Editorial Comment for URL-D-23-01604R1
Oxybutynin, first introduced in 1975, has long been the pharmacologic mainstay of overactive bladder (OAB) treatment. It has demonstrated clinical success in addressing bothersome OAB and urge urinary incontinence symptoms and maintains a strong clinical foothold in managing neurogenic bladder in both pediatric and adult populations. However, a growing body of evidence as outlined in this review, has demonstrated that both short and long-term use may result in adverse cognitive outcomes, including impaired memory and increased dementia risk. (Source: Urology)
Source: Urology - January 27, 2024 Category: Urology & Nephrology Authors: Michelle E. Van Kuiken Source Type: research
Editorial Comment for URL-D-23-01604R1: Oxybutynin-associated Cognitive Impairment: Evidence and Implications for Overactive Bladder Treatment
Oxybutynin, first introduced in 1975, has long been the pharmacologic mainstay of overactive bladder (OAB) treatment. It has demonstrated clinical success in addressing bothersome OAB and urge urinary incontinence symptoms and maintains a strong clinical foothold in managing neurogenic bladder in both pediatric and adult populations. However, a growing body of evidence as outlined in this review, has demonstrated that both short and long-term use may result in adverse cognitive outcomes, including impaired memory and increased dementia risk. (Source: Urology)
Source: Urology - January 27, 2024 Category: Urology & Nephrology Authors: Michelle E. Van Kuiken Tags: Editorial Comment Source Type: research
Editorial Comment on “ Oxybutynin-associated Cognitive Impairment: Evidence and Implications for Overactive Bladder Treatment”
Oxybutynin, first introduced in 1975, has long been the pharmacologic mainstay of overactive bladder (OAB) treatment. It has demonstrated clinical success in addressing bothersome OAB and urge urinary incontinence symptoms and maintains a strong clinical foothold in managing neurogenic bladder in both pediatric and adult populations. However, a growing body of evidence as outlined in this review, has demonstrated that both short and long-term use may result in adverse cognitive outcomes, including impaired memory and increased dementia risk. (Source: Urology)
Source: Urology - January 27, 2024 Category: Urology & Nephrology Authors: Michelle E. Van Kuiken Tags: Editorial Comment Source Type: research
Evaluating noninvasive brain stimulation to treat overactive bladder in individuals with multiple sclerosis: a randomized controlled trial protocol
Multiple Sclerosis (MS) is an often debilitating disease affecting the myelin sheath that encompasses neurons. It can be accompanied by a myriad of pathologies and adverse effects such as neurogenic lower urin... (Source: BMC Urology)
Source: BMC Urology - January 25, 2024 Category: Urology & Nephrology Authors: Betsy H. Salazar, Kristopher A. Hoffman, John A. Lincoln, Christof Karmonik, Hamida Rajab, Santosh A. Helekar and Rose Khavari Tags: Study Protocol Source Type: research
Gene Therapy and Overactive Bladder
AbstractPurpose of ReviewWithin the last decade, a number of gene therapies have been developed as a treatment option for monogenic diseases. Overactive bladder is a multifactorial syndrome with likely many underlying causes and regulatory components. The goal of this paper is to review current gene therapy in and outside of the genitourinary system, review the pathophysiology and genetics of OAB, and discuss recent advances in application of this technology for OAB treatment.Recent FindingsVarious genes have been found to be upregulated in OAB patients including receptors involved in purinergic signaling, gap junctions be...
Source: Current Bladder Dysfunction Reports - January 15, 2024 Category: Urology & Nephrology Source Type: research
Microstructural white matter abnormalities in overactive bladder syndrome evaluation with diffusion kurtosis imaging tract-based spatial statistics analysis
ConclusionDKI is a promising approach to the investigation of the pathophysiology of OAB and a potential biomarker for clinical diagnosis of OAB. (Source: World Journal of Urology)
Source: World Journal of Urology - January 13, 2024 Category: Urology & Nephrology Source Type: research
Machine Learning and Artificial Intelligence to Improve Interpretation of Urodynamics
This study is not a clinical trial and thus does not warrant registration as such. (Source: Current Bladder Dysfunction Reports)
Source: Current Bladder Dysfunction Reports - January 13, 2024 Category: Urology & Nephrology Source Type: research
Use of a Mobile Application for Pelvic Floor Muscle Training in Women With Urinary Incontinence: a Randomized Control Trial
ConclusionsThe study findings suggest that PFMT guided by a mobile app with visual guidance leads to greater improvements in storage symptoms and quality of life than the home-based PFMT guidance. (Source: International Urogynecology Journal and Pelvic Floor Dysfunction)
Source: International Urogynecology Journal and Pelvic Floor Dysfunction - January 12, 2024 Category: OBGYN Source Type: research
Use of a Mobile Application for Pelvic Floor Muscle Training in Women With Urinary Incontinence: a Randomized Control Trial
ConclusionsThe study findings suggest that PFMT guided by a mobile app with visual guidance leads to greater improvements in storage symptoms and quality of life than the home-based PFMT guidance. (Source: International Urogynecology Journal)
Source: International Urogynecology Journal - January 12, 2024 Category: OBGYN Source Type: research
Association between oral frailty and lower urinary tract symptoms among middle-aged and older adults in community-dwelling individuals: a cross-sectional study
ConclusionsOral frailty was independently associated with LUTS. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - January 12, 2024 Category: Urology & Nephrology Source Type: research
Effects of Transcutaneous Tibial Nerve Stimulation in Women Refractory to and Never Used Pharmacological Agents for Idiopathic Overactive Bladder
ConclusionsAlthough TTNS is more effective in PhA-naive women with iOAB, it appears to be an effective therapy that can also be used in the management of PhA-resistant women with iOAB. (Source: International Urogynecology Journal)
Source: International Urogynecology Journal - January 11, 2024 Category: OBGYN Source Type: research
Effects of Transcutaneous Tibial Nerve Stimulation in Women Refractory to and Never Used Pharmacological Agents for Idiopathic Overactive Bladder
ConclusionsAlthough TTNS is more effective in PhA-naive women with iOAB, it appears to be an effective therapy that can also be used in the management of PhA-resistant women with iOAB. (Source: International Urogynecology Journal and Pelvic Floor Dysfunction)
Source: International Urogynecology Journal and Pelvic Floor Dysfunction - January 11, 2024 Category: OBGYN Source Type: research
Is bladder outlet obstruction rat model to induce overactive bladder (OAB) has similarity to human OAB? Research on the events in smooth muscle, collagen, interstitial cell and telocyte distribution
Cellular and cytoskeletal events of overactive bladder (OAB) have not been sufficiently explored in human bladder due to different limitations. Bladder outlet obstruction (BOO) had been induced in different an... (Source: BMC Research Notes)
Source: BMC Research Notes - January 11, 2024 Category: Research Authors: Mohamed Wishahi, Sarah Hassan, Nabawya Kamal, Mohamed Badawy and Ehab Hafiz Tags: Research Note Source Type: research
Clinical tools for evaluating the severity of overactive bladder: A systematic review of psychometric properties
CONCLUSION: Overactive Bladder Symptom Score, the Overactive Bladder Questionnaire and the Neurogenic Bladder Symptoms Score are promising psychometrically sound measures. The Overactive Bladder Symptom Score has been applied to the most culturally diverse populations supported by studies of good methodological and high-GRADE evidence quality.PMID:38192076 | DOI:10.1177/02692155231225662 (Source: Clinical Rehabilitation)
Source: Clinical Rehabilitation - January 9, 2024 Category: Rehabilitation Authors: Mohammed Usman Ali Stanley John Winser Priya Kannan Georg S Kranz Kenneth Nai-Kuen Fong Source Type: research
Clinical tools for evaluating the severity of overactive bladder: A systematic review of psychometric properties
CONCLUSION: Overactive Bladder Symptom Score, the Overactive Bladder Questionnaire and the Neurogenic Bladder Symptoms Score are promising psychometrically sound measures. The Overactive Bladder Symptom Score has been applied to the most culturally diverse populations supported by studies of good methodological and high-GRADE evidence quality.PMID:38192076 | DOI:10.1177/02692155231225662 (Source: Clinical Rehabilitation)
Source: Clinical Rehabilitation - January 9, 2024 Category: Rehabilitation Authors: Mohammed Usman Ali Stanley John Winser Priya Kannan Georg S Kranz Kenneth Nai-Kuen Fong Source Type: research
