Safety of fertility sparing management in invasive mucinous ovarian carcinoma
CONCLUSIONS: Fertility-sparing surgery in stage I MOC is not associated with worse outcomes compared to radical surgery and is reasonable to offer to those with early stage disease who wish to retain fertility.PMID:37182433 | DOI:10.1016/j.ygyno.2023.05.003 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 14, 2023 Category: Cancer & Oncology Authors: Soyoun Rachel Kim Ainhoa Madariaga Liat Hogen Danielle Vicus Allan Covens Carlos Parra-Herran Stephanie Lheureux Lilian T Gien Source Type: research
Safety of fertility sparing management in invasive mucinous ovarian carcinoma
CONCLUSIONS: Fertility-sparing surgery in stage I MOC is not associated with worse outcomes compared to radical surgery and is reasonable to offer to those with early stage disease who wish to retain fertility.PMID:37182433 | DOI:10.1016/j.ygyno.2023.05.003 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 14, 2023 Category: Cancer & Oncology Authors: Soyoun Rachel Kim Ainhoa Madariaga Liat Hogen Danielle Vicus Allan Covens Carlos Parra-Herran Stephanie Lheureux Lilian T Gien Source Type: research
Treatments for relapsed, BRCA-wild type, platinum-sensitive ovarian cancer: A systematic review and network meta-analysis
Epithelial ovarian cancer includes different histotypes: high-grade serous, low-grade serous, mucinous, clear cell, and endometrioid. The aim of ovarian cancer treatment is complete remission through surgery and the administration of chemotherapy (CT), usually carboplatin in combination with paclitaxel +/- bevacizumab). First-line treatment for advanced ovarian cancer can be followed by relapse (occurring in approximately 70% of patients within 3 years of first-line treatment)1 and is characterized by a dismal prognosis for stage III (5-year survival rate:20%) and stage IV (5-year survival rate:5%)2. (Source: Cancer Treatment Reviews)
Source: Cancer Treatment Reviews - May 11, 2023 Category: Cancer & Oncology Authors: Fausto Petrelli, Carmen Rea, Cinzia Solinas, Antonio Ghidini, Karen Borgonovo, Andrea Celotti, Antonella Villa, Andrea Luciani, Domenica Lorusso Tags: Systematic or Meta-analysis Studies Source Type: research
A Clinical and Immunopathological Analysis of Carcinoma of the Ovary with an Emphasis on Post-chemotherapy Histopathologic Changes
AbstractOvarian cancers are a heterogeneous group of malignant tumors that differ with respect to pathogenesis, morphology, molecular features, and behavior. Pathologists and clinicians need to be aware of the advances in diagnosis and the changes which occur after chemotherapy to offer the optimal treatment to each patient. The present work aims to study the morphologic and immunohistochemical (IHC) profile of primary ovarian cancers with an assessment of post-chemotherapy changes. A total of 51 cases were included in the study from June 2017 to June 2019 (prospective and retrospective). The demographic and clinical detai...
Source: Indian Journal of Surgical Oncology - May 10, 2023 Category: Cancer & Oncology Source Type: research
Nuclear receptor co-repressor NCOR2 and its relation to GPER with prognostic impact in ovarian cancer
CONCLUSION: Our results support the hypothesis that nuclear co-repressors such as NCOR2 may influence the transcription of target genes in EOC such as GPER. Understanding the role of nuclear co-repressors on signaling pathways will allow a better understanding of the factors involved in prognosis and clinical outcome of EOC patients.PMID:37131060 | DOI:10.1007/s00432-023-04708-z (Source: Clin Med Res)
Source: Clin Med Res - May 2, 2023 Category: Research Authors: Juliane Reichenbach Patricia Fraungruber Doris Mayr Christina Buschmann Fabian B T Kraus Nicole Elisabeth Topalov Anca Chelariu-Raicu Thomas Kolben Alexander Burges Sven Mahner Mirjana Kessler Udo Jeschke Bastian Czogalla Fabian Trillsch Source Type: research
Nuclear receptor co-repressor NCOR2 and its relation to GPER with prognostic impact in ovarian cancer
CONCLUSION: Our results support the hypothesis that nuclear co-repressors such as NCOR2 may influence the transcription of target genes in EOC such as GPER. Understanding the role of nuclear co-repressors on signaling pathways will allow a better understanding of the factors involved in prognosis and clinical outcome of EOC patients.PMID:37131060 | DOI:10.1007/s00432-023-04708-z (Source: Clin Med Res)
Source: Clin Med Res - May 2, 2023 Category: Research Authors: Juliane Reichenbach Patricia Fraungruber Doris Mayr Christina Buschmann Fabian B T Kraus Nicole Elisabeth Topalov Anca Chelariu-Raicu Thomas Kolben Alexander Burges Sven Mahner Mirjana Kessler Udo Jeschke Bastian Czogalla Fabian Trillsch Source Type: research
UK consensus recommendations for clinical management of cancer risk for women with germline pathogenic variants in cancer predisposition genes: RAD51C, RAD51D, BRIP1 and PALB2
Germline pathogenic variants (GPVs) in the cancer predisposition genes BRCA1, BRCA2, MLH1, MSH2, MSH6, BRIP1, PALB2, RAD51D and RAD51C are identified in approximately 15% of patients with ovarian cancer (OC). While there are clear guidelines around clinical management of cancer risk in patients with GPV in BRCA1, BRCA2, MLH1, MSH2 and MSH6, there are few guidelines on how to manage the more moderate OC risk in patients with GPV in BRIP1, PALB2, RAD51D and RAD51C, with clinical questions about appropriateness and timing of risk-reducing gynaecological surgery. Furthermore, while recognition of RAD51C and RAD51D as OC predis...
Source: Journal of Medical Genetics - April 20, 2023 Category: Genetics & Stem Cells Authors: Hanson, H., Kulkarni, A., Loong, L., Kavanaugh, G., Torr, B., Allen, S., Ahmed, M., Antoniou, A. C., Cleaver, R., Dabir, T., Evans, D. G., Golightly, E., Jewell, R., Kohut, K., Manchanda, R., Murray, A., Murray, J., Ong, K.-R., Rosenthal, A. N., Woodward, Tags: Open access Position statement Source Type: research
Genetic analysis for mucinous ovarian carcinoma with infiltrative and expansile invasion and mucinous borderline tumor: a retrospective analysis
Mucinous carcinoma (MC) is a histological subtype of ovarian cancer that has a worse prognosis at advanced stages than the most prevalent histological subtype, high-grade serous carcinomas. Invasive patterns h... (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - April 20, 2023 Category: Pathology Authors: Taira Hada, Morikazu Miyamoto, Yuka Ohtsuka, Jin Suminokura, Tsubasa Ito, Naohisa Kishimoto, Soko Nishitani, Minori Takada, Akari Imauji, Risa Tanabe and Masashi Takano Tags: Research Source Type: research
Giant mucinous borderline ovarian tumor presenting alongside perforated peptic ulcers
J Obstet Gynaecol Can. 2023 Apr 13:S1701-2163(23)00259-1. doi: 10.1016/j.jogc.2023.04.005. Online ahead of print.NO ABSTRACTPMID:37061221 | DOI:10.1016/j.jogc.2023.04.005 (Source: Journal of Obstetrics and Gynaecology Canada : JOGC)
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - April 15, 2023 Category: OBGYN Authors: Sydney Pence Abigail Christiansen Estee George Source Type: research
Secondary Cytoreductive Surgery With Hyperthermic Intraperitoneal Chemotherapy for Advanced or Recurrent Mucinous Ovarian Cancer
CONCLUSION: Secondary CRS with HIPEC represents a potential therapeutic option for women with recurrent primary mucinous ovarian cancer.PMID:37023452 | DOI:10.1097/AOG.0000000000005154 (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - April 6, 2023 Category: OBGYN Authors: Aliyah B Conley Keith F Fournier Anil K Sood Michael Frumovitz Source Type: research
The robotic future of minimally invasive cytoreduction and hyperthermic intraperitoneal chemotherapy for peritoneal surface malignancies
Chin Clin Oncol. 2023 Mar 13:cco-22-118. doi: 10.21037/cco-22-118. Online ahead of print.ABSTRACTCytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) has been increasingly utilized for peritoneal surface malignancies. This has been commonly utilized for a variety of neoplasms, but, especially mucinous neoplasms of the appendix, ovarian cancer, gastric cancer, colorectal cancer and mesothelioma. Traditionally, CRS/HIPEC has been performed as an open, extensive operation associated with prolonged hospitalization. However, when the peritoneal carcinomatosis index (PCI) is small (<10), minimally ...
Source: Clinical Colorectal Cancer - March 22, 2023 Category: Cancer & Oncology Authors: Joanna Ortega Theofano Orfanelli Edward Levine Ioannis T Konstantinidis Source Type: research
