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Level of Education Modifies Asthma Mortality in Norway and Sweden. The Nordic EpiLung Study
(Source: Journal of Asthma and Allergy)
Source: Journal of Asthma and Allergy - March 18, 2024 Category: Allergy & Immunology Tags: Journal of Asthma and Allergy Source Type: research

GSE245916 Species-specific responses during Seoul orthohantavirus infection in human and rat lung microvascular endothelial cells
In this study, host responses to SEOV infection in primary human and rat LMECs were directly compared on a transcriptional level. As infection of rat LMECs was more efficient than human LMECs, most anti-viral defense responses were also observed earlier in rat LMECs. Most prominently SEOV-induced processes in both species included responses to cytokine stimulus, negative regulation of innate immune responses, responses to type I and II interferons, regulation of pattern recognition receptor signaling and MHC-I signaling. However, over time, in the rat LMECs, responses shifted from an anti-viral towards a more immunotolera...
Source: GEO: Gene Expression Omnibus - March 18, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Rattus norvegicus Source Type: research

Rare copy number variation in autoimmune Addison ’s disease
In conclusion, rare CNVs do not appear to be a major cause of AAD but further studies are needed to ascertain the potential contribution of rare deletions to the polygenic load of AAD susceptibility. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - March 18, 2024 Category: Allergy & Immunology Source Type: research

Evaluation of the offset static rope evacuation procedure: insights from a safe job analysis
Recently, the Norwegian Helicopter Emergency Medical Service (HEMS) has developed a procedure for a special type of static rope rescue operation, referred to as the offset technique. In this technique, the hel... (Source: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine)
Source: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine - March 18, 2024 Category: Emergency Medicine Authors: Eirik Bjorheim Abrahamsen, H åvard Mattingsdal and Håkon Bjorheim Abrahamsen Tags: Original research Source Type: research

Functional outcome and associations with prehospital time and urban-remote disparities in trauma: A Norwegian national population-based study
CONCLUSIONS: The majority of trauma patients admitted to a trauma hospital in Norway were discharged with minimal change in functional outcome. Patients with severe injuries (NISS > 15) and patients with injuries from falls experienced the greatest decline in function. Every minute increase in total prehospital time was linked to an increased likelihood of moderate disability in children and adults. Furthermore, incurring injuries in urban areas was found to be associated with higher odds of moderate disability in all age groups, while remote areas were found to be associated with higher odds of severe disability or veg...
Source: Rural Remote Health - March 15, 2024 Category: Rural Health Authors: Imw Nilsbakken T Wisborg S Sollid E Jeppesen Source Type: research

Exploring Norwegian homecare healthcare professionals perceptions of risk and the link to high-quality care: a qualitative multiple case study
Conclusions To make sense of risk when aspiring for high-quality care in everyday work, the healthcare professionals in this sample mainly used their clinical gaze, gut feeling and experience to detect subtle changes in the patients’ condition. Assessing risk information, not only individually but also as a team, was reportedly crucial for high-quality care. Healthcare professionals emphasised the well-being, safety and soundness of the patients when acting on risk information. They felt obliged to act on their gut feeling, moral compass and clinical understanding of quality. (Source: BMJ Open)
Source: BMJ Open - March 15, 2024 Category: General Medicine Authors: Idsoe-Jakobsen, I., Dombestein, H., Bronnick, K. K., Wiig, S. Tags: Open access, Health services research Source Type: research

Norway's Battery Electric Vehicles and Public Health- Findings From the Literature
Environ Health Insights. 2024 Mar 12;18:11786302241238171. doi: 10.1177/11786302241238171. eCollection 2024.ABSTRACTThe transportation sector is among the highest contributors to the increase in greenhouse gas emissions in European nations, with private cars emerging as the primary source. Although reducing emissions presents a formidable challenge, the emergence of battery electric vehicles (BEVs) offers a promising and sustainable avenue toward achieving zero greenhouse gases within the transportation infrastructure. Since the 1990s, the Norwegian parliament has fervently supported this transition, leveraging public awar...
Source: Environmental Health Insights - March 14, 2024 Category: Environmental Health Authors: Olalekan John Okesanya John Michael B Saclolo Kristine Bernadette Presno Mia Blaise Ntacyabukura Victorita Corman Attaullah Ahmadi Ryan Rachmad Nugraha Jiangchuan He Joeydann M Telin Ugyen Utse Tshering Ynusa Abdullahi Jerico Bautista Ogaya Florante E Del Source Type: research

Incidence of invasive infections with Group B streptococcus in adults in Norway 1996-2019: a nationwide registry-based case-control study
CONCLUSIONS: The incidence of invasive GBS disease in adults increased significantly from 1996 to 2019. The increasing age of the population with accompanying underlying comorbid conditions might contribute to the increasing burden of invasive GBS disease. Interestingly, type 1 diabetes was also associated with the occurrence of invasive GBS disease.PMID:38483786 | DOI:10.1007/s15010-024-02210-3 (Source: Cancer Control)
Source: Cancer Control - March 14, 2024 Category: Cancer & Oncology Authors: Elise Uggen Camilla Olaisen Randi Vals ø Lyng Gunnar Skov Simonsen Roar Magne B ævre-Jensen Frode Width Gran Bj ørn Olav Åsvold Tom Ivar Lund Nilsen Jan Kristian Dam ås Jan Egil Afset Source Type: research

Common single-base insertions in the VNTR of the carboxyl ester lipase (CEL) gene are benign and also likely to arise somatically in the exocrine pancreas
Hum Mol Genet. 2024 Mar 14:ddae034. doi: 10.1093/hmg/ddae034. Online ahead of print.ABSTRACTThe CEL gene encodes carboxyl ester lipase, a pancreatic digestive enzyme. CEL is extremely polymorphic due to a variable number tandem repeat (VNTR) located in the last exon. Single-base deletions within this VNTR cause the inherited disorder MODY8, whereas little is known about VNTR single-base insertions in pancreatic disease. We therefore mapped CEL insertion variants (CEL-INS) in 200 Norwegian patients with pancreatic neoplastic disorders. Twenty-eight samples (14.0%) carried CEL-INS alleles. Most common were insertions in repe...
Source: Cancer Control - March 14, 2024 Category: Cancer & Oncology Authors: Ranveig S Brekke Anny Gravdal Khadija El Jellas Grace E Curry Jianguo Lin Steven J Wilhelm Solrun J Steine Eric Mas Stefan Johansson Mark E Lowe Bente B Johansson Xunjun Xiao Karianne Fjeld Anders Molven Source Type: research

Implementing MyChoice ® CDx HRD testing for the Nordics: lessons from 2021 to 2023
Acta Oncol. 2024 Mar 14;63:70-75. doi: 10.2340/1651-226X.2024.34139.ABSTRACTBACKGROUND: Assessment of homologous recombinant deficient (HRD) phenotypes is key for managing Poly (ADP-ribose) polymerase inhibitor (PARPi) treatment. To accommodate the need for a validated HRD platform and enhance targeted treatment of ovarian cancer patients, a Nordic core facility for the myChoice® CDx platform was established in Denmark.MATERIALS AND METHODS: Comparative calculations and statistics are based on information from test requisitions and results (Genome Instability Score [GIS], BRCA status and combined HRD status) obtained from...
Source: Acta Oncologica - March 14, 2024 Category: Cancer & Oncology Authors: Lea Milling Korsholm Verena Broecker Mansoor Raza Mirza Maria Rossing Source Type: research