Molecules, Vol. 29, Pages 1901: Anti-Tumor Activity and Mechanism of Silibinin Based on Network Pharmacology and Experimental Verification
This study aimed to assess the anti-tumor effects of silibinin in adenoid cystic carcinoma (ACC2) cells and Balb/c nude mice, and explore its potential mechanism based on network pharmacology prediction and experimental verification. A total of 347 targets interacting with silibinin were collected, and 75 targets related to the tumor growth process for silibinin were filtrated. Based on the PPI analysis, CASP3, SRC, ESR1, JAK2, PRKACA, HSPA8 and CAT showed stronger interactions with other factors and may be the key targets of silibinin for treating tumors. The predicted target proteins according to network pharmacology wer...
Source: Molecules - April 22, 2024 Category: Chemistry Authors: Peihai Li Dexu Wang Xueliang Yang Changyu Liu Xiaobin Li Xuanming Zhang Kechun Liu Yun Zhang Mengqi Zhang Changyun Wang Rongchun Wang Tags: Article Source Type: research
Administration of silymarin in NAFLD/NASH: A systematic review and meta-analysis
CONCLUSIONS: Silymarin can regulate energy metabolism, attenuate liver damage, and improve liver histology in NAFLD patients. However, the effects of silymarin will need to be confirmed by further research.PMID:38579127 | DOI:10.1016/j.aohep.2023.101174 (Source: Annals of Hepatology)
Source: Annals of Hepatology - April 5, 2024 Category: Gastroenterology Authors: Shudi Li Fei Duan Suling Li Baoping Lu Source Type: research
Genetic activity and cytotoxic effect of < em > Silybum marianum < /em > extract in comparison with the impact of antitumor drugs etoposide and methotrexate: a study on < em > Drosophila melanogaster < /em >
Nat Prod Res. 2024 Mar 27:1-4. doi: 10.1080/14786419.2024.2334315. Online ahead of print.ABSTRACTOne of the most important directions in medical practice involves the exploration of protectors and adaptogens to mitigate side effects associated with the use of antitumor and potent medications. The extracts of medicinal plants are actively tested as protectors. In connection with this, the aim of the research was to determine the effectiveness of the protective properties of Silybum marianum extract against the drugs 'etoposide' and 'methotrexate' at concentrations of 800 μg/kg using the model object Drosophila melanogaster...
Source: Natural Product Research - March 27, 2024 Category: Biochemistry Authors: Olga Nikolaevna Antosyuk Elena Aleksandrovna Sharova Anastasiya Konstantinovna Verbitskaya Source Type: research
Genetic activity and cytotoxic effect of < em > Silybum marianum < /em > extract in comparison with the impact of antitumor drugs etoposide and methotrexate: a study on < em > Drosophila melanogaster < /em >
Nat Prod Res. 2024 Mar 27:1-4. doi: 10.1080/14786419.2024.2334315. Online ahead of print.ABSTRACTOne of the most important directions in medical practice involves the exploration of protectors and adaptogens to mitigate side effects associated with the use of antitumor and potent medications. The extracts of medicinal plants are actively tested as protectors. In connection with this, the aim of the research was to determine the effectiveness of the protective properties of Silybum marianum extract against the drugs 'etoposide' and 'methotrexate' at concentrations of 800 μg/kg using the model object Drosophila melanogaster...
Source: Cell Research - March 27, 2024 Category: Cytology Authors: Olga Nikolaevna Antosyuk Elena Aleksandrovna Sharova Anastasiya Konstantinovna Verbitskaya Source Type: research
Metabolic profiling of milk thistle different organs using UPLC-TQD-MS/MS coupled to multivariate analysis in relation to their selective antiviral potential
Silybum marianum commonly known as milk thistle is one of the most imperative medicinal plants due to its remarkable pharmacological activities. Lately, the antiviral activities of S. marianum extract have been s... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - March 7, 2024 Category: Complementary Medicine Authors: Alaa A. El-Banna and Reham S. Ibrahim Tags: Research Source Type: research
A new flavonolignan from milk thistle (Silybum marianum)
. (Source: Journal of Asian Natural Products Research)
Source: Journal of Asian Natural Products Research - February 8, 2024 Category: Complementary Medicine Authors: Waed HammadNuha SweidanMusa Abu Zarqaa Department of Chemistry, School of Sciences, University of Jordan, Amman 11942, Jordanb Department of Chemistry, Faculty of Arts and Sciences, University of Petra, Amman 961343, Jordan Source Type: research
Feasible feeding strategies for sustainable management of serve heat stress conditions: Effect of Milk Thistle extract on growth performance and health status of newly weaned rabbits
In conclusion, the supplementation of MT extract at levels of 10 or 15 g/kg diet enhanced growth performance, feed utilisation, dressing percentage, hemato-biochemical attributes, i mmunity and redox balance of heat stressed growing rabbits during the hot season. (Source: Journal of Animal Physiology and Animal Nutrition)
Source: Journal of Animal Physiology and Animal Nutrition - February 5, 2024 Category: Zoology Authors: Mahmoud A. E. Hassan,
Mona A. Ragab,
Soheir A. Shazly,
Mohamed E. Ahmed,
Mohamed E. El ‐Kholany,
Ali Ali El‐Raghi Tags: ORIGINAL ARTICLE Source Type: research
Mitigation of intrahepatic cholestasis induced by 17 α-ethinylestradiol via nanoformulation of Silybum marianum L.
Cholestasis is an important predisposing factor for hepatocyte damage, liver fibrosis, primary biliary cirrhosis, and even liver failure. Silybum marianum L. (SM) plant is used in teas or eaten in some countries ... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - January 23, 2024 Category: Complementary Medicine Authors: Maha B. Salem, Dina Mostafa Mohammed, Olfat A. Hammam and Mohamed Elzallat Tags: Research Source Type: research
Neuroactivity screening of botanical extracts using microelectrode array (MEA) recordings
Food Chem Toxicol. 2024 Jan 6:114438. doi: 10.1016/j.fct.2024.114438. Online ahead of print.ABSTRACTToxicity testing of botanicals is challenging because of their chemical complexity and variability. Since botanicals may affect many different modes of action involved in neuronal function, we used microelectrode array (MEA) recordings of primary rat cortical cultures to screen 16 different botanical extracts for their effects on cell viability and neuronal network function in vitro. Our results demonstrate that extract materials (50 μg/mL) derived from goldenseal, milk thistle, tripterygium, and yohimbe decrease mitochondr...
Source: Food and Chemical Toxicology - January 8, 2024 Category: Food Science Authors: Regina G D M van Kleef Michelle R Embry Constance A Mitchell Remco H S Westerink Source Type: research
Green and sustainable practices for an energy plant cultivation on naturally versus spiked soils. The impact of ageing soil pollution in the circular economy framework
Environ Res. 2024 Jan 6:118130. doi: 10.1016/j.envres.2024.118130. Online ahead of print.ABSTRACTSilybum marianum L. Gaertn. or milk thistle is an energy-produced weed that has been shown to be tolerant of heavy metal-contaminated soils. In the present study, its cultivation was studied in soils laboratory-spiked (artificial) with Cu and Zn solutions. Meanwhile, plant growing on naturally contaminated soils of Mediterranean regions, both urban and rural, was investigated. The metal concentrations spiked in artificial polluted soils were estimated to be roughly equivalent to those in naturally contaminated soils. Plants gro...
Source: Environmental Research - January 8, 2024 Category: Environmental Health Authors: Sotiria G Papadimou Evangelia E Golia Source Type: research
Molecules, Vol. 29, Pages 64: Effects of Silybum marianum L. Seed Extracts on Multi Drug Resistant (MDR) Bacteria
d Y. Shala
Wound infections became a great challenge, especially after the emergence of bacterial resistance to commonly used antibiotics. Medicinal plants can be the source of alternative antibacterial agents effective against multi drug resistant (MDR) bacteria. This research aimed to evaluate the effectiveness of different Silybum marianum seed extracts in fighting MDR bacteria that infect wounds. First, thirty purified bacterial cultures obtained from superficial, infected wounds were subjected to antibiotic sensitivity tests. The selected MDR isolates were then used to test the antimicrobial effects of different S...
Source: Molecules - December 21, 2023 Category: Chemistry Authors: Shimaa El-Sapagh Nanis G. Allam Mohamed Nour El-Dein El-Sayed Asmaa Ahmed El-Hefnawy Gra żyna Korbecka-Glinka Awad Y. Shala Tags: Article Source Type: research
In Vitro Evaluation of the Effects of 7-Ketocholesterol and 7 β-Hydroxycholesterol on the Peroxisomal Status: Prevention of Peroxisomal Damages and Concept of Pexotherapy
Adv Exp Med Biol. 2024;1440:437-452. doi: 10.1007/978-3-031-43883-7_21.ABSTRACT7-Ketocholesterol and 7β-hydroxycholesterol are most often derived from the autoxidation of cholesterol. Their quantities are often increased in the body fluids and/or diseased organs of patients with age-related diseases such as cardiovascular diseases, Alzheimer's disease, age-related macular degeneration, and sarcopenia which are frequently associated with a rupture of RedOx homeostasis leading to a high oxidative stress contributing to cell and tissue damages. On murine cells from the central nervous system (158N oligodendrocytes, microglia...
Source: Advances in Experimental Medicine and Biology - November 30, 2023 Category: Research Authors: Imen Ghzaiel Samah Maaloul Mohamed Ksila Amira Namsi Aline Yammine Meriam Debbabi Asma Badreddine Wiem Meddeb Vivien Pires Thomas Nury Franck M énétrier Laure Avoscan Amira Zarrouk Mauhamad Baarine Olfa Masmoudi-Kouki Taoufik Ghrairi Raoudha Abdellaoui Source Type: research
Chemical and Biochemical Features of Spinasterol and Schottenol
Adv Exp Med Biol. 2024;1440:45-55. doi: 10.1007/978-3-031-43883-7_3.ABSTRACTPhytosterols, which are produced in plants, are structurally similar to cholesterol. Their basic structures consist of a cyclo pentano-perhydrophenanthrene nucleus composed of 3 hexane rings and of a pentane ring with an alkyl side chain. There are around more than 250 phytosterols and related compounds that have been identified in natural resources. Among them, spinasterol and schottenol, its dihydro analog, are often found in seeds, and consequently in seed oils, and in other botanical parts of some plant families such as Sapotaceae, Cactaceae, a...
Source: Advances in Experimental Medicine and Biology - November 30, 2023 Category: Research Authors: Farid Khallouki Mohamed Ksila Imen Ghzaiel Soukaina Essadek Mounia Tahri Joutey Samah Maaloul Wafa Zennouhi Laila Benbacer Mohamed Bourhia Lhoussain Hajji Amira Zarrouk Leila Rezig Sandrine Rup-Jacques Raoudha Abdellaoui Taoufik Ghrairi Olfa Masmoudi-Kouk Source Type: research
