Pharma blockchains AI for drug development
Publication date: 15–21 June 2019Source: The Lancet, Volume 393, Issue 10189Author(s): Talha Burki (Source: The Lancet)
Source: The Lancet - June 14, 2019 Category: General Medicine Source Type: research

Artificial Intelligence for Pharma: Time for Internal Investment
Publication date: Available online 13 June 2019Source: Trends in Pharmacological SciencesAuthor(s): Peter V. HenstockArtificial intelligence (AI) has achieved human-level capabilities and continues to rapidly improve. For the pharmaceutical industry, AI can improve decision-making and transform the quest for better medicines. The keys are investing in data management and in internal AI talent who can create value by leveraging corporate data to tackle crucial business problems. (Source: Trends in Pharmacological Sciences)
Source: Trends in Pharmacological Sciences - June 14, 2019 Category: Drugs & Pharmacology Source Type: research

Pharmacovigilance systems in resource-limited settings: an evaluative case study of Sierra Leone
This study sought to assess the current status of pharmacovigilance in Sierra Leone since it became the 87th member of the World Health Organisation International Drug Monitoring Programme. This study evaluated the pharmacovigilance system in Sierra Leone through a comprehensive and system-based approach that covered the national medicines regulatory authority, health facilities and public health programmes. A descriptive cross-sectional study design was employed. Using a convenience sampling method, 14 respondents from the national medicines regulatory authority, six health facilities and six public health programmes were...
Source: Journal of Pharmaceutical Policy and Practice - June 11, 2019 Category: Pharmaceuticals Source Type: research

Short-Term Cost-Effectiveness of Switching to Insulin Degludec in Japanese Patients with Type 2 Diabetes Receiving Basal –Bolus Therapy
ConclusionBased on Japanese real-world evidence, our analysis suggests that switching Japanese patients with T2D receiving a basal –bolus regimen from their previous basal insulin to degludec would be highly cost-effective. These data may help decision-makers in Japan allocate healthcare resources efficiently.Trial RegistrationThe KIDUNA study is registered with the University Hospital Medical Information Network Clinical Trials Registry (UMIN-CTR): UMIN000021569.FundingNovo Nordisk Pharma Ltd. Japan. (Source: Diabetes Therapy)
Source: Diabetes Therapy - June 5, 2019 Category: Endocrinology Source Type: research

Access to and use of medicines in the Annapurna region of Western Nepal and possible impacting factors
This study investigates access to and use of medicines through health facility and household-based studies using standardised tools and through a series of structured key informant interviews with various stakeholders in health.Overall, access to essential medicines at public health facilities was good, but this was not benefitting households as much as it should. People were using the private sector for medicines because of their perception about the quality and limited numbers  of government-supplied free medicines. They utilised money from remittances and tourism, and subsidised healthcare from non-government organ...
Source: Journal of Pharmaceutical Policy and Practice - June 4, 2019 Category: Pharmaceuticals Source Type: research

Physicians in the pharmaceutical industry: their roles, motivations, and perspectives.
Abstract Although physicians occupy a significant number of key positions in the pharmaceutical industry, practicing clinicians are often unaware of the variety of career paths within this industry, or of the structure of a pharmaceutical company. Here, we address questions that practicing clinicians frequently ask their colleagues in the pharmaceutical industry. In addition to providing an overview of the common roles occupied by physicians in pharma, we also describe the various motivations for transitioning into the industry and discuss different scenarios regarding the timing of the career change. Furthermore,...
Source: Drug Discovery Today - May 31, 2019 Category: Drugs & Pharmacology Authors: Sweiti H, Wiegand F, Bug C, Vogel M, Lavie F, Winiger-Candolfi I, Schuier M Tags: Drug Discov Today Source Type: research

A predictive policy model to forecast outcomes of drug development in developing countries
International Journal of Health Governance, Ahead of Print. Purpose The World Health Organization has pointed out that the majority of developing countries currently rely on imported drugs, in spite of the fact that there is potential for them to produce their own drugs. The purpose of this paper is to present a framework as an innovation policy model that can strategically predict the outcome of drug development investment in developing countries. Design/methodology/approach In order to explore a model relevant to the policy-making process, the literature was systematically reviewed with a focus on the impact of policy ch...
Source: International Journal of Health Governance - May 31, 2019 Category: International Medicine & Public Health Source Type: research

WHO Drug Pricing Talks May Fail to End Secrecy, Activists Fear
GENEVA (Reuters)—Governments are working on a drug pricing transparency deal at the World Health Organization's (WHO) annual assembly, but activists said on Thursday they fear crucial costs may be left out, enabling pharmaceutical firms to keep prices high. Campaigners say some drugs are exhorbitantly priced, even though they are often developed with public funding, and... [Read More] (Source: The Rheumatologist)
Source: The Rheumatologist - May 27, 2019 Category: Rheumatology Authors: Tom Miles Tags: Drug Updates Pharma Co. News drug pricing transparency drug pricing transparency deal pharmaceutical industry World Health Organization (WHO) Source Type: research

Ligand Potency, Efficiency and Drug-likeness: A Story of Intuition, Misinterpretation and Serendipity.
Abstract The concept of ligand potency is briefly discussed here as well as why this is still a challenge for its complete comprehension. In this context, we explain also the meaning of ligand efficiency (LE), which has been greeted with both enthusiasm and criticism among the drug design audience. A full understanding of LE requires the complex interpretation of the potency concept presenting the uncertainty similar to this of the Zeno paradox. In reality, the efficiency of LE is caused by the high degree of preference for slim pharma drug candidates. PMID: 31131749 [PubMed - as supplied by publisher] (Sourc...
Source: Current Protein and Peptide Science - May 26, 2019 Category: Biochemistry Authors: Polanski J, Pedrys A, Duszkiewicz R, Kucia U Tags: Curr Protein Pept Sci Source Type: research

Pharmacy ‐based interdisciplinary intervention for patients with chronic heart failure: results of the PHARM‐CHF randomized controlled trial
ConclusionPharmacy care safely improved adherence to heart failure medications and quality of life. (Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - May 25, 2019 Category: Cardiology Authors: Martin Schulz, Nina Griese ‐Mammen, Stefan D. Anker, Friedrich Koehler, Peter Ihle, Christian Ruckes, Pia M. Schumacher, Dietmar Trenk, Michael Böhm, Ulrich Laufs, for the PHARM‐CHF investigators, S. von Haehling, H. Bechtold, S. Genth Tags: Research Article Source Type: research

Polymerase Chain Reaction Versus Blood Culture to Detect Candida Species in High-Risk Patients with Suspected Invasive Candidiasis: The MICAFEM Study
ConclusionThe sensitivity of serum PCR forCandida detection was low and the rate of concordance was low between serum PCR and the other diagnostic techniques used to identifyCandida infections. Hospital-based diagnostic tests need optimising to improve outcomes in patients with suspected invasive candidiasis.FundingAstellas Pharma Inc. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - May 24, 2019 Category: Infectious Diseases Source Type: research

Comparison of [ 18F]D3FSP([18F]P16-129) and [18F] AV45 in Alzheimers Disease
Conclusions: In this small sample of 6 AD subjects, there were no substantial differences between [18F]D3FSP vs. [18F]AV45 but, 50% of the subjects did have slightly higher global cortical SUVR with [18F]D3FSP vs. [18F]AV45. Although all had a clinical diagnosis of AD, some of the subjects had only moderate quantitative uptake using the [18F]AV45 criteria. Visual inspection suggests [18F]D3FSP vs. [18F]AV45 may have some subtle differences in clinical readings and there may be quantitative differences in some individual cases but a larger population is needed with more severe patients before concluding the potential improv...
Source: Journal of Nuclear Medicine - May 21, 2019 Category: Nuclear Medicine Authors: Wong, D., Kuwabara, H., Kitzmiller, K., Nandi, A., Brinson, Z., George, N., Alexoff, D., Brasic, J., Fan, H., Holt, D., Gapasin, L., Roberts, J., Lesniak, W., Ye, W., Zhou, Y., Dannals, R., Kung, H. Tags: Neurology & amp; Psychiatry Imaging Posters Source Type: research

18F-FDG PET/CT assess tumor response in Chinese patients with relapsed/refractory classical Hodgkin lymphoma treated by novel Programmed Death-1 (PD-1) Inhibitors, Tislelizumab or Camrelizumab
Conclusions: Tislelizumab or Camrelizumab could be a new treatment option for patients with relapsed or refractory classical Hodgkin lymphoma in China. Three-month 18F-FDG PET/CT scans detected HL patients responding to anti-PD1. New patterns were encountered in 15% of patients, emphasizing the need for further evaluation in larger series and close collaboration between imaging and oncology specialists on a per-patient basis. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 21, 2019 Category: Nuclear Medicine Authors: Wang, X. Tags: Lymphoma / Leukemia / Myeloma Posters Source Type: research

Initial evaluation of the PSMA-targeted PET agent [68Ga]Ga-P16-093, and comparison with [68Ga]Ga-PSMA-11, in prostate cancer patients presenting with biochemical recurrence.
Conclusions: In this initial assessment, the [68Ga]Ga-P16-093 radiopharmaceutical appears at least equivalent to [68Ga]Ga-PSMA-11 for PET detection of the site of prostate cancer recurrence. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 21, 2019 Category: Nuclear Medicine Authors: Green, M., Hutchins, G., Fletcher, J., Bahler, C., Tann, M., Sims, J., Mathias, C., Territo, W., Polson, H., Alexoff, D., Kung, H. Tags: Oncology, Basic and Translational - PSMA based agents Source Type: research

Current status and future prospects of pharmacovigilance in Pakistan
AbstractCountries all around the globe are working to establish robust pharmacovigilance systems. Whereas the majority of the developed countries have established well-organized pharmacovigilance systems, the developing countries still lack the basic infrastructure to establish such systems. This commentary focuses on the need of pharmacovigilance and its current status and future trends in Pakistan. (Source: Journal of Pharmaceutical Policy and Practice)
Source: Journal of Pharmaceutical Policy and Practice - May 21, 2019 Category: Pharmaceuticals Source Type: research

The Antimicrobial and Wound Healing Potential of Opuntia ficus indica L. inermis Extracted Oil from Tunisia.
Conclusion: OFI extracted oil has in vitro antimicrobial/fungal properties and in vivo wound healing activity. It seems to be efficient in the treatment of cutaneous infections and the promoting of the scarring process. PMID: 31097975 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - May 18, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Real-World Outcomes with Lomitapide Use in Paediatric Patients with Homozygous Familial Hypercholesterolaemia
ConclusionsLomitapide demonstrated promising effectiveness in paediatric HoFH patients. Adverse events were manageable, and the clinical profile of the drug is apparently similar to that in adult patients.FundingAmryt Pharma. (Source: Advances in Therapy)
Source: Advances in Therapy - May 17, 2019 Category: Drugs & Pharmacology Source Type: research

Peficitinib: First Global Approval
This article summarizes the milestones in the development of peficitinib leading to this first approval as a treatment for rheumatoid arthritis in patients who have an inadequate response to conventional therapies. (Source: Drugs)
Source: Drugs - May 15, 2019 Category: Drugs & Pharmacology Source Type: research

ASCPT Annual Meeting Pre ‐conferences
This article is protected by copyright. All rights reserved. (Source: CPT: Pharmacometrics and Systems Pharmacology)
Source: CPT: Pharmacometrics and Systems Pharmacology - May 14, 2019 Category: Drugs & Pharmacology Authors: Jane PF Bai, Cynthia J. Musante, Suzana Petanceska, Lei Zhang, Liang Zhao, Ping Zhao Tags: Editorial Source Type: research

Hypertension control among euvolemic hypertensive hemodialysis patients in Malaysia: a prospective follow-up study
This study included 145 euvolemic eligible hypertensive patients. Various sociodemographic, clinical factors and drugs were investigated and analyzed by using appropriate statistical methods to determine the factors influencing hypertension control among the study participants.ResultsOn baseline visit, the mean pre-dialysis systolic and diastolic BP (mmHg) of study participants was 161.2  ± 24. and 79.21 ± 11.8 retrospectively, and 30 (20.6%) patients were on pre-dialysis goal BP. At the end of the 6-months follow-up, the mean pre-dialysis systolic BP and diastolic BP (mmHg) of the...
Source: Journal of Pharmaceutical Policy and Practice - May 14, 2019 Category: Pharmaceuticals Source Type: research

Trump Slams Drugmakers, Vows to Let U.S. States Buy Cheaper Medicines Abroad
WASHINGTON (Reuters)—U.S. President Donald Trump slammed the pharmaceutical industry for high prices of prescription drugs on Thursday and vowed to allow U.S. states to buy medicines from other countries if they cost less. Trump, who campaigned on a platform to reduce drug prices for U.S. consumers, has taken few concrete steps to lower medication costs... [Read More] (Source: The Rheumatologist)
Source: The Rheumatologist - May 9, 2019 Category: Rheumatology Authors: Reuters Staff Tags: Drug Updates Pharma Co. News buying drugs abroad high drug prices pharmaceutical industry Trump administration Source Type: research

U.S. to Require Drugmakers to Show Prices in TV Ads
(Reuters)—U.S. Centers for Medicare & Medicaid Services on Wednesday said it will require drugmakers to disclose the list price for their prescription drugs in direct-to-consumer television advertisements, part of the Trump administration’s efforts to lower costs for U.S. consumers. The list price should be included if it is equal to or greater than $35 for... [Read More] (Source: The Rheumatologist)
Source: The Rheumatologist - May 9, 2019 Category: Rheumatology Authors: Reuters Staff Tags: Drug Updates Pharma Co. News drug price disclosure President Donald Trump's blueprint television advertisements U.S. Centers for Medicare & Medicaid Services Source Type: research

US obtains first criminal conviction of a pharma CEO over opioid doctor kickbacks
(Source: BMJ News)
Source: BMJ News - May 8, 2019 Category: General Medicine Source Type: research

World Pharma Pricing and Market Access Congress - 11th Terrapinn Congress (March 19-20, 2019 - Amsterdam, the Netherlands).
Authors: Barkan J Abstract The 11th World Pharma Pricing and Market Access Congress 2019, organized by Terrapinn and held in Amsterdam, the Netherlands, brought together speakers and delegates from across the Globe, and enabled discussions surrounding market access, pricing, value and evidence generation. There was a focus on developments in rare diseases and advanced therapies, with emphasis on the growing importance of digital health and big data to generate results and manage real-world evidence (RWE). The conference was divided into both keynote plenaries and six parallel-running tracks, with deliberations conc...
Source: Drugs of Today - May 7, 2019 Category: Drugs & Pharmacology Tags: Drugs Today (Barc) Source Type: research

Rationing for medicines by health care providers in Indonesia National Health Insurance System at hospital setting: a qualitative study
ConclusionsAlthough rationing strategies were facilitating the implementation of National Formulary, they potentially raise problems related to the principles of medical ethics and distort a national health system ’s ability to progress towards UHC. If performed in the more standardized decision-making process, rationing would be of great benefits to patients and the system. Guidance for more explicit, fair and transparent of rationing should be developed at the hospital level. (Source: Journal of Pharmaceutical Policy and Practice)
Source: Journal of Pharmaceutical Policy and Practice - May 7, 2019 Category: Pharmaceuticals Source Type: research

Current Clinical Trials in Pemphigus and Pemphigoid
Conclusions The clinical trials discussed here, which include several trials investigating novel therapeutic targets, demonstrate that translational research in pemphigus and pemphigoid is a fast-growing field. We thus expect that several novel treatments will be shortly available for the treatment of pemphigus and pemphigoid patients. Given the high, and thus far unmet, medical need in this field (110), this is highly encouraging and will hopefully improve the quality of life of the affected patients. In addition to the compounds and targets described here, several new targets have been recently identified in preclinical...
Source: Frontiers in Immunology - May 3, 2019 Category: Allergy & Immunology Source Type: research

Evaluation of Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) for Poorly Water-Soluble Talinolol: Preparation, in vitro and in vivo Assessment
Conclusion: Talinolol loaded SNEDDS formulations could be a potential oral pharmaceutical product with high drug-loading capacity, improved drug dissolution, increased gut permeation, reduced/no human RBC toxicity, and enhanced oral bioavailability. GRAPHICAL ABSTRACT Graphical Abstract. Self-nanoemulsifying drug delivery systems (SNEDDS) of talinolol (TAL) were developed using lipid formulation classification systems (LFCS) that improved the solubility and released the drug completely in dissolution media. In vitro toxicity studies with human red blood cells (RBC) showed that the SNEDDS formulations were n...
Source: Frontiers in Pharmacology - May 3, 2019 Category: Drugs & Pharmacology Source Type: research

Schizophrenia and Hereditary Polyneuropathy: PMP22 Deletion as a Common Pathophysiological Link?
Conclusion: There may be an association between schizophrenia and HNPP. In observational studies, the deletion of interest (chromosome 17p12) was nearly 10 times more common in schizophreniform patients than in controls. This potential association could be pathophysiologically explained by the role of PMP22, which is mainly expressed in the peripheral nervous system. However, PMP22 mRNA and protein can also be found in the brain. PMP22 seems to play an important role in regulating cell growth and myelination, functions that are disturbed in schizophrenia. Such a connection obviously cannot be clarified on the basis of one ...
Source: Frontiers in Psychiatry - May 2, 2019 Category: Psychiatry Source Type: research

Safety and Efficacy of Anti-PD-1 Monoclonal Antibodies in Patients With Relapsed or Refractory Lymphoma: A Meta-Analysis of Prospective Clinic Trails
Hui Zhou, Xiaoyan Fu, Qian Li and Ting Niu* Department of Hematology and Research Laboratory of Hematology, West China Hospital, Sichuan University, Chengdu, China Background: Immune checkpoint inhibition therapy with monoclonal antibody against programmed cell death protein 1 (PD-1), including nivolumab and pembrolizumab, has demonstrated powerful clinical efficacy in the treatment of advanced cancers. However, there is no evidence-based systematic review on the safety and efficacy of anti-PD-1 antibody in treating lymphoma. Methods: To evaluate the safety and efficacy of nivolumab/pembrolizumab, we analyzed clin...
Source: Frontiers in Pharmacology - May 1, 2019 Category: Drugs & Pharmacology Source Type: research

Rare Functional Variants in Complement Genes and Anti-FH Autoantibodies-Associated aHUS
In conclusion, we have confirmed in our cohort of patients, the strong association between FHR1 deficiency and aHUS with anti-FH autoantibodies. Through an innovative approach based on the comparison with “supercontrols” carrying the homozygous CFHR1 deletion, identified by screening a large number of healthy adult subjects, we have documented that patients with anti-FHs aHUS are enriched in complement gene LPVs. This observation indicates that the pathogenesis of anti-FHs aHUS is complex and multiple “hits” are required for its clinical manifestation. We also document that the CFH H3 and the CD46GG...
Source: Frontiers in Immunology - May 1, 2019 Category: Allergy & Immunology Source Type: research

Genetic Counseling in Huntington's Disease: Potential New Challenges on Horizon?
Conclusion and Recommendations In this review we attempt to summarize current knowledge about the HD mutation and how information about CAG repeats in the HTT gene can be used to provide sound genetic counseling, which can possibly extend to other neurodegenerative diseases (44). By involving families in observational (i.e., ENROLL-HD platform) and interventional trials, clinicians have an opportunity to include adult patients and their relatives (e.g., partners, symptomatic minors, premanifest adults) in research-based networks that provide current knowledge about developments in genetic testing and novel therapies in HD...
Source: Frontiers in Neurology - April 30, 2019 Category: Neurology Source Type: research

Oligonucleotide Microarrays Identified Potential Regulatory Genes Related to Early Outward Arterial Remodeling Induced by Tissue Plasminogen Activator
Olga Plekhanova1,2*, Yelena Parfyonova1,2, Irina Beloglazova1,2, Bradford C. Berk3 and Vsevolod Tkachuk1,2 1Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia 2National Medical Research Center of Cardiology, Moscow, Russia 3Aab Cardiovascular Research Institute, University of Rochester Medical Center, Rochester, NY, United States Constrictive vascular remodeling limiting blood flow, as well as compensatory outward remodeling, has been observed in many cardiovascular diseases; however, the underlying mechanisms regulating the remodeling response of the vessels remain unclear. Plasminogen acti...
Source: Frontiers in Physiology - April 30, 2019 Category: Physiology Source Type: research

Effect of ultra-short-term treatment of patients with iron deficiency or anaemia undergoing cardiac surgery: a prospective randomised trial
This study assessed whether immediate preoperative treatment could result in reduced perioperative red blood cell (RBC) transfusions and improved outcome.MethodsIn this single-centre, randomised, double-blind, parallel-group controlled study, patients undergoing elective cardiac surgery with anaemia (n=253; haemoglobin concentration (Hb)
Source: The Lancet - April 27, 2019 Category: General Medicine Source Type: research

Powered by Open Innovation: Opportunities and Challenges in the Pharma Sector
AbstractThe value of innovation in medicines is clear. Despite all of the progress in the twenty-first century, there are still many unmet medical needs and opportunities to improve healthcare. The challenges for pharmaceutical companies include ways in which to stay competitive and flexible in an environment of constant knowledge growth and increasingly sophisticated technologies, and ways to generate sufficient revenues to sustain their own growth. To that end, pharmaceutical companies are compelled to adapt different business models in the face of new challenges. The industry is plagued with long research and developmen...
Source: Pharmaceutical Medicine - April 26, 2019 Category: Drugs & Pharmacology Source Type: research

Radiomics Signature on Computed Tomography Imaging: Association With Lymph Node Metastasis in Patients With Gastric Cancer
Conclusions: The newly developed radiomic signature was a powerful predictor of LN metastasis and the radiomics nomogram could facilitate the preoperative individualized prediction of LN status. Introduction Gastric cancer (GC) is one of the most common malignant tumors and the second leading cause of cancer-related deaths worldwide (1). Accurate evaluation of lymph node metastasis (LNM) status in GC patients is vital for prognosis and treatment decisions (2–4). Some histopathologic factors and biomarkers (e.g., lymphatic invasion, matrix metalloproteinase-2) are found to be able to predict LNM in GC, but mos...
Source: Frontiers in Oncology - April 26, 2019 Category: Cancer & Oncology Source Type: research

Endometrial Tumor Microenvironment Alters Human NK Cell Recruitment, and Resident NK Cell Phenotype and Function
Clara Degos1, Mellie Heinemann2, Julien Barrou2, Nicolas Boucherit1, Eric Lambaudie2, Ariel Savina3†, Laurent Gorvel1* and Daniel Olive1* 1Tumor Immunology Team, IBISA Immunomonitoring Platform, Cancer Research Center of Marseillle, INSERM U1068, CNRS U7258, Institut Paoli-Calmettes, Aix-Marseille University, Marseille, France 2Department of Surgical Oncology 2, CNRS, INSERM, Institut Paoli-Calmettes, CRCM, Aix-Marseille University, Marseille, France 3Institut Roche, Boulogne Billancourt, France Endometrial Cancer is the most common cancer in the female genital tract in developed countries, and with its ...
Source: Frontiers in Immunology - April 26, 2019 Category: Allergy & Immunology Source Type: research

BDNF Actions in the Cardiovascular System: Roles in Development, Adulthood and Response to Injury
This study also identified the cardiac myocyte as a significant local source of BDNF, as cardiac myocyte-specific deletion of BDNF induced a similar cardiomyopathy phenotype. While these results do not exclude a role for other neurotrophins, particularly in injury states, they point to the requirement for continued, local synthesis of BDNF to maintain optimal cardiac function. A major, unresolved question relates to how the truncated TrkB isoform (TrkBT1) transduces the inotropic effects of BDNF, which will require additional study. A concurrent study evaluated the potential impact of the BDNF-mediated activation of the k...
Source: Frontiers in Physiology - April 26, 2019 Category: Physiology Source Type: research

A Symphytum officinale Root Extract Exerts Anti-inflammatory Properties by Affecting Two Distinct Steps of NF- κB Signaling
A Symphytum officinale Root Extract Exerts Anti-inflammatory Properties by Affecting Two Distinct Steps of NF-κB Signaling Jacqueline Seigner1, Marc Junker-Samek2, Alberto Plaza2, Gilda D‘Urso3, Milena Masullo3, Sonia Piacente3, Yvonne M. Holper-Schichl4*† and Rainer de Martin1*† 1Department of Vascular Biology, Medical University of Vienna, Vienna, Austria 2R&D, Procter & Gamble Health, Darmstadt, Germany 3Dipartimento di Farmacia, Università degli Studi di Salerno, Salerno, Italy 4Drehm Pharma GmbH, Vienna, Austria Symphytum officinale, commonly known as comfrey, const...
Source: Frontiers in Pharmacology - April 26, 2019 Category: Drugs & Pharmacology Source Type: research

Neoadjuvant Chemotherapy Alters Neuropilin-1, PlGF, and SNAI1 Expression Levels and Predicts Breast Cancer Patients Response
In this report, we are adding an extra finding, in which we show that the levels of circulating NRP-1 were significantly increased in patients who received NAC and had a partial response. Assessing patients who underwent NAC indicated that the levels of NRP-1 measured post-NAC were significantly higher in younger patients and patients with either a low or a medium body mass index (BMI), as well as in patients who remained with larger tumor size and partial response. Previously, we showed that SNAI1 expression in the immune cells collected from the peripheral blood of breast cancer patients was significantly higher in patie...
Source: Frontiers in Oncology - April 25, 2019 Category: Cancer & Oncology Source Type: research

Systemic Lupus Erythematosus With Isolated Psychiatric Symptoms and Antinuclear Antibody Detection in the Cerebrospinal Fluid
Conclusion: Some patients with psychiatric syndromes and increased ANA titers may suffer from psychiatric variants of SLE, even if the American College of Rheumatology criteria for SLE are not met. Whether the psychiatric symptoms in our patient represent a prodromal stage with the later manifestation of full-blown SLE or a subtype of SLE with isolated CNS involvement remains unclear. Regardless, early diagnosis and initiation of immunosuppressive treatment are essential steps in preventing further disease progression and organ damage. Intrathecal ANAs with extractable nuclear antigen differentiation may be a more sensitiv...
Source: Frontiers in Psychiatry - April 25, 2019 Category: Psychiatry Source Type: research

Beta Amyloid Deposition Is Not Associated With Cognitive Impairment in Parkinson's Disease
Beta Amyloid Deposition Is Not Associated With Cognitive Impairment in Parkinson's Disease Tracy R. Melzer1,2,3†, Megan R. Stark1,2†, Ross J. Keenan1,4, Daniel J. Myall1, Michael R. MacAskill1,2, Toni L. Pitcher1,2,3, Leslie Livingston1,2, Sophie Grenfell1, Kyla-Louise Horne1,2, Bob N. Young1, Maddie J. Pascoe1, Mustafa M. Almuqbel1,2,4, Jian Wang5, Steven H. Marsh6, David H. Miller1,2,7, John C. Dalrymple-Alford1,2,3,8 and Tim J. Anderson1,2,3,9* 1New Zealand Brain Research Institute, Christchurch, New Zealand 2Department of Medicine, University of Otago, Christchurch, New Zealand 3Brain Rese...
Source: Frontiers in Neurology - April 24, 2019 Category: Neurology Source Type: research

Ability to Suppress TGF- β-Activated Myofibroblast Differentiation Distinguishes the Anti-pulmonary Fibrosis Efficacy of Two Danshen-Containing Chinese Herbal Medicine Prescriptions
Conclusion: This study suggests that a clinically efficacious cardiovascular Chinese herbal medicine (DLP) can be successfully repurposed to treat a lung disease in pulmonary fibrosis guided by TCM theory. Our comparative study between DLP and DHP demonstrated a critical requirement of suppressing both pro-inflammatory and pro-fibrotic pathways for the treatment of pulmonary fibrosis, supporting that a multi-component prescription capable of “removing both phlegm and blood stasis” will better achieve co-protection of heart and lung in PHD. Introduction Idiopathic pulmonary fibrosis (IPF) is a chronic an...
Source: Frontiers in Pharmacology - April 24, 2019 Category: Drugs & Pharmacology Source Type: research

Oligonucleotides —A Novel Promising Therapeutic Option for IBD
This study showed a good safety and tolerability profile of the studied substance (Monteleone et al., 2012). Since TGFβ has been described to induce the profibrogenetic response of fibroblasts, patients were monitored for 6 months with intestinal ultrasonography, not showing signs of intestinal stenosis. Moreover, half of the patients maintained remission during the 6 months follow up period (Zorzi et al., 2012). Afterwards, a randomized, double-blind, phase 2 study was conducted in CD patients with inflammatory lesions in the terminal ileum and/or right colon, with steroid-dependence/resistance, randomized to three ...
Source: Frontiers in Pharmacology - April 24, 2019 Category: Drugs & Pharmacology Source Type: research

The Analysis of Key Factors Related to ADCs Structural Design
Conclusion and Perspective With in-depth understandings of antibodies, linkers, and payloads, ADCs have also achieved great development. The linkage strategy and target diversity have already improved the delivery of the payloads to tumor tissues and reduced exposure to normal tissues. With the development of payloads, some novel potent payloads are used by ADCs, which allows researchers to exploit novel linkers to attach the antibody and payloads without disturbing their potency (Dragovich et al., 2018). Furthermore, some irrelevant antigen-target ADCs also may exert toxicity to tumor cells due to the vascular gap of tum...
Source: Frontiers in Pharmacology - April 24, 2019 Category: Drugs & Pharmacology Source Type: research

Rescued from a war zone, an Iraqi chemist finds a future in pharma
A scholarship led Firas Jumaah to graduate studies at Lund University, which then saved him and his family from Islamic State militants (Source: Chemical and Engineering News)
Source: Chemical and Engineering News - April 21, 2019 Category: Chemistry Authors: Alla Katsnelson, special to C & amp;EN Source Type: research

The Association of Tacrolimus Formulation Switching with Trough Concentration Variability: A Retrospective Cohort Study of Tacrolimus Use Post-Kidney Transplantation Based on National Drug Code (NDC) Numbers
ConclusionA variable tacrolimus formulation regimen was associated with a higher frequency of trough level measurements and a greater number of excursions in trough levels compared with continuing on a fixed formulation regimen of tacrolimus in this retrospective chart review study.FundingAstellas Pharma Global Development, Inc.Plain Language SummaryPlain language summary available for this article. (Source: Advances in Therapy)
Source: Advances in Therapy - April 19, 2019 Category: Drugs & Pharmacology Source Type: research

Impact of Hepatitis Virus on the Feasibility and Efficacy of Anticancer Agents in Patients With Hepatocellular Carcinoma in Phase I Clinical Trials
This study was approved by the NCCH institutional review board and performed in compliance with our institutional guidelines. Patients positive for anti-HCV antibody or HBV antigen (HBsAg) were considered to have HCC due to chronic viral hepatitis, whereas those without anti-HCV antibody nor HBsAg were considered to have HCC by another etiology (non-B/non-C). All medical records were reviewed to summarize the patients' clinical characteristics, treatments, and outcomes based on the status of chronic viral hepatitis. The baseline clinical characteristics included age, gender, ECOG-performance status (PS), treatmen...
Source: Frontiers in Oncology - April 18, 2019 Category: Cancer & Oncology Source Type: research