Milk Thistle Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Medicinal Plant-Derived Phytochemicals in Detoxification
Curr Pharm Des. 2023 Aug 9. doi: 10.2174/1381612829666230809094242. Online ahead of print.ABSTRACTThe average worldwide human life expectancy is 70 years, with a significantly higher value in Western societies. Many modern diseases are not associated with premature mortality but with a decreased quality of life in aged patients and an excessive accumulation of various toxic compounds in the human body during life. Today, scientists are especially interested in finding compounds that can help increase a healthy lifespan by detoxifying the body. Phytotherapy with specific approaches is used in alternative medicine to remove ...
Source: Current Pharmaceutical Design - August 10, 2023 Category: Drugs & Pharmacology Authors: Geir Bj ørklund Nat ália Cruz-Martins Bey Hing Goh Olha Mykhailenko Roman Lysiuk Mariia Shanaida Larysa Lenchyk Taras Upyr Marius Emil Rusu Antonina Pryshlyak Volodymyr Shanaida Salvatore Chirumbolo Source Type: research

Authentication of milk thistle commercial products using UHPLC-QTOF-ESI + MS metabolomics and DNA metabarcoding
Milk thistle is one of the most popular hepatoprotectants, and is often sold in combination with other ingredients. Botanical supplements are known to be vulnerable to contamination and adulteration, and emerg... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - July 21, 2023 Category: Complementary Medicine Authors: Ancu ța Cristina Raclariu-Manolică, Quentin Mauvisseau, Renato Paranaiba, Hugo J. De Boer and Carmen Socaciu Tags: Research Source Type: research

Silibinin ameliorates STING-mediated neuroinflammation via downregulation of ferroptotic damage in a sporadic Alzheimer's disease model
Arch Biochem Biophys. 2023 Jul 18:109691. doi: 10.1016/j.abb.2023.109691. Online ahead of print.ABSTRACTFerroptosis, an iron-dependent cell death, is caused by lipid peroxidation. Noteworthily, accumulation of iron and lipid peroxidation are found in the proximity of the neuritic plaque, a hallmark of Alzheimer's disease (AD), but the relationship between ferroptosis and neuroinflammation in AD is unclear. Silibinin, extracted from the Silybum marianum, is possibly developed as an agent for AD treatment from its neuroprotective effect, but the effect of silibinin on sporadic AD that accounts for more than 95% of AD remains...
Source: Archives of Biochemistry and Biophysics - July 20, 2023 Category: Biochemistry Authors: Panwen Liu Wenhui Chen Yu Kang Chenkang Wang Xiaoling Wang Weiwei Liu Toshihiko Hayashi Zhiyue Qiu Kazunori Mizuno Shunji Hattori Hitomi Fujisaki Takashi Ikejima Source Type: research

Molecules, Vol. 28, Pages 5484: Health Benefits, Antioxidant Activity, and Sensory Attributes of Selected Cold-Pressed Oils
This study focused on the estimation and comparison of the physicochemical properties and sensory quality of six CPOs: linseed oil (CPLO), pumpkin oil (CPPO), milk thistle oil (CPMTO), rapeseed oil (CPRO), camelina oil (CPCO), and sunflower oil (CPSO), which are the most popular in the Polish market. These oils were analysed for their fatty acid composition (FAC), their tocopherol, sterol, polycyclic aromatic hydrocarbon (PAHs), water, and volatile matter (WVM) contents, as well as their antioxidant activity (AA) and oxidative stability parameters. Moreover, quantitative descriptive analysis (QDA) was performed to obtain d...
Source: Molecules - July 18, 2023 Category: Chemistry Authors: Dobrochna Rabiej-Kozio ł Monika Momot-Ruppert Barbara Stawicka Aleksandra Szyd łowska-Czerniak Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4754: LC & ndash;MS Metabolomic Profiling of Five Types of Unrefined, Cold-Pressed Seed Oils to Identify Markers to Determine Oil Authenticity and to Test for Oil Adulteration
Molecules, Vol. 28, Pages 4754: LC–MS Metabolomic Profiling of Five Types of Unrefined, Cold-Pressed Seed Oils to Identify Markers to Determine Oil Authenticity and to Test for Oil Adulteration Molecules doi: 10.3390/molecules28124754 Authors: Agata Sumara Anna Stachniuk Alicja Trzpil Adrian Bartoszek Magdalena Montowska Emilia Fornal The authenticity of food products marketed as health-promoting foods&mdash;especially unrefined, cold-pressed seed oils&mdash;should be controlled to ensure their quality and safeguard consumers and patients. Metabolomic profiling using liquid chrom...
Source: Molecules - June 14, 2023 Category: Chemistry Authors: Agata Sumara Anna Stachniuk Alicja Trzpil Adrian Bartoszek Magdalena Montowska Emilia Fornal Tags: Article Source Type: research

Forecasting of potential anti-inflammatory targets of some immunomodulatory plants and their constituents using in vitro, molecular docking and network pharmacology-based analysis
Sci Rep. 2023 Jun 12;13(1):9539. doi: 10.1038/s41598-023-36540-3.ABSTRACTMost synthetic immunomodulatory medications are extremely expensive, have many disadvantages and suffer from a lot of side effects. So that, introducing immunomodulatory reagents from natural sources will have great impact on drug discovery. Therefore, this study aimed to comprehend the mechanism of the immunomodulatory activity of some natural plants via network pharmacology together with molecular docking and in vitro testing. Apigenin, luteolin, diallyl trisulfide, silibinin and allicin had the highest percentage of C-T interactions while, AKT1, CA...
Source: Atherosclerosis - June 12, 2023 Category: Cardiology Authors: Asmaa Khairy Doaa A Ghareeb Ismail Celik Hala M Hammoda Hala H Zaatout Reham S Ibrahim Source Type: research

In vitro effects of undifferentiated callus extracts from Plantago major L, Rhodiola rosea L and Silybum marianum L in normal and malignant human skin cells
CONCLUSION: All in all, we have confirmed that undifferentiated callus extracts of S. marianum possess properties such as antioxidant and anti-inflammatory activities in both normal and malignant keratinocytes, and thus could be a promising agent controlling the pro-inflammatory IL-6 production.PMID:37292297 | PMC:PMC10245016 | DOI:10.1016/j.heliyon.2023.e16480 (Source: Cancer Control)
Source: Cancer Control - June 9, 2023 Category: Cancer & Oncology Authors: Anette Gj örloff Wingren Riyam Ziyad Faik Anna Holefors Edina Filecovic Anna Gustafsson Source Type: research

Molecules, Vol. 28, Pages 4491: A Descriptive Review of the Action Mechanisms of Berberine, Quercetin and Silymarin on Insulin Resistance/Hyperinsulinemia and Cardiovascular Prevention
ffuso Insulin resistance (IR) and the associated hyperinsulinemia are early pathophysiological changes which, if not well treated, can lead to type 2 diabetes, endothelial dysfunction and cardiovascular disease. While diabetes care is fairly well standardized, the prevention and treatment of IR lacks a single pharmaceutical approach and many lifestyle and dietary interventions have been proposed, including a wide range of food supplements. Among the most interesting and well-known natural remedies, alkaloid berberine and the flavonol quercetin have particular relevance in the literature, while silymarin&mdash;t...
Source: Molecules - June 1, 2023 Category: Chemistry Authors: Paolo Bellavite Serafino Fazio Flora Affuso Tags: Review Source Type: research

Silibinin supplementation ameliorates the toxic effects of butyl benzyl phthalate on porcine oocytes by eliminating oxidative stress and autophagy
Environ Pollut. 2023 Apr 27:121734. doi: 10.1016/j.envpol.2023.121734. Online ahead of print.ABSTRACTButyl benzyl phthalate (BBP) is a common environmental pollutant, it is high in paints, adhesives and other decorative materials, food packaging bags, cleaning agents, is a plasticizer is very widely used in daily life. However, it remains unknown whether BBP causes damage to oocytes cultured in vitro and whether there is an effective rescue strategy. Here, we evaluated the effects of exposure to different concentrations of BBP (10, 50, and 100 μM) on the meiosis of porcine oocytes. The results showed that exposure to BBP ...
Source: Environmental Pollution - April 29, 2023 Category: Environmental Health Authors: Yu Li Bo Xiong Yilong Miao Qian Gao Source Type: research

Development of an Effective Acne Treatment Based on CBD and Herbal Extracts: Preliminary In Vitro , Ex Vivo, and Clinical Evaluation
Evid Based Complement Alternat Med. 2023 Apr 17;2023:4474255. doi: 10.1155/2023/4474255. eCollection 2023.ABSTRACTAcne vulgaris, the most common form of acne, is characterized by a mixed eruption of inflammatory and noninflammatory skin lesions primarily affecting the face, upper arms, and trunk. The pathogenesis of acne is multifactorial and includes abnormal keratinization and plugging of the hair follicles, increased sebum production, proliferation and activation of Cutibacterium acnes (C. acnes; formerly Propionibacterium acnes, P. acnes), and finally inflammation. Recent studies have found that cannabidiol (CBD) may b...
Source: Evidence-based Complementary and Alternative Medicine - April 27, 2023 Category: Complementary Medicine Authors: Guy Cohen Jeannette Jakus Sumer Baroud Raanan Gvirtz Sharon Rozenblat Source Type: research