Discovery of cyperenoic acid as a potent and novel entry inhibitor of influenza A virus
Antiviral Res. 2024 Feb 11:105822. doi: 10.1016/j.antiviral.2024.105822. Online ahead of print.ABSTRACTInfluenza therapeutics with new targets and modes of action are urgently needed due to the frequent emergence of mutants resistant to currently available anti-influenza drugs. Here we report the in vitro and in vivo anti-influenza A virus activities of cyperenoic acid, a natural compound, which was isolated from a Chinese medicine Croton crassifolius Geise. Cyperenoic acid could potently suppress H1N1, H3N2 and H9N2 virus replication with IC50 values ranging from 0.12 to 15.13 μM, and showed a low cytotoxicity against MD...
Source: Antiviral Research - February 13, 2024 Category: Virology Authors: Xiaoli Zhang Yiping Xia Peibo Li Zhongnan Wu Ruilin Li Jialiao Cai Yubo Zhang Guocai Wang Yaolan Li Wei Tang Weiwei Su Source Type: research
Discovery of new antiviral agents through artificial intelligence: In vitro and in vivo results
Antiviral Res. 2024 Feb;222:105818. doi: 10.1016/j.antiviral.2024.105818. Epub 2024 Jan 25.ABSTRACTIn this research, we employed a deep reinforcement learning (RL)-based molecule design platform to generate a diverse set of compounds targeting the neuraminidase (NA) of influenza A and B viruses. A total of 60,291 compounds were generated, of which 86.5 % displayed superior physicochemical properties compared to oseltamivir. After narrowing down the selection through computational filters, nine compounds with non-sialic acid-like structures were selected for in vitro experiments. We identified two compounds, DS-22-inf-009 a...
Source: Antiviral Research - January 27, 2024 Category: Virology Authors: Roza Izmailyan Mher Matevosyan Hamlet Khachatryan Anastasiya Shavina Smbat Gevorgyan Artur Ghazaryan Irina Tirosyan Yeva Gabrielyan Marusya Ayvazyan Boris Martirosyan Vardan Harutyunyan Hovakim Zakaryan Source Type: research
Obesity and its Relationship with Covid-19: A Review of the Main Pharmaceutical Aspects
Curr Pharm Biotechnol. 2024 Jan 22. doi: 10.2174/0113892010264503231108070917. Online ahead of print.ABSTRACTImportant physiological changes are observed in patients with obesity, such as intestinal permeability, gastric emptying, cardiac output, and hepatic and renal function. These differences can determine variations in the pharmacokinetics of different drugs and can generate different concentrations at the site of action, which can lead to sub therapeutic or toxic concentrations. Understanding the physiological and immunological processes that lead to the clinical manifestations of COVID-19 is essential to correlate ob...
Source: Current Pharmaceutical Biotechnology - January 23, 2024 Category: Biotechnology Authors: Katharine Hodel Ananda Fonseca Islania Barbosa Caio Medina Brenda Alves Carine Maciel Daniel Nascimento Gessualdo Oliveira-Junior Lorena Pedreira Monielly de Souza Ana Leonor Godoy Source Type: research
The impact of PA/I38 substitutions and PA polymorphisms on the susceptibility of zoonotic influenza A viruses to baloxavir
AbstractGenetic reassortment of avian, swine, and human influenza A viruses (IAVs) poses potential pandemic risks. Surveillance is important for influenza pandemic preparedness, but the susceptibility of zoonotic IAVs to the cap-dependent endonuclease inhibitor baloxavir acid (BXA) has not been thoroughly researched. Although an amino acid substitution at position 38 in the polymerase acidic protein (PA/I38) in seasonal IAVs reduces BXA susceptibility, PA polymorphisms at position 38 are rarely seen in zoonotic IAVs. Here, we examined the impact of PA/I38 substitutions on the BXA susceptibility of recombinant A(H5N1) virus...
Source: Archives of Virology - January 12, 2024 Category: Virology Source Type: research
Comorbidity of Mitral Valve Stenosis with Influenza in Pregnancy, A Case Report
Adv Biomed Res. 2023 Nov 29;12:252. doi: 10.4103/abr.abr_104_23. eCollection 2023.ABSTRACTIn this case, a 44-year-old pregnant woman at a gestational age of 28 weeks and 6 days with symptoms of cold, shortness of breath, and cough since a week ago. She had received remdesivir ampoule, Tamiflu tablet, meropenem and linezolid, and dexamethasone. She received oxygen through a 14-liter reservoir bag mask and hydrocortisone, heparin, and ceftriaxone. Nine hours after hospitalization, the patient suffered a cardiorespiratory arrest, resuscitation was performed, and the patient was intubated. Emergency cesarean section was done i...
Source: Biomed Res - January 9, 2024 Category: Research Authors: Minoo Movahedi Maryam Goharian Azita Kabiri Shadi Zamansaraei Source Type: research
Influenza associated cardiac arrhythmia- a systematic review
CONCLUSIONS: Therefore, ACE 2 binder influenza viruses have more prone to be associated with cardiac conduction disorder. Oseltamivir for influenza infection is also associated with bradycardia and can shorten or lengthen QT segment. Influenza vaccination has found to be protective.PMID:38185405 | DOI:10.1016/j.amjms.2024.01.004 (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - January 7, 2024 Category: General Medicine Authors: Md Mashiul Alam Timir Paul Abhinav Aggarwal Stuart Zarich Source Type: research
Influenza associated cardiac arrhythmia- a systematic review
CONCLUSIONS: Therefore, ACE 2 binder influenza viruses have more prone to be associated with cardiac conduction disorder. Oseltamivir for influenza infection is also associated with bradycardia and can shorten or lengthen QT segment. Influenza vaccination has found to be protective.PMID:38185405 | DOI:10.1016/j.amjms.2024.01.004 (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - January 7, 2024 Category: General Medicine Authors: Md Mashiul Alam Timir Paul Abhinav Aggarwal Stuart Zarich Source Type: research
GSE245051 Oseltamivir enhances 5-FU sensitivity in esophageal squamous carcinoma with high SPNS1
Conclusion: Our findings indicated that SPNS1 may promote the progression of ESCC by upregulating NEU1 expression and influencing chemotherapy sensitivity. These results provide new insights into potential therapeutic targets for ESCC treatment. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - January 1, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Misclassification of Influenza Infection and Oseltamivir Exposure
This cross-sectional study examines documented hospitalization for influenza and administration of neuraminidase inhibitors in US children. (Source: JAMA Pediatrics)
Source: JAMA Pediatrics - December 26, 2023 Category: Pediatrics Source Type: research
Viruses, Vol. 15, Pages 2447: Pre-Clinical Evaluation of the Antiviral Activity of Epigalocatechin-3-Gallate, a Component of Green Tea, against Influenza A(H1N1)pdm Viruses
This study aimed to explore the antiviral efficacy of EGCG in vitro and in ferrets. We first performed studies in Madin-Darby Canine Kidney (MDCK) and human lung carcinoma (Calu-3) cells, which demonstrated antiviral activity. In MDCK cells, we observed a selective index (SI, CC50/IC50) of 77 (290 µM/3.8 µM) and 96 (290 µM/3.0 µM) against A/California/07/2009 and A/Victoria/2570/2019 (H1N1)pdm09 influenza virus, respectively. Calu-3 cells demonstrated a SI of 16 (420 µM/26 µM) and 18 (420 µM/24 µM). Ferrets infec...
Source: Viruses - December 16, 2023 Category: Virology Authors: Harry Stannard Paulina Koszalka Nikita Deshpande Yves Desjardins Mariana Baz Tags: Article Source Type: research
Successful treatment with oseltamivir phosphate in children with ITP who failed first-line therapy: a case series report
AbstractImmune thrombocytopenia (ITP) is a common bleeding disorder in children. First-line medicines (glucocorticoids and immunoglobulin) may not be effective for some children, endangering their lives, posing challenges for healthcare facilities, and leading to an unfavorable prognosis. As a sialidase inhibitor, oseltamivir phosphate can reduce the destruction of platelets in liver macrophages by inhibiting the sialylation of platelets, and finally achieve the purpose of increasing platelet count. In this paper, three cases of children with ITP who failed first-line therapy and were cured by oral administration of oselta...
Source: Annals of Hematology - December 14, 2023 Category: Hematology Source Type: research
Pan-antiviral effects of a PIKfyve inhibitor on respiratory virus infection in human nasal epithelium and mice
In this study, we demonstrated the antiviral effects of PIKfyve inhibitors on influenza virus and respiratory syncytial virus in vitro and in vivo. PIKfyve inhibitors Apilimod mesylate (AM) and YM201636 concentration-dependently inhibited several influenza strains in an MDCK cell-cytopathic assay. AM also reduced the viral load and cytokine release, while improving the cell integrity of human nasal air-liquid interface cultured epithelium infected with influenza PR8. In PR8-infected mice, AM (2 mg/mL), when intranasally treated, exhibited a significant reduction of viral load and inflammation and inhibited weight loss caus...
Source: Antimicrobial Agents and Chemotherapy - December 8, 2023 Category: Microbiology Authors: Jonathan Baker Hugo Ombredane Leah Daly Ian Knowles Garth Rapeport Kazuhiro Ito Source Type: research
Pan-antiviral effects of a PIKfyve inhibitor on respiratory virus infection in human nasal epithelium and mice
In this study, we demonstrated the antiviral effects of PIKfyve inhibitors on influenza virus and respiratory syncytial virus in vitro and in vivo. PIKfyve inhibitors Apilimod mesylate (AM) and YM201636 concentration-dependently inhibited several influenza strains in an MDCK cell-cytopathic assay. AM also reduced the viral load and cytokine release, while improving the cell integrity of human nasal air-liquid interface cultured epithelium infected with influenza PR8. In PR8-infected mice, AM (2 mg/mL), when intranasally treated, exhibited a significant reduction of viral load and inflammation and inhibited weight loss caus...
Source: Antimicrobial Agents and Chemotherapy - December 8, 2023 Category: Microbiology Authors: Jonathan Baker Hugo Ombredane Leah Daly Ian Knowles Garth Rapeport Kazuhiro Ito Source Type: research
Pan-antiviral effects of a PIKfyve inhibitor on respiratory virus infection in human nasal epithelium and mice
In this study, we demonstrated the antiviral effects of PIKfyve inhibitors on influenza virus and respiratory syncytial virus in vitro and in vivo. PIKfyve inhibitors Apilimod mesylate (AM) and YM201636 concentration-dependently inhibited several influenza strains in an MDCK cell-cytopathic assay. AM also reduced the viral load and cytokine release, while improving the cell integrity of human nasal air-liquid interface cultured epithelium infected with influenza PR8. In PR8-infected mice, AM (2 mg/mL), when intranasally treated, exhibited a significant reduction of viral load and inflammation and inhibited weight loss caus...
Source: Antimicrobial Agents and Chemotherapy - December 8, 2023 Category: Microbiology Authors: Jonathan Baker Hugo Ombredane Leah Daly Ian Knowles Garth Rapeport Kazuhiro Ito Source Type: research
