Pelvic floor muscle training patient reported Outcome Measures (PROM) (PFMT-P): Turkish adaptation and its validity and relibiality
Pelvic floor muscles play an important role in supporting the pelvic organs and maintaining urinary and faecal continence [1]. Conditions that cause chronically increased intra-abdominal pressure such as aging, previous pelvic surgery, pregnancy, parity, vaginal birth, obesity, respiratory tract diseases, and constipation and high-effect exercises are risk factors for the development of dysfunction in pelvic floor muscles [2 –6]. Development of dysfunction in pelvic floor muscles negatively affect life quality in approximately 25 % of adult women by leading to a wide range of problems such as urinary and anal incontine...
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - April 3, 2024 Category: OBGYN Authors: Fatma Nil üfer Topkara, Elif Dağlı, Nebahat Özerdoğan Tags: Full length article Source Type: research
Activation of Beta-3 Adrenergic Receptors with the Selective Agonist Mirabegron Elicits Multi-Site Mechanical Hypersensitivity, Grimace, and Increased Interleukin-6 Levels in Mice
Mirabegron is an adrenergic receptor beta-3 (Adrb3) selective agonist that is currently FDA-approved for the treatment of overactive bladder, with common side effects including headache and multi-site body pain. Our prior work has demonstrated that catecholamine activation of Adrb3 leads to chronic primary pain (CPP) through increased secretion of interleukin-6 (IL-6) from adipocytes. Pain development is blocked by pharmacologic inhibition or genetic knockdown of Adrb3. We evaluated the effects of mirabegron on evoked and spontaneous measures of pain, and IL-6 production. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Jennifer Ricano, Jiegen Chen, Yaomin Wang, Andrea Nackley Source Type: research
Sacral Neuromodulation: Device Improvement and Current Applications in Urology
Medicina (Kaunas). 2024 Mar 20;60(3):509. doi: 10.3390/medicina60030509.ABSTRACTSacral neuromodulation (SNM) offers a therapeutic approach to urological patients suffering from idiopathic overactive bladder (OAB) syndrome, with or without incontinence and non-obstructive urinary retention (NOR), who are not responding to or are not compliant with conservative or medical therapies. The exact mechanism of action of SNM is not fully understood but modulation of the spinal cord reflexes and brain networks by peripheral afferents is regarded as the main pathway. Over the years, surgical techniques improved, leading to the devel...
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Marco Spilotros Salvatore Gerbasi Francesco Lasorsa Gaetano de Rienzo Lorenzo Balducci Pasquale Ditonno Giuseppe Lucarelli Source Type: research
Sacral Neuromodulation: Device Improvement and Current Applications in Urology
Medicina (Kaunas). 2024 Mar 20;60(3):509. doi: 10.3390/medicina60030509.ABSTRACTSacral neuromodulation (SNM) offers a therapeutic approach to urological patients suffering from idiopathic overactive bladder (OAB) syndrome, with or without incontinence and non-obstructive urinary retention (NOR), who are not responding to or are not compliant with conservative or medical therapies. The exact mechanism of action of SNM is not fully understood but modulation of the spinal cord reflexes and brain networks by peripheral afferents is regarded as the main pathway. Over the years, surgical techniques improved, leading to the devel...
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Marco Spilotros Salvatore Gerbasi Francesco Lasorsa Gaetano de Rienzo Lorenzo Balducci Pasquale Ditonno Giuseppe Lucarelli Source Type: research
Sacral Neuromodulation: Device Improvement and Current Applications in Urology
Medicina (Kaunas). 2024 Mar 20;60(3):509. doi: 10.3390/medicina60030509.ABSTRACTSacral neuromodulation (SNM) offers a therapeutic approach to urological patients suffering from idiopathic overactive bladder (OAB) syndrome, with or without incontinence and non-obstructive urinary retention (NOR), who are not responding to or are not compliant with conservative or medical therapies. The exact mechanism of action of SNM is not fully understood but modulation of the spinal cord reflexes and brain networks by peripheral afferents is regarded as the main pathway. Over the years, surgical techniques improved, leading to the devel...
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Marco Spilotros Salvatore Gerbasi Francesco Lasorsa Gaetano de Rienzo Lorenzo Balducci Pasquale Ditonno Giuseppe Lucarelli Source Type: research
Sacral Neuromodulation: Device Improvement and Current Applications in Urology
Medicina (Kaunas). 2024 Mar 20;60(3):509. doi: 10.3390/medicina60030509.ABSTRACTSacral neuromodulation (SNM) offers a therapeutic approach to urological patients suffering from idiopathic overactive bladder (OAB) syndrome, with or without incontinence and non-obstructive urinary retention (NOR), who are not responding to or are not compliant with conservative or medical therapies. The exact mechanism of action of SNM is not fully understood but modulation of the spinal cord reflexes and brain networks by peripheral afferents is regarded as the main pathway. Over the years, surgical techniques improved, leading to the devel...
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Marco Spilotros Salvatore Gerbasi Francesco Lasorsa Gaetano de Rienzo Lorenzo Balducci Pasquale Ditonno Giuseppe Lucarelli Source Type: research
Sacral Neuromodulation: Device Improvement and Current Applications in Urology
Medicina (Kaunas). 2024 Mar 20;60(3):509. doi: 10.3390/medicina60030509.ABSTRACTSacral neuromodulation (SNM) offers a therapeutic approach to urological patients suffering from idiopathic overactive bladder (OAB) syndrome, with or without incontinence and non-obstructive urinary retention (NOR), who are not responding to or are not compliant with conservative or medical therapies. The exact mechanism of action of SNM is not fully understood but modulation of the spinal cord reflexes and brain networks by peripheral afferents is regarded as the main pathway. Over the years, surgical techniques improved, leading to the devel...
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Marco Spilotros Salvatore Gerbasi Francesco Lasorsa Gaetano de Rienzo Lorenzo Balducci Pasquale Ditonno Giuseppe Lucarelli Source Type: research
Sacral Neuromodulation: Device Improvement and Current Applications in Urology
Medicina (Kaunas). 2024 Mar 20;60(3):509. doi: 10.3390/medicina60030509.ABSTRACTSacral neuromodulation (SNM) offers a therapeutic approach to urological patients suffering from idiopathic overactive bladder (OAB) syndrome, with or without incontinence and non-obstructive urinary retention (NOR), who are not responding to or are not compliant with conservative or medical therapies. The exact mechanism of action of SNM is not fully understood but modulation of the spinal cord reflexes and brain networks by peripheral afferents is regarded as the main pathway. Over the years, surgical techniques improved, leading to the devel...
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Marco Spilotros Salvatore Gerbasi Francesco Lasorsa Gaetano de Rienzo Lorenzo Balducci Pasquale Ditonno Giuseppe Lucarelli Source Type: research
Sacral Neuromodulation: Device Improvement and Current Applications in Urology
Medicina (Kaunas). 2024 Mar 20;60(3):509. doi: 10.3390/medicina60030509.ABSTRACTSacral neuromodulation (SNM) offers a therapeutic approach to urological patients suffering from idiopathic overactive bladder (OAB) syndrome, with or without incontinence and non-obstructive urinary retention (NOR), who are not responding to or are not compliant with conservative or medical therapies. The exact mechanism of action of SNM is not fully understood but modulation of the spinal cord reflexes and brain networks by peripheral afferents is regarded as the main pathway. Over the years, surgical techniques improved, leading to the devel...
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Marco Spilotros Salvatore Gerbasi Francesco Lasorsa Gaetano de Rienzo Lorenzo Balducci Pasquale Ditonno Giuseppe Lucarelli Source Type: research
Sacral Neuromodulation: Device Improvement and Current Applications in Urology
Medicina (Kaunas). 2024 Mar 20;60(3):509. doi: 10.3390/medicina60030509.ABSTRACTSacral neuromodulation (SNM) offers a therapeutic approach to urological patients suffering from idiopathic overactive bladder (OAB) syndrome, with or without incontinence and non-obstructive urinary retention (NOR), who are not responding to or are not compliant with conservative or medical therapies. The exact mechanism of action of SNM is not fully understood but modulation of the spinal cord reflexes and brain networks by peripheral afferents is regarded as the main pathway. Over the years, surgical techniques improved, leading to the devel...
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Marco Spilotros Salvatore Gerbasi Francesco Lasorsa Gaetano de Rienzo Lorenzo Balducci Pasquale Ditonno Giuseppe Lucarelli Source Type: research
Sacral Neuromodulation: Device Improvement and Current Applications in Urology
Medicina (Kaunas). 2024 Mar 20;60(3):509. doi: 10.3390/medicina60030509.ABSTRACTSacral neuromodulation (SNM) offers a therapeutic approach to urological patients suffering from idiopathic overactive bladder (OAB) syndrome, with or without incontinence and non-obstructive urinary retention (NOR), who are not responding to or are not compliant with conservative or medical therapies. The exact mechanism of action of SNM is not fully understood but modulation of the spinal cord reflexes and brain networks by peripheral afferents is regarded as the main pathway. Over the years, surgical techniques improved, leading to the devel...
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Marco Spilotros Salvatore Gerbasi Francesco Lasorsa Gaetano de Rienzo Lorenzo Balducci Pasquale Ditonno Giuseppe Lucarelli Source Type: research
Sacral Neuromodulation: Device Improvement and Current Applications in Urology
Medicina (Kaunas). 2024 Mar 20;60(3):509. doi: 10.3390/medicina60030509.ABSTRACTSacral neuromodulation (SNM) offers a therapeutic approach to urological patients suffering from idiopathic overactive bladder (OAB) syndrome, with or without incontinence and non-obstructive urinary retention (NOR), who are not responding to or are not compliant with conservative or medical therapies. The exact mechanism of action of SNM is not fully understood but modulation of the spinal cord reflexes and brain networks by peripheral afferents is regarded as the main pathway. Over the years, surgical techniques improved, leading to the devel...
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Marco Spilotros Salvatore Gerbasi Francesco Lasorsa Gaetano de Rienzo Lorenzo Balducci Pasquale Ditonno Giuseppe Lucarelli Source Type: research
Sacral Neuromodulation: Device Improvement and Current Applications in Urology
Medicina (Kaunas). 2024 Mar 20;60(3):509. doi: 10.3390/medicina60030509.ABSTRACTSacral neuromodulation (SNM) offers a therapeutic approach to urological patients suffering from idiopathic overactive bladder (OAB) syndrome, with or without incontinence and non-obstructive urinary retention (NOR), who are not responding to or are not compliant with conservative or medical therapies. The exact mechanism of action of SNM is not fully understood but modulation of the spinal cord reflexes and brain networks by peripheral afferents is regarded as the main pathway. Over the years, surgical techniques improved, leading to the devel...
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Marco Spilotros Salvatore Gerbasi Francesco Lasorsa Gaetano de Rienzo Lorenzo Balducci Pasquale Ditonno Giuseppe Lucarelli Source Type: research
Sacral Neuromodulation: Device Improvement and Current Applications in Urology
Medicina (Kaunas). 2024 Mar 20;60(3):509. doi: 10.3390/medicina60030509.ABSTRACTSacral neuromodulation (SNM) offers a therapeutic approach to urological patients suffering from idiopathic overactive bladder (OAB) syndrome, with or without incontinence and non-obstructive urinary retention (NOR), who are not responding to or are not compliant with conservative or medical therapies. The exact mechanism of action of SNM is not fully understood but modulation of the spinal cord reflexes and brain networks by peripheral afferents is regarded as the main pathway. Over the years, surgical techniques improved, leading to the devel...
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Marco Spilotros Salvatore Gerbasi Francesco Lasorsa Gaetano de Rienzo Lorenzo Balducci Pasquale Ditonno Giuseppe Lucarelli Source Type: research
