CT-Guided Percutaneous Microwave Ablation of Sclerosing Hepatic Carcinoma.
Authors: Song H, Ding H, Zhu C Abstract Sclerosing hepatic carcinoma (SHC) is a rare subtype of hepatic carcinoma that can be caused by various pathogeneses. The histological characteristics of SHC demonstrate its high resistance to chemoembolization and thermal ablation; thus, surgical resection represents the primary option for the majority of patients. However, a small proportion of patients who cannot withstand surgery or who have inoperable tumors may not receive adequate treatment, causing the progression of cancer and related high mortality. To overcome the high puncture resistance, high thermal resistance, ...
Source: Canadian Journal of Gastroenterology - August 2, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Transmission of HIV and HCV within Former Soviet Union Countries.
Conclusion: This study highlights the need to focus harm reduction efforts toward controlling transmission of blood-borne infections among the abovementioned high-risk populations in the FSU countries. PMID: 32733822 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - August 2, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Verification of the Nutritional and Dietary Factors Associated with Skeletal Muscle Index in Japanese Patients with Nonalcoholic Fatty Liver Disease.
Authors: Himoto T, Miyatake K, Maeba T, Masaki T Abstract We sought to identify the frequencies of presarcopenia, sarcopenia, and sarcopenic obesity in patients with nonalcoholic fatty liver disease (NAFLD) and to cross-sectionally determine the nutritional and dietary factors associated with loss of skeletal muscle mass in such patients. Dietary and body component changes produced by a diet intervention were longitudinally investigated. Forty-six NAFLD patients (24 males and 22 females) were enrolled. A second diet treatment was performed at 6 months after entry in 19 of the enrolled patients (6 males and 1...
Source: Canadian Journal of Gastroenterology - July 24, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Role of Terlipressin in Cirrhotic Patients with Ascites and without Hepatorenal Syndrome: A Systematic Review of Current Evidence.
Authors: Bai Z, An Y, Guo X, Teschke R, Méndez-Sánchez N, Li H, Qi X Abstract Ascites, a common complication in cirrhosis, is prone to the development of acute kidney injury or hepatorenal syndrome and can be complicated by circulatory dysfunction after paracentesis. Terlipressin has not been considered as the mainstay treatment option for ascites in cirrhosis yet. The present work aimed to systematically review the current evidence regarding the use of terlipressin in cirrhosis with ascites and without hepatorenal syndrome. PubMed, EMBASE, and Cochrane Library databases were searched for relevant stu...
Source: Canadian Journal of Gastroenterology - July 19, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Caveolin-1 Knockdown Decreases SMMC7721 Human Hepatocellular Carcinoma Cell Invasiveness by Inhibiting Vascular Endothelial Growth Factor-Induced Angiogenesis.
Conclusion: Our results reveal a novel mechanism, whereby caveolin-1 positively regulates human HCC cell invasiveness by coordinating VEGF-induced angiogenesis. PMID: 32676485 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - July 19, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

FLOT Neoadjuvant Chemotherapy Followed by Laparoscopic D2 Gastrectomy in the Treatment of Locally Resectable Advanced Gastric Cancer.
Conclusions: These findings suggest that FLOT neoadjuvant chemotherapy, followed by laparoscopic D2 gastrectomy, is effective and safe in advanced, resectable advanced gastric cancer. PMID: 32566545 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - June 24, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Clinical Patterns and Outcome of Hepatocellular Carcinoma in Patients with Nonalcoholic Fatty Liver Disease.
Conclusions: NAFLD-related HCCs were more often detected at an advanced stage with infiltrative patterns, although they showed no significant difference in survival compared to ALD-related or HBV-related HCCs. A future prospective research should be focused on identifying NAFLD patients who require strict surveillance in order to early detect and timely treat HCC. PMID: 32566546 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - June 24, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Effect of Melatonin as an Antioxidant Drug to Reverse Hepatic Steatosis: Experimental Model.
Conclusions: In this study, it has not been possible to demonstrate a beneficial effect of melatonin in the improvement or reversal of liver steatosis once established and induced by diet in the porcine model. It is true that signs of improvement have been found at the histological level, at the level of lipid metabolism, and at the level of oxidative stress phenomena, when comparing animals with established steatosis that are treated with melatonin with those who do not take it. This work is the first study conducted in a large animal model in which the effect of melatonin is studied as a treatment in the reversal of esta...
Source: Canadian Journal of Gastroenterology - June 24, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Effectiveness of Conservative Treatment without Early Colonoscopy in Patients with Colonic Diverticular Hemorrhage.
This study was aimed to clarify the effectiveness of conservative treatment without performing early colonoscopy and the indications for early colonoscopy in patients with colonic diverticular hemorrhage. Methods: This retrospective study included 142 participants who were urgently hospitalized due to bloody stools and were diagnosed with colonic diverticular hemorrhage between April 2012 and December 2016. At the time of hospital visit, only when both shock based on vital signs and intestinal extravasation on abdominal contrast-enhanced computed tomography were observed, early colonoscopy was performed within 24 hours...
Source: Canadian Journal of Gastroenterology - May 15, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Clinicopathological Features, Treatment Strategy, and Prognosis of Primary Non-Hodgkin's Lymphoma of the Duodenum: A SEER Database Analysis.
In this study, we sought to describe clinical features and identify factors affecting survival in patients with PDL using a large population cohort. Methods: The Surveillance, Epidemiology, and End Results (SEER) database was queried from 1998 to 2015. Results: A total of 1060 cases of PDLs were identified. Clinicopathological features as well as survival data of PDLs were analyzed and compared with 10573 primary gastric lymphomas (PGLs) and 3239 primary small intestinal lymphomas (PSILs) from the SEER database. PDL patients were younger in age (60.96 ± 15.205), and the proportion of stage I (5...
Source: Canadian Journal of Gastroenterology - May 15, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Clinical Significance of Hepatocyte Growth Factor and Transforming Growth Factor-Beta-1 Levels in Assessing Disease Activity in Inflammatory Bowel Disease.
Conclusion. Serum levels of TGF-β and HGF were significantly higher in IBD patients compared with the control group. In the UC group, the levels of HGF and TGF-β were significantly higher than in the CD group. Levels of TGF-β and HGF correlate with the activity of IBD. PMID: 32377513 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - May 8, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Prevalence of Hepatitis C Virus Infection in a Surgical Population of Southeast China: A Large-Scale Multicenter Study.
Authors: Chen P, Zheng Y, Cai Y, Zou P, Li N, Peng C, Gao H, Liu J, Chen Y, Tong Z, Li L Abstract Background: Chronic HCV infection affects 80 million people globally and may progress to advanced liver disease. The present study aims to investigate the present epidemiology of HCV infection in a southeastern Chinese surgical patient cohort. Methods: Blood samples obtained from 78,484 surgical patients from 18 different city and county hospitals were enrolled. The incidence of serum HCV antibody positivity, HCV RNA load, and HCV genotyping, as well as demographics and relevant clinical history, were investigated....
Source: Canadian Journal of Gastroenterology - May 8, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Role of Albumin as a Nutritional and Prognostic Marker in Elective Intestinal Surgery.
Authors: Galata C, Busse L, Birgin E, Weiß C, Hardt J, Reißfelder C, Otto M Abstract Background: The aim of this study was to investigate albumin, nutritional status, and inflammation in the perioperative course of patients undergoing elective intestinal surgery. Methods: A retrospective analysis of patients with preoperative measurements of nutritional parameters who underwent intestinal surgery between April 2017 and August 2018 at our institution was performed. Preoperatively, the correlation of albumin levels with markers for inflammation and nutritional status was investigated. Postoperatively,...
Source: Canadian Journal of Gastroenterology - May 1, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Hepatitis C Virus Screening of High-Risk Patients in a Canadian Emergency Department.
This study shows that ED HCV screening is feasible and that a small number of previously undiagnosed patients can be identified and linked to potentially life-changing care. PMID: 32211349 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - March 28, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Electroacupuncture Relieves Suppression of Autophagy in Interstitial Cells of Cajal of Diabetic Gastroparesis Rats.
In this study, we aimed to figure out the relationship between DGP and autophagy of ICCs. Methods: Sixty Sprague-Dawley (SD) rats were randomly divided into normal control group (NC, 10) and modeling group (50). Rats in the modeling group were injected 2% streptozotocin (STZ) and fed with high-glucose and high-fat diet for 8 weeks in order to establish DGP rat model. After modeling, 30 successfully modeled rats were randomly selected and separated into diabetic gastroparesis group (DGP, 10), GDP rats with electroacupuncture group (EA, 10), and GDP rats with metoclopramide group (MP, 10). When the intervention was compl...
Source: Canadian Journal of Gastroenterology - March 28, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Adherence to Azathioprine/6-Mercaptopurine in Children and Adolescents with Inflammatory Bowel Diseases: A Multimethod Study.
Conclusion: Results provide evidence for ongoing adherence challenges in the paediatric population with IBD. It is recommended that parents/guardians (particularly of older children) and older children themselves, should receive enhanced counselling and education about their prescribed medicines. PMID: 32185153 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - March 19, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Bredemolic Acid Ameliorates Selected Liver Function Biomarkers in a Diet-Induced Prediabetic Rat Model.
Conclusion: BA administration improved liver function in diet-induced prediabetic rats in the presence or absence of dietary intervention. PMID: 32149046 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - March 11, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

A Potential Linking between Vitamin D and Adipose Metabolic Disorders.
Authors: Miao Z, Wang S, Wang Y, Guo L, Zhang J, Liu Y, Yang Q Abstract Vitamin D has been discovered centuries ago, and current studies have focused on the biological effects of vitamin D on adipogenesis. Besides its role in calcium homeostasis and energy metabolism, vitamin D is also involved in the regulation of development and process of metabolic disorders. Adipose tissue is a major storage depot of vitamin D. This review summarized studies on the relationship between vitamin D and adipogenesis and furthermore focuses on adipose metabolic disorders. We reviewed the biological roles and functionalities of vitam...
Source: Canadian Journal of Gastroenterology - March 11, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Gastric Xanthoma Associated with Gastric Cancer Development: An Updated Review.
Authors: Moumin FA, Mohamed AA, Osman AA, Cai J Abstract Gastric xanthelasma (GX) is a rare tumor-like lesion customarily found as an incidental finding due to its asymptomatic appearance. Grossly, it is a well-marked yellow-white plaque created in the lamina propria by microscopic clusters of foamy macrophages. Xanthelasma is rarely correlated with gastric hyperplastic polyps; gastric xanthomas are rare benign lesions that appear to be associated with inflammation of the gastric mucosa. Etiopathogenesis is also unclear, but it has been suggested to be involved in chronic gastritis, infection with Helicobacter pylo...
Source: Canadian Journal of Gastroenterology - March 11, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Comparison of the Effects of TIPS versus BRTO on Bleeding Gastric Varices: A Meta-Analysis.
Conclusions: In this meta-analysis, BRTO brought more benefits to patients, with a higher OS rate and lower rebleeding rate. BRTO is a feasible method for GVB. PMID: 32104670 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - February 28, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Serum Neutrophil Gelatinase-Associated Lipocalin (NGAL) in HCV-Positive Egyptian Patients Treated with Sofosbuvir.
Conclusions: Sofosbuvir appears to have no nephrotoxic effects and is safe to treat patients with chronic HCV infection. PMID: 32083035 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - February 23, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Natural History of Nonalcoholic Fatty Liver Disease: Implications for Clinical Practice and an Individualized Approach.
Authors: Grgurevic I, Podrug K, Mikolasevic I, Kukla M, Madir A, Tsochatzis EA Abstract Nonalcoholic fatty liver disease (NAFLD) is becoming the most prevalent liver disease worldwide, associated with epidemics of overweight and resulting metabolic syndrome (MetS). Around 20-30% of patients with NAFLD develop progressive liver fibrosis, which is the most important predictor of liver-related and overall morbidity and mortality. In contrast to classical understanding, no significant association has been demonstrated between the inflammatory component of NAFLD, i.e., nonalcoholic steatohepatitis (NASH), and the advers...
Source: Canadian Journal of Gastroenterology - February 15, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Deficiency of Dietary Fiber in Slc5a8-Null Mice Promotes Bacterial Dysbiosis and Alters Colonic Epithelial Transcriptome towards Proinflammatory Milieu.
Authors: Sivaprakasam S, Ganapathy PK, Sikder MOF, Elmassry M, Ramachandran S, Kottapalli KR, Ganapathy V Abstract Inflammatory bowel disease (IBD) is characterized by chronic inflammation in the intestinal tract due to disruption of the symbiotic relationship between the host immune system and microbiota. Various factors alter the gut microbiota which lead to dysbiosis; in particular, diet and dietary fibers constitute important determinants. Dietary fiber protects against IBD; bacteria ferment these dietary fibers in colon and generate short-chain fatty acids (SCFAs), which mediate the anti-inflammatory actions o...
Source: Canadian Journal of Gastroenterology - January 25, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Intestinal Microbiome Changes in Fecal Microbiota Transplant (FMT) vs. FMT Enriched with Lactobacillus in the Treatment of Recurrent Clostridioides difficile Infection.
Conclusion: Fecal microbiota transplant by capsules was clinically and genomically similar between traditional FMT and enriched FMT with Lactobacillus spp. Restoration of bacterial diversity and resolution of dysbiosis at days 7 and 28 were observed. Patients with a first episode of recurrence treated with FMT had an excellent response without severe adverse events; FMT should be considered as an early treatment during R-CDI. PMID: 31976311 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - January 25, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

A Randomized Placebo-Controlled N-of-1 Trial: The Effect of Proton Pump Inhibitor in the Management of Gastroesophageal Reflux Disease.
Conclusion: There was no significant improvement in the patient GERD symptoms increasing the dose of oral esomeprazole during the 6 months of study. N-of-1 trials in chronic pathologies including GERD are recommended due to their potential value as systematic methods that evaluate therapies without strong scientific evidence. PMID: 31929980 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - January 15, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Clinical Features of Liver Injury Induced by Immune Checkpoint Inhibitors in Japanese Patients.
Conclusions: Our findings suggest that ICIs could cause microscopic biliary disorder without any abnormal image finding. Because the hepatic irAE presents diverse clinical features, liver biopsy is recommended to provide appropriate treatments. PMID: 31929981 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - January 15, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Association between Hemoglobin Glycation Index and NAFLD in Chinese Nondiabetic Individuals.
Authors: Hu DS, Zhu SH, Li X, Chen QF, Lin CJ, Fang DH, Wu JS Abstract Purpose: Limited studies have preliminarily identified a positive association between nonalcoholic fatty liver disease (NAFLD) and hemoglobin glycation index (HGI). However, this association has not been fully established. We aim to investigate the association between NAFLD and HGI in Chinese nondiabetic individuals and to construct a risk score based on HGI to predict a person's risk of NAFLD. Methods: After strict exclusion criteria, 5,903 individuals were included in this retrospective cross-sectional study. We randomly selected 1,967 sub...
Source: Canadian Journal of Gastroenterology - January 15, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Expression Analysis of ATP-Binding Cassette Transporters ABCB11 and ABCB4 in Primary Sclerosing Cholangitis and Variety of Pediatric and Adult Cholestatic and Noncholestatic Liver Diseases.
In this study, we investigated the expression and localization pattern of ABCB11 and ABCB4 using immunohistochemistry and RNA profiling in liver samples from patients with different types and stages of chronic cholestatic liver disease, with emphasis on primary sclerosing cholangitis (PSC), compared to a variety of cholestatic and noncholestatic hepatopathies. Therefore, ABCB11 and ABCB4 expressions were investigated on formalin-fixed and paraffin-embedded (FFPE) material in a patient cohort of total 43 patients with or without cholestatic liver diseases, on protein level using immunohistochemistry and on RNA level using n...
Source: Canadian Journal of Gastroenterology - January 1, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Blueberry Attenuates Liver Fibrosis, Protects Intestinal Epithelial Barrier, and Maintains Gut Microbiota Homeostasis.
Authors: Yan Z, Yang F, Hong Z, Wang S, Jinjuan Z, Han B, Xie R, Leng F, Yang Q Abstract Objective: Recently, blueberry has been identified as a candidate for the treatment of liver fibrosis. Given the role of gut-liver axis in liver fibrosis and the importance of the gut microbiota homeostasis to the maintenance of the intestinal epithelial barrier, this study aimed to investigate whether blueberry could attenuate liver fibrosis and protect the intestinal epithelial barrier by maintaining the homeostasis of the gut microbiota. Method: A CCl4-induced rat liver fibrosis model was used to detect the roles of blue...
Source: Canadian Journal of Gastroenterology - January 1, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

In Vivo Evaluation of Histopathological Alterations and Trace Metals Estimation of the Small Intestine in Bisphenol A-Intoxicated Rats.
Authors: Ambreen S, Akhtar T, Hameed N, Ashfaq I, Sheikh N Abstract BPA, a ubiquitously used plasticizer, has become one of the contaminants of emerging concern and causes many serious health implications in humans due to multiple exposure pathways. The current study was aimed at investigating the deformities of structures that arise by exposure of the small intestine to BPA through trace elements estimation of tissues as well as the study of serum profile. Two major groups of Wistar rats were established: one control group and the other experimental group, which was further divided into four groups based on dose (...
Source: Canadian Journal of Gastroenterology - January 1, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Long Noncoding RNA GATA3-AS1 Promotes Cell Proliferation and Metastasis in Hepatocellular Carcinoma by Suppression of PTEN, CDKN1A, and TP53.
Conclusion: Our data suggested that GATA3-AS1 promotes cell proliferation and metastasis of HCC by suppression of PTEN, CDKN1A, and TP53. PMID: 31871924 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - December 26, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Association between Serum Uric Acid and Non-Alcoholic Fatty Liver Disease according to Different Menstrual Status Groups.
Conclusions: Menstrual status was significantly correlated with NAFLD. High levels of SUA were associated with NAFLD in females during the three menstrual periods. PMID: 31871925 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - December 26, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Simple Bedside Predictors of Survival after Percutaneous Gastrostomy Tube Insertion.
Authors: Sbeit W, Kadah A, Mari A, Mahamid M, Khoury T Abstract Background: Percutaneous endoscopic gastrostomy (PEG) tube insertion is an increasingly used minimally invasive method for long-term enteral feeding. Identification of simple predictors for short-term mortality (up to one month) after PEG insertion is of paramount importance. Aim: We aimed to explore a simple noninvasive parameter that would predict survival following PEG insertion. Methods: We performed a retrospective study of all patients who underwent PEG insertion at the Galilee Medical Center from January 1, 2014 to December 30, 2018. We ...
Source: Canadian Journal of Gastroenterology - December 13, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

A Prospective, Randomized Comparison of Duodenoscope Reprocessing Surveillance Methods.
Authors: De Wolfe TJ, Safdar N, Meller M, Marx J, Pfau PR, Nelsen EM, Benson ME, Soni A, Reichelderfer M, Duster M, Gopal DV Abstract Duodenoscope use in healthcare facilities has been associated with transmission of multidrug resistant pathogens between patients. To assist healthcare facilities in monitoring the quality of their duodenoscope reprocessing procedures and limit patient risk of infection, the Centers for Disease Control and Prevention (CDC) deployed voluntary interim duodenoscope sampling and culturing surveillance protocols in 2015. Though the interim methods were widely adopted, alternative surveill...
Source: Canadian Journal of Gastroenterology - December 13, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

As Clinical Markers, Hand-Foot-Skin Reaction and Diarrhea Can Predict Better Outcomes for Hepatocellular Carcinoma Patients Receiving Transarterial Chemoembolization plus Sorafenib.
Authors: Liu L, Wang E, Li L, Chen D, Peng K, Wang M, Han G Abstract Background: Combination therapy of transarterial chemoembolization plus sorafenib (TACE-S) has been proven to be safe and effective for hepatocellular carcinoma (HCC); however, this combination therapy is associated with a high incidence of adverse events (AEs). Our study focused on the relationships between AEs and treatment outcomes and aimed to discover AE-based clinical markers that can predict the survival benefits of combination treatment. Methods: From January 2010 to June 2014, a total of 235 HCC patients treated with TACE-S were retro...
Source: Canadian Journal of Gastroenterology - December 10, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

The Impact of Revascularisation on Quality of Life in Chronic Mesenteric Ischemia.
Conclusion: Quality of life of CMI patients is improved after mesenteric artery revascularisation. PMID: 31781520 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - November 30, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Lymphopenia Is Associated with Gross Target Volumes and Fractions in Hepatocellular Carcinoma Patients Treated with External Beam Radiation Therapy and Also Indicates Worse Overall Survival.
Authors: Zhang HG, Yang P, Jiang T, Zhang JY, Jin XJ, Hu Y, Sun J, Du SS, Zeng ZC Abstract Purpose: To investigate whether lymphocyte nadir induced by radiation is associated with survival and explore its underlying risk factors in patients with hepatocellular carcinoma (HCC). Methods: Total lymphocyte counts were collected from 184 HCC patients treated by radiotherapy (RT) with complete follow-up. Associations between gross tumor volumes (GTVs) and radiation-associated parameters with lymphocyte nadir were evaluated by Pearson/Spearman correlation analysis and multiple linear regression. Kaplan-Meier analysis,...
Source: Canadian Journal of Gastroenterology - November 30, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Diagnosis and Treatment of Esophageal Candidiasis: Current Updates.
Authors: Mohamed AA, Lu XL, Mounmin FA Abstract Esophageal candidiasis (EC) is the most common type of infectious esophagitis. In the gastrointestinal tract, the esophagus is the second most susceptible to candida infection, only after the oropharynx. Immunocompromised patients are most at risk, including patients with HIV/AIDS, leukemia, diabetics, and those who are receiving corticosteroids, radiation, and chemotherapy. Another group includes those who used antibiotics frequently and those who have esophageal motility disorder (cardiac achalasia and scleroderma). Patients complained of pain on swallowing, difficu...
Source: Canadian Journal of Gastroenterology - November 29, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Plasma α-Glutathione S-Transferase Evaluation in Patients with Acute and Chronic Liver Injury.
Plasma α-Glutathione S-Transferase Evaluation in Patients with Acute and Chronic Liver Injury. Can J Gastroenterol Hepatol. 2019;2019:5850787 Authors: Czuczejko J, Mila-Kierzenkowska C, Szewczyk-Golec K Abstract High concentration of alpha-glutathione S-transferase (α-GST) in the liver and its short half-life make this enzyme clinically useful in assessing hepatocellular damage. We aimed to investigate the significance of α-GST evaluation in monitoring of liver injury in acute and chronic liver diseases. 20 healthy volunteers and 52 patients were included in the study. The patients we...
Source: Canadian Journal of Gastroenterology - November 29, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Association between Smoking and Liver Fibrosis among Patients with Nonalcoholic Fatty Liver Disease.
Conclusion: This study showed that smoking was closely associated with liver fibrosis among the patients with NAFLD. For patients with NAFLD who smoke, priority screening and timely intervention should be provided if they are at risk of liver fibrosis. PMID: 31737583 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - November 19, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

The Triglyceride and Glucose Index Is a Predictor of Incident Nonalcoholic Fatty Liver Disease: A Population-Based Cohort Study.
Authors: Kitae A, Hashimoto Y, Hamaguchi M, Obora A, Kojima T, Fukui M Abstract Background: The triglyceride and glucose index (TyG), defined as the product of triglycerides (TG) and fasting plasma glucose (FPG), is reported as a surrogate index for insulin resistance. Although a cross-sectional study revealed the association between the TyG-index and the prevalence of nonalcoholic fatty liver disease (NAFLD), few studies have investigated the association between the TyG-index and incident NAFLD. Here we investigated whether the TyG-index can be used to predict incident NAFLD. Methods: This historical cohort st...
Source: Canadian Journal of Gastroenterology - November 8, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Renal Dysfunction is a Risk Factor of Death after Gastric Endoscopic Submucosal Dissection in Elderly Patients Aged ≥80 Years.
This study aimed to investigate the prognosis and long-term outcomes of ESD for EGC in elderly patients aged ≥80 years by comparing their findings to the findings of patients aged
Source: Canadian Journal of Gastroenterology - October 6, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Circulating miRNAs as Novel Diagnostic Biomarkers in Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis.
Conclusion: Circulating miRNAs, especially miR-122, might be promising diagnostic biomarkers for NAFLD with high-accuracy, and more large-sample studies are required to support the above findings in the future. PMID: 31531307 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - September 20, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Telbivudine Treatment during Late Pregnancy Prevents Mother-to-Child Transmission of Hepatitis B Virus: A Retrospective Study.
Authors: Cai M, Hao Y, Zhong J, Yao W, Cao X, Gu G, Qin G Abstract Purpose: To investigate the efficacy of telbivudine (LdT) in blocking mother-to-child transmission (MTCT) of hepatitis B virus (HBV) during late pregnancy. Methods: A total of 651 pregnant women aged 18-40 in Nantong Third People's Hospital and Hospital affiliated to Nantong University with positive hepatitis B surface antigen (HBsAg) and HBV DNA were enrolled between January 2011 and December 2015. Patients with HBV DNA≥106 copies/mL (n=251) received LdT during late pregnancy according to the patients' will, while 136 high viral patients wit...
Source: Canadian Journal of Gastroenterology - August 7, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Analysis of Mortality and Survival Rate of Liver Cancer in Zhejiang Province in China: A General Population-Based Study.
Authors: Fei FR, Hu RY, Gong WW, Pan J, Wang M Abstract Background: Few accurate up-to-date studies provide liver cancer mortality and survival information in Zhejiang province. This research aimed to depict the mortality and survival of liver cancer in Zhejiang province in China during 2005-2010. Methods: The data were collected from the Zhejiang Chronic Disease Surveillance Information and Management System, and the mortality rates of liver cancer were calculated by gender, age, and areas. Chinese population census in 2000 and Segi's world population were used for age-standardized mortality rate. The observed...
Source: Canadian Journal of Gastroenterology - August 1, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

An Update on Clinicopathological and Molecular Features of Plexiform Fibromyxoma.
Authors: Su HA, Yen HH, Chen CJ Abstract Plexiform fibromyxoma is a rare and newly described gastric mesenchymal tumor with only 121 reported cases in the literature. Our understanding of plexiform fibromyxoma requires updating since the first case has been reported by Takahashi et al. 12 years ago. The present review summarized reported cases in the literature, and both clinical and pathological aspects of plexiform fibromyxoma were comprehensively discussed. Plexiform fibromyxoma usually causes nonspecific or bleeding signs or symptoms, and therefore clinical recognition of the disease is challenging. Plexiform f...
Source: Canadian Journal of Gastroenterology - August 1, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Causes and Clinical Profiles of Ascites at University of Gondar Hospital, Northwest Ethiopia: Institution-Based Cross-Sectional Study.
Conclusion: In conclusion, liver cirrhosis is the major cause of ascites in Gondar, Ethiopia, while chronic viral hepatitis infections (hepatitis B (HBV) and C (HCV) viruses) are the main causes of liver cirrhosis. The other major causes included heart failure, tuberculosis, and hepatosplenic schistosomiasis. It is wise to consider and give priority to these diseases whenever one is evaluating a patient with ascites. PMID: 31360695 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - August 1, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Clinical Significance of Prothrombin Time in Cholangiocarcinoma Patients with Surgeries.
This study aims to investigate the predictive values of PT levels in patients with cholangiocarcinoma (CCA). Methods: We retrospectively analyzed the PT from 86 CCA patients who underwent curative resection in our hospital from December 2008 to August 2017. The relationship between PT and survival times was analyzed through univariate and multivariate analyses (Cox proportional hazards model). Kaplan-Meier curves and log-rank test were used to assess the effects of PT on overall survival (OS) and tumor recurrence-free survival (RFS). Results: Increased PT level was an effective predictor for OS (P = 0.021; hazard r...
Source: Canadian Journal of Gastroenterology - July 31, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Potential Role of HMGCS2 in Tumor Angiogenesis in Colorectal Cancer and Its Potential Use as a Diagnostic Marker.
Conclusion: These findings implying HMGCS2 may have a negative regulation of tumor angiogenesis and provide an approach to inhibit tumor angiogenesis. PMID: 31355161 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - July 31, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Helicobacter pylori Mutations Conferring Resistance to Fluoroquinolones and Clarithromycin among Dyspeptic Patients Attending a Tertiary Hospital, Tanzania.
Conclusion. A significant proportion of dyspeptic patients attending tertiary hospital in Tanzania are infected with H. pylori strains harbouring clarithromycin or fluoroquinolones resistance mutations. Detection of more than 50% of strains with fluoroquinolones resistance mutations makes the H. pylori second line treatment questionable in our setting. There is a need of surveillance of H. pylori resistance patterns in Tanzania to provide data that can guide empirical treatment to reduce associated morbidity of H. pylori infections. The correlation between A92T fluoroquinolone mutation and phenotypic resistance requires fu...
Source: Canadian Journal of Gastroenterology - July 31, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research