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Molecules, Vol. 28, Pages 1716: Enhanced Production of Active Photosynthetic and Biochemical Molecules in Silybum marianum L. Using Biotic and Abiotic Elicitors in Hydroponic Culture
ed Al-Shehri Sally Negm Elicitors are stressors that activate secondary pathways that lead to the increased production of bioactive molecules in plants. Different elicitors including the fungus Aspergillus niger (0.2 g/L), methyl jasmonate (MeJA, 100 &micro;M/L), and silver nanoparticles (1 &micro;g/L) were added, individually and in combination, in a hydroponic medium. The application of these elicitors in hydroponic culture significantly increased the concentration of photosynthetic pigments and total phenolic contents. The treatment with MeJA (methyl jasmonate) (100 &micro;M/L) and the co-t...
Source: Molecules - February 10, 2023 Category: Chemistry Authors: Bismillah Mubeen Ammarah Hasnain Wang Jie Hanxian Zheng Willie J. G. M. Peijnenburg Shahril Efzueni Rozali Rabia Rasool Syed Atif Hasan Naqvi Muhammad Junaid Rao Muhammad Amir Sohail Mahmoud Moustafa Mohammed Al-Shehri Sally Negm Tags: Article Source Type: research

Pharmacological screening of silibinin for antischizophrenic activity along with its acute toxicity evaluation in experimental animals
Silibinin (SIL), a flavolignan extracted from the medicinal plant “silybum marianum (milk thistle)”, has traditionally been used to treat liver disease. This phytochemical has displayed neuroprotective properties, its activity against schizophrenia is not elucidated. The present study was designed to evaluate the antipsychotic potential of silibinin and probe its toxic potential. The acute oral toxicity study was assessed as per OECD 425 guidelines. Animals were divided into two groups of female rats (n = 6): one group served as the normal control and the other group received a 2,000 mg/kg dose of SIL. We also evaluat...
Source: Frontiers in Pharmacology - February 2, 2023 Category: Drugs & Pharmacology Source Type: research

The protective effects of silymarin on the reproductive toxicity: a comprehensive review
Curr Med Chem. 2023 Jan 30. doi: 10.2174/0929867330666230130115332. Online ahead of print.ABSTRACTThe reproductive system is extremely vulnerable to chemotherapy drugs, ionizing radiation, toxic heavy metals, chemicals, and so on. These harmful stimuli are able to induce oxidative damage, apoptosis, inflammation, and other mechanisms in the reproductive organs, leading to different adverse reproductive effects. It was shown that using medicinal plants (medicinal herbs) can be an effective medication for the prevention and treatment of multiple health conditions. Silymarin is a medicinal herb extract, obtained from the seed...
Source: Current Medicinal Chemistry - January 31, 2023 Category: Chemistry Authors: Tita Hariyanti Ria Margiana Moaed Emran Al-Gazally Indrajit Patra Ghaidaa Raheem Lateef Al-Awsi Noora M Hameed Dilrabo Kayumova Mohammad Javed Ansari Larry Miguel Torres-Criollo Yasser Fakri Mustafa Razzagh Abedi-Firouzjah Bagher Farhood Source Type: research

Novel nutraceutical supplements with yeast β-glucan, prebiotics, minerals, and Silybum marianum (silymarin) ameliorate obesity-related metabolic and clinical parameters: A double-blind randomized trial
ConclusionsIn a condition associated with sedentary and no nutritional intervention, the new nutraceutical supplement composition demonstrated the ability to be a strong and newfangled tool to improve important biomarkers associated with obesity and its comorbidities. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - January 27, 2023 Category: Endocrinology Source Type: research

Use of Milk Thistle in Farm and Companion Animals: A Review
Planta Med DOI: 10.1055/a-1969-2440Milk thistle, Silybum marianum, is a medicinal plant grown for its bioactive compounds with well-documented antioxidant and hepatoprotective properties. Milk thistle has a well-established pharmacological reputation for treatments of human liver disease, but it is also used in animals. This review summarizes the experimental evidence of milk thistleʼs effects on animals when administered as silymarin extract (feed additive) or a feed ingredient, if administered as seed or expeller/cake with the seed residue still containing the bioactive components. The use as a feed addit...
Source: Planta Medica - January 10, 2023 Category: Drugs & Pharmacology Authors: Tedesco, Doriana Eurosia Angela Guerrini, Alessandro Tags: Reviews Source Type: research

GSE162336 Global transcriptome analysis of long RNA molecules expressed in human keratinocyte cell line HaCaT pre-treated with TGF- β1 in response to silymarin, a natural plant extract involved in skin tissue regeneration
Contributors : Elodie Henriet ; Patrick BarilSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe goal of this study is to find out the exact mechanisms of action of silymarin (SM), a complex mixture of flavonolignans structures isolated from milk thistle (Silybum marianum), on the biological behavior (phenotype) of human HaCaT keratinocytes. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - December 21, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

586 Interest of Silybum marianum extract, Manganese PCA and Lespedeza capitata extract in a new anti-hair loss serum to stimulate hair growth and prolong anagen phase
The hair follicle (HF) undergoes cycles of growth (anagen), regression (catagen) and rest (telogen) phases. Chronic and reactive hair loss are linked to dysfunctions of the hair growth cycle. The association of active ingredients targeting specifically the HF could help to restore hair cycle and promote hair growth. The efficacy of 3 active ingredients was evaluated on hair growth/anchorage markers in human HF dermal papilla cells (DPC): a new extract from Silybum marianum (SME) stimulating hair shaft anchorage by keratin 75 modulation, Manganese PCA (MnPCA) and a Lespedeza capitata extract (LCE). (Source: Journal of Inves...
Source: Journal of Investigative Dermatology - November 18, 2022 Category: Dermatology Authors: D. Bacqueville, M. Leveque, C. Mas, M. Haure, A. Noustens, V. Mengeaud, S. Carr ère, N. Castex-Rizzi, S. Bessou-Touya, H. Duplan Source Type: research

Inhibition of UGT1A1*1 and UGT1A1*6 catalyzed glucuronidation of SN-38 by silybins
Chem Biol Interact. 2022 Nov 4:110248. doi: 10.1016/j.cbi.2022.110248. Online ahead of print.ABSTRACTUGT1A1 is the main enzyme that catalyzes the metabolic elimination and detoxification of SN-38, the active form of anti-cancer drug irinotecan. Milk thistle products have been used widely to protect the liver from injury associated with the use of chemotherapeutic agents. To evaluate whether SN-38 metabolism can be affected by milk thistle products, the inhibitory effects of silybins on UGT1A1*1 and UGT1A1*6 were evaluated in the present investigation. Both silybin A and silybin B potently inhibited SN-38 glucuronidation ca...
Source: Chemico-Biological Interactions - November 7, 2022 Category: Molecular Biology Authors: Wei Li Yin-Nan Che Yue-Yue Chen Zhe Wang Zhen Wang Li-Li Jiang Hong-Can Shi Yong Liu Source Type: research

Dietary supplements and bleeding
In conclusion, physicians must be aware of the potential anticoagulant effects of these supplements. It is imperative to report dietary and herbal supplement usage to physicians and is best to discontinue nonessential supplement use 2 weeks prior to surgery.PMID:36304597 | PMC:PMC9586694 | DOI:10.1080/08998280.2022.2121575 (Source: Baylor University Medical Center Proceedings)
Source: Baylor University Medical Center Proceedings - October 28, 2022 Category: Universities & Medical Training Authors: Jess Hatfield Saadeddine Saad Chad Housewright Source Type: research