Sale of WHO AWaRe groups antibiotics without a prescription in Pakistan: a simulated client study
ConclusionCurrently, antibiotics are easily acquired without a legitimate prescription in Pakistan. There is a need for strict adherence to regulations combined with a multi-dimensional approach to enhance appropriate dispensing of antibiotics and limit any dispensing of WHO restricted antibiotics without a prescription. (Source: Journal of Pharmaceutical Policy and Practice)
Source: Journal of Pharmaceutical Policy and Practice - August 3, 2020 Category: Pharmaceuticals Source Type: research

Molecules, Vol. 25, Pages 3510: In Silico Study Identified Methotrexate Analog as Potential Inhibitor of Drug Resistant Human Dihydrofolate Reductase for Cancer Therapeutics
In conclusion, we report on an MTX analog which is capable of inhibiting hDHFR in wild type form, as well as in cases where the enzyme acquires resistance to drugs during chemotherapy treatment. (Source: Molecules)
Source: Molecules - July 31, 2020 Category: Chemistry Authors: Rabia Mukhtar Rana Shailima Rampogu Noman Bin Abid Amir Zeb Shraddha Parate Gihwan Lee Sanghwa Yoon Yumi Kim Donghwan Kim Keun Woo Lee Tags: Article Source Type: research

Digital Pharmaceutical Sciences.
Abstract Artificial intelligence (AI) and machine learning, in particular, have gained significant interest in many fields, including pharmaceutical sciences. The enormous growth of data from several sources, the recent advances in various analytical tools, and the continuous developments in machine learning algorithms have resulted in a rapid increase in new machine learning applications in different areas of pharmaceutical sciences. This review summarizes the past, present, and potential future impacts of machine learning technologies on different areas of pharmaceutical sciences, including drug design and disco...
Source: AAPS PharmSciTech - July 26, 2020 Category: Drugs & Pharmacology Authors: Damiati SA Tags: AAPS PharmSciTech Source Type: research

COVID-19 therapeutics: how to sow confusion and break public trust during international  public health emergencies
AbstractSince SARS-CoV2 was declared aPublic Health Emergency of International Concern, those tasked with the stewardship of public health at a global, regional, and local level —policymakers, politicians, scientists, drug regulators, health officials, professional associations, journal editors, publishers, and clinicians—have displayed rushed decisions and lapses in judgment in their handling of chloroquine and hydroxychloroquine as potential COVID-19 therapeutics and prophylactics. These lapses merit noting as they hold lessons for how the guardians of medicines regulation and public health can inadvertently ...
Source: Journal of Pharmaceutical Policy and Practice - July 24, 2020 Category: Pharmaceuticals Source Type: research

Treatment outcomes of extrapulmonary tuberculosis in Bahawalpur, Pakistan; a record review
ConclusionThe treatment success (favorable outcome) rate among EPTB patients was less than the target (i.e., ≥ 90%) set by the WHO. Highest proportion of patients lost to follow-up during the treatment. (Source: Journal of Pharmaceutical Policy and Practice)
Source: Journal of Pharmaceutical Policy and Practice - July 24, 2020 Category: Pharmaceuticals Source Type: research

Ustilago maydis Serves as a Novel Production Host for the Synthesis of Plant and Fungal Sesquiterpenoids
Sesquiterpenoids are important secondary metabolites with various pharma- and nutraceutical properties. In particular, higher basidiomycetes possess a versatile biosynthetic repertoire for these bioactive compounds. To date, only a few microbial production systems for fungal sesquiterpenoids have been established. Here, we introduce Ustilago maydis as a novel production host. This model fungus is a close relative of higher basidiomycetes. It offers the advantage of metabolic compatibility and potential tolerance for substances toxic to other microorganisms. We successfully implemented a heterologous pathway to produce the ...
Source: Frontiers in Microbiology - July 24, 2020 Category: Microbiology Source Type: research

The impact of pharmacist/physician care on quality of life in elderly heart failure patients: results of the PHARM ‐CHF randomized controlled trial
ConclusionsA pharmacy ‐based interdisciplinary intervention was well received by the patients and suggests clinically important improvements in QoL. (Source: ESC Heart Failure)
Source: ESC Heart Failure - July 23, 2020 Category: Cardiology Authors: Martin Schulz, Nina Griese ‐Mammen, Pia M. Schumacher, Stefan D. Anker, Friedrich Koehler, Christian Ruckes, Volker Rettig‐Ewen, Rolf Wachter, Dietmar Trenk, Michael Böhm, Ulrich Laufs Tags: Original Research Article Source Type: research

The NIMH ‘Fast-Fail Trials’ (FAST) Initiative: Rationale, Promise, and Progress
AbstractIn 2012, the US National Institute of Mental Health launched three clinical trial contracts under a new FAST initiative. The overall goal for these contracts (Fast-Fail Trials) was to focus early-stage trials, testing novel pharmacologic agents that target the central nervous system, on pharmacologic-based designs to objectively identify doses that produce central nervous system effects. The three contracts targeted different psychiatric populations: psychotic (FAST-PS), mood and anxiety (FAST-MAS), and autism spectrum disorders (FAST-AS). The FAST initiative was a first attempt for the National Institute of Mental...
Source: Pharmaceutical Medicine - July 23, 2020 Category: Drugs & Pharmacology Source Type: research

The impact of pharmacist/physician care on quality of life in heart failure patients: the PHARM ‐CHF randomized controlled trial
ConclusionsA pharmacy ‐based interdisciplinary intervention was well received by the patients and suggests clinically important improvements in QoL. (Source: ESC Heart Failure)
Source: ESC Heart Failure - July 23, 2020 Category: Cardiology Authors: Martin Schulz, Nina Griese ‐Mammen, Pia M. Schumacher, Stefan D. Anker, Friedrich Koehler, Christian Ruckes, Volker Rettig‐Ewen, Rolf Wachter, Dietmar Trenk, Michael Böhm, Ulrich Laufs Tags: Original Research Article Source Type: research

Shuttling of Peptide-Drug Conjugates by G Protein-coupled Receptors is Significantly Improved by Pulsed Application.
AG Abstract G protein-coupled receptors (GPCR) can be used to shuttle peptide drug conjugates into cells. But, for efficient therapy, high concentration of cargo needs to be delivered. To explore this, we studied the pharma-cologically interesting neuropeptide Y1 receptor (Y1R) in recombinant and three oncogenic cell systems that endogenously express the receptor. We demonstrate that recycled receptors behave identically to newly synthesized receptors with respect to ligand binding and internalization pathways. Depending on the cell system, biosynthesis, recycling efficiency and peptide uptake differ partially, b...
Source: ChemMedChem - July 22, 2020 Category: Chemistry Authors: Ziffert I, Kaiser A, Hoppenz P, Mörl K, Beck-Sickinger AG Tags: ChemMedChem Source Type: research

Mental health issues impacting pharmacists during COVID-19
This article seeks to address the specific implications of COVID-19 on the mental health of pharmacists. (Source: Journal of Pharmaceutical Policy and Practice)
Source: Journal of Pharmaceutical Policy and Practice - July 22, 2020 Category: Pharmaceuticals Source Type: research

Scientific diligence for oncology drugs: a pharmacology, translational medicine and clinical perspective.
Abstract Increasingly, new drug development by major pharma companies relies on in-licensing of innovative therapies. Often there are limited data accompanying these novel entities. By focusing on scientific principles and generating key preclinical and clinical data, discovery companies can improve their valuations. From the lens of large pharma, we highlight key scientific aspects that are assessed to mitigate risk in valuations and deal terms. Our focus is on clinical development aspects for oncology drugs by stage of development. However, these lessons apply equally to other therapeutic areas. PMID: 32693...
Source: Drug Discovery Today - July 18, 2020 Category: Drugs & Pharmacology Authors: Parasrampuria DA, Bandekar R, Puchalski TA Tags: Drug Discov Today Source Type: research

Unrealized potential of drug repositioning in Europe during COVID-19 and beyond: a physician's perspective?
AbstractDrug repositioning is the scientific strategy of investigating existing drugs for additional clinical indications. The advantages of drug repositioning are that it benefits patients and that it adds new indications to existing drugs for lower costs compared to de novo drug development. Clinical research groups recognizing efficacy of these “old” drugs for a new indications often face an uphill struggle due to a lack of funding and support because of poor structural and regulatory support for clinical drug development. The current framework for drug repositioning allows “venture capital” comp...
Source: Journal of Pharmaceutical Policy and Practice - July 17, 2020 Category: Pharmaceuticals Source Type: research

Diazaboryl-Naphthyl-Ketone: a New Scaffold with Bright Fluorescence, Aggregation-Induced Emission, and Application in the Quantitation of Trace Boronic Acids in Pharma Intemediates.
This study describes the synthesis, structure, and photophysical properties of a new luminescent polyaromatic boronic acid scaffold, diazaboryl-naphthyl-ketones (DNKs). These stable compounds display extremely bright fluorescence, aggregation-induced emission, positive solvatochromism, and solid state fluorescence. DFT calculations and X-ray crystallographic study revealed notable electronic and structural differences between these compounds and the parent diaminonaphthalene (DAN) adducts, Acylation of the DAN system causes a localization of both HOMO and LUMO onto the DNK unit, which supports the negligible influence of t...
Source: Chemistry - July 17, 2020 Category: Chemistry Authors: Hackney HE, Paladino M, Fu H, Hall DG Tags: Chemistry Source Type: research

Unrealized potential of drug repositioning in europe during COVID-19 and beyond: a physcian ’s perspective
AbstractDrug repositioning is the scientific strategy of investigating existing drugs for additional clinical indications. The advantages of drug repositioning are that it benefits patients and that it adds new indications to existing drugs for lower costs compared to de novo drug development. Clinical research groups recognizing efficacy of these “old” drugs for a new indications often face an uphill struggle due to a lack of funding and support because of poor structural and regulatory support for clinical drug development. The current framework for drug repositioning allows “venture capital” comp...
Source: Journal of Pharmaceutical Policy and Practice - July 17, 2020 Category: Pharmaceuticals Source Type: research

The impact of a multifaceted intervention to reduce potentially inappropriate prescribing among discharged  older adults: a before-and-after study
ConclusionsThe smartphone app coupled with academic detailing was effective in reducing the prevalence of PPO at discharge. However, it did not significantly affect the prevalence or pattern of PIM. (Source: Journal of Pharmaceutical Policy and Practice)
Source: Journal of Pharmaceutical Policy and Practice - July 17, 2020 Category: Pharmaceuticals Source Type: research

Integrated metabolomic and transcriptomic profiling reveals the tissue-specific flavonoid compositions and their biosynthesis pathways in Ziziphora bungeana
Ziziphora bungeana Juz. is a folk medicine from the Xinjiang Uygur Autonomous Region. The herb or the aerial parts of it have been used to medicinally treat cardiovascular diseases. Flavonoids are the main pharma... (Source: Chinese Medicine)
Source: Chinese Medicine - July 16, 2020 Category: Complementary Medicine Authors: Jiang He, Weijun Yang, Bo Cheng, Lina Ma, Dilinuer Tursunjiang, Zimian Ding, Yong Li, Zhaofeng Wang, Yimian Ma and Guan Li Tags: Research Source Type: research

Systematic reviews of ten pharmaceutical pricing policies – a research protocol
DiscussionThe results of the review will be used as part of the update of the WHO Guideline on Country Pharmaceutical Pricing Policies. The current protocol may serve as an example for performing systematic literature reviews to inform policy makers. (Source: Journal of Pharmaceutical Policy and Practice)
Source: Journal of Pharmaceutical Policy and Practice - July 16, 2020 Category: Pharmaceuticals Source Type: research

Identification of the awareness level by the public of Arab countries toward COVID-19: cross-sectional study following an outbreak
ConclusionsThe COVID-19 pandemic is causing global panic; thus, awareness and practices of preventive measures of COVID-19 should be increased through public educational campaigns, which should be planned in accordance with communities ’ and countries’ attitudes toward COVID-19. Collaborative efforts between ministries of heath and residents of every country should be implemented. (Source: Journal of Pharmaceutical Policy and Practice)
Source: Journal of Pharmaceutical Policy and Practice - July 15, 2020 Category: Pharmaceuticals Source Type: research

Risks to the community pharmacists and pharmacy personnel during COVID-19 pandemic: perspectives from a low-income country
AbstractCoronavirus disease 2019 (COVID-19) is an infectious disease that has become a global pandemic. COVID-19 is spreading in Africa, and Zimbabwe has not been spared. The cases in Zimbabwe are mainly from imported cases due  to high volume of travellers from the COVID-19 hotspots. In Zimbabwe, local transmission is also anticipated due to inter- and intracity travelling. Frontline health workers are at risk of infection due to contact with infected people as they discharge their duties. In this setting, the risk to co mmunity pharmacists and pharmacy personnel is poorly understood and characterised. This paper loo...
Source: Journal of Pharmaceutical Policy and Practice - July 15, 2020 Category: Pharmaceuticals Source Type: research

Transient droplets organize biochemical reactions inside cells
Called condensates, the droplets pull together proteins and RNA when and where they're needed. Now, they're on pharma's radar (Source: Chemical and Engineering News)
Source: Chemical and Engineering News - July 13, 2020 Category: Chemistry Authors: Carrie Arnold, special to C&EN Source Type: research

Taro starch: Isolation, morphology, modification and novel applications concern - A review.
Abstract Tuber and root crops are matured as fundamental food crops universally especially in tropical and subtropical regions. Among them, Taro (Colocasia esculenta) considered as 5th chief root crop due to its medicinal, ornamental and food formulation facets. Competitively it holds a considerable amount of starch even more than that to potato, sweet potato, cassava and so on. Taro corms starch (70-80%) contemplate as a cheapest abode for food industries due to its multifarious potentiality in food like stabilizer, emulsifier, fat substitute and as filler agent too. Baby foods, packaging material novelties, geri...
Source: International Journal of Biological Macromolecules - July 13, 2020 Category: Biochemistry Authors: Singla D, Singh A, Dhull SB, Kumar P, Malik T, Kumar P Tags: Int J Biol Macromol Source Type: research

Luspatercept to treat β-thalassemia.
Luspatercept to treat β-thalassemia. Drugs Today (Barc). 2020 Jul;56(7):447-458 Authors: Pilo F, Angelucci E Abstract Recently, after years of research often characterized by disappointments and frustrations, finally a new drug impacting on pathological human erythropoiesis has been developed and approved. This drug, luspatercept-aamt (Reblozyl), proved to be effective in both malignant and nonmalignant disease characterized by ineffective erythropoiesis with consequent life-threatening severe anemia. Moreover, for the first time, a medication demonstrated efficacy and effectiveness in β-thal...
Source: Drugs of Today - July 12, 2020 Category: Drugs & Pharmacology Tags: Drugs Today (Barc) Source Type: research

Saudi Arabia, pharmacists and COVID-19 pandemic
This article discusses the role of pharmacists in Saudi Arabia during the current Covid-19 pandemic. Pharmacists are an important part of everyday healthcare in Saudi Arabia. Pharmacists helped to protect the public from Covid-19 pandemic disease by participating in various initiatives including health education and promotion, medication dispensing, medication reconciliation, medication and patient counselling, training for self-management in current outbreak and emergency preparedness. Full utilization of skills of pharmacists boosted the safety response of Saudi Arabia to Covid-19 pandemic. (Source: Journal of Pharmaceut...
Source: Journal of Pharmaceutical Policy and Practice - July 11, 2020 Category: Pharmaceuticals Source Type: research

Bayer's in silico ADMET platform: a journey of machine learning over the past two decades.
h A Abstract Over the past two decades, an in silico absorption, distribution, metabolism, and excretion (ADMET) platform has been created at Bayer Pharma with the goal to generate models for a variety of pharmacokinetic and physicochemical endpoints in early drug discovery. These tools are accessible to all scientists within the company and can be a useful tool in assisting with the selection and design of novel leads, as well as the process of lead optimization. Here. we discuss the development of machine-learning (ML) approaches with special emphasis on data, descriptors, and algorithms. We show that high compa...
Source: Drug Discovery Today - July 8, 2020 Category: Drugs & Pharmacology Authors: Göller AH, Kuhnke L, Montanari F, Bonin A, Schneckener S, Ter Laak A, Wichard J, Lobell M, Hillisch A Tags: Drug Discov Today Source Type: research

Eagle Pharm. Inc. v. Slayback Pharma LLC
Biotechnology Law Report, Ahead of Print. (Source: Biotechnology Law Report)
Source: Biotechnology Law Report - July 8, 2020 Category: Medical Law Authors: Christopher M. Holman Source Type: research

Rationales and arguments behind the adoption of self-selection of nonprescription medicines in Denmark
ConclusionThe formal rationale behind the adoption of self-selection of NPMs was increased accessibility. However, bearing in mind the rationales and their supporting arguments, economic interests and previous changes within the sector, it could be argued that an underlying rationale behind adopting the policy was to liberalize the Danish pharmacy sector even further. (Source: Journal of Pharmaceutical Policy and Practice)
Source: Journal of Pharmaceutical Policy and Practice - July 8, 2020 Category: Pharmaceuticals Source Type: research

Declarations of pharma funding to doctors are hit by covid-19 crisis
(Source: BMJ News)
Source: BMJ News - July 6, 2020 Category: General Medicine Source Type: research

Experimental determination and modelling of the co-solvent and antisolvent behaviour of binary systems on the dissolution of pharma drug; L-aspartic acid and thermodynamic correlations
Publication date: 15 September 2020Source: Journal of Molecular Liquids, Volume 314Author(s): Sudhakar Pabba, Alka Kumari, Mary Gold Ravuri, Prathap Kumar Thella, Bankupalli Satyavathi, Kalpit Shah, Sazal Kundu, Suresh Kumar Bhargava (Source: Journal of Molecular Liquids)
Source: Journal of Molecular Liquids - July 5, 2020 Category: Molecular Biology Source Type: research

Dose-Response Study on Surfactant Nebulization Therapy During Nasal Continuous Positive Airway Pressure Ventilation in Spontaneously Breathing Surfactant-Deficient Newborn Piglets*
Conclusions: In newborn piglets with severe bronchoalveolar lavage–induced respiratory distress syndrome, our results demonstrate that the administration of nebulized poractant alfa using an investigational customized eFlow-Neos nebulizer is an effective and safe noninvasive surfactant administration technique. (Source: Pediatric Critical Care Medicine)
Source: Pediatric Critical Care Medicine - July 1, 2020 Category: Pediatrics Tags: Online Laboratory Investigations Source Type: research

3 tips for pharma startup success.
PMID: 32593661 [PubMed - as supplied by publisher] (Source: Drug Discovery Today)
Source: Drug Discovery Today - June 25, 2020 Category: Drugs & Pharmacology Authors: Cunningham S Tags: Drug Discov Today Source Type: research

Integrating pharmaceutical systems strengthening in the current global health scenario: three ‘uncomfortable truths’
AbstractThe response to emergency public health challenges such as HIV, TB, and malaria has been successful in mobilising resources and scaling up treatment for communicable diseases. However, many of the remaining challenges in improving access to and appropriate use of medicines and services require pharmaceutical systems strengthening. Incorporating pharmaceutical systems strengthening into global health programmes requires recognition of a few ‘truths’. Systems strengthening is a lengthy and resource-intensive process that requires sustained engagement, which may not align with the short time frame for achi...
Source: Journal of Pharmaceutical Policy and Practice - June 25, 2020 Category: Pharmaceuticals Source Type: research

Clinical preceptor competencies for a better pharmacy education: a suggested framework for Lebanon
Conclusionall aforementioned competencies are expected to improve the acquisition of learning by pharmacy trainees in Lebanon. This framework can be used by pharmacy program directors and preceptors for developmental purposes through self- or peer-evaluation processes, identifying gaps, and helping to fill the needs for a better workforce in academic and experiential pharmacy education. (Source: Journal of Pharmaceutical Policy and Practice)
Source: Journal of Pharmaceutical Policy and Practice - June 24, 2020 Category: Pharmaceuticals Source Type: research

Therapeutic Equivalence of a New Preparation of Liquid Levothyroxine with Tablets in Patients with Overt Primary Hypothyroidism
Conclusions: In hypothyroid patients, the new liquid LT4 preparation (T4 ® drops) is therapeutically equivalent to the tablet form (T4® tablets).Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - June 23, 2020 Category: Endocrinology Source Type: research

Shedding Light on Metal ‐Based Nanoparticles in Zebrafish by Computed Tomography with Micrometer Resolution
In this study, synchrotron radiation‐based hard X‐ray tomography (SRμCT) in absorption and phase contrast modes is evaluated for the localization of superparamagnetic iron oxide nanoparticles (SPIONs) in soft tissues based on their electron density and X‐ray attenuation. Biodistributio n of SPIONs is studied using zebrafish embryos as a vertebrate screening model. This label‐free approach gives rise to an isotropic, 3D, direct space visualization of the entire 2.5 mm‐long animal with a spatial resolution of around 2 µm. High resolution image stacks are available on a dedicate d internet page (http://zebr...
Source: Small - June 22, 2020 Category: Nanotechnology Authors: Emre C örek, Griffin Rodgers, Stefan Siegrist, Tomaz Einfalt, Pascal Detampel, Christian M. Schlepütz, Sandro Sieber, Pascal Fluder, Georg Schulz, Harald Unterweger, Christoph Alexiou, Bert Müller, Maxim Puchkov, Jörg Huwyler Tags: Full Paper Source Type: research

Shedding Light on Metal ‐Based Nanoparticles in Zebrafish by Computed Tomography with Micrometer Resolution
In this study, synchrotron radiation‐based hard X‐ray tomography (SRμCT) in absorption and phase contrast modes is evaluated for the localization of superparamagnetic iron oxide nanoparticles (SPIONs) in soft tissues based on their electron density and X‐ray attenuation. Biodistributio n of SPIONs is studied using zebrafish embryos as a vertebrate screening model. This label‐free approach gives rise to an isotropic, 3D, direct space visualization of the entire 2.5 mm‐long animal with a spatial resolution of around 2 µm. High resolution image stacks are available on a dedicate d internet page (http://zebr...
Source: Small - June 22, 2020 Category: Nanotechnology Authors: Emre C örek, Griffin Rodgers, Stefan Siegrist, Tomaz Einfalt, Pascal Detampel, Christian M. Schlepütz, Sandro Sieber, Pascal Fluder, Georg Schulz, Harald Unterweger, Christoph Alexiou, Bert Müller, Maxim Puchkov, Jörg Huwyler Tags: Full Paper Source Type: research

Digitizing the Pharma Neurons - A Technological Operation in Progress!
CONCLUSIONS: With unfolding data on impact of science and technology amalgamation, we need a need shared mindset between data scientists and medical professionals to maximize the utility of enormous health and medical data. To tackle this efficiently, there is a need of cross-collaboration and education, and align with ethical and regulatory requirements. A perfect blend of industry, regulatory, and academia will ensure a successful digitization of pharma neurons. PMID: 32564760 [PubMed - as supplied by publisher] (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - June 21, 2020 Category: Cancer & Oncology Authors: Bhardwaj P, Yadav RK, Kurian S Tags: Rev Recent Clin Trials Source Type: research

A prospective analysis of potential and observed Drug-Drug Interactions, Adverse Events and its associated factors in hospitalized Cardiology Patients in Benin.
CONCLUSION: This study highlights the need to optimize treatments by strictly regulating blood pressure, serum sodium and potassium levels, coagulation parameters and looking for clinical signs of hemorrhage. Physician should be aware of certain drug associations that may carry a risk of severe adverse events. PMID: 32564759 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - June 21, 2020 Category: Drugs & Pharmacology Authors: Allabi AC, Chabi Y, Hounkponou M, Quenum R, Vehounkpe-Sacca J Tags: Curr Drug Saf Source Type: research

Pharmacists and COVID-19
AbstractIn the fight against COVID-19, frontline health workers have been vital to keeping the pandemic at bay, but recognition of individual professions ’ efforts have been inconsistent at all levels. Pharmacists around the world have continued to provide direct patient care and perform frontline duties for their communities during this pandemic, but are often relegated to the background and overlooked when frontline workers are heralded. Communit y pharmacists are the most accessible healthcare practitioners, which is further proven during the pandemic as they continued to provide direct patient care despite restri...
Source: Journal of Pharmaceutical Policy and Practice - June 19, 2020 Category: Pharmaceuticals Source Type: research

[ASAP] Evolving Outsourcing Landscape in Pharma R & D: Different Collaborative Models and Factors To Consider When Choosing a Contract Research Organization < subtitle > Miniperspective < /subtitle >
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00176 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 18, 2020 Category: Chemistry Authors: Bart L. DeCorte* †‡ Source Type: research

Anticipating SARS-CoV-2 Vaccine Testing, Licensure, and Recommendations for Use
K.E. receives contract funding from the NIH and CDC and is a consultant to BioNet, IBM, and Merck and is on Data Safety and Monitoring Committees for Sanofi, Moderna, Pfizer, and X-4 Pharma. W.O. declares no conflicts of interest. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 18, 2020 Category: Pediatrics Authors: Kathryn M. Edwards, Walter A. Orenstein Tags: Commentary Source Type: research

Dipeptidyl Peptidase-4 inhibitors use in type II diabetic patients in a tertiary hospital
This study aimed to identify the outcomes of DPP-4i use in one of the largest tertiary public hospital in Southeast Asia.MethodsThis is a retrospective cross sectional study conducted in 2016, where stratified sampling method was used. Patients with T2DM treated with available DPP-4i; namely Linagliptin, Saxagliptin, Sitagliptin and Vildagliptin, for at least 3 months were identified from the pharmacy record. Medical records from Physician Clinic in Hospital Kuala Lumpur (HKL) were reviewed. Data on demographic, anthropometric, antidiabetic treatment modalities, laboratory and documented outcomes were collected. Outcomes e...
Source: Journal of Pharmaceutical Policy and Practice - June 18, 2020 Category: Pharmaceuticals Source Type: research

Why do SARS-COV vaccines not exist? The pharma scientific intelligence and business model must be revisited!
. (Source: Expert Opinion on Drug Discovery)
Source: Expert Opinion on Drug Discovery - June 16, 2020 Category: Drugs & Pharmacology Authors: Mohamed Boudjelal Atef Nehdi Imadul Islam Source Type: research

Predictors of prolonged length of hospital stay and in-hospital mortality among adult patients admitted at the surgical ward of Jimma University medical center, Ethiopia: prospective observational study
AbstractBackgroundData regarding prolonged length of hospital stay (PLOS) and in-hospital mortality are paramount to evaluate efficiency and quality of surgical care as well as for rational resource utilization, allocation, and administration. Thus, PLOS and in-hospital mortality have been used as a surrogate indicator of satisfactory treatment outcome and efficient utilization of resources for a given health institution. However, there was a scarcity of data regarding these issues in Ethiopia. Therefore, this study aimed to assess treatment outcome, length of hospital stay, in-hospital mortality, and their determinants.Me...
Source: Journal of Pharmaceutical Policy and Practice - June 16, 2020 Category: Pharmaceuticals Source Type: research

[ASAP] Cross-Pharma Collaboration on the Development and Evaluation of a New Mid-Scale Preparative Supercritical Fluid Chromatography Instrument
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.0c00136 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - June 15, 2020 Category: Chemistry Authors: Mirlinda Biba* †, Mengling Wong*‡, Anne Akin*§, Eric T. Manning*?, Lisa Schaffter?, Larry Miller#, Yingru Zhang¶, William Farrell?, Jimmy O. DaSilva†, Lisa Nogle?, Benjamin Hritzko¶, Frank Riley§, Robert P. DePianta§, Kevin Barry?, Donghong A. Source Type: research

The upside of being a digital pharma player.
Abstract We investigated the state of artificial intelligence (AI) in pharmaceutical research and development (R&D) and outline here a risk and reward perspective regarding digital R&D. Given the novelty of the research area, a combined qualitative and quantitative research method was chosen, including the analysis of annual company reports, investor relations information, patent applications, and scientific publications of 21 pharmaceutical companies for the years 2014 to 2019. As a result, we can confirm that the industry is in an 'early mature' phase of using AI in R&D. Furthermore, we can demonstra...
Source: Drug Discovery Today - June 15, 2020 Category: Drugs & Pharmacology Authors: Schuhmacher A, Gatto A, Hinder M, Kuss M, Gassmann O Tags: Drug Discov Today Source Type: research

COVID-19 and community pharmacy services in Pakistan: challenges, barriers and solution for progress
AbstractIn the wake of atrocious rise in COVID-19 cases, developed countries are leveraging a range of community pharmacy services with the goal of improving access to essential medication and healthcare services. While in the developing nations, including Pakistan, pharmacists are unable to perform COVID-19 containment roles in community, since presence of pharmacists at community pharmacy settings and delivery of pharmacy services have historically been plagued by shortcomings at various levels. In this document, we identified these shortcomings which need to be resolved on many fronts. Broadly, a number of intertwined g...
Source: Journal of Pharmaceutical Policy and Practice - June 15, 2020 Category: Pharmaceuticals Source Type: research

The Diverse Search for Synthetic, Semisynthetic and Natural Product Antibiotics From the 1940s and Up to 1960 Exemplified by a Small Pharmaceutical Player
The 1940s and 1950s witnessed a diverse search for not just natural product antibiotics but also for synthetic and semisynthetic compounds. This review revisits this epoch, using the research by a Danish pharmaceutical company, LEO Pharma, as an example. LEO adopted a strategy searching for synthetic antibiotics toward specific bacterial pathogens, in particular Mycobacterium tuberculosis, leading to the discovery of a new derivative of a known drug. Work on penicillin during and after WWII lead to the development of associated salts/esters and a search for new natural product antibiotics. This led initially to no new, mar...
Source: Frontiers in Microbiology - June 12, 2020 Category: Microbiology Source Type: research

Correction to: Amid COVID-19: the importance of developing an positive adverse drug reaction (ADR) and medical device incident (MDI) reporting culture for Global Health and public safety
An amendment to this paper has been published and can be accessed via the original article. (Source: Journal of Pharmaceutical Policy and Practice)
Source: Journal of Pharmaceutical Policy and Practice - June 11, 2020 Category: Pharmaceuticals Source Type: research

Evaluation of drive-through pharmacy service in Queen Elizabeth Hospital Malaysia
ConclusionCompliance in medication collection is acceptable within stipulated grace period. Despite low occurrence, identification of near-missed medication errors provides useful insights for future improvement of the service. Generally, our patients are satisfied with the service. However, we need to re-evaluate on the opening hours and location of the service. (Source: Journal of Pharmaceutical Policy and Practice)
Source: Journal of Pharmaceutical Policy and Practice - June 11, 2020 Category: Pharmaceuticals Source Type: research