Cancers, Vol. 16, Pages 136: Genomic Landscape of Endometrial, Ovarian, and Cervical Cancers in Japan from the Database in the Center for Cancer Genomics and Advanced Therapeutics
This study aimed to comprehensively clarify the genomic landscape and its association with tumor mutational burden-high (TMB-H, ≥10 mut/Mb) and microsatellite instability-high (MSI-H) in endometrial, cervical, and ovarian cancers. We obtained genomic datasets of a comprehensive genomic profiling test, FoundationOne® CDx, with clinical information using the “Center for Cancer Genomics and Advanced Therapeutics” (C-CAT) database in Japan. Patients can undergo the tests only after standardized treatments under universal health insurance coverage. Endometrial cancers were char...
Source: Cancers - December 27, 2023 Category: Cancer & Oncology Authors: Qian Xi Hidenori Kage Miho Ogawa Asami Matsunaga Akira Nishijima Kenbun Sone Kei Kawana Katsutoshi Oda Tags: Article Source Type: research
An algorithm for the pre-operative differentiation of benign ovarian tumours based on magnetic resonance imaging interpretation in a regional core hospital: A retrospective study
CONCLUSIONS: Among four types of OTs (OEC, OMCT, OEA and OCCA), MRI interpretation was able to differentiate between Be-OTs and Bo/Ma-OTs almost perfectly. Additionally, to mitigate the difficulty in differentiating SM-OTs, OT size may be useful in combination with MRI findings, although further accumulation and analysis of OT cases is needed.PMID:38058586 | PMC:PMC10696378 | DOI:10.1016/j.eurox.2023.100260 (Source: Reproductive Biology)
Source: Reproductive Biology - December 7, 2023 Category: Reproduction Medicine Authors: Wataru Isono Hiroko Tsuchiya Reiko Matsuyama Akihisa Fujimoto Osamu Nishii Source Type: research
An algorithm for the pre-operative differentiation of benign ovarian tumours based on magnetic resonance imaging interpretation in a regional core hospital: A retrospective study
CONCLUSIONS: Among four types of OTs (OEC, OMCT, OEA and OCCA), MRI interpretation was able to differentiate between Be-OTs and Bo/Ma-OTs almost perfectly. Additionally, to mitigate the difficulty in differentiating SM-OTs, OT size may be useful in combination with MRI findings, although further accumulation and analysis of OT cases is needed.PMID:38058586 | PMC:PMC10696378 | DOI:10.1016/j.eurox.2023.100260 (Source: Reproductive Biology)
Source: Reproductive Biology - December 7, 2023 Category: Reproduction Medicine Authors: Wataru Isono Hiroko Tsuchiya Reiko Matsuyama Akihisa Fujimoto Osamu Nishii Source Type: research
An algorithm for the pre-operative differentiation of benign ovarian tumours based on magnetic resonance imaging interpretation in a regional core hospital: A retrospective study
CONCLUSIONS: Among four types of OTs (OEC, OMCT, OEA and OCCA), MRI interpretation was able to differentiate between Be-OTs and Bo/Ma-OTs almost perfectly. Additionally, to mitigate the difficulty in differentiating SM-OTs, OT size may be useful in combination with MRI findings, although further accumulation and analysis of OT cases is needed.PMID:38058586 | PMC:PMC10696378 | DOI:10.1016/j.eurox.2023.100260 (Source: Reproductive Biology)
Source: Reproductive Biology - December 7, 2023 Category: Reproduction Medicine Authors: Wataru Isono Hiroko Tsuchiya Reiko Matsuyama Akihisa Fujimoto Osamu Nishii Source Type: research
Molecular landscape of ERBB2/HER2 gene amplification among patients with gynecologic malignancies; clinical implications and future directions
CONCLUSION: ERBB2 amplification is frequently encountered among patients with uterine serous carcinoma, and mucinous ovarian carcinoma. In addition, a high incidence was also observed among those with uterine clear cell carcinoma, and uterine carcinosarcoma. For patients with endometrioid endometrial carcinoma, incidence of ERBB2 amplification is low, especially in the absence of TP53 mutations.PMID:38029652 | DOI:10.1016/j.ygyno.2023.11.021 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - November 29, 2023 Category: Cancer & Oncology Authors: Dimitrios Nasioudis Stefan Gysler Nawar Latif Lory Cory Robert L Giuntoli Sarah H Kim Fiona Simpkins Lainie Martin Emily M Ko Source Type: research
Molecular landscape of ERBB2/HER2 gene amplification among patients with gynecologic malignancies; clinical implications and future directions
CONCLUSION: ERBB2 amplification is frequently encountered among patients with uterine serous carcinoma, and mucinous ovarian carcinoma. In addition, a high incidence was also observed among those with uterine clear cell carcinoma, and uterine carcinosarcoma. For patients with endometrioid endometrial carcinoma, incidence of ERBB2 amplification is low, especially in the absence of TP53 mutations.PMID:38029652 | DOI:10.1016/j.ygyno.2023.11.021 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - November 29, 2023 Category: Cancer & Oncology Authors: Dimitrios Nasioudis Stefan Gysler Nawar Latif Lory Cory Robert L Giuntoli Sarah H Kim Fiona Simpkins Lainie Martin Emily M Ko Source Type: research
Rare non-serous fallopian tube cancers: institutional experience and literature review
ConclusionRare non-serous malignant fallopian tube tumors are very similar to serous and endometrioid FTC in terms of clinical manifestations and diagnosis. (Source: Wiener Medizinische Wochenschrift)
Source: Wiener Medizinische Wochenschrift - November 28, 2023 Category: General Medicine Source Type: research
Clinicopathological and Oncological Outcomes of Borderline Mucinous Tumours of Ovary: a Large Case Series
The objective is to study the clinico-demographic profile, treatment patterns and oncological outcomes in borderline mucinous tumours of the ovary. Retrospective cohort analysis was carried out between January 2017 and December 2019 for patients with a diagnosis of borderline mucinous tumours of the ovary who were treated at our centre. Kaplan –Meier method was used for the estimation of the probability of DFS and OS. Univariate and multivariate analyses based on the Cox proportional hazard model were performed to identify factors associated with DFS and OS. Ap-value ≤ 0.05 in a two-tailed test was considered stat...
Source: Indian Journal of Surgical Oncology - November 24, 2023 Category: Cancer & Oncology Source Type: research
Cancers, Vol. 15, Pages 5356: New Achievements from Molecular Biology and Treatment Options for Refractory/Relapsed Ovarian Cancer & mdash;A Systematic Review
The objective is to highlight the molecular mechanisms of the most promising targeted agents under clinical investigation to demonstrate their potential relevance in recurrent/refractory OC. (Source: Cancers)
Source: Cancers - November 10, 2023 Category: Cancer & Oncology Authors: Cornelia Bachmann Tags: Systematic Review Source Type: research
Cancers, Vol. 15, Pages 5327: Fertility and Pregnancy Outcomes after Fertility-Sparing Surgery for Early-Stage Borderline Ovarian Tumors and Epithelial Ovarian Cancer: A Single-Center Study
This study examined treatment outcomes, including preserved fertility, menstrual regularity, and pregnancy outcomes, in patients with stage I epithelial ovarian cancer (EOC) or borderline ovarian tumors (BOTs) who underwent fertility-sparing surgery (FSS). Patients with stage I EOC and BOTs who were aged 18–45 years and underwent FSS between 2007 and 2022 were retrospectively reviewed. Significant differences between various subgroups in terms of disease recurrence, menstrual irregularity due to the disease, and pregnancy outcomes were analyzed. A total of 71 patients with BOTs and 33 patients with EOC were i...
Source: Cancers - November 8, 2023 Category: Cancer & Oncology Authors: Mu-En Ko Yi-Heng Lin Kuan-Ju Huang Wen-Chun Chang Bor-Ching Sheu Tags: Article Source Type: research
Prognostic impact of chemerin expression in colorectal cancer: A detailed analysis based on histological components and meta-analysis
This study aimed to elucidate the clinicopathological significance of chemerin immunohistochemical expression in colorectal cancer (CRC) based on histologic components. Immunohistochemistry was performed to detect chemerin in 266 human CRC tissues. Correlation between chemerin expression, clinicopathological characteristics, and survival in CRC. A meta-analysis was performed to claify the prognostic role of chemerin tissue expression in malignant tumors. Chemerin was expressed in 125 of 266 CRC tissues (47.0 %) and was significantly correlated with distant metastasis (P = 0.012). However, no significant correlation was obs...
Source: Pathology, Research and Practice - October 28, 2023 Category: Pathology Authors: Il Hwan Oh Jung-Soo Pyo Kyueng-Whan Min One Zoong Kim Byoung Kwan Son Source Type: research
Prognostic impact of chemerin expression in colorectal cancer: A detailed analysis based on histological components and meta-analysis
This study aimed to elucidate the clinicopathological significance of chemerin immunohistochemical expression in colorectal cancer (CRC) based on histologic components. Immunohistochemistry was performed to detect chemerin in 266 human CRC tissues. Correlation between chemerin expression, clinicopathological characteristics, and survival in CRC. A meta-analysis was performed to claify the prognostic role of chemerin tissue expression in malignant tumors. Chemerin was expressed in 125 of 266 CRC tissues (47.0 %) and was significantly correlated with distant metastasis (P = 0.012). However, no significant correlation was obs...
Source: Pathology, Research and Practice - October 28, 2023 Category: Pathology Authors: Il Hwan Oh Jung-Soo Pyo Kyueng-Whan Min One Zoong Kim Byoung Kwan Son Source Type: research
Prognostic impact of chemerin expression in colorectal cancer: A detailed analysis based on histological components and meta-analysis
This study aimed to elucidate the clinicopathological significance of chemerin immunohistochemical expression in colorectal cancer (CRC) based on histologic components. Immunohistochemistry was performed to detect chemerin in 266 human CRC tissues. Correlation between chemerin expression, clinicopathological characteristics, and survival in CRC. A meta-analysis was performed to claify the prognostic role of chemerin tissue expression in malignant tumors. Chemerin was expressed in 125 of 266 CRC tissues (47.0 %) and was significantly correlated with distant metastasis (P = 0.012). However, no significant correlation was obs...
Source: Pathology, Research and Practice - October 28, 2023 Category: Pathology Authors: Il Hwan Oh Jung-Soo Pyo Kyueng-Whan Min One Zoong Kim Byoung Kwan Son Source Type: research
GSE245725 Double ratio of microRNA signatures as promising diagnosis biomarkers for mucinous borderline and malignant ovarian tumors
In this study, miRNA expres-sion profiling generates using FFPE patient samples followed by qRT-PCR validation allows to identify 10 down-regulated and 5 up-regulated miRNAs between Malignant and Borderline tumors. To overcome issues linked to data normalization and to improve the accuracy of the results, a ratio analysis combining up-regulated and down-regulated miRNAs was used. Alt-hough 21/50 miRNA expression ratio were significantly different between Malignant and Bor-derline tumor samples, any ratio could perfectly discriminate the two groups. However, a combination of 14 miRNAs expression ratio (double ratio) showed ...
Source: GEO: Gene Expression Omnibus - October 19, 2023 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Homo sapiens synthetic construct Source Type: research
