Antiviral susceptibility of clade 2.3.4.4b highly pathogenic avian influenza A(H5N1) viruses isolated from birds and mammals in the United States, 2022
Antiviral Res. 2023 Jul 24:105679. doi: 10.1016/j.antiviral.2023.105679. Online ahead of print.ABSTRACTClade 2.3.4.4 b highly pathogenic avian influenza (HPAI) A (H5N1) viruses that are responsible for devastating outbreaks in birds and mammals pose a potential threat to public health. Here, we evaluated their susceptibility to influenza antivirals. Of 1015 sequences of HPAI A (H5N1) viruses collected in the United States during 2022, eight viruses (∼0.8%) had a molecular marker of drug resistance to an FDA-approved antiviral: three adamantane-resistant (M2-V27A), four oseltamivir-resistant (NA-H275Y), and one baloxavir-...
Source: Antiviral Research - July 26, 2023 Category: Virology Authors: Ha T Nguyen Anton Chesnokov Juan De La Cruz Philippe Noriel Q Pascua Vasiliy P Mishin Yunho Jang Joyce Jones Han Di Andrei A Ivashchenko Mary Lea Killian Mia K Torchetti Kristina Lantz David E Wentworth Charles T Davis Alexandre V Ivachtchenko Larisa V Gu Source Type: research
The Utilization and Development of Viral Vectors in Vaccines as a Prophylactic Treatment Against Ebola Virus as an Emerging and Zoonotic Infectious Disease
Mini Rev Med Chem. 2023 Jul 25. doi: 10.2174/1389557523666230725115324. Online ahead of print.ABSTRACTAlongside the prescription of commonly used antivirals, such as acyclovir, remdesivir, oseltamivir, and ciprofloxacin, the most efficient way to prevent or treat communicable diseases is by vaccination. Vaccines have been the most efficient way to prevent or treat highly transmissible infectious agents, such as Ebola, Anthrax, and Dengue Fever. Most epidemics of these highly transmissible infectious agents occur in places, such as South America, Central America, Tropical Asia, and Africa, where the availability of resource...
Source: Mini Reviews in Medicinal Chemistry - July 25, 2023 Category: Chemistry Authors: Anthony Garcia Oliver Grundmann Source Type: research
The Utilization and Development of Viral Vectors in Vaccines as a Prophylactic Treatment Against Ebola Virus as an Emerging and Zoonotic Infectious Disease
Mini Rev Med Chem. 2023 Jul 25. doi: 10.2174/1389557523666230725115324. Online ahead of print.ABSTRACTAlongside the prescription of commonly used antivirals, such as acyclovir, remdesivir, oseltamivir, and ciprofloxacin, the most efficient way to prevent or treat communicable diseases is by vaccination. Vaccines have been the most efficient way to prevent or treat highly transmissible infectious agents, such as Ebola, Anthrax, and Dengue Fever. Most epidemics of these highly transmissible infectious agents occur in places, such as South America, Central America, Tropical Asia, and Africa, where the availability of resource...
Source: Mini Reviews in Medicinal Chemistry - July 25, 2023 Category: Chemistry Authors: Anthony Garcia Oliver Grundmann Source Type: research
Severe forms of influenza infections admitted in intensive care units: Analysis of mortality factors
CONCLUSION: Patient's underlying conditions influence hospital admission and secondary ICU admission but were not found to impact ICU mortality except in patients age >65, history of cancer, and bacterial coinfections. Pulmonary involvement was often present, required MV, and often evolved toward ARDS. ICU mortality was strongly related to ARDS severity. We recommend rapid ICU admission of patients with influenza-related pneumonia, management of bacterial coinfection, and early administration of oseltamivir.PMID:37483265 | PMC:PMC10359970 | DOI:10.1111/irv.13168 (Source: Respiratory Care)
Source: Respiratory Care - July 24, 2023 Category: Respiratory Medicine Authors: Victor Verdier Fran çois Lilienthal Arnaud Desvergez Virgile Gazaille Arnaud Winer Fabrice Paganin Source Type: research
Viruses, Vol. 15, Pages 1540: Fc-Effector-Independent in vivo Activity of a Potent Influenza B Neuraminidase Broadly Neutralizing Antibody
es J. Kobie
Influenza B virus (IBV) contributes to substantial influenza-mediated morbidity and mortality, particularly among children. Similar to influenza A viruses (IAV), the hemagglutinin (HA) and neuraminidase (NA) of IBV undergo antigenic drift, necessitating regular reformulation of seasonal influenza vaccines. NA inhibitors, such as oseltamivir, have reduced activity and clinical efficacy against IBV, while M2 channel inhibitors are only effective against IAV, highlighting the need for improved vaccine and therapeutics for the treatment of seasonal IBV infections. We have previously described a potent human mon...
Source: Viruses - July 13, 2023 Category: Virology Authors: Ahmed M. Khalil Michael S. Piepenbrink Ian Markham Madhubanti Basu Luis Martinez-Sobrido James J. Kobie Tags: Article Source Type: research
Pediatric Update: Top 10 Articles of 2022
This study shows a surge in pediatric firearm injuries presenting to US children’s hospitals during the COVID-19 pandemic. The unequal rates of injury in black children and children with public insurance reflects the disproportionate impact of COVID-19 in minority groups due to the exacerbation of previously present healthcare disparities. This data should be used to support advocacy efforts and healthcare policy aimed at injury prevention.
Common Diagnoses and Costs in Pediatric Hospitalization in the U.S.
Kaiser SV, et al. Common diagnoses and costs in pediatric hospitalization in the US. JAMA Pediatr. 2022;176(3):316...
Source: The Hospitalist - July 5, 2023 Category: Hospital Management Authors: Ronda Whitaker Tags: Adolescent Medicine Business of Medicine Hospital Medicine Pediatrics Transitions of Care Source Type: research
Investigation of Methyl-5-(pentan-3-yloxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxyhydrazide Derivatives as Potential Inhibitors of COVID-19 Main Protease: DFT and Molecular Docking Study
In this study, hydrazones derived from oseltamivir intermediate, methyl 5-(pentan-3-yloxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxylate have been investigated for their potential as drug candidates against the COVID-19 virus using computational methods, including density functional theory (DFT) studies, molecular docking, and absorption, distribution, metabolism, excretion and toxicity (ADMET) analysis. The DFT studies provide information on the electronic properties of the compounds while the molecular docking results using AutoDock reported the binding energies between the main protease of COVID-19 and the compounds. The ...
Source: Bioinformatics and Biology Insights - June 28, 2023 Category: Bioinformatics Authors: Olawale Folorunso Akinyele Emmanuel Gabriel Fakola Omolara Olubunmi Adeboye Sunday Chimela Chinuomah Source Type: research
In Silico Design of an Oseltamivir Derivative with Increased Affinity against Wild-Type and Mutant Variants of Neuraminidase and Hemagglutinin of Influenza A H1N1 Virus
Chem Biodivers. 2023 Jun 28:e202201077. doi: 10.1002/cbdv.202201077. Online ahead of print.ABSTRACTAntiviral resistance has turned into a world concern nowadays. Influenza A H1N1 emerged as a problem at the world level due to the neuraminidase (NA) mutations. The NA mutants conferred resistance to oseltamivir and zanamivir. Several efforts were conducted to develop better anti-influenza A H1N1 drugs. Our research group combined in silico methods to create a compound derived from oseltamivir to be tested in vitro against influenza A H1N1. Here we show the results of a new compound derived from oseltamivir but with specific ...
Source: Chemistry and Biodiversity - June 28, 2023 Category: Biochemistry Authors: Garc ía-Machorro Jazmin Mirzaeicheshmeh Elaheh Fragoso-V ázquez Manuel Jonathan Bello Martiniano M éndez-Luna David Le ón-Cardona Alám Correa-Basurto Jos é Source Type: research
Investigation of Methyl-5-(pentan-3-yloxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxyhydrazide Derivatives as Potential Inhibitors of COVID-19 Main Protease: DFT and Molecular Docking Study
In this study, hydrazones derived from oseltamivir intermediate, methyl 5-(pentan-3-yloxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxylate have been investigated for their potential as drug candidates against the COVID-19 virus using computational methods, including density functional theory (DFT) studies, molecular docking, and absorption, distribution, metabolism, excretion and toxicity (ADMET) analysis. The DFT studies provide information on the electronic properties of the compounds while the molecular docking results using AutoDock reported the binding energies between the main protease of COVID-19 and the compounds. The ...
Source: Bioinformatics and Biology Insights - June 28, 2023 Category: Bioinformatics Authors: Olawale Folorunso Akinyele Emmanuel Gabriel Fakola Omolara Olubunmi Adeboye Sunday Chimela Chinuomah Source Type: research
In Silico Design of an Oseltamivir Derivative with Increased Affinity against Wild-Type and Mutant Variants of Neuraminidase and Hemagglutinin of Influenza A H1N1 Virus
Chem Biodivers. 2023 Jun 28:e202201077. doi: 10.1002/cbdv.202201077. Online ahead of print.ABSTRACTAntiviral resistance has turned into a world concern nowadays. Influenza A H1N1 emerged as a problem at the world level due to the neuraminidase (NA) mutations. The NA mutants conferred resistance to oseltamivir and zanamivir. Several efforts were conducted to develop better anti-influenza A H1N1 drugs. Our research group combined in silico methods to create a compound derived from oseltamivir to be tested in vitro against influenza A H1N1. Here we show the results of a new compound derived from oseltamivir but with specific ...
Source: Chemistry and Biodiversity - June 28, 2023 Category: Biochemistry Authors: Garc ía-Machorro Jazmin Mirzaeicheshmeh Elaheh Fragoso-V ázquez Manuel Jonathan Bello Martiniano M éndez-Luna David Le ón-Cardona Alám Correa-Basurto Jos é Source Type: research
Investigation of Methyl-5-(pentan-3-yloxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxyhydrazide Derivatives as Potential Inhibitors of COVID-19 Main Protease: DFT and Molecular Docking Study
In this study, hydrazones derived from oseltamivir intermediate, methyl 5-(pentan-3-yloxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxylate have been investigated for their potential as drug candidates against the COVID-19 virus using computational methods, including density functional theory (DFT) studies, molecular docking, and absorption, distribution, metabolism, excretion and toxicity (ADMET) analysis. The DFT studies provide information on the electronic properties of the compounds while the molecular docking results using AutoDock reported the binding energies between the main protease of COVID-19 and the compounds. The ...
Source: Bioinformatics and Biology Insights - June 28, 2023 Category: Bioinformatics Authors: Olawale Folorunso Akinyele Emmanuel Gabriel Fakola Omolara Olubunmi Adeboye Sunday Chimela Chinuomah Source Type: research
Investigation of Methyl-5-(pentan-3-yloxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxyhydrazide Derivatives as Potential Inhibitors of COVID-19 Main Protease: DFT and Molecular Docking Study
In this study, hydrazones derived from oseltamivir intermediate, methyl 5-(pentan-3-yloxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxylate have been investigated for their potential as drug candidates against the COVID-19 virus using computational methods, including density functional theory (DFT) studies, molecular docking, and absorption, distribution, metabolism, excretion and toxicity (ADMET) analysis. The DFT studies provide information on the electronic properties of the compounds while the molecular docking results using AutoDock reported the binding energies between the main protease of COVID-19 and the compounds. The ...
Source: Bioinformatics and Biology Insights - June 28, 2023 Category: Bioinformatics Authors: Olawale Folorunso Akinyele Emmanuel Gabriel Fakola Omolara Olubunmi Adeboye Sunday Chimela Chinuomah Source Type: research
Investigation of Methyl-5-(pentan-3-yloxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxyhydrazide Derivatives as Potential Inhibitors of COVID-19 Main Protease: DFT and Molecular Docking Study
In this study, hydrazones derived from oseltamivir intermediate, methyl 5-(pentan-3-yloxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxylate have been investigated for their potential as drug candidates against the COVID-19 virus using computational methods, including density functional theory (DFT) studies, molecular docking, and absorption, distribution, metabolism, excretion and toxicity (ADMET) analysis. The DFT studies provide information on the electronic properties of the compounds while the molecular docking results using AutoDock reported the binding energies between the main protease of COVID-19 and the compounds. The ...
Source: Bioinformatics and Biology Insights - June 28, 2023 Category: Bioinformatics Authors: Olawale Folorunso Akinyele Emmanuel Gabriel Fakola Omolara Olubunmi Adeboye Sunday Chimela Chinuomah Source Type: research
Investigation of Methyl-5-(pentan-3-yloxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxyhydrazide Derivatives as Potential Inhibitors of COVID-19 Main Protease: DFT and Molecular Docking Study
In this study, hydrazones derived from oseltamivir intermediate, methyl 5-(pentan-3-yloxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxylate have been investigated for their potential as drug candidates against the COVID-19 virus using computational methods, including density functional theory (DFT) studies, molecular docking, and absorption, distribution, metabolism, excretion and toxicity (ADMET) analysis. The DFT studies provide information on the electronic properties of the compounds while the molecular docking results using AutoDock reported the binding energies between the main protease of COVID-19 and the compounds. The ...
Source: Bioinformatics and Biology Insights - June 28, 2023 Category: Bioinformatics Authors: Olawale Folorunso Akinyele Emmanuel Gabriel Fakola Omolara Olubunmi Adeboye Sunday Chimela Chinuomah Source Type: research
Investigation of Methyl-5-(pentan-3-yloxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxyhydrazide Derivatives as Potential Inhibitors of COVID-19 Main Protease: DFT and Molecular Docking Study
In this study, hydrazones derived from oseltamivir intermediate, methyl 5-(pentan-3-yloxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxylate have been investigated for their potential as drug candidates against the COVID-19 virus using computational methods, including density functional theory (DFT) studies, molecular docking, and absorption, distribution, metabolism, excretion and toxicity (ADMET) analysis. The DFT studies provide information on the electronic properties of the compounds while the molecular docking results using AutoDock reported the binding energies between the main protease of COVID-19 and the compounds. The ...
Source: Bioinformatics and Biology Insights - June 28, 2023 Category: Bioinformatics Authors: Olawale Folorunso Akinyele Emmanuel Gabriel Fakola Omolara Olubunmi Adeboye Sunday Chimela Chinuomah Source Type: research
