Investigation of Methyl-5-(pentan-3-yloxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxyhydrazide Derivatives as Potential Inhibitors of COVID-19 Main Protease: DFT and Molecular Docking Study
In this study, hydrazones derived from oseltamivir intermediate, methyl 5-(pentan-3-yloxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxylate have been investigated for their potential as drug candidates against the COVID-19 virus using computational methods, including density functional theory (DFT) studies, molecular docking, and absorption, distribution, metabolism, excretion and toxicity (ADMET) analysis. The DFT studies provide information on the electronic properties of the compounds while the molecular docking results using AutoDock reported the binding energies between the main protease of COVID-19 and the compounds. The ...
Source: Bioinformatics and Biology Insights - June 28, 2023 Category: Bioinformatics Authors: Olawale Folorunso Akinyele Emmanuel Gabriel Fakola Omolara Olubunmi Adeboye Sunday Chimela Chinuomah Source Type: research
Investigation of Methyl-5-(pentan-3-yloxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxyhydrazide Derivatives as Potential Inhibitors of COVID-19 Main Protease: DFT and Molecular Docking Study
In this study, hydrazones derived from oseltamivir intermediate, methyl 5-(pentan-3-yloxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxylate have been investigated for their potential as drug candidates against the COVID-19 virus using computational methods, including density functional theory (DFT) studies, molecular docking, and absorption, distribution, metabolism, excretion and toxicity (ADMET) analysis. The DFT studies provide information on the electronic properties of the compounds while the molecular docking results using AutoDock reported the binding energies between the main protease of COVID-19 and the compounds. The ...
Source: Bioinformatics and Biology Insights - June 28, 2023 Category: Bioinformatics Authors: Olawale Folorunso Akinyele Emmanuel Gabriel Fakola Omolara Olubunmi Adeboye Sunday Chimela Chinuomah Source Type: research
The combined effect of oseltamivir and favipiravir on influenza a virus evolution in patients hospitalized with severe influenza
In this study, we collected longitudinal respiratory samples from influenza patients who underwent combination therapy and applied them to next generation sequencing of the whole genome of the influenza A virus (IAV). We also included a cohort untreated with any antivirals to serve as the control. In total, 62 samples from 19 patients treated with combination therapy and 20 samples from 20 patients untreated were successfully sequenced. The nucleotide diversity in the whole genome of IAV in the combination group showed no difference compared to that in the control group (P > 0.05). Moreover, we observed 174 kinds of non...
Source: Antiviral Research - June 27, 2023 Category: Virology Authors: Shengrui Mu Xiaohui Zou Yeming Wang Xiaoyan Deng Dan Cui Shuai Liu Bin Cao Source Type: research
The combined effect of oseltamivir and favipiravir on influenza a virus evolution in patients hospitalized with severe influenza
In this study, we collected longitudinal respiratory samples from influenza patients who underwent combination therapy and applied them to next generation sequencing of the whole genome of the influenza A virus (IAV). We also included a cohort untreated with any antivirals to serve as the control. In total, 62 samples from 19 patients treated with combination therapy and 20 samples from 20 patients untreated were successfully sequenced. The nucleotide diversity in the whole genome of IAV in the combination group showed no difference compared to that in the control group (P > 0.05). Moreover, we observed 174 kinds of non...
Source: Antiviral Research - June 27, 2023 Category: Virology Authors: Shengrui Mu Xiaohui Zou Yeming Wang Xiaoyan Deng Dan Cui Shuai Liu Bin Cao Source Type: research
Nine-valent oleanolic acid conjugates as potent inhibitors blocking the entry of influenza A virus
This study collectively demonstrates that multivalent structure-activity binding strategy is an effective method for designing influenza virus inhibitors.PMID:37354741 | DOI:10.1016/j.ejmech.2023.115562 (Source: European Journal of Medicinal Chemistry)
Source: European Journal of Medicinal Chemistry - June 24, 2023 Category: Chemistry Authors: Liang Shao Yangqing Su Yuan Zhang Fan Yang Jihong Zhang Tao Tang Fei Yu Source Type: research
Nine-valent oleanolic acid conjugates as potent inhibitors blocking the entry of influenza A virus
This study collectively demonstrates that multivalent structure-activity binding strategy is an effective method for designing influenza virus inhibitors.PMID:37354741 | DOI:10.1016/j.ejmech.2023.115562 (Source: European Journal of Medicinal Chemistry)
Source: European Journal of Medicinal Chemistry - June 24, 2023 Category: Chemistry Authors: Liang Shao Yangqing Su Yuan Zhang Fan Yang Jihong Zhang Tao Tang Fei Yu Source Type: research
A systematic review of the clinical characteristics of influenza-COVID-19 co-infection
AbstractCOVID-19 has impacted populations across the globe and has been a major cause of morbidity and mortality. Influenza is another potentially deadly respiratory infection that affects people worldwide. While both of these infections pose major health threats, little is currently understood regarding the clinical aspects of influenza and COVID-19 co-infection. Our objective was to therefore provide a systematic review of the clinical characteristics, treatments, and outcomes for patients who are co-infected with influenza and COVID-19. Our review, which was conducted in accordance with the Preferred Reporting Items for...
Source: Clinical and Experimental Medicine - June 16, 2023 Category: Research Source Type: research
Pharmaceutical approaches for COVID-19: An update on current therapeutic opportunities
This study examined the most recent evidence on the efficacy and safety of several therapeutic options available including natural substances, synthetic drugs and vaccines in the treatment of COVID-19. Various natural compounds such as sarsapogenin, lycorine, biscoclaurine, vitamin B12, glycyrrhizic acid, riboflavin, resveratrol and kaempferol, various vaccines and drugs such as AZD1222, mRNA-1273, BNT162b2, Sputnik V, and remdesivir, lopinavir, favipiravir, darunavir, oseltamivir, and umifenovir, resp., have been discussed comprehensively. We attempted to provide exhaustive information regarding the various prospective th...
Source: Acta Pharmaceutica - June 12, 2023 Category: Drugs & Pharmacology Authors: Sijia Fan Hongling Wang Dean Wu Lu Liu Source Type: research
Pharmaceutical approaches for COVID-19: An update on current therapeutic opportunities
This study examined the most recent evidence on the efficacy and safety of several therapeutic options available including natural substances, synthetic drugs and vaccines in the treatment of COVID-19. Various natural compounds such as sarsapogenin, lycorine, biscoclaurine, vitamin B12, glycyrrhizic acid, riboflavin, resveratrol and kaempferol, various vaccines and drugs such as AZD1222, mRNA-1273, BNT162b2, Sputnik V, and remdesivir, lopinavir, favipiravir, darunavir, oseltamivir, and umifenovir, resp., have been discussed comprehensively. We attempted to provide exhaustive information regarding the various prospective th...
Source: Acta Pharmaceutica - June 12, 2023 Category: Drugs & Pharmacology Authors: Sijia Fan Hongling Wang Dean Wu Lu Liu Source Type: research
Pharmaceutical approaches for COVID-19: An update on current therapeutic opportunities
This study examined the most recent evidence on the efficacy and safety of several therapeutic options available including natural substances, synthetic drugs and vaccines in the treatment of COVID-19. Various natural compounds such as sarsapogenin, lycorine, biscoclaurine, vitamin B12, glycyrrhizic acid, riboflavin, resveratrol and kaempferol, various vaccines and drugs such as AZD1222, mRNA-1273, BNT162b2, Sputnik V, and remdesivir, lopinavir, favipiravir, darunavir, oseltamivir, and umifenovir, resp., have been discussed comprehensively. We attempted to provide exhaustive information regarding the various prospective th...
Source: Acta Pharmaceutica - June 12, 2023 Category: Drugs & Pharmacology Authors: Sijia Fan Hongling Wang Dean Wu Lu Liu Source Type: research
Pharmaceutical approaches for COVID-19: An update on current therapeutic opportunities
This study examined the most recent evidence on the efficacy and safety of several therapeutic options available including natural substances, synthetic drugs and vaccines in the treatment of COVID-19. Various natural compounds such as sarsapogenin, lycorine, biscoclaurine, vitamin B12, glycyrrhizic acid, riboflavin, resveratrol and kaempferol, various vaccines and drugs such as AZD1222, mRNA-1273, BNT162b2, Sputnik V, and remdesivir, lopinavir, favipiravir, darunavir, oseltamivir, and umifenovir, resp., have been discussed comprehensively. We attempted to provide exhaustive information regarding the various prospective th...
Source: Acta Pharmaceutica - June 12, 2023 Category: Drugs & Pharmacology Authors: Sijia Fan Hongling Wang Dean Wu Lu Liu Source Type: research
Pharmaceutical approaches for COVID-19: An update on current therapeutic opportunities
This study examined the most recent evidence on the efficacy and safety of several therapeutic options available including natural substances, synthetic drugs and vaccines in the treatment of COVID-19. Various natural compounds such as sarsapogenin, lycorine, biscoclaurine, vitamin B12, glycyrrhizic acid, riboflavin, resveratrol and kaempferol, various vaccines and drugs such as AZD1222, mRNA-1273, BNT162b2, Sputnik V, and remdesivir, lopinavir, favipiravir, darunavir, oseltamivir, and umifenovir, resp., have been discussed comprehensively. We attempted to provide exhaustive information regarding the various prospective th...
Source: Acta Pharmaceutica - June 12, 2023 Category: Drugs & Pharmacology Authors: Sijia Fan Hongling Wang Dean Wu Lu Liu Source Type: research
Pharmaceutical approaches for COVID-19: An update on current therapeutic opportunities
This study examined the most recent evidence on the efficacy and safety of several therapeutic options available including natural substances, synthetic drugs and vaccines in the treatment of COVID-19. Various natural compounds such as sarsapogenin, lycorine, biscoclaurine, vitamin B12, glycyrrhizic acid, riboflavin, resveratrol and kaempferol, various vaccines and drugs such as AZD1222, mRNA-1273, BNT162b2, Sputnik V, and remdesivir, lopinavir, favipiravir, darunavir, oseltamivir, and umifenovir, resp., have been discussed comprehensively. We attempted to provide exhaustive information regarding the various prospective th...
Source: Acta Pharmaceutica - June 12, 2023 Category: Drugs & Pharmacology Authors: Sijia Fan Hongling Wang Dean Wu Lu Liu Source Type: research
Pharmaceutical approaches for COVID-19: An update on current therapeutic opportunities
This study examined the most recent evidence on the efficacy and safety of several therapeutic options available including natural substances, synthetic drugs and vaccines in the treatment of COVID-19. Various natural compounds such as sarsapogenin, lycorine, biscoclaurine, vitamin B12, glycyrrhizic acid, riboflavin, resveratrol and kaempferol, various vaccines and drugs such as AZD1222, mRNA-1273, BNT162b2, Sputnik V, and remdesivir, lopinavir, favipiravir, darunavir, oseltamivir, and umifenovir, resp., have been discussed comprehensively. We attempted to provide exhaustive information regarding the various prospective th...
Source: Acta Pharmaceutica - June 12, 2023 Category: Drugs & Pharmacology Authors: Sijia Fan Hongling Wang Dean Wu Lu Liu Source Type: research
Pharmaceutical approaches for COVID-19: An update on current therapeutic opportunities
This study examined the most recent evidence on the efficacy and safety of several therapeutic options available including natural substances, synthetic drugs and vaccines in the treatment of COVID-19. Various natural compounds such as sarsapogenin, lycorine, biscoclaurine, vitamin B12, glycyrrhizic acid, riboflavin, resveratrol and kaempferol, various vaccines and drugs such as AZD1222, mRNA-1273, BNT162b2, Sputnik V, and remdesivir, lopinavir, favipiravir, darunavir, oseltamivir, and umifenovir, resp., have been discussed comprehensively. We attempted to provide exhaustive information regarding the various prospective th...
Source: Acta Pharmaceutica - June 12, 2023 Category: Drugs & Pharmacology Authors: Sijia Fan Hongling Wang Dean Wu Lu Liu Source Type: research
