A Future European Scientific Dialogue Regulatory Framework: Connecting the Dots
This article provides an overview of these challenges and reflects on the ways in which the already available SA options could be consolidated and optimized for building an integrated, easy-to-navigate process. The key elements of the proposal are improved orientation and navigation support, a simplified process of managing parallel interactions with multiple bodies, competitive SA timelines, consistency and harmonization across stakeholders, a strengthened horizon scanning to increase network preparedness, and a mechanism for building an institutional memory. The article builds on ongoing dialogues driven by the European ...
Source: Clinical Therapeutics - January 16, 2024 Category: Drugs & Pharmacology Authors: Claudia Hey Alexa Hunter Mireille Muller Nadege Le Roux Simon Bennett Kasia Nowok Laura Oliveira Source Type: research
Antibacterial agents and the fight against antibiotic resistance: A real-world evidence analysis of consumption and spending by an Italian healthcare company
CONCLUSION: This real-world evidence analysis aimed to support the justified and comprehensible global concerns regarding bacterial resistance. The extensive consumption of antibiotics will inevitably lead to the development of increasingly drug-resistant bacteria for which no antibiotic may be efficacious. National programs addressing antibiotic resistance and the awareness of all healthcare personnel must be accorded the utmost priority to enhance consumption data and, consequently, safeguard future human survival.PMID:38218426 | DOI:10.1016/j.pharma.2024.01.001 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - January 13, 2024 Category: Drugs & Pharmacology Authors: Francesco Ferrara Maurizio Capuozzo Roberta Pasquinucci Roberto Langella Ugo Trama Eduardo Nava Andrea Zovi Source Type: research
Chronic kidney disease in America, Africa, and Asia: Overview of treatment cost and options
Ann Pharm Fr. 2024 Jan 11:S0003-4509(24)00002-6. doi: 10.1016/j.pharma.2024.01.002. Online ahead of print.ABSTRACTChronic kidney disease (CKD) is one of the non-infectious diseases that threaten patients' lives on a daily basis. Its prevalence is high, but under-reported by patients and those living with the disease, as it is silent and asymptomatic in the early stages. Kidney disease increases the risk of heart and vascular disease. These problems can manifest themselves slowly, over a long period of time. Early detection and treatment can often prevent chronic kidney disease from worsening. As kidney disease progresses, ...
Source: Annales Pharmaceutiques Francaises - January 13, 2024 Category: Drugs & Pharmacology Authors: Rania Mourchid Amal Yassine Mohammed Bellahcen Yahya Cherrah Samira Serragui Source Type: research
Molecules, Vol. 29, Pages 322: Hydroxylated Tetramethoxyflavone Affects Intestinal Cell Permeability and Inhibits Cytochrome P450 Enzymes
This study aims to provide insights into the chemical and biological properties of hydroxylated TMF and evaluates its effects on intestinal cell permeability and cytochrome P450 (CYP) inhibition. Liquid chromatography–mass spectrometry (LC-MS) and microsomes analyze the TMFs and hydroxylated TMFs, elucidating cell penetration and metabolic inhibition potential. 3H7-TMF shows the fastest (1-h) transport efficiency in intestinal cells. The Caco-2 cell model exhibits significant transport and absorption efficiency. Dissolved hydroxyl-TMF with hydrophilicity possibly permeates the gut. 3H7-TMF has higher transpor...
Source: Molecules - January 9, 2024 Category: Chemistry Authors: Kuo-Ching Jan Mohsen Gavahian Tags: Article Source Type: research
From Farms to Pharma: A "Natural" History of Vaccine Production and Vaccine Skepticism
This article puts the relationship between vaccines and concepts like "nature" and "natural" in historical perspective. In the mid- to late 19th century, the smallpox vaccine, then the only vaccine available, was propagated on farms. Vaccine farmers-usually enterprising physicians-kept herds of cattle infected with cowpox, cultivating the virus "stock" from which the vaccine was derived. By exploring how vaccine farmers established and maintained public confidence in their products, we can see that debates over vaccine safety have always involved concerted efforts to persuade the public to place their trust in technologies...
Source: American Journal of Public Health - January 4, 2024 Category: International Medicine & Public Health Authors: Tess Lanzarotta Source Type: research
From Farms to Pharma: A "Natural" History of Vaccine Production and Vaccine Skepticism
This article puts the relationship between vaccines and concepts like "nature" and "natural" in historical perspective. In the mid- to late 19th century, the smallpox vaccine, then the only vaccine available, was propagated on farms. Vaccine farmers-usually enterprising physicians-kept herds of cattle infected with cowpox, cultivating the virus "stock" from which the vaccine was derived. By exploring how vaccine farmers established and maintained public confidence in their products, we can see that debates over vaccine safety have always involved concerted efforts to persuade the public to place their trust in technologies...
Source: Am J Public Health - January 4, 2024 Category: International Medicine & Public Health Authors: Tess Lanzarotta Source Type: research
From Farms to Pharma: A "Natural" History of Vaccine Production and Vaccine Skepticism
This article puts the relationship between vaccines and concepts like "nature" and "natural" in historical perspective. In the mid- to late 19th century, the smallpox vaccine, then the only vaccine available, was propagated on farms. Vaccine farmers-usually enterprising physicians-kept herds of cattle infected with cowpox, cultivating the virus "stock" from which the vaccine was derived. By exploring how vaccine farmers established and maintained public confidence in their products, we can see that debates over vaccine safety have always involved concerted efforts to persuade the public to place their trust in technologies...
Source: Am J Public Health - January 4, 2024 Category: International Medicine & Public Health Authors: Tess Lanzarotta Source Type: research
From Farms to Pharma: A "Natural" History of Vaccine Production and Vaccine Skepticism
This article puts the relationship between vaccines and concepts like "nature" and "natural" in historical perspective. In the mid- to late 19th century, the smallpox vaccine, then the only vaccine available, was propagated on farms. Vaccine farmers-usually enterprising physicians-kept herds of cattle infected with cowpox, cultivating the virus "stock" from which the vaccine was derived. By exploring how vaccine farmers established and maintained public confidence in their products, we can see that debates over vaccine safety have always involved concerted efforts to persuade the public to place their trust in technologies...
Source: American Journal of Public Health - January 4, 2024 Category: International Medicine & Public Health Authors: Tess Lanzarotta Source Type: research
Production, purification, and functional characterization of glucan exopolysaccharide produced by Enterococcus hirae strain OL616073 of fermented food origin
In this study, we report the extraction of an EPS from Enterococcus hirae OL616073 strain originally isolated from Indian fermented food and its purification by ion exchange and size exclusion chromatography for physical-functional analyses. The EPS showed two prominent fractions (EPS F1 and EPS F2) with molecular mass 7.7 × 104 and 6.5 × 104 Da respectively by gel permeation chromatography. These fractions were further characterized by FTIR, HPTLC, GC-MS, and NMR as a homopolysaccharide of glucose linked with α-(1 → 6) and α-(1 → 3) glycosidic linkages. The porous, spongy, granular morphology of EPS was observed u...
Source: International Journal of Biological Macromolecules - January 4, 2024 Category: Biochemistry Authors: Digambar Kavitake Swati Tiwari Palanisamy Bruntha Devi Irshad Ahmad Shah G Bhanuprakash Reddy Prathapkumar Halady Shetty Source Type: research
From Farms to Pharma: A "Natural" History of Vaccine Production and Vaccine Skepticism
This article puts the relationship between vaccines and concepts like "nature" and "natural" in historical perspective. In the mid- to late 19th century, the smallpox vaccine, then the only vaccine available, was propagated on farms. Vaccine farmers-usually enterprising physicians-kept herds of cattle infected with cowpox, cultivating the virus "stock" from which the vaccine was derived. By exploring how vaccine farmers established and maintained public confidence in their products, we can see that debates over vaccine safety have always involved concerted efforts to persuade the public to place their trust in technologies...
Source: Am J Public Health - January 4, 2024 Category: International Medicine & Public Health Authors: Tess Lanzarotta Source Type: research
From Farms to Pharma: A "Natural" History of Vaccine Production and Vaccine Skepticism
This article puts the relationship between vaccines and concepts like "nature" and "natural" in historical perspective. In the mid- to late 19th century, the smallpox vaccine, then the only vaccine available, was propagated on farms. Vaccine farmers-usually enterprising physicians-kept herds of cattle infected with cowpox, cultivating the virus "stock" from which the vaccine was derived. By exploring how vaccine farmers established and maintained public confidence in their products, we can see that debates over vaccine safety have always involved concerted efforts to persuade the public to place their trust in technologies...
Source: American Journal of Public Health - January 4, 2024 Category: International Medicine & Public Health Authors: Tess Lanzarotta Source Type: research
Production, purification, and functional characterization of glucan exopolysaccharide produced by Enterococcus hirae strain OL616073 of fermented food origin
In this study, we report the extraction of an EPS from Enterococcus hirae OL616073 strain originally isolated from Indian fermented food and its purification by ion exchange and size exclusion chromatography for physical-functional analyses. The EPS showed two prominent fractions (EPS F1 and EPS F2) with molecular mass 7.7 × 104 and 6.5 × 104 Da respectively by gel permeation chromatography. These fractions were further characterized by FTIR, HPTLC, GC-MS, and NMR as a homopolysaccharide of glucose linked with α-(1 → 6) and α-(1 → 3) glycosidic linkages. The porous, spongy, granular morphology of EPS was observed u...
Source: International Journal of Biological Macromolecules - January 4, 2024 Category: Biochemistry Authors: Digambar Kavitake Swati Tiwari Palanisamy Bruntha Devi Irshad Ahmad Shah G Bhanuprakash Reddy Prathapkumar Halady Shetty Source Type: research
From Farms to Pharma: A "Natural" History of Vaccine Production and Vaccine Skepticism
This article puts the relationship between vaccines and concepts like "nature" and "natural" in historical perspective. In the mid- to late 19th century, the smallpox vaccine, then the only vaccine available, was propagated on farms. Vaccine farmers-usually enterprising physicians-kept herds of cattle infected with cowpox, cultivating the virus "stock" from which the vaccine was derived. By exploring how vaccine farmers established and maintained public confidence in their products, we can see that debates over vaccine safety have always involved concerted efforts to persuade the public to place their trust in technologies...
Source: Am J Public Health - January 4, 2024 Category: International Medicine & Public Health Authors: Tess Lanzarotta Source Type: research
From Farms to Pharma: A "Natural" History of Vaccine Production and Vaccine Skepticism
This article puts the relationship between vaccines and concepts like "nature" and "natural" in historical perspective. In the mid- to late 19th century, the smallpox vaccine, then the only vaccine available, was propagated on farms. Vaccine farmers-usually enterprising physicians-kept herds of cattle infected with cowpox, cultivating the virus "stock" from which the vaccine was derived. By exploring how vaccine farmers established and maintained public confidence in their products, we can see that debates over vaccine safety have always involved concerted efforts to persuade the public to place their trust in technologies...
Source: American Journal of Public Health - January 4, 2024 Category: International Medicine & Public Health Authors: Tess Lanzarotta Source Type: research
Development and validation of stability indicating RP-HPLC method for simultaneous estimation of silodosin and mirabegron in synthetic mixture
Ann Pharm Fr. 2023 Dec 30:S0003-4509(23)00171-2. doi: 10.1016/j.pharma.2023.12.013. Online ahead of print.ABSTRACTThe study focuses to validate and develop a precise, simple and accurate stability indicating RP-HPLC method for estimation simultaneously of and silodosin and mirabegron in synthetic mixture. The chromatographic separation was achieved by using Shimpack Solar C18 column (250×4.5mm, 5μm) with acetonitrile: 5mM ammonium acetate in ratio of 90:10% v/v as a mobile phase at a constant flow rate of about 1.2mL/min. The development and validation were carried out at detection wavelength of 229nm. We developed a rob...
Source: Annales Pharmaceutiques Francaises - January 1, 2024 Category: Drugs & Pharmacology Authors: Shweta Mishra Ninama Surekha Ashlesha Chauhan Source Type: research
