Evaluation of Outcomes Between the Top-down Versus the Bottom-up Approach for Retropubic Midurethral Sling
ConclusionsThe top-down approach to retropubic MUS placement was associated with lower rates of mesh erosion in this population of patients. Neither approach is associated with an increased overall risk of complications or de novo overactive bladder symptoms. (Source: International Urogynecology Journal and Pelvic Floor Dysfunction)
Source: International Urogynecology Journal and Pelvic Floor Dysfunction - February 20, 2024 Category: OBGYN Source Type: research
Reply to Shuying Jang, Ruiquin Wang, and Jian Liao ’s Letter to the Editor re: Neu S, Matta R, Locke JA, et al. The use of metformin in overactive bladder: a retrospective nested case-control, population-based analysis. Urology. 2023 Oct 5:S0090-4295(23)00871-3.
We appreciate the interest in our recent study1 from Dr. Jiang and colleagues. We agree that as a retrospective database study we are limited in our ability to say with certainty that metformin use is linked to overactive bladder (OAB). What we can conclude is that in a large population of diabetics, those with a prescription for metformin were more likely to have a coinciding prescription for an OAB medication (aOR = 1.07, 95% CI = 1.03-1.12). We chose to use OAB prescription as a surrogate for OAB diagnosis, as there is no available OAB code in the International Classification of Diseases (ICD) that could be used as part...
Source: Urology - February 16, 2024 Category: Urology & Nephrology Authors: Sarah Neu, Rano Matta, Jennifer A. Locke, Natalie Troke, Mina Tadrous, Refik Saskin, Karla Rebullar, Robert Nam, Sender Herschorn Source Type: research
Reply to “The Role of Metformin in Overactive Bladder: More Studies Are Warranted”
We appreciate the interest in our recent study1 from Dr Jiang and colleagues. We agree that as a retrospective database study, we are limited in our ability to say with certainty that metformin use is linked to overactive bladder (OAB). What we can conclude is that in a large population of diabetics, those with a prescription for metformin were more likely to have a coinciding prescription for an OAB medication (aOR=1.07, 95% CI=1.03 –1.12). We chose to use OAB prescription as a surrogate for OAB diagnosis, as there is no available OAB code in the International Classification of Diseases (ICD) that could be used as part ...
Source: Urology - February 16, 2024 Category: Urology & Nephrology Authors: Sarah Neu, Rano Matta, Jennifer A. Locke, Natalie Troke, Mina Tadrous, Refik Saskin, Karla Rebullar, Robert Nam, Sender Herschorn Tags: Letters to the Editor Source Type: research
The role of metformin in overactive bladder: more studies are warranted
Dear Editor: (Source: Urology)
Source: Urology - February 15, 2024 Category: Urology & Nephrology Authors: Shuying Jiang, Ruiqian Wang, Jian Liao Source Type: research
Prevalence of overactive bladder among overweight and obese women: A prospective cross-sectional cohort study
CONCLUSION: The risk of developing OAB symptomatology is significantly greater in overweight and obese patients. As BMI increases, the symptomatology, perceived discomfort and QoL of patients with OAB worsen.PMID:38340591 | DOI:10.1016/j.ejogrb.2024.02.010 (Source: Reproductive Biology)
Source: Reproductive Biology - February 10, 2024 Category: Reproduction Medicine Authors: Baydaa Alsannan Antonio Simone Lagan à Jehad Alhermi Shaikha Almansoor Amal Ayed Renato Venezia Andrea Etrusco Source Type: research
Prevalence of overactive bladder among overweight and obese women: A prospective cross-sectional cohort study
Overactive bladder (OAB) is an entity that affects and negatively impacts the quality of life (QoL) and sexual function of approximately 12 % of the adult female population [1]. The International Urogynecological Association (IUGA) and the International Continence Society (ICS) define urinary urgency as a complex of symptoms defined by increased daytime frequency and nocturia with or without urinary incontinence in the absence of pat hologic or metabolic conditions that may explain these symptoms [2]. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - February 5, 2024 Category: OBGYN Authors: Baydaa Alsannan, Antonio Simone Lagan à, Jehad Alhermi, Shaikha Almansoor, Amal Ayed, Renato Venezia, Andrea Etrusco Tags: Full length article Source Type: research
Robotic-assisted intravesical mesh excision following retropubic midurethral sling
ConclusionsRobotic excision of intravesical mesh after synthetic midurethral sling was safely performed in this patient who had multiple areas of intravesical mesh. Management aspects reported here may be helpful for complex presentations of intravesical mesh. (Source: International Urogynecology Journal and Pelvic Floor Dysfunction)
Source: International Urogynecology Journal and Pelvic Floor Dysfunction - February 3, 2024 Category: OBGYN Source Type: research
Giggle incontinence: a scoping review
Pediatr Res. 2024 Feb 2. doi: 10.1038/s41390-024-03065-y. Online ahead of print.ABSTRACTGiggle incontinence (GI) is poorly described, defined, and understood. It is considered a bladder storage disorder in which laughter causes an uncontrollable episode of urinary incontinence that cannot be stopped until the bladder is completely emptied. It has been confused with stress urinary incontinence and overactive bladder. A thorough analysis of 26 articles on the subject of "giggle incontinence" and associated terms was performed, including all articles since the phrase first appeared. To date, 351 GI cases have been reported. I...
Source: Pediatric Research - February 2, 2024 Category: Pediatrics Authors: Adri án A González-Maldonado Manuel Garc ía-Mérida Source Type: research
Evaluation of the therapeutic effectiveness of a 6-point vaginal mesh in the treatment of high degree pelvic organ prolapse
Introduction: The study aimed to assess the recurrence rate of pelvic organ prolapse in females who underwent a 6 -point Ingynious anterior mesh implementation and to identify potential differences between POPQ grade III and IV in terms of treatment effectiveness and selected patient characteristics. Patient characteristics included age, BMI and parity. The number of prolapse recurrences, complications, stress urinary incontinence and overactive bladder de novo in the follow-up was analysed. Recurrence included diagnosis of POPQ stage II or higher of the apical or anterior compartment. (Source: European Journal of Obstetri...
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - February 1, 2024 Category: OBGYN Authors: Iga Siarkowska, Anna Orze ł, Ewelina Mabiala, Małgorzata Starzec- Proserpio, Agata Krawczyk, Wioletta Bojanowska, Piotr Kukulski, Jacek Szymańsk Source Type: research
Efficacy of sacral neuromodulation in the treatment of refractory overactive bladder and non-obstructive urinary retention –A preliminary report
Introduction: Sacral neuromodulation (SNM) is a minimally invasive treatment approved for refractory OAB and non-obstructive urinary retention. The procedure has been performed in our Clinic since 2020. The report is aimed to share our experience in the field. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - February 1, 2024 Category: OBGYN Authors: Iga Siarkowska, Ewelina Mabiala, Piotr Kukulski, Jacek Szyma ński Source Type: research
Psychiatric disorders in women with pelvic floor disorders
Introduction: Nowadays pelvic floor diseases are very often diagnosed and the frequency of this disorders is very high ageing population in developed countries. Most of authors agree that overactive bladder syndrome negatively influence many aspects of affected patients including their sanity. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - February 1, 2024 Category: OBGYN Authors: Urszula Kalata, Jarkiewicz Michal, Vitalij Kondratskyi, Andrzej Pomian, Ewa Barcz Source Type: research
Concomitant Use of Sodium-Glucose Cotransporter 2 Inhibitors and Overactive Bladder Drugs and the Risk of Urinary Tract Infection
This study found a similar risk of UTIs in concomitant users of SGLT-2i and DPP-4i (weighted HR 1.08, 95% confidence interval: 0.88-1.32) with OAB drugs. In the second cohort, 2,387 and 280 new-users of SGLT-2i and GLP-1RA with OAB drugs were identified, respectively. Initiation of SGLT-2i while on OAB treatment was not associated with increased risk of UTI (0.89, 0.50-1.60), compared with initiation of GLP-1RA. These results show that the concomitant use of SGLT-2i with OAB drugs was not associated with an increased risk of UTI compared with the concomitant use of DPP-4i or GLP-1RA with OAB drugs.PMID:38284421 | DOI:10.10...
Source: Clinical Pharmacology and Therapeutics - January 29, 2024 Category: Drugs & Pharmacology Authors: Sungho Bea Hyesung Lee Sohee Park Young Min Cho Won Suk Choi Katsiaryna Bykov Ju-Young Shin Source Type: research
Oxybutynin-Associated Cognitive Impairment: Evidence and Implications for Overactive Bladder Treatment
Anticholinergic medications have long been mainstays of overactive bladder (OAB) treatment. Oxybutynin, a first-generation anticholinergic, still accounts for more than half of all OAB medication prescriptions, despite associations with impaired memory and cognition, as well as mounting evidence that it may increase the risk of incident dementia. This review details the current literature regarding oxybutynin and cognition, including evidence from preclinical, clinical, and real-world studies that show that oxybutynin binds nonspecifically to muscarinic receptors in the brain and is associated with adverse cognitive outcom...
Source: Urology - January 29, 2024 Category: Urology & Nephrology Authors: Michael B. Chancellor, Alvaro Lucioni, David Staskin Source Type: research
