Oseltamivir phosphate for suspension is bioequivalent to TAMIFLU in healthy volunteers: a randomized, open-label clinical study
CONCLUSION: Two Oseltamivir phosphate for suspensions are safe and bioequivalent.PMID:36810140 | PMC:PMC9942619 | DOI:10.1186/s40360-023-00646-1 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - February 22, 2023 Category: Drugs & Pharmacology Authors: Ying Wang Bangzhong Tang Jing Xie Xiaoqin Wang Peng Ren Guangmei Wu Cuixia He Minhui Zhu Yue Su Jiaxiang Ding Yuanyuan Xu Ling Fan Qin Ge Yuzhou Ding Juan Zhu Bingyan Liu Rongfang Shan Huan Zhou Source Type: research
Oseltamivir phosphate for suspension is bioequivalent to TAMIFLU in healthy volunteers: a randomized, open-label clinical study
The study was aimed at evaluating the bioequivalence and safety of oseltamivir phosphate for suspension, provided by Shenzhen Beimei Pharmaceutical Co. Ltd. and manufactured by Hetero Labs Limited, and the ref... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - February 21, 2023 Category: Drugs & Pharmacology Authors: Ying Wang, Bangzhong Tang, Jing Xie, Xiaoqin Wang, Peng Ren, Guangmei Wu, Cuixia He, Minhui Zhu, Yue Su, Jiaxiang Ding, Yuanyuan Xu, Ling Fan, Qin Ge, Yuzhou Ding, Juan Zhu, Bingyan Liu & hellip; Tags: Research Source Type: research
Synthesis and structure-activity optimization of 7-azaindoles containing aza- β-amino acids targeting the influenza PB2 subunit
Eur J Med Chem. 2023 Feb 6;250:115185. doi: 10.1016/j.ejmech.2023.115185. Online ahead of print.ABSTRACTThe PB2 subunit of influenza virus polymerase has been demonstrated as a promising drug target for anti-influenza therapy. In this work, 7-azaindoles containing aza-β3- or β2,3 -amino acids were synthesized possessing a good binding affinity of PB2. The aza-β-amino acid moieties with diverse size, shape, steric hindrance and configuration were investigated. Then a lead HAA-09 was validated, and the attached aza-β3-amino acid moiety with acyclic tertiary carbon side chain well occupied in the key hydrophobic cavity of...
Source: European Journal of Medicinal Chemistry - February 11, 2023 Category: Chemistry Authors: Sihan Wang Zhimin Ying Youchun Huang Yuting Li Menglong Hu Ke Kang Haiyang Wang Jiaan Shao Gaoqi Wu Yongping Yu Yushen Du Wenteng Chen Source Type: research
Determination of the synergistic anti-influenza effect of Huangqin Su tablet and Oseltamivir and investigation of mechanism of the tablet based on gut microbiota and network pharmacology
Huangqin Su (HQS) tablet is mainly composed of baicalein which has been evaluated for its ability to inhibit influenza. The present study aimed to investigate the effect of HQS and oseltamivir phosphate (OS) (... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - February 4, 2023 Category: Complementary Medicine Authors: Xuran Cui, Xibao Liu, Feng Wang, Kun Lou, Junping Hong, Hequn Bai, Rongchu Chen, Yang Yang and Qingquan Liu Tags: Research Source Type: research
Assessment of influenza A (H1N1, H3N2) oseltamivir resistance during 2017-2019 in Iran
CONCLUSION: Evaluation of NA gene sequences, showed no resistant viruses to oseltamivir. Given that the viruses in the present study were the last viruses circulating in Iran before COVID-19 pandemic, the results will be beneficial to have a worthy comparison with the strains circulating after the pandemic. Constant monitoring for the emergence of drug-resistant variants and antigenic changes are crucial for all countries.PMID:36721506 | PMC:PMC9867638 | DOI:10.18502/ijm.v14i4.10241 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - February 1, 2023 Category: Microbiology Authors: Amytis Gholami Nazanin Zahra Shafiei-Jandaghi Nastaran Ghavami Forough Tavakoli Jila Yavarian Talat Mokhtari-Azad Source Type: research
