Medicinal plants show remarkable antiproliferative potential in human cancer cell lines
Biosci Biotechnol Biochem. 2022 Jan 4:zbab225. doi: 10.1093/bbb/zbab225. Online ahead of print.ABSTRACTMolecules isolated and identified from plant origin are used to manufacture most chemotherapeutic drugs for cancer treatment. We assumed that these plant extracts contain prolific bioactive compounds with potent antiproliferative activities and could be effective against different human cancer cells. Ethanolic extracts were prepared from Chelidonium majus, Myrica cerifera, Fumaria indica, Nigella sativa, and Silybum marianum, and the antiproliferative assay was performed in HepG2 and HeLa human cancer cell lines. All plan...
Source: Bioscience, Biotechnology, and Biochemistry - January 4, 2022 Category: Biochemistry Authors: Aisha Nawaz Amina Arif Adil Jamal Muhammad Naveed Shahid Ibtesam Nomani Fayez Saeed Bahwerth Source Type: research
Research of resilience and elastic properties of short pastry with the meals of soy, sunflower and milk thistle
Vitalii Mihailik, Oksana Vitriak, Inna Danyliuk, Mykola Valko, Olga Mamai, Tatyana Popovych, Anna Ryabinina, Lyudmila Vishnevskaya, Valentyna Burak, Ludmila Vognivenko
Nutrition & Food Science, Vol. ahead-of-print, No. ahead-of-print, pp.-
The purpose of this paper is to study the resilience and elastic properties of short pastry with the meals of soy, sunflower and milk thistle.
Recent studies in the emerging food technologies of short pastry with use of meals were considered. Their focus on the improvement of the functional peculiarities of short pastry and benefits for people were t...
Source: Nutrition and Food Science - December 16, 2021 Category: Nutrition Authors: Vitalii Mihailik
Oksana Vitriak
Inna Danyliuk
Mykola Valko
Olga Mamai
Tatyana Popovych
Anna Ryabinina
Lyudmila Vishnevskaya
Valentyna Burak
Ludmila Vognivenko Source Type: research
Valuable Hepatoprotective Plants - How Can We Optimize Waste Free Uses of Such Highly Versatile Resources?
Humans used plants for thousand of years as food, drugs, or fuel to keep homes warm. People commonly used fruits and roots, and other parts of the plant were often wasted. This review aims to discuss the potential of rational stem-to-stern use of three highly versatile and valuable plants with hepatoprotective properties. Milk thistle (Silybum marianum L. Gaertn.), artichoke (Cynara cardunculus), and chicory (Cichorium intybus L.) have well-characterized hepatoprotective properties. These plants have been chosen since liver diseases are significant diseases of concern worldwide, and all parts of plants can be potentially u...
Source: Frontiers in Pharmacology - November 18, 2021 Category: Drugs & Pharmacology Source Type: research
Silybum marianum total extract, silymarin and silibinin abate hepatocarcinogenesis and hepatocellular carcinoma growth via modulation of the HGF/c-Met, Wnt/ β-catenin, and PI3K/Akt/mTOR signaling pathways
Biomed Pharmacother. 2021 Nov 12;145:112409. doi: 10.1016/j.biopha.2021.112409. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) has been identified as one of the most deadly malignancies with limited therapeutic efficacy worldwide. However, understanding the molecular mechanisms of crosstalk between signaling pathways in HCC and predicting cancer cell responses to targeted therapeutic interventions remain to be challenge. Thus, in this study, we aimed to evaluate the anticancerous efficacy of Silybum marianum total extract (STE), silymarin (Sm), and silibinin (Sb) against experimentally-induced HCC in rats. In...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 15, 2021 Category: Drugs & Pharmacology Authors: Nour Y S Yassin Sameh F AbouZid Asmaa M El-Kalaawy Tarek M Ali Mazen M Almehmadi Osama M Ahmed Source Type: research
Silybum marianum total extract, silymarin and silibinin abate hepatocarcinogenesis and hepatocellular carcinoma growth via modulation of the HGF/c-Met, Wnt/ β-catenin, and PI3K/Akt/mTOR signaling pathways
Biomed Pharmacother. 2021 Nov 12;145:112409. doi: 10.1016/j.biopha.2021.112409. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) has been identified as one of the most deadly malignancies with limited therapeutic efficacy worldwide. However, understanding the molecular mechanisms of crosstalk between signaling pathways in HCC and predicting cancer cell responses to targeted therapeutic interventions remain to be challenge. Thus, in this study, we aimed to evaluate the anticancerous efficacy of Silybum marianum total extract (STE), silymarin (Sm), and silibinin (Sb) against experimentally-induced HCC in rats. In...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 15, 2021 Category: Drugs & Pharmacology Authors: Nour Y S Yassin Sameh F AbouZid Asmaa M El-Kalaawy Tarek M Ali Mazen M Almehmadi Osama M Ahmed Source Type: research
Dietary supplements, cytochrome metabolism, and pharmacogenetic considerations
ConclusionCYP P450 activity is an important consideration for any patient but becomes increasingly critical if patients have certain CYP P450 phenotypes that impact metabolism. These popular supplements have the potential for changes in supplement exposure, and adverse effects based on pharmacogenetic profiles. Furthermore, these sites of metabolism are shared with many medications, setting the stage for possibly more profound interactions between medications and supplements. This paper highlights the mechanisms in which dietary supplements may constitute a risk for patients with certain CYP P450 phenotypes. Further resear...
Source: Irish Journal of Medical Science - November 4, 2021 Category: General Medicine Source Type: research
Evaluation the effect of Silybum marianum ointment on episiotomy wound healing and pain intensity in primiparous women: a randomized triple blind clinical trial
Episiotomy is the most commonn surgical procedure in midwifery which as any other wounds can cause infection or delay in healing. (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - October 7, 2021 Category: Complementary Medicine Authors: Elmira Toomari, Sepideh Hajian, Faraz Mojab, Tayebe Omidkhah and Malihe Nasiri Tags: Research article Source Type: research
Bioactive Foods and Medicinal Plants for Cardiovascular Complications of Type II Diabetes: Current Clinical Evidence and Future Perspectives
Evid Based Complement Alternat Med. 2021 Sep 16;2021:6681540. doi: 10.1155/2021/6681540. eCollection 2021.ABSTRACTCardiovascular diseases (CVDs) are the main cause of mortality in type 2 diabetes mellitus (T2DM); however, not all patients are fully satisfied with the current available treatments. Medicinal plants have been globally investigated regarding their effect in CVD, yet the field is far from getting exhausted. The current paper aims to provide an evidence-based review on the clinically evaluated medicinal plants and their main therapeutic targets for the management of CVD in T2DM. Electronic databases including Pu...
Source: Evidence-based Complementary and Alternative Medicine - September 27, 2021 Category: Complementary Medicine Authors: Roodabeh Bahramsoltani Mohammad Hosein Farzaei Mahboobe Ram Shekoufeh Nikfar Roja Rahimi Source Type: research
Silybin Alleviates Experimental Autoimmune Encephalomyelitis by Suppressing Dendritic Cell Activation and Th17 Cell Differentiation
Silybin, a peculiar flavonoid compound derived from the fruit and seeds of Silybum marianum, exhibits strong anti-inflammatory activities. In the present study, we found that silybin effectively alleviated experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), via inhibition of dendritic cell (DC) activation and Th17 cell differentiation. Silybin treatment greatly ameliorated the disease severity and significantly declined inflammation and demyelination of the central nervous system (CNS) of EAE mice. Consistent with the disease development, silybin-treated bone marrow-derived DCs (BM-...
Source: Frontiers in Neurology - September 7, 2021 Category: Neurology Source Type: research
Taxifolin Targets PI3K and mTOR and Inhibits Glioblastoma Multiforme
J Oncol. 2021 Aug 20;2021:5560915. doi: 10.1155/2021/5560915. eCollection 2021.ABSTRACTGlioblastoma multiforme (GBM), the most common malignant primary brain tumor, has a very poor prognosis. With increasing knowledge of tumor molecular biology, targeted therapies are becoming increasingly integral to comprehensive GBM treatment strategies. mTOR is a key downstream molecule of the PI3K/Akt signaling pathway, integrating input signals from growth factors, nutrients, and energy sources to regulate cell growth and cell proliferation through multiple cellular responses. mTOR/PI3K dual-targeted therapy has shown promise in mana...
Source: Journal of Oncology - August 31, 2021 Category: Cancer & Oncology Authors: Weiqi Yao Hongyun Gong Heng Mei Lei Shi Jinming Yu Yu Hu Source Type: research
Silymarin (milk thistle extract) as a therapeutic agent in gastrointestinal cancer
Biomed Pharmacother. 2021 Aug 13;142:112024. doi: 10.1016/j.biopha.2021.112024. Online ahead of print.ABSTRACTSilymarin contains a group of closely-related flavonolignan compounds including silibinin, and is extracted from Silybum marianum species, also called milk thistle. Silymarin has been shown to protect the liver in both experimental models and clinical studies. The chemopreventive activity of silymarin has shown some efficacy against cancer both in vitro and in vivo. Silymarin can modulate apoptosis in vitro and survival in vivo, by interfering with the expression of cell cycle regulators and apoptosis-associated pr...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 16, 2021 Category: Drugs & Pharmacology Authors: Maryam Fallah Amirhossein Davoodvandi Shahin Nikmanzar Sarehnaz Aghili Seyed Mohammad Ali Mirazimi Michael Aschner Amir Rashidian Michael R Hamblin Mohsen Chamanara Navid Naghsh Hamed Mirzaei Source Type: research
Recapitulation of Evidence of Phytochemical, Pharmacokinetic and
Biomedical Application of Silybin
Drug Res (Stuttg) DOI: 10.1055/a-1528-2721Silymarin is a standardized extract obtained from seeds of Silybum marianum (SM)
belonging to the family Asteraceae. It is a flavonolignan complex and consists
of various compounds like silybin A silybin B, isosilybin A, isosilybin B,
silydianin, silychristin and isosilychristin. Silybin is the major active
component present in 60–70% of the silymarin extract. It has
been used traditionally for the treatment of various liver disorders like
cirrhosis, jaundice, and hepatitis. Silymarin possesses antioxidant and
...
Source: Drug Research - July 27, 2021 Category: Drugs & Pharmacology Authors: Islam, Anas Mishra, Anuradha Siddiqui, Md Aftab Siddiquie, Saman Tags: Review Source Type: research
Exploration of plant products and phytochemicals against aflatoxin toxicity in broiler chicken production: Present status
Toxicon. 2021 Jul 3:S0041-0101(21)00187-2. doi: 10.1016/j.toxicon.2021.06.017. Online ahead of print.ABSTRACTAflatoxins (AFs) are a class of mycotoxins produced by the toxigenic Aspergillus fungi and are common contaminants of foods and feeds. Aflatoxin B1 (AFB1), the most potent aflatoxin, is well characterized to reduce productive performance and mortality in broilers. This exclusive review summarizes the efficacy of various plant products and phytochemicals to counteract AFB1 toxicity in broilers. The biochemical and molecular mode of action of AFB1 to induce liver damage, genotoxicity, immunosuppression and the protect...
Source: Toxicon - July 6, 2021 Category: Toxicology Authors: Umaya Suganthi R Y C Vijayalakshmi V Sejian Source Type: research
Exploration of plant products and phytochemicals against aflatoxin toxicity in broiler chicken production: Present status
Toxicon. 2021 Jul 3:S0041-0101(21)00187-2. doi: 10.1016/j.toxicon.2021.06.017. Online ahead of print.ABSTRACTAflatoxins (AFs) are a class of mycotoxins produced by the toxigenic Aspergillus fungi and are common contaminants of foods and feeds. Aflatoxin B1 (AFB1), the most potent aflatoxin, is well characterized to reduce productive performance and mortality in broilers. This exclusive review summarizes the efficacy of various plant products and phytochemicals to counteract AFB1 toxicity in broilers. The biochemical and molecular mode of action of AFB1 to induce liver damage, genotoxicity, immunosuppression and the protect...
Source: Toxicon - July 6, 2021 Category: Toxicology Authors: Umaya Suganthi R Y C Vijayalakshmi V Sejian Source Type: research
