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Gardnerella pickettii sp. nov. (formerly Gardnerella genomic species 3) and Gardnerella greenwoodii sp. nov. (formerly Gardnerella genomic species 8) isolated from female urinary microbiome
Int J Syst Evol Microbiol. 2023 Nov;73(11). doi: 10.1099/ijsem.0.006140.ABSTRACTDuring an ongoing female urinary microbiome research study, strains c17Ua_112T and c31Ua_26T isolated from urine samples of a patient diagnosed with overactive bladder and a healthy postmenopausal woman, respectively, could not be allocated to any Gardnerella species with valid names. In this work, we aimed to characterize these strains. The 16S rRNA gene sequences confirmed that these strains are members of the genus Gardnerella. Phylogenetic analysis based on cpn60 strongly supported two clades, one encompassing c17Ua_112T and nine other stra...
Source: International Journal of Systematic and Evolutionary Microbiology - November 3, 2023 Category: Microbiology Authors: M árcia Sousa Magdalena Ksiezarek Svetlana Ugarcina Perovic Tiago Antunes-Lopes Filipa Grosso Teresa Gon çalves Ribeiro Lu ísa Peixe Source Type: research

Management of Urgency Urinary Incontinence After Orthotopic Neobladder
AbstractPurpose of ReviewThe current literature available to providers on urgency urinary incontinence in orthotopic neobladder patients will be reviewed.Recent FindingsIn this review, we will examine the most recent studies evaluating potential therapies for urgency urinary incontinence in neobladder patients.SummaryUrgency urinary incontinence in patients with neobladders is a challenging symptom to manage for both patients and providers, both due to the pathophysiology as well as a lack of data on effective therapies. Given the similar symptom profile to patients with overactive bladder as well as comparable functional ...
Source: Current Bladder Dysfunction Reports - November 1, 2023 Category: Urology & Nephrology Source Type: research

Prevalence and severity of functional urinary and anorectal disorders and their impact on quality of life in cystic fibrosis
Urinary incontinence (UI) is defined as "the complaint of any involuntary loss of urine" (International Continence Society ICS-,2002). The most common type of UI is stress urinary incontinence (SUI), defined as UI on effort or physical exertion, such as during sporting activities or on sneezing or coughing. The second type is urge urinary incontinence (UUI), defined as UI associated with urgency (a sudden compelling need to urinate that is difficult to defer), which is part of overactive bladder syndrome (OAB). (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - October 29, 2023 Category: Respiratory Medicine Authors: Katelyne Hubeaux, Laetitia Gueganton, Emmanuel Nowak, Baptiste Arnouat, Chantal Belleguic, Isabelle Danner-Boucher, Julie Mankikian, Annabelle Payet, Thierry Urban, Marion Buyse, Sophie Ramel Tags: Original Article Source Type: research

Importance of Regular Examination and Follow-up in Pediatric Patients with Neurogenic Bladder: 24-Month Follow-up Study Using a Japanese Health Insurance Database
ConclusionPatients with use of CIC and/or having spina bifida and constipation had a higher risk of UTI, suggesting the need for careful follow-up. More guideline-compliant and diligent patient management is necessary in Japanese children with NGB. (Source: Advances in Therapy)
Source: Advances in Therapy - October 27, 2023 Category: Drugs & Pharmacology Source Type: research

Congenital lower urinary tract obstruction with spontaneous fetal bladder rupture due to posterior urethral valves: a case report
ConclusionsLUTO might lead to important renal dysfunction and pulmonary hypoplasia in case of increasing disease severity. Spontaneous bladder rupture might improve renal prognosis, acting as a pop-off mechanism by decompression of the urinary tract. However, fetal bladder rupture is rare and only few cases have been reported. Prenatal intervention can be considered for moderate or severe LUTO, but the benefit for long-term outcome remains uncertain and further studies are needed. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - October 25, 2023 Category: General Medicine Source Type: research

Association between voiding lower urinary tract symptoms and findings on dynamic magnetic resonance imaging with regard to pelvic organs and their supportive structures
ConclusionsvLUTS may be associated with the proximity of the bladder and cervix to the pubic bone and consequent compression of the urethra by the prolapsed organs. vLUTS with OAB might indicate more advanced lower urinary tract dysfunction than vLUTS alone. (Source: LUTS: Lower Urinary Tract Symptoms)
Source: LUTS: Lower Urinary Tract Symptoms - October 23, 2023 Category: Urology & Nephrology Authors: Shoutarou Watanabe, Kurenai Kinno, Yasuharu Takeuchi, Yoshitomo Sawada, Noritoshi Sekido Tags: ORIGINAL ARTICLE Source Type: research

Management of Patients with Detrusor Hyperactivity with Impaired Contractility
AbstractPurpose of ReviewDetrusor hyperactivity and impaired contractility (DHIC) is a common condition seen in elderly patients who suffered from lower urinary tract symptoms. Hypothetical pathogenesis and debatable definition of diagnosis may have caused difficulties in developing effective treatments through the past decades. In this review, we aim to discuss currently available treatments of DHIC.Recent FindingsMirabegron was an effective treatment option with subjective symptom improvement and reduced post-void residual volume at 6 months. Intravesical injection of onabotulinumtoxinA improved overactive bladder (OAB) ...
Source: Current Bladder Dysfunction Reports - October 23, 2023 Category: Urology & Nephrology Source Type: research

Over Active Bladder Index (OABI): A new objective tool based on uroflow parameters for diagnosis of overactive bladder in children
The aim of this study is to propose an objective uroflow based index for diagnosing over active bladder (OAB) (Source: Journal of Pediatric Surgery)
Source: Journal of Pediatric Surgery - October 20, 2023 Category: Surgery Authors: Ramesh Babu, Muthukumar Ashwin Source Type: research

Importance of Regular Examination and Follow-up in Pediatric Patients with Neurogenic Bladder: 24-Month Follow-up Study Using a Japanese Health Insurance Database
CONCLUSION: Patients with use of CIC and/or having spina bifida and constipation had a higher risk of UTI, suggesting the need for careful follow-up. More guideline-compliant and diligent patient management is necessary in Japanese children with NGB.PMID:37843724 | DOI:10.1007/s12325-023-02692-x (Source: Adv Data)
Source: Adv Data - October 16, 2023 Category: Epidemiology Authors: Naoko Izumi Takeya Kitta Takahiko Mitsui Source Type: research

Non-pharmacological and drug treatment of autonomic dysfunction in multiple system atrophy: current status and future directions
AbstractMultiple system atrophy (MSA) is a sporadic, fatal, and rapidly progressive neurodegenerative disease of unknown etiology that is clinically characterized by autonomic failure, parkinsonism, cerebellar ataxia, and pyramidal signs in any combination. Early onset and extensive autonomic dysfunction, including cardiovascular dysfunction characterized by orthostatic hypotension (OH) and supine hypertension, urinary dysfunction characterized by overactive bladder and incomplete bladder emptying, sexual dysfunction characterized by sexual desire deficiency and erectile dysfunction, and gastrointestinal dysfunction charac...
Source: Journal of Neurology - October 14, 2023 Category: Neurology Source Type: research

Insights into urinary incontinence after robot-assisted radical prostatectomy: urgent urinary incontinence or stress urinary incontinence
ConclusionThe occurrence rate of SUI after RARP was persistently higher than that of UUI. Nearly all of the patients with UUI simultaneously had SUI. The risk factors of UUI and SUI after RARP were absolutely different. (Source: World Journal of Urology)
Source: World Journal of Urology - October 11, 2023 Category: Urology & Nephrology Source Type: research

Bladder training for treating overactive bladder in adults
CONCLUSIONS: This review focused on the effect of bladder training to treat OAB. However, most of the evidence was low or very-low certainty. Based on the low- or very low-certainty evidence, bladder training may cure or improve OAB compared to no treatment. Bladder training may be more effective to cure or improve OAB than anticholinergics, and there may be fewer adverse events. There may be no difference in efficacy or safety between bladder training and PFMT. More well-designed trials are needed to reach a firm conclusion.PMID:37811598 | DOI:10.1002/14651858.CD013571.pub2 (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - October 9, 2023 Category: General Medicine Authors: Satoshi Funada Takashi Yoshioka Yan Luo Akira Sato Shusuke Akamatsu Norio Watanabe Source Type: research

Bladder training for treating overactive bladder in adults
CONCLUSIONS: This review focused on the effect of bladder training to treat OAB. However, most of the evidence was low or very-low certainty. Based on the low- or very low-certainty evidence, bladder training may cure or improve OAB compared to no treatment. Bladder training may be more effective to cure or improve OAB than anticholinergics, and there may be fewer adverse events. There may be no difference in efficacy or safety between bladder training and PFMT. More well-designed trials are needed to reach a firm conclusion.PMID:37811598 | PMC:PMC10561149 | DOI:10.1002/14651858.CD013571.pub2 (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - October 9, 2023 Category: General Medicine Authors: Satoshi Funada Takashi Yoshioka Yan Luo Akira Sato Shusuke Akamatsu Norio Watanabe Source Type: research

Comparative Study Between Behavior Therapy and Behavior Therapy Plus Mirabegron 50 mg in Sexually Active Men With Bothersome Overactive Bladder Symptoms - A Multicenter, Randomized Study
CONCLUSION: Behavioral therapy combined with mirabegron had more significant impact on the improvement of OAB than behavior therapy alone. However, both groups did not have significant changes in erectile or ejaculatory function.PMID:37798885 | DOI:10.5213/inj.2346148.074 (Source: International Neurourology Journal)
Source: International Neurourology Journal - October 6, 2023 Category: Urology & Nephrology Authors: Chih-Chieh Lin Hann-Chorng Kuo Jian-Ri Li Yao-Chi Chuang Source Type: research