Silymarin inhibits the progression of Ehrlich solid tumor via targeting molecular pathways of cell death, proliferation, angiogenesis, and metastasis in female mice
CONCLUSIONS: The anticancer effect was associated with apparent apoptosis in neoplastic cells with abundance of multifocal necrotic areas. SMN was found to inhibit ET growth via enhancing apoptosis, inhibition of cell division and reduction in angiogenesis in vivo. Hypothetical scheme of SMN antitumor effects (mechanism of signaling) in solid ET in vivo. SMN anticancer effect may be mediated by molecular mediators that affect proliferation, cell cycle activity, apoptotic pathways, angiogenesis, and metastasis.PMID:35305227 | DOI:10.1007/s11033-022-07315-2 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - March 19, 2022 Category: Molecular Biology Authors: Maggie E Amer Maher A Amer Azza I Othman Doaa A Elsayed Mohamed Amr El-Missiry Omar A Ammar Source Type: research
Silymarin inhibits the progression of Ehrlich solid tumor via targeting molecular pathways of cell death, proliferation, angiogenesis, and metastasis in female mice
CONCLUSIONS: The anticancer effect was associated with apparent apoptosis in neoplastic cells with abundance of multifocal necrotic areas. SMN was found to inhibit ET growth via enhancing apoptosis, inhibition of cell division and reduction in angiogenesis in vivo. Hypothetical scheme of SMN antitumor effects (mechanism of signaling) in solid ET in vivo. SMN anticancer effect may be mediated by molecular mediators that affect proliferation, cell cycle activity, apoptotic pathways, angiogenesis, and metastasis.PMID:35305227 | DOI:10.1007/s11033-022-07315-2 (Source: Mol Biol Cell)
Source: Mol Biol Cell - March 19, 2022 Category: Molecular Biology Authors: Maggie E Amer Maher A Amer Azza I Othman Doaa A Elsayed Mohamed Amr El-Missiry Omar A Ammar Source Type: research
Silymarin inhibits the progression of Ehrlich solid tumor via targeting molecular pathways of cell death, proliferation, angiogenesis, and metastasis in female mice
CONCLUSIONS: The anticancer effect was associated with apparent apoptosis in neoplastic cells with abundance of multifocal necrotic areas. SMN was found to inhibit ET growth via enhancing apoptosis, inhibition of cell division and reduction in angiogenesis in vivo. Hypothetical scheme of SMN antitumor effects (mechanism of signaling) in solid ET in vivo. SMN anticancer effect may be mediated by molecular mediators that affect proliferation, cell cycle activity, apoptotic pathways, angiogenesis, and metastasis.PMID:35305227 | DOI:10.1007/s11033-022-07315-2 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - March 19, 2022 Category: Molecular Biology Authors: Maggie E Amer Maher A Amer Azza I Othman Doaa A Elsayed Mohamed Amr El-Missiry Omar A Ammar Source Type: research
Silymarin inhibits the progression of Ehrlich solid tumor via targeting molecular pathways of cell death, proliferation, angiogenesis, and metastasis in female mice
CONCLUSIONS: The anticancer effect was associated with apparent apoptosis in neoplastic cells with abundance of multifocal necrotic areas. SMN was found to inhibit ET growth via enhancing apoptosis, inhibition of cell division and reduction in angiogenesis in vivo. Hypothetical scheme of SMN antitumor effects (mechanism of signaling) in solid ET in vivo. SMN anticancer effect may be mediated by molecular mediators that affect proliferation, cell cycle activity, apoptotic pathways, angiogenesis, and metastasis.PMID:35305227 | DOI:10.1007/s11033-022-07315-2 (Source: Mol Biol Cell)
Source: Mol Biol Cell - March 19, 2022 Category: Molecular Biology Authors: Maggie E Amer Maher A Amer Azza I Othman Doaa A Elsayed Mohamed Amr El-Missiry Omar A Ammar Source Type: research
Therapeutic Effects of Milk Thistle ( < em > Silybum marianum < /em > L.) and Artichoke ( < em > Cynara scolymus < /em > L.) on Nonalcoholic Fatty Liver Disease in Type 2 Diabetic Rats
CONCLUSIONS: Milk thistle could be a promising pharmacological option for the treatment of NAFLD. Nonetheless, long-term randomized clinical trials are necessary to confirm the observed results.PMID:35186807 | PMC:PMC8856812 | DOI:10.1155/2022/2868904 (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - February 21, 2022 Category: Gastroenterology Authors: Aida Doostkam Mohammad Fathalipour Mohammad Hossein Anbardar Azar Purkhosrow Hossein Mirkhani Source Type: research
Silibinin exerts anti-cancer activity on human ovarian cancer cells by increasing apoptosis and inhibiting epithelial-mesenchymal transition (EMT)
CONCLUSION: silibinin could be considered a potent agent against ovarian cancer based on the results.PMID:35189245 | DOI:10.1016/j.gene.2022.146275 (Source: Gene)
Source: Gene - February 21, 2022 Category: Genetics & Stem Cells Authors: Narges Maleki Negar Yavari Maryam Ebrahimi Ahmad Faisal Faiz Roya Khosh Ravesh Aysan Sharbati Mohammad Panji Keivan Lorian Abdollah Gravand Mojtaba Abbasi Omid Abazari Mehdi Shafiee Mehr Yasin Eskandari Source Type: research
Therapeutic Effects of Milk Thistle ( < em > Silybum marianum < /em > L.) and Artichoke ( < em > Cynara scolymus < /em > L.) on Nonalcoholic Fatty Liver Disease in Type 2 Diabetic Rats
CONCLUSIONS: Milk thistle could be a promising pharmacological option for the treatment of NAFLD. Nonetheless, long-term randomized clinical trials are necessary to confirm the observed results.PMID:35186807 | PMC:PMC8856812 | DOI:10.1155/2022/2868904 (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - February 21, 2022 Category: Gastroenterology Authors: Aida Doostkam Mohammad Fathalipour Mohammad Hossein Anbardar Azar Purkhosrow Hossein Mirkhani Source Type: research
Silibinin exerts anti-cancer activity on human ovarian cancer cells by increasing apoptosis and inhibiting epithelial-mesenchymal transition (EMT)
CONCLUSION: silibinin could be considered a potent agent against ovarian cancer based on the results.PMID:35189245 | DOI:10.1016/j.gene.2022.146275 (Source: Gene)
Source: Gene - February 21, 2022 Category: Genetics & Stem Cells Authors: Narges Maleki Negar Yavari Maryam Ebrahimi Ahmad Faisal Faiz Roya Khosh Ravesh Aysan Sharbati Mohammad Panji Keivan Lorian Abdollah Gravand Mojtaba Abbasi Omid Abazari Mehdi Shafiee Mehr Yasin Eskandari Source Type: research
Therapeutic Effects of Milk Thistle ( < em > Silybum marianum < /em > L.) and Artichoke ( < em > Cynara scolymus < /em > L.) on Nonalcoholic Fatty Liver Disease in Type 2 Diabetic Rats
CONCLUSIONS: Milk thistle could be a promising pharmacological option for the treatment of NAFLD. Nonetheless, long-term randomized clinical trials are necessary to confirm the observed results.PMID:35186807 | PMC:PMC8856812 | DOI:10.1155/2022/2868904 (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - February 21, 2022 Category: Gastroenterology Authors: Aida Doostkam Mohammad Fathalipour Mohammad Hossein Anbardar Azar Purkhosrow Hossein Mirkhani Source Type: research
Silibinin exerts anti-cancer activity on human ovarian cancer cells by increasing apoptosis and inhibiting epithelial-mesenchymal transition (EMT)
CONCLUSION: silibinin could be considered a potent agent against ovarian cancer based on the results.PMID:35189245 | DOI:10.1016/j.gene.2022.146275 (Source: Gene)
Source: Gene - February 21, 2022 Category: Genetics & Stem Cells Authors: Narges Maleki Negar Yavari Maryam Ebrahimi Ahmad Faisal Faiz Roya Khosh Ravesh Aysan Sharbati Mohammad Panji Keivan Lorian Abdollah Gravand Mojtaba Abbasi Omid Abazari Mehdi Shafiee Mehr Yasin Eskandari Source Type: research
Therapeutic Effects of Milk Thistle ( < em > Silybum marianum < /em > L.) and Artichoke ( < em > Cynara scolymus < /em > L.) on Nonalcoholic Fatty Liver Disease in Type 2 Diabetic Rats
CONCLUSIONS: Milk thistle could be a promising pharmacological option for the treatment of NAFLD. Nonetheless, long-term randomized clinical trials are necessary to confirm the observed results.PMID:35186807 | PMC:PMC8856812 | DOI:10.1155/2022/2868904 (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - February 21, 2022 Category: Gastroenterology Authors: Aida Doostkam Mohammad Fathalipour Mohammad Hossein Anbardar Azar Purkhosrow Hossein Mirkhani Source Type: research
Protective effects of silibinin against ethanol- or acetaldehyde-caused damage in liver cell lines involve the repression of mitochondrial fission
This study investigated the protective role of silibinin in ethanol- or acetaldehyde-induced apoptosis in human carcinomatous liver HepG2 cells and immortalized liver HL7702 cells, focusing on elucidation of the underlying mechanism in vitro. The toxicity of ethanol or acetaldehyde was evaluated by MTT assay. Apoptosis-related proteins, mitochondrial fission-associated proteins and mitochondrial fusion-associated proteins were analyzed by western blotting and immunofluorescence microscopy. Present experimental results demonstrated that silibinin improved cell viability, reduced the enzyme activities of AST/ALT and ALDH/ADH...
Source: Toxicology in Vitro - February 14, 2022 Category: Toxicology Authors: Xiao-Yu Song Peng-Cheng Liu Wei-Wei Liu Toshihiko Hayashi Kazunori Mizuno Shunji Hattori Hitomi Fujisaki Takashi Ikejima Source Type: research
Protective effects of silibinin against ethanol- or acetaldehyde-caused damage in liver cell lines involve the repression of mitochondrial fission
This study investigated the protective role of silibinin in ethanol- or acetaldehyde-induced apoptosis in human carcinomatous liver HepG2 cells and immortalized liver HL7702 cells, focusing on elucidation of the underlying mechanism in vitro. The toxicity of ethanol or acetaldehyde was evaluated by MTT assay. Apoptosis-related proteins, mitochondrial fission-associated proteins and mitochondrial fusion-associated proteins were analyzed by western blotting and immunofluorescence microscopy. Present experimental results demonstrated that silibinin improved cell viability, reduced the enzyme activities of AST/ALT and ALDH/ADH...
Source: Toxicology in Vitro - February 14, 2022 Category: Toxicology Authors: Xiao-Yu Song Peng-Cheng Liu Wei-Wei Liu Toshihiko Hayashi Kazunori Mizuno Shunji Hattori Hitomi Fujisaki Takashi Ikejima Source Type: research
Protective effects of silibinin against ethanol- or acetaldehyde-caused damage in liver cell lines involve the repression of mitochondrial fission
This study investigated the protective role of silibinin in ethanol- or acetaldehyde-induced apoptosis in human carcinomatous liver HepG2 cells and immortalized liver HL7702 cells, focusing on elucidation of the underlying mechanism in vitro. The toxicity of ethanol or acetaldehyde was evaluated by MTT assay. Apoptosis-related proteins, mitochondrial fission-associated proteins and mitochondrial fusion-associated proteins were analyzed by western blotting and immunofluorescence microscopy. Present experimental results demonstrated that silibinin improved cell viability, reduced the enzyme activities of AST/ALT and ALDH/ADH...
Source: Toxicology in Vitro - February 14, 2022 Category: Toxicology Authors: Xiao-Yu Song Peng-Cheng Liu Wei-Wei Liu Toshihiko Hayashi Kazunori Mizuno Shunji Hattori Hitomi Fujisaki Takashi Ikejima Source Type: research
System biology-based investigation of Silymarin to trace hepatoprotective effect
Comput Biol Med. 2022 Jan 6;142:105223. doi: 10.1016/j.compbiomed.2022.105223. Online ahead of print.ABSTRACTSilymarin is used as a hepatoprotective agent since ancient times which could be via its potent anti-oxidant effect. However, the mode of silymarin for the hepatoprotective effect has not been established with the targets involved in hepatic cirrhosis. The present study investigated the multiple interactions of the flavonolignans from Silybum marianum with targets involved in hepatic cirrhosis using a series of system biology approaches. Chemo-informative tools and databases i.e. DIGEP-Pred and DisGeNET were used to...
Source: Molecular Medicine - January 16, 2022 Category: Molecular Biology Authors: Prarambh S R Dwivedi Vishal S Patil Pukar Khanal Vishwambhar V Bhandare Shailendra Gurav Darasaguppe R Harish B M Patil Subarna Roy Source Type: research
