Solubilization of drugs using beta-cyclodextrin: Experimental data and modeling
In this study, the solubility enhancement of some drugs in the presence of 10 mM βCD at 25°C was experimentally determined or collected from the literature. Two different models to predict the solubilization by βCD were developed by binary logistic regression using structural properties of drugs with more than 80% accuracy. Polar surface area and excess molar refraction are the main parameters for estimating solubilization by βCD. Moreover, other descriptors related to hydrophobicity and the capability of hydrogen bonding formation of molecules could improve the accuracy of the established models.PMID:38340807 | DOI:10...
Source: Annales Pharmaceutiques Francaises - February 10, 2024 Category: Drugs & Pharmacology Authors: Navid Kaboudi Saba Ghasemi Asl Nasim Nourani Ali Shayanfar Source Type: research
Can Drug Production be Democractized?
Drug Discov Today. 2024 Feb 7:103912. doi: 10.1016/j.drudis.2024.103912. Online ahead of print.ABSTRACTIn a post-COVID world, the pharmaceutical industry faces a critical juncture, necessitating a transformative shift in drug development approaches. Dr. Gennaro D'Urso, a professor at the University of Miami and the visionary behind Genetic Networks and Pharma Collective, highlights the industry's historical profit-centric model and its shortcomings in addressing essential healthcare needs. The scarcity of critical drugs, such as Cisplatin, due to dwindling profitability, has led to a call for change. Enter Pharma Collectiv...
Source: Drug Discovery Today - February 9, 2024 Category: Drugs & Pharmacology Authors: Gennaro D'Urso Source Type: research
ALSFRS-R decline rate prior to baseline is not useful for stratifying subsequent progression of functional decline
. (Source: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration)
Source: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration - February 7, 2024 Category: Neurology Authors: Tatsuto HamataniNaoki AtsutaFumiya SanoRyoichi NakamuraYukikazu HayashiGen Sobue1 Drug Development Division, Sumitomo Pharma Co., Ltd, Tokyo, Japan2 Clinical Research, Sumitomo Pharma America, Inc, USA3 Department of Neurology, Aichi Medical University Sc Source Type: research
Development and Pilot Testing of an Algorithm-Based Approach to Anticholinergic Deprescribing in Older Patients
ConclusionsThe approach was well received by the participating physicians and might support standardized anticholinergic deprescribing. (Source: Drugs and Aging)
Source: Drugs and Aging - February 6, 2024 Category: Geriatrics Source Type: research
Dose –response effects on HbA1c and bodyweight reduction of survodutide, a dual glucagon/GLP-1 receptor agonist, compared with placebo and open-label semaglutide in people with type 2 diabetes: a randomised clinical trial
Conclusions/interpretationSurvodutide reduced HbA1c levels and bodyweight after 16 weeks ’ treatment in participants with type 2 diabetes. Dose-related gastrointestinal AEs could be mitigated with slower dose escalations.Trial registrationClinicalTrials.gov NCT04153929 and EudraCT 2019-002390-60.FundingBoehringer Ingelheim Pharma GmbH& Co. KG, Ingelheim, Germany.Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - February 5, 2024 Category: Endocrinology Source Type: research
Postoperative Intimal Hyperplasia: Review from My Research
Int J Angiol DOI: 10.1055/s-0044-1779300Postoperative intimal hyperplasia is the major cause of the vein graft occlusion. It is very important to establish an animal model for the start of research. After my vascular surgery residency in Japan, I started my research work on postoperative intimal hyperplasia at the University of Wisconsin-Madison. My research showed that endothelial injury and monocyte infiltration is the key for postoperative intimal hyperplasia, which is very similar to Ross' pathogenesis of atherosclerosis as an inflammatory disease. Focusing on postoperative intimal hyperplasia as an inflammatory diseas...
Source: International Journal of Angiology - February 5, 2024 Category: Cardiology Authors: Yamamura, Mitsuhiro Tags: Review Article Source Type: research
Ceragenin-coated endotracheal tubes for the reduction of ventilator-associated pneumonia: a prospective, longitudinal, cross-over, interrupted time, implementation study protocol (CEASE VAP study)
This study has been approved by the Health Sciences Research Ethics Board at Queen’s University. The results of this study will be actively disseminated through manuscript publication and conference presentations.
Trial registration number
NCT05761613. (Source: BMJ Open)
Source: BMJ Open - February 2, 2024 Category: General Medicine Authors: Symonds, N. E., Meng, E. X. M., Boyd, J. G., Boyd, T., Day, A., Hobbs, H., Maslove, D. M., Norman, P. A., Semrau, J. S., Sibley, S., Muscedere, J. Tags: Open access, Intensive care Source Type: research
Clinical Outcomes After Personalized Dosimetry for 90Y Radioembolization of Advanced Hepatocellular Carcinoma: Defining the Role of a Device in a Pharma-Centric Landscape
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 1, 2024 Category: Nuclear Medicine Authors: Soulen, M. C., Rilling, W. S. Tags: INVITED PERSPECTIVE Source Type: research
Editorial: Treating Autoimmune Hepatitis – more science, more progress, better therapy
GMH has consulted for Intercept, Advanz, Ipsen, Cymabay, Pliant, Mirum, GSK, Kowa; AWL occasional lecture fees from Falk Pharma; consulting for investigational drugs and trial design for Genfit, Merck and Roche. Coordinator of the European Reference Network for Hepatological Diseases (ERN RARE-LIVER). (Source: Journal of Hepatology)
Source: Journal of Hepatology - February 1, 2024 Category: Gastroenterology Authors: Gideon M. Hirschfield, Ansgar W. Lohse Tags: Editorial Source Type: research
Risk factors for and outcomes of ring expulsions with a 1-year contraceptive vaginal system
The US Food and Drug Administration –approved segesterone acetate and ethinyl estradiol ring-shaped contraceptive vaginal system, known as Annovera (Sever Pharma Solutions/QPharma, Malmö, Sweden), was inserted and removed under a woman’s control for a 21 day in and 7 day out regimen for up to 13 cycles of use. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - January 29, 2024 Category: OBGYN Authors: Marlena G. Plagianos, Shaalini Ramanadhan, Ruth B. Merkatz, Vivian Brache, Barbara A. Friedland, Lisa B. Haddad Tags: Original Research Source Type: research
Risk Factors for and Outcomes of Ring Expulsions with a One Year Contraceptive Vaginal System
The FDA-approved, segesterone acetate/ethinyl estradiol, ring-shaped contraceptive vaginal system, known was Annovera (Sever Pharma Solutions/QPharma, Malm ö, Sweden inserted and removed under a woman’s control for a 21 day in/7 day out regimen for up to 13 cycles of use. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - January 29, 2024 Category: OBGYN Authors: Marlena G. Plagianos, Shaalini Ramanadhan, Ruth B. Merkatz, Vivian Brache, Barbara A. Friedland, Lisa B. Haddad Tags: Original Research: Gynecology Source Type: research
Antioxidant and cytotoxicity activity of a nanoemulsion from Satureja kermanica (Lamiaceae)
CONCLUSION: MSK and NEK showed antioxidant and cytotoxic activity, but in NEK, the antioxidant and cytotoxic potential of the plant was more prominent, which may be due to the rapid release of the bioactive component from the nanoemulsion.PMID:38280447 | DOI:10.1016/j.pharma.2024.01.005 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - January 27, 2024 Category: Drugs & Pharmacology Authors: Navid Hassanabadi Zahra Mahdavi Meymand Anis Ashrafzadeh Fariba Sharififar Source Type: research
3D evaluation of the extracellular matrix of hypoxic pancreatic islets using light sheet fluorescence microscopy
Volume 16, Issue 1, December 2024 . (Source: Islets)
Source: Islets - January 25, 2024 Category: Hematology Authors: Matias RamirezEstelle BastienHeeyoung ChaePierre GianelloPatrick GilonCaroline Bouzina Pole of Experimental Surgery and Transplantation, Institute of Experimental and Clinical Research, Universit é catholique de Louvain, Brussels, Belgiumb Pole of Pharma Source Type: research
