GSE261637 Integrative multi-omics analyses to identify the genetic and functional mechanisms underlying ovarian cancer risk regions [H3K4me3]
This study seeks to fill in this gap by generating an integrative Ovarian Cancer Regulatory Atlas (OCRA) of 18 ovarian normal and cancer cells profiled for epigenomic, transcriptomic, chromatin state and chromatin looping signatures. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - March 18, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
GSE261636 ChIP-Seq of H4K4me1 in a panel of ovarian cancer related cell lines.
Contributors : Michelle Jones ; Simon GaytherSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensIn the current study we performed epigenomic characterization of 13 different in vitro models of high-grade serous (HGSOC), low-grade serous (LGSOC), mucinous (MOC), endometrioid (ENOC) and clear cell (CCOC) carcinoma using ChIP-Seq for histone modication H3K4me1. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - March 18, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
Case report: Metastatic ovarian mucinous carcinoma to the breast: diagnostic challenges and pitfalls
We report a case of breast metastases from advanced stage ovarian mucinous carcinoma in a 48-year-old female— a case hitherto unreported in the literature. The case is noteworthy for its atypical presentation marked by an areolar rash, clinically suggestive of Paget disease of the nipple. This unique clinical scenario, coupled with histopathological examination revealing in-situ-like carcinoma component, posed a diagnostic challenge in discerning the tumour origin. We emphasize the need for heightened awareness among pathologists to avoid misdiagnosing metastatic carcinomas as primary breast tumours, a potential pitfall ...
Source: Frontiers in Oncology - March 18, 2024 Category: Cancer & Oncology Source Type: research
Fertility potential and safety assessment of residual ovarian cortex in young women diagnosed with epithelial borderline and early-stage malignant ovarian tumors
CONCLUSIONS: Personalized counseling for fertility preservation is required in the event of BOTs and early-stage EOCs. Fertility-sparing surgery and adjuvant gamete preservation should be considered, balancing the oncological risks according to tumor stage and histotype and fertility potential, especially at a younger age.PMID:38492474 | DOI:10.1016/j.ygyno.2024.03.008 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - March 16, 2024 Category: Cancer & Oncology Authors: L Cacciottola A Camboni E Gatti E Marbaix M Vignali J Donnez M M Dolmans Source Type: research
Fertility potential and safety assessment of residual ovarian cortex in young women diagnosed with epithelial borderline and early-stage malignant ovarian tumors
CONCLUSIONS: Personalized counseling for fertility preservation is required in the event of BOTs and early-stage EOCs. Fertility-sparing surgery and adjuvant gamete preservation should be considered, balancing the oncological risks according to tumor stage and histotype and fertility potential, especially at a younger age.PMID:38492474 | DOI:10.1016/j.ygyno.2024.03.008 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - March 16, 2024 Category: Cancer & Oncology Authors: L Cacciottola A Camboni E Gatti E Marbaix M Vignali J Donnez M M Dolmans Source Type: research
