Reducing neonatal Fc receptor binding enhances clearance and brain-to-blood ratio of TfR-delivered bispecific amyloid- β antibody
Volume 16, Issue 1, January-December 2024 . (Source: mAbs)
Source: mAbs - April 18, 2024 Category: Biomedical Science Authors: Eva SchleinKen G. AnderssonTiffany DallasStina Syv änenDag Sehlina Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Swedenb Biotechnology, BioArctic AB, Stockholm, Sweden Source Type: research
Can antibodies be “vegan”? A guide through the maze of today’s antibody generation methods
Volume 16, Issue 1, January-December 2024 . (Source: mAbs)
Source: mAbs - April 18, 2024 Category: Biomedical Science Authors: Stefan D übelInstitute of Biochemistry, Biotechnology and Bioinformatics, Technische Universität Braunschweig, Braunschweig, Germany Source Type: research
Enrichment strategy and initial characterization of heterodimers enriched from a co-formulated cocktail of therapeutic antibodies against SARS-COV-2
Volume 16, Issue 1, January-December 2024 . (Source: mAbs)
Source: mAbs - April 9, 2024 Category: Biomedical Science Authors: Sophia LiuYuetian YanCody M. SecorZachary R. OberholtzerDonna J. SkowMushhood SheikhYoumi MoonYue FuCristinel SanduShunhai WangNing LiJennifer B. NguyenMichael P. RosconiErica A. Pyles1 Protein Biochemistry, Regeneron Pharmaceuticals, Inc ., Tarrytown, NY Source Type: research
Predicting deamidation and isomerization sites in therapeutic antibodies using structure-based in silico approaches
Volume 16, Issue 1, January-December 2024 . (Source: mAbs)
Source: mAbs - March 28, 2024 Category: Biomedical Science Authors: David HoffmannJoschka BauerMarkus KossnerAndrew HenryAnne R. Karow-ZwickGiuseppe Licaria Early Stage Pharmaceutical Development Biologicals, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach/Riss, Germanyb In Silico Team, Boehringer Ingelheim, Biberach Source Type: research
Correction
Volume 16, Issue 1, January-December 2024 . (Source: mAbs)
Source: mAbs - March 28, 2024 Category: Biomedical Science Source Type: research
In silico methods for immunogenicity risk assessment and human homology screening for therapeutic antibodies
Volume 16, Issue 1, January-December 2024 . (Source: mAbs)
Source: mAbs - March 27, 2024 Category: Biomedical Science Authors: Aimee E. MatteiAndres H. GutierrezSoorya SeshadriJacob TivinMatt ArditoAmy S. RosenbergWilliam D. MartinAnne S. De GrootEpiVax, Inc, Providence, RI, USA Source Type: research
Evaluation of the impact of antibody fragments on aggregation of intact molecules via size exclusion chromatography coupled with native mass spectrometry
Volume 16, Issue 1, January-December 2024 . (Source: mAbs)
Source: mAbs - March 27, 2024 Category: Biomedical Science Authors: Jing XuJohn E. CoughlinMalgorzata SzyjkaSerene JabarySonal SalujaZoran SosicYunqiu ChenChong-Feng Xua Analytical Development, Biogen, Cambridge, MA, USAb Process Biochemistry, Biogen, Cambridge, MA, USAc Analytical Biochemistry, Biogen, Cambridge, MA, USA Source Type: research
RUBY ® – a tetravalent (2+2) bispecific antibody format with excellent functionality and IgG-like stability, pharmacology and developability properties
Volume 16, Issue 1, January-December 2024 . (Source: mAbs)
Source: mAbs - March 26, 2024 Category: Biomedical Science Authors: Barnabas NyesigaMattias LevinAnna S ällAnna RosénKim JanssonSara FritzellKarin HägerbrandDietmar WeilgunyLaura von Schantza Alligator Bioscience AB, Medicon Village, Lund, Swedenb Faculty of Health and Society, Malmö University, Malmö, Sweden Source Type: research
T and B cell epitope analysis for the immunogenicity evaluation and mitigation of antibody-based therapeutics
Volume 16, Issue 1, January-December 2024 . (Source: mAbs)
Source: mAbs - March 21, 2024 Category: Biomedical Science Authors: Ruoxuan SunMark G. QianXiaobin ZhangGlobal Drug Metabolism, Pharmacokinetics & Modeling, Preclinical & Translational Sciences, Takeda Development Center Americas, Inc. (TDCA), Cambridge, MA, USA Source Type: research
Antibody-epitope conjugates deliver immunogenic T-cell epitopes more efficiently when close to cell surfaces
Volume 16, Issue 1, January-December 2024 . (Source: mAbs)
Source: mAbs - March 18, 2024 Category: Biomedical Science Authors: W. van der WulpW. LuuM. E. RessingJ. SchuurmanS. I. van KasterenL. GuelenR. C. HoebenB. BleijlevensM. H. M. Heemskerka Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlandsb Department of Hematology, Leiden Uni Source Type: research
Do antibody CDR loops change conformation upon binding?
Volume 16, Issue 1, January-December 2024 . (Source: mAbs)
Source: mAbs - March 13, 2024 Category: Biomedical Science Authors: Chu ’nan LiuLilian M. DenzlerOliver E.C. HoodAndrew C.R. MartinStructural and Molecular Biology, Division of Biosciences, University College London, London, UK Source Type: research
Reduction of monoclonal antibody viscosity using interpretable machine learning
Volume 16, Issue 1, January-December 2024 . (Source: mAbs)
Source: mAbs - March 13, 2024 Category: Biomedical Science Authors: Emily K. MakowskiHsin-Ting ChenTiexin WangLina WuJie HuangMarissa MockPatrick UnderhillEmma Pelegri-O ’DayErick MaglalangDwight WintersPeter M. Tessiera Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, USAb Biointerfaces Ins Source Type: research
A pivotal decade for bispecific antibodies?
Volume 16, Issue 1, January-December 2024 . (Source: mAbs)
Source: mAbs - March 11, 2024 Category: Biomedical Science Authors: Marlena SurowkaChristian KleinRoche Innovation Center Zurich, Roche Pharma Research & Early Development, Roche Glycart AG, Schlieren, Switzerland Source Type: research
A novel conditional active biologic anti-EpCAM x anti-CD3 bispecific antibody with synergistic tumor selectivity for cancer immunotherapy
Volume 16, Issue 1, January-December 2024 . (Source: mAbs)
Source: mAbs - March 6, 2024 Category: Biomedical Science Authors: Gerhard FreyAna Paula G. CugnettiHaizhen LiuCharles XingChristina WheelerHwai Wen ChangWilliam J. BoyleJay M. ShortResearch & Development, BioAtla Inc, San Diego, CA, USA Source Type: research
Improving the integrity and reproducibility of research that uses antibodies: a technical, data sharing, behavioral and policy challenge
Volume 16, Issue 1, January-December 2024 . (Source: mAbs)
Source: mAbs - March 6, 2024 Category: Biomedical Science Authors: M. BiddleP. StylianouM. RekasA. WrightJ. SousaD. RuddyM. I. StefanaK. KmiecikA. BandrowskiR.A. KahnC. LaflammeE. M. KrockowH.S. Virka NIHR Respiratory BRC, Department of Respiratory Sciences, University of Leicester, Leicester, UKb JDRF/Wellcome Diabetes Source Type: research
