Sacral Neuromodulation: Device Improvement and Current Applications in Urology
Medicina (Kaunas). 2024 Mar 20;60(3):509. doi: 10.3390/medicina60030509.ABSTRACTSacral neuromodulation (SNM) offers a therapeutic approach to urological patients suffering from idiopathic overactive bladder (OAB) syndrome, with or without incontinence and non-obstructive urinary retention (NOR), who are not responding to or are not compliant with conservative or medical therapies. The exact mechanism of action of SNM is not fully understood but modulation of the spinal cord reflexes and brain networks by peripheral afferents is regarded as the main pathway. Over the years, surgical techniques improved, leading to the devel...
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Marco Spilotros Salvatore Gerbasi Francesco Lasorsa Gaetano de Rienzo Lorenzo Balducci Pasquale Ditonno Giuseppe Lucarelli Source Type: research
Sacral Neuromodulation: Device Improvement and Current Applications in Urology
Medicina (Kaunas). 2024 Mar 20;60(3):509. doi: 10.3390/medicina60030509.ABSTRACTSacral neuromodulation (SNM) offers a therapeutic approach to urological patients suffering from idiopathic overactive bladder (OAB) syndrome, with or without incontinence and non-obstructive urinary retention (NOR), who are not responding to or are not compliant with conservative or medical therapies. The exact mechanism of action of SNM is not fully understood but modulation of the spinal cord reflexes and brain networks by peripheral afferents is regarded as the main pathway. Over the years, surgical techniques improved, leading to the devel...
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Marco Spilotros Salvatore Gerbasi Francesco Lasorsa Gaetano de Rienzo Lorenzo Balducci Pasquale Ditonno Giuseppe Lucarelli Source Type: research
Sacral Neuromodulation: Device Improvement and Current Applications in Urology
Medicina (Kaunas). 2024 Mar 20;60(3):509. doi: 10.3390/medicina60030509.ABSTRACTSacral neuromodulation (SNM) offers a therapeutic approach to urological patients suffering from idiopathic overactive bladder (OAB) syndrome, with or without incontinence and non-obstructive urinary retention (NOR), who are not responding to or are not compliant with conservative or medical therapies. The exact mechanism of action of SNM is not fully understood but modulation of the spinal cord reflexes and brain networks by peripheral afferents is regarded as the main pathway. Over the years, surgical techniques improved, leading to the devel...
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Marco Spilotros Salvatore Gerbasi Francesco Lasorsa Gaetano de Rienzo Lorenzo Balducci Pasquale Ditonno Giuseppe Lucarelli Source Type: research
Sacral Neuromodulation: Device Improvement and Current Applications in Urology
Medicina (Kaunas). 2024 Mar 20;60(3):509. doi: 10.3390/medicina60030509.ABSTRACTSacral neuromodulation (SNM) offers a therapeutic approach to urological patients suffering from idiopathic overactive bladder (OAB) syndrome, with or without incontinence and non-obstructive urinary retention (NOR), who are not responding to or are not compliant with conservative or medical therapies. The exact mechanism of action of SNM is not fully understood but modulation of the spinal cord reflexes and brain networks by peripheral afferents is regarded as the main pathway. Over the years, surgical techniques improved, leading to the devel...
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Marco Spilotros Salvatore Gerbasi Francesco Lasorsa Gaetano de Rienzo Lorenzo Balducci Pasquale Ditonno Giuseppe Lucarelli Source Type: research
Sacral Neuromodulation: Device Improvement and Current Applications in Urology
Medicina (Kaunas). 2024 Mar 20;60(3):509. doi: 10.3390/medicina60030509.ABSTRACTSacral neuromodulation (SNM) offers a therapeutic approach to urological patients suffering from idiopathic overactive bladder (OAB) syndrome, with or without incontinence and non-obstructive urinary retention (NOR), who are not responding to or are not compliant with conservative or medical therapies. The exact mechanism of action of SNM is not fully understood but modulation of the spinal cord reflexes and brain networks by peripheral afferents is regarded as the main pathway. Over the years, surgical techniques improved, leading to the devel...
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Marco Spilotros Salvatore Gerbasi Francesco Lasorsa Gaetano de Rienzo Lorenzo Balducci Pasquale Ditonno Giuseppe Lucarelli Source Type: research
Sacral Neuromodulation: Device Improvement and Current Applications in Urology
Medicina (Kaunas). 2024 Mar 20;60(3):509. doi: 10.3390/medicina60030509.ABSTRACTSacral neuromodulation (SNM) offers a therapeutic approach to urological patients suffering from idiopathic overactive bladder (OAB) syndrome, with or without incontinence and non-obstructive urinary retention (NOR), who are not responding to or are not compliant with conservative or medical therapies. The exact mechanism of action of SNM is not fully understood but modulation of the spinal cord reflexes and brain networks by peripheral afferents is regarded as the main pathway. Over the years, surgical techniques improved, leading to the devel...
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Marco Spilotros Salvatore Gerbasi Francesco Lasorsa Gaetano de Rienzo Lorenzo Balducci Pasquale Ditonno Giuseppe Lucarelli Source Type: research
Medicinal plants and natural products for treating overactive bladder
Overactive bladder (OAB) presents a high prevalence of 16 –18% worldwide. The pathophysiology of OAB is still poorly understood while effective therapy or countermeasure are very limited. On the other hand, med... (Source: Chinese Medicine)
Source: Chinese Medicine - March 27, 2024 Category: Complementary Medicine Authors: Huanxian Chen, Maggie Pui Man Hoi and Simon Ming Yuen Lee Tags: Review Source Type: research
A muscarinic receptor antagonist reverses multiple indices of diabetic peripheral neuropathy: preclinical and clinical studies using oxybutynin
AbstractPreclinical studies indicate that diverse muscarinic receptor antagonists, acting via the M1 sub-type, promote neuritogenesis from sensory neurons in vitro and prevent and/or reverse both structural and functional indices of neuropathy in rodent models of diabetes. We sought to translate this as a potential therapeutic approach against structural and functional indices of diabetic neuropathy using oxybutynin, a muscarinic antagonist approved for clinical use against overactive bladder. Studies were performed using sensory neurons maintained in vitro, rodent models of type 1 or type 2 diabetes and human subjects w...
Source: Acta Neuropathologica - March 25, 2024 Category: Neurology Source Type: research
Real-World Adherence to and Persistence with Vibegron in Patients with Overactive Bladder: A Retrospective Claims Analysis
CONCLUSION: Nearly half of the patients initiating vibegron were adherent. Factors associated with adherence and persistence were more likely to be related to prescribing practices than patient characteristics. These results suggest it may be best to follow up with patients approximately 4 to 5 months after initiating treatment with vibegron.PMID:38520502 | DOI:10.1007/s12325-024-02824-x (Source: Adv Data)
Source: Adv Data - March 23, 2024 Category: Epidemiology Authors: Benjamin Chastek Adam Carrera Christina Landis Daniel Snyder Laleh Abedinzadeh Tim Bancroft Jeffrey Nesheim Michael Kennelly David Staskin Source Type: research
Real-World Adherence to and Persistence with Vibegron in Patients with Overactive Bladder: A Retrospective Claims Analysis
CONCLUSION: Nearly half of the patients initiating vibegron were adherent. Factors associated with adherence and persistence were more likely to be related to prescribing practices than patient characteristics. These results suggest it may be best to follow up with patients approximately 4 to 5 months after initiating treatment with vibegron.PMID:38520502 | DOI:10.1007/s12325-024-02824-x (Source: Adv Data)
Source: Adv Data - March 23, 2024 Category: Epidemiology Authors: Benjamin Chastek Adam Carrera Christina Landis Daniel Snyder Laleh Abedinzadeh Tim Bancroft Jeffrey Nesheim Michael Kennelly David Staskin Source Type: research
Examining the safety of mirabegron: an analysis of real-world pharmacovigilance data from the US FDA adverse event reporting system (FAERS) database
Conclusion: This study provided valuable evidence for the real-world safety of mirabegron, helping clinical professionals enhance their understanding of mirabegron’s safety in clinical practice. It also contributed valuable evidence for further safety studies on mirabegron. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 18, 2024 Category: Drugs & Pharmacology Source Type: research
Colporrhaphies versus Colpocleisis Following Vaginal Hysterectomy for the Treatment of Advanced Pelvic Organ Prolapse: A Comparative Study
CONCLUSIONS: VHC is associated with lower perioperative blood loss, shorter operative time, shorter hospital stay, shorter time with an indwelling catheter, and lower long-term objective POP recurrence rates.PMID:38493328 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - March 17, 2024 Category: General Medicine Authors: Eiman Shalabna Nir Haya Ariel Zilberlicht Rotem Sadeh Yoram Abramov Source Type: research
