Development and characterization of 3D printed ethylene vinyl acetate (EVA) as drug delivery device for the treatment of overactive bladder
Drug Dev Ind Pharm. 2024 Mar 14:1-12. doi: 10.1080/03639045.2024.2311177. Online ahead of print.ABSTRACTThe overactive bladder is a condition characterized by a sudden urge to urinate, even with small volumes of urine present in the bladder. The current treatments available for this pathology consist on conservative approaches and the continuous administration of drugs, which when made by conventional methods has limitations related to the first pass metabolism, bioavailability, severe side effects, and low patient adherence to treatments, ultimately leading to low effectiveness. Within this context, the present work propo...
Source: Drug Development and Industrial Pharmacy - March 15, 2024 Category: Drugs & Pharmacology Authors: Gustavo Ferrari Loise Silveira da Silva Renata Cerruti Izabelle de Mello Gindri Gean Vitor Salmoria Carlos Rodrigo de Mello Roesler Source Type: research
Transcutaneous tibial nerve stimulation in patients with multiple sclerosis and overactive bladder: a real-life clinical and urodynamic assessment
ConclusionTTNS improves OAB symptoms in PwMS, without significant changes on urodynamics. A high rate of strong or urgent need to void in daily life was associated with higher satisfaction. (Source: World Journal of Urology)
Source: World Journal of Urology - March 13, 2024 Category: Urology & Nephrology Source Type: research
Overactive bladder negatively affects erectile function and promotes premature ejaculation: findings from large representative population-level study
ConclusionOveractive bladder did not significantly affect men ’s sexual activity, but it significantly correlated with ED and PE. Our results suggest a need in daily clinical practice to screen for OAB symptoms for persons who report ED or PE. (Source: World Journal of Urology)
Source: World Journal of Urology - March 13, 2024 Category: Urology & Nephrology Source Type: research
Unraveling the interplay between dyskinesia and overactive bladder symptoms in Parkinson ’s disease: a comprehensive cohort study based on the long-term follow-up database of Parkinson’s disease
Overactive bladder (OAB) and dyskinesia are frequent complications in patients with Parkinson ’s disease (PD). However, the correlation between OAB and dyskinesia has been insufficiently explored. The purpose o... (Source: BMC Neurology)
Source: BMC Neurology - March 12, 2024 Category: Neurology Authors: Hong Jin, Yiheng Du, Jiahui Yan, Jinru Zhang, Xiaoyu Cheng, Chengjie Mao, Jing Chen and Chun-feng Liu Tags: Research Source Type: research
Pathophysiology of Overactive Bladder and Pharmacologic Treatments Including β3-Adrenoceptor Agonists -Basic Research Perspectives
Int Neurourol J. 2024 Feb;28(Suppl 1):12-33. doi: 10.5213/inj.2448002.001. Epub 2024 Feb 29.ABSTRACTOveractive bladder (OAB) is a symptom-based syndrome defined by urinary urgency, frequency, and nocturia with or without urge incontinence. The causative pathology is diverse; including bladder outlet obstruction (BOO), bladder ischemia, aging, metabolic syndrome, psychological stress, affective disorder, urinary microbiome, localized and systemic inflammatory responses, etc. Several hypotheses have been suggested as mechanisms of OAB generation; among them, neurogenic, myogenic, and urothelial mechanisms are well-known hypo...
Source: International Neurourology Journal - March 10, 2024 Category: Urology & Nephrology Authors: Joonbeom Kwon Duk Yoon Kim Kang Jun Cho Mamoru Hashimoto Kanako Matsuoka Tadanobu Kamijo Zhou Wang Sergei Karnup Anne M Robertson Pradeep Tyagi Naoki Yoshimura Source Type: research
Pathophysiology of Overactive Bladder and Pharmacologic Treatments Including β3-Adrenoceptor Agonists -Basic Research Perspectives
Int Neurourol J. 2024 Feb;28(Suppl 1):12-33. doi: 10.5213/inj.2448002.001. Epub 2024 Feb 29.ABSTRACTOveractive bladder (OAB) is a symptom-based syndrome defined by urinary urgency, frequency, and nocturia with or without urge incontinence. The causative pathology is diverse; including bladder outlet obstruction (BOO), bladder ischemia, aging, metabolic syndrome, psychological stress, affective disorder, urinary microbiome, localized and systemic inflammatory responses, etc. Several hypotheses have been suggested as mechanisms of OAB generation; among them, neurogenic, myogenic, and urothelial mechanisms are well-known hypo...
Source: International Neurourology Journal - March 10, 2024 Category: Urology & Nephrology Authors: Joonbeom Kwon Duk Yoon Kim Kang Jun Cho Mamoru Hashimoto Kanako Matsuoka Tadanobu Kamijo Zhou Wang Sergei Karnup Anne M Robertson Pradeep Tyagi Naoki Yoshimura Source Type: research
