Efficacy and Safety of Huashi Baidu Granules in the Treatment of Children Suffering from Influenza with Exterior-cold and Interior-heat Syndrome: A Multi-center, Randomized Controlled Trial Protocol
CONCLUSION: This study is intended to apply Huashi Baidu Granules to treat influenza with exterior-cold and interior-heat syndrome to identify the clinical efficacy and safety of this recipe. Simultaneously, our study will also discuss the characteristics of clinical syndrome in traditional Chinese medicine and syndrome distribution of influenza in the studied children.PMID:37917893 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - November 2, 2023 Category: Complementary Medicine Authors: Xiaoqian Li Zhengguang Chen Huiling Liang Lei Xu Lisheng Wan Source Type: research
Efficacy and Safety of Huashi Baidu Granules in the Treatment of Children Suffering from Influenza with Exterior-cold and Interior-heat Syndrome: A Multi-center, Randomized Controlled Trial Protocol
CONCLUSION: This study is intended to apply Huashi Baidu Granules to treat influenza with exterior-cold and interior-heat syndrome to identify the clinical efficacy and safety of this recipe. Simultaneously, our study will also discuss the characteristics of clinical syndrome in traditional Chinese medicine and syndrome distribution of influenza in the studied children.PMID:37917893 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - November 2, 2023 Category: Complementary Medicine Authors: Xiaoqian Li Zhengguang Chen Huiling Liang Lei Xu Lisheng Wan Source Type: research
Bisabolane-type sesquiterpenoids and bacillibactin from the marine-derived fungus < em > Aspergillus sydowii < /em > SCSIO 41041 and their enzyme inhibiting activity
Nat Prod Res. 2023 Oct 18:1-4. doi: 10.1080/14786419.2023.2269470. Online ahead of print.ABSTRACTTwelve compounds, including eleven bisabolane-type sesquiterpenoids (1 - 11), and one bacillibactin (12) were identified from marine-derived fungus Aspergillus sydowii SCSIO 41041 isolated from Creseis acicula. The chemical structures were elucidated by the basis of spectroscopic evidences, including HRESIMS, NMR and optical rotation. Biologically, all compounds were evaluated for their acetyl cholin-esterase (AChE) enzyme, pancreatic lipase (PL) enzyme, neuraminidase (NA) and phosphodiesterase 4 (PDE4) inhibitory activities. C...
Source: Natural Product Research - October 18, 2023 Category: Biochemistry Authors: Ying-Ying Song Qing-Xia Liu Xiao-Yan Pang Zhi-Yun Chen Hong-Hui Huang Jun-Feng Wang Yong-Hong Liu Source Type: research
Bisabolane-type sesquiterpenoids and bacillibactin from the marine-derived fungus < em > Aspergillus sydowii < /em > SCSIO 41041 and their enzyme inhibiting activity
Nat Prod Res. 2023 Oct 18:1-4. doi: 10.1080/14786419.2023.2269470. Online ahead of print.ABSTRACTTwelve compounds, including eleven bisabolane-type sesquiterpenoids (1 - 11), and one bacillibactin (12) were identified from marine-derived fungus Aspergillus sydowii SCSIO 41041 isolated from Creseis acicula. The chemical structures were elucidated by the basis of spectroscopic evidences, including HRESIMS, NMR and optical rotation. Biologically, all compounds were evaluated for their acetyl cholin-esterase (AChE) enzyme, pancreatic lipase (PL) enzyme, neuraminidase (NA) and phosphodiesterase 4 (PDE4) inhibitory activities. C...
Source: Natural Product Research - October 18, 2023 Category: Biochemistry Authors: Ying-Ying Song Qing-Xia Liu Xiao-Yan Pang Zhi-Yun Chen Hong-Hui Huang Jun-Feng Wang Yong-Hong Liu Source Type: research
Development of chalcone-like derivatives and their biological and mechanistic investigations as novel influenza nuclear export inhibitors
Eur J Med Chem. 2023 Sep 29;261:115845. doi: 10.1016/j.ejmech.2023.115845. Online ahead of print.ABSTRACTConcerning the emergence of resistance to current anti-influenza drugs, our previous phenotypic-based screening study identified the compound A9 as a promising lead compound. This chalcone analog, containing a 2,6-dimethoxyphenyl moiety, exhibited significant inhibitory activity against oseltamivir-resistant strains (H1N1 pdm09), with an EC50 value of 1.34 μM. However, it also displayed notable cytotoxicity, with a CC50 value of 41.46 μM. Therefore, compound A9 was selected as a prototype structure for further structu...
Source: European Journal of Medicinal Chemistry - October 7, 2023 Category: Chemistry Authors: Chuanfeng Liu Ying Zhang Ping Li Huinan Jia Han Ju Jiwei Zhang Edeildo Ferreira da Silva-J únior Sunanda Samanta Parimal Kar Bing Huang Xinyong Liu Peng Zhan Source Type: research
Development of chalcone-like derivatives and their biological and mechanistic investigations as novel influenza nuclear export inhibitors
Eur J Med Chem. 2023 Sep 29;261:115845. doi: 10.1016/j.ejmech.2023.115845. Online ahead of print.ABSTRACTConcerning the emergence of resistance to current anti-influenza drugs, our previous phenotypic-based screening study identified the compound A9 as a promising lead compound. This chalcone analog, containing a 2,6-dimethoxyphenyl moiety, exhibited significant inhibitory activity against oseltamivir-resistant strains (H1N1 pdm09), with an EC50 value of 1.34 μM. However, it also displayed notable cytotoxicity, with a CC50 value of 41.46 μM. Therefore, compound A9 was selected as a prototype structure for further structu...
Source: European Journal of Medicinal Chemistry - October 7, 2023 Category: Chemistry Authors: Chuanfeng Liu Ying Zhang Ping Li Huinan Jia Han Ju Jiwei Zhang Edeildo Ferreira da Silva-J únior Sunanda Samanta Parimal Kar Bing Huang Xinyong Liu Peng Zhan Source Type: research
Rapid health technology assessment of the novel endonuclease inhibitor baloxavir for the treatment of influenza
J Chemother. 2023 Sep 28:1-16. doi: 10.1080/1120009X.2023.2263270. Online ahead of print.ABSTRACTThrough a Rapid Health Technology Assessment (RHTA), we evaluated the efficacy, safety and cost-effectiveness of baloxavir in the treatment of influenza, providing the necessary scientific information and evidence-based basis for healthcare professionals and health insurance decision-makers in making rational selections. Through systematic searches of Pubmed, Embase, Web of Science, The Cochrane Register of Clinical Trials database and the official website of Health Technology Assessment (HTA) agencies, we collected systematic ...
Source: Journal of Chemotherapy - September 28, 2023 Category: Cancer & Oncology Authors: Guangliang Huang Yunfei Tian Wenyan Cui Xinhui Zhang Yonghong Zhao Xiuju Liu Source Type: research
Molecules, Vol. 28, Pages 6678: Pharmacoinformatics and Breed-Based De Novo Hybridization Studies to Develop New Neuraminidase Inhibitors as Potential Anti-Influenza Agents
A. Kawsar
Influenza represents a profoundly transmissible viral ailment primarily afflicting the respiratory system. Neuraminidase inhibitors constitute a class of antiviral therapeutics employed in the management of influenza. These inhibitors impede the liberation of the viral neuraminidase protein, thereby impeding viral dissemination from the infected cell to host cells. As such, neuraminidase has emerged as a pivotal target for mitigating influenza and its associated complications. Here, we apply a de novo hybridization approach based on a breed-centric methodology to elucidate novel neuraminidase inhibitors. The ...
Source: Molecules - September 18, 2023 Category: Chemistry Authors: Bourougaa Lotfi Ouassaf Mebarka Bader Y. Alhatlani Emad M. Abdallah Sarkar M. A. Kawsar Tags: Article Source Type: research
Viruses, Vol. 15, Pages 1780: Assessing the Intense Influenza A(H1N1)pdm09 Epidemic and Vaccine Effectiveness in the Post-COVID Season in the Russian Federation
ova
Boyarintseva
Ksenafontov
Shtro
Nikolaeva
Bakaev
Burtseva
Lioznov
The COVID-19 pandemic had a profound impact on influenza activity worldwide. However, as the pandemic progressed, influenza activity resumed. Here, we describe the influenza epidemic of high intensity of the 2022&ndash;2023 season. The epidemic had an early start and peaked in week 51.2022. The extremely high intensity of the epidemic may have been due to a significant decrease in herd immunity. The results of PCR-testing of 220,067 clinical samples revealed that the influenza A(H1N1)pdm09 virus dominated, causing 56.4% of...
Source: Viruses - August 21, 2023 Category: Virology Authors: Sominina Danilenko Komissarov Pisareva Fadeev Konovalova Eropkin Petrova Zheltukhina Musaeva Eder Ivanova Komissarova Stolyarov Karpova Smorodintseva Dorosh Krivitskaya Kuznetzova Majorova Petrova Boyarintseva Ksenafontov Shtro Nik Tags: Article Source Type: research
