), 64% among adolescents, and 65 and 100% among pediatric patients with gastric comorbidity (Go, 2013). Gastric cancer is a common problem in Mongolia; an age-standardized rate of 33.1 per 100,000, which is the second hi...
Source: Frontiers in Pharmacology - April 16, 2019 Category: Drugs & Pharmacology Source Type: research

New Biomarkers for Atherothrombosis in Antiphospholipid Syndrome: Genomics and Epigenetics Approaches
Conclusions In recent years, there have been many advances in the understanding of the molecular basis for vascular involvement in APS, but many areas need to be further investigated, in particular the association between altered genetic/epigenetic profiles, autoantibodies and clinical manifestations, and the effectiveness of new therapeutic strategies. It would be interesting to apply next generation sequencing technologies like RNA-Seq along with GWAS to screen both, the gene profile and the whole transcriptome of large cohorts of primary APS patients, in order to reveal the mutations/polymorphisms, post-transcriptiona...
Source: Frontiers in Immunology - April 16, 2019 Category: Allergy & Immunology Source Type: research

Amerigen Pharm. Ltd. v. UCB Pharma GmbH ; United States Court of Appeals of the Federal Circuit, 2019 ; 913 F.3d 1076
Biotechnology Law Report,Volume 38, Issue 2, Page 116-121, April 2019. (Source: Biotechnology Law Report)
Source: Biotechnology Law Report - April 15, 2019 Category: Medical Law Source Type: research

Liraglutide-Induced Weight Loss May be Affected by Autonomic Regulation in Type 1 Diabetes
Conclusions: The overall CAN diagnosis was not associated with liraglutide-induced weight loss in overweight patients with type 1 diabetes. Assessed separately, better outcomes for several CAN measures were associated with higher weight loss, indicating that autonomic involvement in liraglutide-induced weight loss may exist. Introduction Glucagon-like peptide-1 (GLP-1) is a gut-derived hormone with anorexigenic properties (1). The GLP-1 receptor agonist (GLP-1RA) liraglutide is known to induce weight loss in patients with type 2 diabetes as well as in patients with type 1 diabetes (2–5). However, the exact me...
Source: Frontiers in Endocrinology - April 12, 2019 Category: Endocrinology Source Type: research

NPD-0414-2 and NPD-0414-24, Two Chemical Entities Designed as Aryl Hydrocarbon Receptor (AhR) Ligands, Inhibit Gut Inflammatory Signals
Irene Marafini1, Davide Di Fusco1, Vincenzo Dinallo1, Eleonora Franzè1, Carmine Stolfi1, Giuseppe Sica2, Giovanni Monteleone1 and Ivan Monteleone3* 1Department of Systems Medicine, Gastroenterology, University of Tor Vergata, Rome, Italy 2Department of Surgery, University of Tor Vergata, Rome, Italy 3Department of Biomedicine and Prevention, University of Tor Vergata, Rome, Italy Defects in counterregulatory mechanisms contribute to amplify the detrimental inflammatory response leading to the pathologic process occurring in the gut of patients with Crohn’s disease (CD) and ulcerative colitis (UC), ...
Source: Frontiers in Pharmacology - April 12, 2019 Category: Drugs & Pharmacology Source Type: research

The P2X7 Receptor Is Shed Into Circulation: Correlation With C-Reactive Protein Levels
Anna Lisa Giuliani1, Merhej Berchan1, Juana M. Sanz2, Angelina Passaro2, Stefano Pizzicotti3, Valentina Vultaggio-Poma1, Alba Clara Sarti1 and Francesco Di Virgilio1* 1Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy 2Medical Science Department, University of Ferrara, Ferrara, Italy 3Laboratory Division of the S. Anna Hospital, University of Ferrara, Ferrara, Italy The P2X7 receptor (P2X7R) is a key pro-inflammatory plasma membrane receptor responsible for NLRP3 inflammasome activation and IL-1β release. Various inflammatory plasma membrane receptors (e.g.,...
Source: Frontiers in Immunology - April 12, 2019 Category: Allergy & Immunology Source Type: research

Comparison of malaria treatment outcome of generic and innovator ’s anti-malarial drugs containing artemether–lumefantrine combination in the management of uncomplicated malaria amongst Tanzanian children
In 2006, artemether –lumefantrine (ALU), specifically Coartem® (Novartis Pharma AG, Basel Switzerland), was approved as the first-line drug for treatment of uncomplicated malaria in Tanzania. Due to poor availabil... (Source: Malaria Journal)
Source: Malaria Journal - April 11, 2019 Category: Infectious Diseases Authors: Manase Kilonzi, Omary Minzi, Ritah Mutagonda, Philip Sasi, Appolinary Kamuhabwa and Eleni Aklillu Tags: Research Source Type: research

The impact of external innovation on new drug approvals: A retrospective analysis
Publication date: 30 May 2019Source: International Journal of Pharmaceutics, Volume 563Author(s): Xiong Liu, Craig E. Thomas, Christian C. FelderAbstractPharmaceutical companies are relying more often on external sources of innovation to boost their discovery research productivity. However, more in-depth knowledge about how external innovation may translate to successful product launches is still required in order to better understand how to best leverage the innovation ecosystem. We analyzed the pre-approval publication histories for FDA-approved new molecular entities (NMEs) and new biologic entities (NBEs) launched by 1...
Source: International Journal of Pharmaceutics - April 10, 2019 Category: Drugs & Pharmacology Source Type: research

Compaction analysis and optimisation of convex-faced pharmaceutical tablets using numerical techniques
Publication date: Available online 10 April 2019Source: ParticuologyAuthor(s): Ahmad Baroutaji, Sandra Lenihan, Keith BryanAbstractCapping failure, edge chipping, and non-uniform mechanical properties of convex-faced pharmaceutical tablets are common problems in the pharma industry. In this paper, the finite element method (FEM) and design of experiment techniques are used to determine the optimal shape of convex-faced (CF) pharmaceutical tablet which has more uniform mechanical properties and less capping and chipping tendency. The effects of different geometrical parameters and friction on the compaction responses of con...
Source: Particuology - April 10, 2019 Category: Science Source Type: research

Novel Contribution of Secreted Amyloid- β Precursor Protein to White Matter Brain Enlargement in Autism Spectrum Disorder
Novel Contribution of Secreted Amyloid-β Precursor Protein to White Matter Brain Enlargement in Autism Spectrum Disorder Deborah K. Sokol1, Bryan Maloney2, Cara J. Westmark3 and Debomoy K. Lahiri2,4* 1Pediatrics Section, Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, United States2Indiana Alzheimers Disease Center, Department of Psychiatry, Stark Neuroscience Research Institute, Indiana University School of Medicine, Indianapolis, IN, United States3Department of Neurology, University of Wisconsin, Madison, WI, United States4Department of Medical and Molecular Genetics, Indiana Un...
Source: Frontiers in Psychiatry - April 10, 2019 Category: Psychiatry Source Type: research

Importance of Incorporating Protein Flexibility in Molecule Modeling: A Theoretical Study on Type I1/2 NIK Inhibitors
Conclusion An integrating computational case study, which involves molecule docking, MD simulations, ensemble docking, MM/GB(PB)SA binding free energy calculations and decompositions, has been conducted toward type I1/2 NIK inhibitors to further illuminate their binding mechanisms. As conventional RRD docking methods and IFD cannot well reflect the relative activity, ensemble docking by using MRCs is adopted and the docking result is largely improved, suggesting that protein flexibility is vitally important in type I1/2 inhibitors binding. Then, MD simulations combined with MM/GB(PB)SA binding free energy calculations are...
Source: Frontiers in Pharmacology - April 9, 2019 Category: Drugs & Pharmacology Source Type: research

The Number of Donor-Specific IL-21 Producing Cells Before and After Transplantation Predicts Kidney Graft Rejection
In conclusion, the number of donor-specific IL-21 pc is associated with an increased risk of both early and late rejection, giving it the potential to be a new biomarker in kidney transplantation. Introduction Interleukin (IL)-21 is a pro-inflammatory cytokine and is produced by several T lymphocytes, including CD4+, T follicular helper (Tfh) and T-helper 17 (Th17) cells (1, 2). Natural killer T cells (NKT) cells and CD8+ T cells can also produce IL-21 (3–5). IL-21 has a diverse effect on a broad range of immune cells. IL-21 drives T and B cell dependent responses. This pleiotropic cytokine is crucial for T ...
Source: Frontiers in Immunology - April 9, 2019 Category: Allergy & Immunology Source Type: research

Optimization of antibiotic selection in the emergency department for urine culture follow ups, a retrospective pre-post intervention study: clinical pharmacist efforts
ConclusionNo statistically significant difference was observed between pharmacist driven monitoring and NP driven monitoring. In our institution, asymptomatic bacteriuria was commonly treated even in the absence of indications. We recommend that Pharmacists ’ roles in the ED cultures follow up be expanded to include antibiotic discontinuation in patients who meet asymptomatic bacteriuria criteria or have confirmed negative urine culture. (Source: Journal of Pharmaceutical Policy and Practice)
Source: Journal of Pharmaceutical Policy and Practice - April 9, 2019 Category: Pharmaceuticals Source Type: research

US National Toxicology Program changes course
With a background in pharma and animal testing, Associate Director Brian Berridge seeks to build confidence in novel ways to test chemical hazards (Source: Chemical and Engineering News)
Source: Chemical and Engineering News - April 6, 2019 Category: Chemistry Authors: Britt E. Erickson Source Type: research

Sterling Pharma buys CiVentiChem site
(Source: Chemical and Engineering News)
Source: Chemical and Engineering News - April 5, 2019 Category: Chemistry Authors: Michael McCoy Source Type: research

Roxadustat Treatment of Chronic Kidney Disease-Associated Anemia in Japanese Patients Not on Dialysis: A Phase 2, Randomized, Double-Blind, Placebo-Controlled Trial
This study evaluated efficacy and safety/tolerability of roxadustat, an oral hypoxia-inducible factor prolyl hydroxylase inhibitor, in Japanese anemic non-dialysis-dependent chronic kidney disease (NDD-CKD) patients.MethodsIn this phase 2, double-blind, 24-week study, NDD-CKD patients were randomized to oral placebo or roxadustat (50, 70, or 100  mg) three times weekly (TIW) for 6 weeks followed by dose adjustments to maintain hemoglobin (Hb) at 10–12 g/dL for 18 weeks; patients meeting pre-defined criteria were re-randomized to TIW or once-weekly dosing. The primary end point was rate of rise of ...
Source: Advances in Therapy - April 5, 2019 Category: Drugs & Pharmacology Source Type: research

A Multicenter, Observational, Prospective Study of the Effectiveness of Switching from Budesonide/Formoterol Turbuhaler ® to Budesonide/Formoterol Easyhaler ®
AbstractIntroductionIn real-life practice, asthma remains poorly controlled, with a considerable burden on patients ’ quality of life. Budesonide/formoterol (B/F) Easyhaler® has demonstrated similar dose consistency, therapeutic equivalence, and equivalent bronchodilator efficacy to B/F Turbuhaler®, but no real-life comparisons are yet available in patients switching from B/F Turbuhaler® to B/F Easyhaler®.MethodsThe primary objective of this real-life, non-interventional, observational study was to show non-inferiority of asthma control when adult patients in Swedish primary care with persistent asthm...
Source: Advances in Therapy - April 2, 2019 Category: Drugs & Pharmacology Source Type: research

Integrating Osimertinib in Clinical Practice for Non-Small Cell Lung Cancer Treatment
AbstractTreatment of non-small cell lung cancer (NSCLC) is evolving with the use of precision medicine for patients with sensitizing epidermal growth factor receptor (EGFR) mutation. First- and second-generation EGFR tyrosine kinase inhibitors (TKIs) remained the standard of care for patients with EGFR-mutated advanced NSCLC for about a decade. However, treatment resistance eventually develops for most patients who experience initial response to these agents. The most commonly acquired resistance mechanism is the T790M gatekeeper mutation. Poor drug penetration leading to central nervous system (CNS) relapse and dose-limit...
Source: Advances in Therapy - April 2, 2019 Category: Drugs & Pharmacology Source Type: research

Real-World Study of Once-Daily, Extended-Release Tacrolimus Versus Twice-Daily, Immediate-Release Tacrolimus in Kidney Transplantation: Clinical Outcomes and Healthcare Resource Utilization
ConclusionReal-world clinical outcomes and healthcare resource utilization were similar with ER-T and IR-T. Larger studies will need to investigate the trend toward fewer BCAR events, and increased graft survival with ER-T.FundingAstellas Pharma Global Development, Inc.Plain Language SummaryPlain language summary available for this article. (Source: Advances in Therapy)
Source: Advances in Therapy - April 2, 2019 Category: Drugs & Pharmacology Source Type: research

Alexion signs immune-system development pacts with Affibody and Zealand Pharma
(Source: Chemical and Engineering News)
Source: Chemical and Engineering News - March 29, 2019 Category: Chemistry Authors: Ryan Cross Source Type: research

Investigating the association of proton pump inhibitors with chronic kidney disease and its impact on clinical practice and future research: a review
ConclusionsThe current evidence related to the potential association of CKD with PPI use remains inconclusive in establishing true causality. Further prospective studies including randomised controlled trials and cohort studies would be required to confirm the findings reported in this review and to draw any conclusions. (Source: Journal of Pharmaceutical Policy and Practice)
Source: Journal of Pharmaceutical Policy and Practice - March 29, 2019 Category: Pharmaceuticals Source Type: research