Evaluation of pharmaceutical practice in hospitals: an exploratory study comparing processes in France and Quebec
CONCLUSIONS: This study highlights the evaluation processes of pharmaceutical practice in hospitals. In France as in Quebec, we recognize the importance of the drug circuit in the hospital, the development and operation of a pharmacy department and the practice of pharmacy. While there are more similarities for the assessment of the drug circuit in hospitals and pharmacy department, important differences are observed for the assessment of individuals. We believe that the publication of a comparative analysis can contribute to discussions and exchanges to benefit from the best practices of each country.PMID:38367934 | DOI:1...
Source: Annales Pharmaceutiques Francaises - February 17, 2024 Category: Drugs & Pharmacology Authors: Manon Marc Patrick Rambourg Jean-Fran çois Bussières Source Type: research

Implementation of an Advanced Planning and Scheduling System in a pharmaceutical context
Ann Pharm Fr. 2024 Feb 15:S0003-4509(24)00027-0. doi: 10.1016/j.pharma.2024.02.007. Online ahead of print.ABSTRACTOptimizing its supply chain has now become more than a necessity for any company seeking to expand its national and international market, so that it is able to continue its progress and fulfil its obligations towards its employees and its customers, particularly in the pharmaceutical context. The Covid-19 pandemic has shown the importance of resilience in the pharmaceutical industry to deal with unexpected disruptions and high demand from patients and authorities. Better production planning based on data manage...
Source: Annales Pharmaceutiques Francaises - February 17, 2024 Category: Drugs & Pharmacology Authors: Meriem Belghith Sana Bouajaja Source Type: research

Antioxidant and Anti-Arthritic Activity of Bombax buonopozense P. Beauv. Leaves
CONCLUSION: Phytochemical screening revealed the presence of flavonoids, alkaloids, and phenolics. The brine shrimp lethality assay of the crude extract and fractions gave LC50 value ≥ 1000 µg/mL, compared to Cyclophosphamide (LC50 = 224.7±0.35µg/mL). The BBME had TPC value of 19.8±0.56 mg GAE/g, while the TFC of ethyl acetate fraction was the highest (173.5±0.05 mg QE/g). The ethyl acetate fraction has the highest antioxidant activity (IC50 = 20.96±0.23 µg/mL) as compared to ascorbic acid (2.8±0.01) and rutin (20.6±9.26 µg/mL). BBME significantly reduced the paw circumference. BBME (400 mg/kg) prevented bioche...
Source: Annales Pharmaceutiques Francaises - February 17, 2024 Category: Drugs & Pharmacology Authors: Olusoji Aanuoluwa Fadogba Akingbolabo Daniel Ogunlakin Abayomi Mayowa Ajayi Mubo Adeola Sonibare Source Type: research

L'effet du safran et de ses extraits sur le traitement du cancer du sein: une revue narrative
Ann Pharm Fr. 2024 Feb 15:S0003-4509(24)00031-2. doi: 10.1016/j.pharma.2024.02.011. Online ahead of print.ABSTRACTBreast cancer (BC) is the most prevalent malignancy in women and the second most common disease worldwide, affecting approximately one million individuals annually. Despite the efficacy of conventional chemotherapy, medication resistance and adverse effects limit its effectiveness, leading researchers to explore alternative treatments, including herbal remedies. Saffron, a well-known spice derived from the Crocus sativus L. plant, has shown potential as a BC treatment. The active components of saffron exhibit a...
Source: Annales Pharmaceutiques Francaises - February 17, 2024 Category: Drugs & Pharmacology Authors: Roya Mokhtarian Soodeh Rajabi Setareh Zahedian Saeideh Jafarinejad-Farsangi Morteza Hadizadeh Masoumeh Sadeghinejad Source Type: research

Evaluation of pharmaceutical practice in hospitals: an exploratory study comparing processes in France and Quebec
CONCLUSIONS: This study highlights the evaluation processes of pharmaceutical practice in hospitals. In France as in Quebec, we recognize the importance of the drug circuit in the hospital, the development and operation of a pharmacy department and the practice of pharmacy. While there are more similarities for the assessment of the drug circuit in hospitals and pharmacy department, important differences are observed for the assessment of individuals. We believe that the publication of a comparative analysis can contribute to discussions and exchanges to benefit from the best practices of each country.PMID:38367934 | DOI:1...
Source: Annales Pharmaceutiques Francaises - February 17, 2024 Category: Drugs & Pharmacology Authors: Manon Marc Patrick Rambourg Jean-Fran çois Bussières Source Type: research

Implementation of an Advanced Planning and Scheduling System in a pharmaceutical context
Ann Pharm Fr. 2024 Feb 15:S0003-4509(24)00027-0. doi: 10.1016/j.pharma.2024.02.007. Online ahead of print.ABSTRACTOptimizing its supply chain has now become more than a necessity for any company seeking to expand its national and international market, so that it is able to continue its progress and fulfil its obligations towards its employees and its customers, particularly in the pharmaceutical context. The Covid-19 pandemic has shown the importance of resilience in the pharmaceutical industry to deal with unexpected disruptions and high demand from patients and authorities. Better production planning based on data manage...
Source: Annales Pharmaceutiques Francaises - February 17, 2024 Category: Drugs & Pharmacology Authors: Meriem Belghith Sana Bouajaja Source Type: research

Antioxidant and Anti-Arthritic Activity of Bombax buonopozense P. Beauv. Leaves
CONCLUSION: Phytochemical screening revealed the presence of flavonoids, alkaloids, and phenolics. The brine shrimp lethality assay of the crude extract and fractions gave LC50 value ≥ 1000 µg/mL, compared to Cyclophosphamide (LC50 = 224.7±0.35µg/mL). The BBME had TPC value of 19.8±0.56 mg GAE/g, while the TFC of ethyl acetate fraction was the highest (173.5±0.05 mg QE/g). The ethyl acetate fraction has the highest antioxidant activity (IC50 = 20.96±0.23 µg/mL) as compared to ascorbic acid (2.8±0.01) and rutin (20.6±9.26 µg/mL). BBME significantly reduced the paw circumference. BBME (400 mg/kg) prevented bioche...
Source: Annales Pharmaceutiques Francaises - February 17, 2024 Category: Drugs & Pharmacology Authors: Olusoji Aanuoluwa Fadogba Akingbolabo Daniel Ogunlakin Abayomi Mayowa Ajayi Mubo Adeola Sonibare Source Type: research

L'effet du safran et de ses extraits sur le traitement du cancer du sein: une revue narrative
Ann Pharm Fr. 2024 Feb 15:S0003-4509(24)00031-2. doi: 10.1016/j.pharma.2024.02.011. Online ahead of print.ABSTRACTBreast cancer (BC) is the most prevalent malignancy in women and the second most common disease worldwide, affecting approximately one million individuals annually. Despite the efficacy of conventional chemotherapy, medication resistance and adverse effects limit its effectiveness, leading researchers to explore alternative treatments, including herbal remedies. Saffron, a well-known spice derived from the Crocus sativus L. plant, has shown potential as a BC treatment. The active components of saffron exhibit a...
Source: Annales Pharmaceutiques Francaises - February 17, 2024 Category: Drugs & Pharmacology Authors: Roya Mokhtarian Soodeh Rajabi Setareh Zahedian Saeideh Jafarinejad-Farsangi Morteza Hadizadeh Masoumeh Sadeghinejad Source Type: research

Unveiling the impacts of FDA Breakthrough Therapy Designation: a dual-perspective examination of economic and developmental outcomes for biotechnology companies
Drug Discov Today. 2024 Feb 14:103919. doi: 10.1016/j.drudis.2024.103919. Online ahead of print.ABSTRACTBiotechnology and small pharma companies must recognize the opportunity presented by FDA Breakthrough Therapy Designation (BTD) to expedite drug development for serious conditions. This paper evaluates BTD economic and developmental impacts on such companies. Analysis of 29 BTD events from 2017 to 2022 revealed immediate share price boosts and improved drug approval rates, alongside faster development times. Yet, long-term share prices underperformed relative to the broader market, underscoring the persistent risks in ph...
Source: Drug Discovery Today - February 16, 2024 Category: Drugs & Pharmacology Authors: Joab Williamson Alexander James Spicer Elina Louramo Juho Jalkanen Source Type: research

Unveiling the impacts of FDA Breakthrough Therapy Designation: a dual-perspective examination of economic and developmental outcomes for biotechnology companies
Drug Discov Today. 2024 Feb 14:103919. doi: 10.1016/j.drudis.2024.103919. Online ahead of print.ABSTRACTBiotechnology and small pharma companies must recognize the opportunity presented by FDA Breakthrough Therapy Designation (BTD) to expedite drug development for serious conditions. This paper evaluates BTD economic and developmental impacts on such companies. Analysis of 29 BTD events from 2017 to 2022 revealed immediate share price boosts and improved drug approval rates, alongside faster development times. Yet, long-term share prices underperformed relative to the broader market, underscoring the persistent risks in ph...
Source: Drug Discovery Today - February 16, 2024 Category: Drugs & Pharmacology Authors: Joab Williamson Alexander James Spicer Elina Louramo Juho Jalkanen Source Type: research

Safety and efficacy of peficitinib in Asian patients with rheumatoid arthritis who had an inadequate response or intolerance to methotrexate: results of a multicenter, randomized, double-blind, placebo-controlled phase 3 study
Lancet Reg Health West Pac. 2023 Oct 18;42:100925. doi: 10.1016/j.lanwpc.2023.100925. eCollection 2024 Jan.ABSTRACTBACKGROUND: The efficacy and safety of the oral Janus kinase inhibitor peficitinib were investigated in Asian patients with rheumatoid arthritis (RA).METHODS: In this double-blind, phase 3 study, patients from mainland China, Korea, and Taiwan with RA and an inadequate response/intolerance to methotrexate were randomized (1:1:1) to once-daily placebo (N = 128), peficitinib 100 mg (N = 129), or 150 mg (N = 128) in combination with non-biologic DMARDs. At Week 24, patients receiving placebo switched to peficitin...
Source: Herpes - February 15, 2024 Category: Infectious Diseases Authors: Yue Yang Jingyang Li Ju Liu Lin Liu Yongfu Wang Jiankang Hu Zhijun Li Jieruo Gu Xiao Zhang Zhengyu Xiao Junjie Zheng Lin Liu Zhanguo Li James Cheng-Chung Wei Source Type: research

Safety and efficacy of peficitinib in Asian patients with rheumatoid arthritis who had an inadequate response or intolerance to methotrexate: results of a multicenter, randomized, double-blind, placebo-controlled phase 3 study
Lancet Reg Health West Pac. 2023 Oct 18;42:100925. doi: 10.1016/j.lanwpc.2023.100925. eCollection 2024 Jan.ABSTRACTBACKGROUND: The efficacy and safety of the oral Janus kinase inhibitor peficitinib were investigated in Asian patients with rheumatoid arthritis (RA).METHODS: In this double-blind, phase 3 study, patients from mainland China, Korea, and Taiwan with RA and an inadequate response/intolerance to methotrexate were randomized (1:1:1) to once-daily placebo (N = 128), peficitinib 100 mg (N = 129), or 150 mg (N = 128) in combination with non-biologic DMARDs. At Week 24, patients receiving placebo switched to peficitin...
Source: Herpes - February 15, 2024 Category: Infectious Diseases Authors: Yue Yang Jingyang Li Ju Liu Lin Liu Yongfu Wang Jiankang Hu Zhijun Li Jieruo Gu Xiao Zhang Zhengyu Xiao Junjie Zheng Lin Liu Zhanguo Li James Cheng-Chung Wei Source Type: research

Improvements in Plaque Psoriasis Associated with Calcipotriol/Betamethasone Aerosol Foam Treatment: A Post Hoc Analysis of Non-interventional Studies and Clinical Experience
ConclusionThese results show that regardless of NIS location, Cal/BD foam remains a well-tolerated, efficacious option for patient care that could be used as a first-line topical therapy for mild-to-severe psoriasis. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - February 15, 2024 Category: Dermatology Source Type: research

Review of the pharmacological properties of marine macroalgae used in the treatment of diabetes mellitus in Indonesia
This study provides a comprehensive dataset of pharmacological antidiabetic potential of marine macroalgae used for managing DM and reports on preclinical trials that provide pharmacological evidence. Data on the Indonesian marine macroalgae used to lower blood glucose were obtained from online sources. The bioactive chemicals of marine macroalgae have been found efficient at blocking several diabetes enzymes in in-vivo and in-vitro studies, and such chemicals have anti-inflammatory, anti-obesity, antioxidant, and other therapeutic benefits. The Google Scholar was used to search for the pharmacological literature with the ...
Source: Annales Pharmaceutiques Francaises - February 14, 2024 Category: Drugs & Pharmacology Authors: Agung Giri Samudra Agung Endro Nugroho Retno Murwanti Source Type: research

Anthocyanin: A Potential Phytochemical Candidate for the Amelioration of Non-Alcoholic Fatty Liver Disease
Ann Pharm Fr. 2024 Feb 12:S0003-4509(24)00023-3. doi: 10.1016/j.pharma.2024.02.005. Online ahead of print.ABSTRACTNonalcoholic fatty liver disease (NAFLD) is described by too much hepatic fat deposition causing steatosis, which further develops into nonalcoholic steatohepatitis (NASH), defined by necroinflammation and fibrosis, progressing further to hepatic cirrhosis, hepatocellular carcinoma, and liver failure. NAFLD is linked to different aspects of the metabolic syndrome like obesity, insulin resistance, hypertension, and dyslipidemia, and its pathogenesis involves several elements including diet, obesity, disruption o...
Source: Annales Pharmaceutiques Francaises - February 14, 2024 Category: Drugs & Pharmacology Authors: Bitasta Mandal Rakesh Das Sandip Mondal Source Type: research