Nonalcoholic Fatty Liver Disease-Related Chronic Kidney Disease.
Authors: Cojocariu C, Singeap AM, Girleanu I, Chiriac S, Muzica CM, Sfarti CV, Cuciureanu T, Huiban L, Stanciu C, Trifan A Abstract Nonalcoholic fatty liver disease has become the main concern of hepatologists around the world and the main research topic for identifying effective and safe therapy. Advances in the treatment of chronic viral hepatitis in recent years have opened the way towards reducing mortality in patients with chronic liver disease. This goal has not yet been reached, as the burden of chronic liver disease remains a future major health problem as the incidence of the nonalcoholic fatty liver disea...
Source: Canadian Journal of Gastroenterology - January 20, 2021 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Nonalcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus: A Bidirectional Relationship.
Authors: Muzica CM, Sfarti C, Trifan A, Zenovia S, Cuciureanu T, Nastasa R, Huiban L, Cojocariu C, Singeap AM, Girleanu I, Chiriac S, Stanciu C Abstract Worldwide, the leading cause of chronic liver disease is represented by nonalcoholic fatty liver disease (NAFLD) which has now become a global epidemic of the 21st century, affecting 1 in 4 adults, and which appears to be associated with the steadily increasing rates of metabolic syndrome and its components (obesity, type 2 diabetes mellitus (T2DM), and dyslipidemia). NAFLD has been reported to be associated with extrahepatic manifestations such as cardiovascular d...
Source: Canadian Journal of Gastroenterology - January 13, 2021 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Diospyros kaki and Citrus unshiu Mixture Improves Disorders of Lipid Metabolism in Nonalcoholic Fatty Liver Disease.
Authors: Shin MR, Shin SH, Roh SS Abstract Nonalcoholic fatty liver disease (NAFLD) has been a major cause of a chronic liver disease over recent decades and increasing worldwide in parallel with the remarkable growth of obesity. In the present study, we investigate the ameliorative effects of PCM, a combination of Diospyros kaki fruit and Citrus unshiu peel mixture, on high-fat diet- (HFD-) induced NAFLD and clarify the potential mechanisms. PCM in HFD-fed mice was orally administered at a dose of 50 or 100 mg/kg subsequently for 2 months. Thereafter, lipid metabolism parameters and fat synthesis-related ge...
Source: Canadian Journal of Gastroenterology - January 13, 2021 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

The Prevalence, Predictors, and In-Hospital Mortality of Hepatic Encephalopathy in Patients with Liver Cirrhosis Admitted at St. Dominic Hospital in Akwatia, Ghana.
This study aimed therefore to determine the prevalence, predictors, and treatment outcomes of patients with liver cirrhosis admitted at St. Dominic Hospital (SDH) in Akwatia, Ghana. Materials and Methods: A prospective study was conducted involving one hundred and sixty-seven (167) patients admitted at the medical wards in SDH with liver cirrhosis from January 1st, 2018, to March 24th, 2020. The demographic and clinical features of the patients were collected using a standardized questionnaire. Biochemical, haematological, and abdominal ultrasound scans were done for all patients. Patients were then followed up until d...
Source: Canadian Journal of Gastroenterology - January 13, 2021 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Splenectomy with Portoazygous Disconnection for Correction of Systemic Hemodynamic Disorders in Hepatic Cirrhosis Patients with Portal Hypertension: A Prospective Single-Center Cohort Study.
Authors: Zeng DB, Di L, Guo QL, Ding J, Zhao XF, Lu SC Abstract Objective: To investigate the effect of splenectomy for correction of systemic hemodynamic disorders in hepatic cirrhosis patients with portal hypertension. Methods: Hepatic cirrhosis patients with portal hypertension were enrolled from April 2015 to July 2018. Systemic hemodynamic parameters (heart rate, mean arterial pressure (MAP), cardiac output, and total peripheral vascular resistance (TPR)) were prospectively measured at baseline and 1 week, 1, 3, and 6 months, and 1, 2, and 3 years postoperatively. Paired analysis was conducted. Results...
Source: Canadian Journal of Gastroenterology - January 10, 2021 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

The Clinical Significance of Colon Polyp Pathology in Nonalcoholic Fatty Liver Disease (NAFLD) and Its Impact on Screening Colonoscopy in Daily Practice.
Conclusions: NAFLD is associated with increased risk of any colon polyp, regardless of the histopathological type, compared with patients without NAFLD. This finding implies the necessity to perform screening colonoscopy in patients with NAFLD in the future. PMID: 33376713 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - December 31, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Association and Prediction of Subclinical Atherosclerosis by Nonalcoholic Fatty Liver Disease in Asymptomatic Patients.
Conclusion: NAFLD was strongly associated with CAS. We should be alert about an increased cardiovascular risk in patients with NAFLD and more intensively provide primary prevention by performing tests to detect subclinical atherosclerosis. PMID: 33354557 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - December 30, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Analysis and Follow up of Endoscopy Results in 1099 Patients with Terminal Ileum Lesions.
Conclusion: Coincident diagnosis of ileitis and ileum ulcer is low. Delayed diagnosis of Crohn's disease and lymphoma were observed in a certain proportion of patients with terminal ileum lesions. A follow-up endoscopy was strongly recommended for these suspected patients with terminal ileum lesions. PMID: 33354558 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - December 30, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Selective Esophagogastric Devascularization in the Modified Sugiura Procedure for Patients with Cirrhotic Hemorrhagic Portal Hypertension: A Randomized Controlled Trial.
Conclusions: Selective esophagogastric devascularization in the modified Sugiura procedure may not lower the incidence of rebleeding in the short term based on our findings. However, it may significantly improve quality of life of patients with cirrhotic hemorrhagic portal hypertension, improve liver function, and reduce postoperative dysphagia. PMID: 33354559 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - December 30, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Seroprevalence of Antitransglutaminase and Antiendomysium Antibodies in Adult Colombian Blood Bank Donors.
Authors: Paredes-Echeverri S, Rodríguez AN, Cárdenas WA, Mendoza de Molano B, González JM Abstract Celiac disease (CD) is an autoimmune enteropathy induced by the ingestion of gluten from wheat, barley, and rye in genetically susceptible individuals. The global prevalence of CD is 1.4%. However, most of the prevalence studies have been conducted in Caucasian populations; few studies have been performed in Latin America. The aim of this study is to determine the seroprevalence of auto-antibodies used as markers for CD in a Colombian cohort. In this cross-sectional study, the serum samples from C...
Source: Canadian Journal of Gastroenterology - December 20, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Acute Coronary Syndromes and Nonalcoholic Fatty Liver Disease: "Un Affaire de Coeur".
Conclusions: NAFLD patients are associated with an independently increased risk of developing ACS, mainly in Asian populations, with inconsistent results in North American and European individuals. Moreover, NAFLD and hepatic steatosis severity were both independently correlated with complex multivessel CAD, mortality, and in-hospital MACE in ACS patients. PMID: 33313020 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - December 15, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Causes and Clinical Characteristics of Small Bowel Bleeding in Northern Vietnam.
Authors: Nguyen CL, Pham KK, Nguyen CH, Nguyen HN, Dao TT, Nguyen HN, Nguyen TP, Pham VT, Nguyen TT, Vu AT, Vu TK Abstract Aim: Causes, clinical features, and diagnostic approaches for small bowel (SB) bleeding were analyzed to derive recommendations in dealing with this clinical condition. Methods: We included 54 patients undergoing surgical treatment for SB bleeding, from January 2009 to December 2019. Detailed clinical data, diagnosis procedures, and causes of bleeding were collected. Results: Among 54 cases with SB bleeding, the most common causes were tumors (64.8%), followed by angiopathy (14.8%), ulc...
Source: Canadian Journal of Gastroenterology - December 15, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Efficacy and Prognostic Factors for Y-90 Radioembolization (Y-90) in Metastatic Neuroendocrine Tumors with Liver Metastases.
Conclusions: In our population-based cohort, Y-90 was well-tolerated in patients with metastatic liver-dominant NETs. Prior surgical resection was an important predictor of OS. PMID: 33299824 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - December 13, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

A Drug-Induced Acute Pancreatitis Retrospective Study.
Conclusions: This study has added new evidences about potentially pancreatitis-associated drugs in literature. This is the first study to report definite 5-fluorouracil- and triamcinolone-induced AP. An updated version of the evidence-based literature review is needed to support the clinicians in the identification of the causative drugs. PMID: 33204673 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - November 21, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Comment on "Clinical and Pathological Characteristics of Autoimmune Hepatitis with Acute Presentation".
Comment on "Clinical and Pathological Characteristics of Autoimmune Hepatitis with Acute Presentation". Can J Gastroenterol Hepatol. 2020;2020:3895375 Authors: Muratori P PMID: 33204674 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - November 21, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Nonalcoholic Fatty Liver Disease and Sarcopenia: Where Do We Stand?
Authors: Mikolasevic I, Pavic T, Kanizaj TF, Bender DV, Domislovic V, Krznaric Z Abstract The link between metabolic syndrome (MetS) and sarcopenia has not been extensively studied, but it is evident that they share several common features. Crucial mechanisms involved in sarcopenia-nonalcoholic fatty liver disease (NAFLD) interplay are based on effects of insulin resistance, chronic inflammation, oxidative stress, and crosstalk between organs by secretion of cytokines (hepatokines, adipokines, and myokines). Currently, published studies confirm the association of sarcopenia with the degree of NAFLD defined by liver...
Source: Canadian Journal of Gastroenterology - November 21, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Efficacy and Safety of Sofosbuvir-Based Direct-Acting Antiviral Agents Treatment for Patients with Genotype 3/6 Hepatitis C Virus Infection.
Conclusion: SOF-based DAAs regimen can achieve ideal SVR12 for Chinese patients with both GT3a and GT6a HCV infection. The tolerance and safety of SOF-based DAAs regimen are good. PMID: 33194875 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - November 18, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Complete Response of Synchronous Liver Metastasis in a Pancreatic Ductal Adenocarcinoma, When Surgery Could Represent a Therapeutic Option.
Authors: Argentiero A, Calabrese A, Sciacovelli AM, Delcuratolo S, Solimando AG, Brunetti O Abstract Metastatic pancreatic ductal adenocarcinoma (PDAC) is characterized by poor prognosis and short survival. Today, the use of new polytherapeutic regimens increases clinical outcome of these patients opening new clinical scenario. A crucial issue related to the actual improvement achieved with these new regimens is represented by the occasional possibility to observe a radiological complete response of metastatic lesions in patients with synchronous primary tumor. What could be the best therapeutic management of these...
Source: Canadian Journal of Gastroenterology - October 28, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Characteristics of NAFLD Based on Hypopituitarism.
Conclusion: The hepatic fibrosis grade rapidly progressed in the cranial surgery cases of NAFLD patients with hypopituitarism, possibly in association with BMI, diabetes mellitus, and leptin. In such cranial surgery patients, strong interventions should be considered from the early stage, including diet education, hormone replacement, and more. PMID: 33102399 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - October 28, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Preventive Transhepatic Tract Embolisation after Percutaneous Biliary Interventions: A Systematic Review.
In conclusion, PTTE is feasible and safe. It is effective concerning the prevention of PBI-related pain, and it may be effective concerning haemorrhage. Prevention of biliary leak is not proven. It remains unclear which embolic agent should be preferred. A prospective randomised trial including all preventable adverse events is lacking. PMID: 33083384 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - October 22, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Liver Transplantation for Alcohol-Related Liver Disease (ARLD): An Update on Controversies and Considerations.
Authors: Yadav DK, Zhang Q, Bai X, Li E, Liang T Abstract According to the recent data from the United Network for Organ Sharing database, alcohol-related liver disease (ARLD) accounts to be the most common indication of liver transplantation (LT) waiting lists in the United States among men without hepatocellular carcinoma (HCC). Severe alcoholic hepatitis (AH) is serious and the life-threatening form of ARLD and should be treated timely. However, the LT for severe AH remained to be controversial among the transplant community because of marked interests about the constrained organ supply and the hazard that the A...
Source: Canadian Journal of Gastroenterology - October 6, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Risk Factors for Rebleeding after Emergency Endoscopic Treatment of Dieulafoy Lesion.
Conclusion. Patients who undergo pure injection endoscopic treatment and have a high leukocyte count (>10 × 109/L) or elevated prothrombin time (>12 seconds) have an increased risk of rebleeding within 30 days after endoscopic treatment for gastroduodenal Dieulafoy lesion. Combined endoscopic treatment is the most effective therapy to prevent rebleeding in gastroduodenal Dieulafoy lesion. PMID: 32908851 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - September 12, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Methods for Endoscopic Removal of Over-the-Scope Clip: A Systematic Review.
Conclusions: The remOVE system is the best investigated method, with sufficient efficacy and safety for OTSC removal. This is the first systematic review of OTSC removal and provides significant guidance for clinical practice. PMID: 32908852 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - September 12, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Clinical Features and Dynamics of T Cells-Related Markers in Immunocompetent Patients with Cytomegalovirus Hepatitis.
Conclusions: CMV hepatitis in immunocompetent individuals has a satisfactory outcome, but occasionally results in complications in other organs. The sIL-2R level has potential as a surrogate marker of hepatic inflammation in immunocompetent patients with CMV hepatitis. PMID: 32908853 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - September 12, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Opening a Window on Attention: Adjuvant Therapies for Inflammatory Bowel Disease.
Authors: Wang Q, Mi S, Yu Z, Li Q, Lei J Abstract Inflammatory bowel disease (IBD), most commonly known as Crohn's disease (CD) and ulcerative disease (UC), is a chronic and relapsing intestinal disease which cannot be cured completely. The prevalence of IBD in Europe and in North America has increased over the past 20 years. As most IBD patients are young at onset, their quality of life (QOL) can be influenced to varying degrees. Thus, current treatment goals are typically focused on preventing complications, including maintaining clinical remission and improving the QOL. Adjuvant therapies have been widely concer...
Source: Canadian Journal of Gastroenterology - August 29, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Mortality and Hospitalizations in Mexican Patients with Inflammatory Bowel Disease: Results from a Nationwide Health Registry.
Conclusions: HD for IBD in Mexico is increasing significantly; the number of deaths increased until 2011, but from then on, they are apparently decreasing. IBD affects Mexican people without any gender predominance, often affecting patients between 15 and 44 years of age. UC is three times more frequent than CD. PMID: 32832489 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - August 26, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Malnutrition in Chronic Pancreatitis: Causes, Assessment Methods, and Therapeutic Management.
Conclusion: Patients with CP should be led by a team of gastroenterologist, diabetologist, and psychologist and consulted by a dietitian, specialist of pain treatment, and surgeon. PMID: 32832490 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - August 26, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Associations between Phase Angle Values Obtained by Bioelectrical Impedance Analysis and Nonalcoholic Fatty Liver Disease in an Overweight Population.
Authors: Chen G, Lv Y, Ni W, Shi Q, Xiang X, Li S, Song C, Xiao M, Jin S Abstract Objective: There is a limited diagnosis of nonalcoholic fatty liver disease (NAFLD). Thus, the noninvasive assessments are worth exploring. We determined the associations of phase angles (PhAs) obtained from bioelectric impedance analysis (BIA) with the risk of NAFLD in an overweight population. Methods: A study involving 953 overweight participants was conducted in Wuhan city, China. The associations between PhAs (right arm, left arm, body trunk, right leg, left leg, and whole body) and the risk of NAFLD were conducted using mult...
Source: Canadian Journal of Gastroenterology - August 26, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Effect of Low Positive End of Treatment Viral Load with Direct-Acting Antiviral Therapy on Sustained Virologic Response.
This study was conducted to determine the effect of low positive EOT VLs with DAA therapies on SVR at 12 and 24 weeks. Methods: A retrospective chart review was conducted from January 2014 to December 2018 on 1256 HCV patients of all genotypes (1-6) who had received DAA therapy at two large hepatology referral centers. Baseline demographic data, along with VL at week four, EOT, and SVR12/24 time points were collected for patients that had positive EOT VL. Treatment outcome for any patient with positive EOT VL was noted. Results: Eight out of 1256 patients treated with varying DAA therapies were observed to have low...
Source: Canadian Journal of Gastroenterology - August 19, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Protective Effect of Thalidomide on 2,4,6-Trinitrobenzenesulfonic Acid-Induced Experimental Colitis in Rats via the Inhibition of T Helper 17 Cells.
Authors: Xie Y, Li D, Luan X, Jin S, Yan B, Tian F Abstract Objective: To observe the effects of thalidomide on 2,4,6-trinitrobenzenesulfonic acid- (TNBS-) induced experimental colitis in rats and to explore the possible mechanism of thalidomide in the treatment of CD. Methods: Forty SD rats were randomly assigned into a healthy control group and TNBS-induced colitis groups, including an untreated TNBS-induced colitis group, a low-dose thalidomide group, and a high-dose thalidomide group, with 10 rats in each. After 7 days, the disease activity index (DAI), colon macroscopic damage index (CMDI), and tissue dama...
Source: Canadian Journal of Gastroenterology - August 13, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Granulocyte Colony Stimulating Factor Ameliorates Hepatic Steatosis Associated with Improvement of Autophagy in Diabetic Rats.
Conclusions: Our data suggested that G-CSF potentially improves hepatic steatosis and autophagy in the liver of diabetic rats. PMID: 32775312 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - August 13, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

CT-Guided Percutaneous Microwave Ablation of Sclerosing Hepatic Carcinoma.
Authors: Song H, Ding H, Zhu C Abstract Sclerosing hepatic carcinoma (SHC) is a rare subtype of hepatic carcinoma that can be caused by various pathogeneses. The histological characteristics of SHC demonstrate its high resistance to chemoembolization and thermal ablation; thus, surgical resection represents the primary option for the majority of patients. However, a small proportion of patients who cannot withstand surgery or who have inoperable tumors may not receive adequate treatment, causing the progression of cancer and related high mortality. To overcome the high puncture resistance, high thermal resistance, ...
Source: Canadian Journal of Gastroenterology - August 2, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Transmission of HIV and HCV within Former Soviet Union Countries.
Conclusion: This study highlights the need to focus harm reduction efforts toward controlling transmission of blood-borne infections among the abovementioned high-risk populations in the FSU countries. PMID: 32733822 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - August 2, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Verification of the Nutritional and Dietary Factors Associated with Skeletal Muscle Index in Japanese Patients with Nonalcoholic Fatty Liver Disease.
Authors: Himoto T, Miyatake K, Maeba T, Masaki T Abstract We sought to identify the frequencies of presarcopenia, sarcopenia, and sarcopenic obesity in patients with nonalcoholic fatty liver disease (NAFLD) and to cross-sectionally determine the nutritional and dietary factors associated with loss of skeletal muscle mass in such patients. Dietary and body component changes produced by a diet intervention were longitudinally investigated. Forty-six NAFLD patients (24 males and 22 females) were enrolled. A second diet treatment was performed at 6 months after entry in 19 of the enrolled patients (6 males and 1...
Source: Canadian Journal of Gastroenterology - July 24, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Role of Terlipressin in Cirrhotic Patients with Ascites and without Hepatorenal Syndrome: A Systematic Review of Current Evidence.
Authors: Bai Z, An Y, Guo X, Teschke R, Méndez-Sánchez N, Li H, Qi X Abstract Ascites, a common complication in cirrhosis, is prone to the development of acute kidney injury or hepatorenal syndrome and can be complicated by circulatory dysfunction after paracentesis. Terlipressin has not been considered as the mainstay treatment option for ascites in cirrhosis yet. The present work aimed to systematically review the current evidence regarding the use of terlipressin in cirrhosis with ascites and without hepatorenal syndrome. PubMed, EMBASE, and Cochrane Library databases were searched for relevant stu...
Source: Canadian Journal of Gastroenterology - July 18, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Caveolin-1 Knockdown Decreases SMMC7721 Human Hepatocellular Carcinoma Cell Invasiveness by Inhibiting Vascular Endothelial Growth Factor-Induced Angiogenesis.
Conclusion: Our results reveal a novel mechanism, whereby caveolin-1 positively regulates human HCC cell invasiveness by coordinating VEGF-induced angiogenesis. PMID: 32676485 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - July 18, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

FLOT Neoadjuvant Chemotherapy Followed by Laparoscopic D2 Gastrectomy in the Treatment of Locally Resectable Advanced Gastric Cancer.
Conclusions: These findings suggest that FLOT neoadjuvant chemotherapy, followed by laparoscopic D2 gastrectomy, is effective and safe in advanced, resectable advanced gastric cancer. PMID: 32566545 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - June 24, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Clinical Patterns and Outcome of Hepatocellular Carcinoma in Patients with Nonalcoholic Fatty Liver Disease.
Conclusions: NAFLD-related HCCs were more often detected at an advanced stage with infiltrative patterns, although they showed no significant difference in survival compared to ALD-related or HBV-related HCCs. A future prospective research should be focused on identifying NAFLD patients who require strict surveillance in order to early detect and timely treat HCC. PMID: 32566546 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - June 24, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Effect of Melatonin as an Antioxidant Drug to Reverse Hepatic Steatosis: Experimental Model.
Conclusions: In this study, it has not been possible to demonstrate a beneficial effect of melatonin in the improvement or reversal of liver steatosis once established and induced by diet in the porcine model. It is true that signs of improvement have been found at the histological level, at the level of lipid metabolism, and at the level of oxidative stress phenomena, when comparing animals with established steatosis that are treated with melatonin with those who do not take it. This work is the first study conducted in a large animal model in which the effect of melatonin is studied as a treatment in the reversal of esta...
Source: Canadian Journal of Gastroenterology - June 24, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Effectiveness of Conservative Treatment without Early Colonoscopy in Patients with Colonic Diverticular Hemorrhage.
This study was aimed to clarify the effectiveness of conservative treatment without performing early colonoscopy and the indications for early colonoscopy in patients with colonic diverticular hemorrhage. Methods: This retrospective study included 142 participants who were urgently hospitalized due to bloody stools and were diagnosed with colonic diverticular hemorrhage between April 2012 and December 2016. At the time of hospital visit, only when both shock based on vital signs and intestinal extravasation on abdominal contrast-enhanced computed tomography were observed, early colonoscopy was performed within 24 hours...
Source: Canadian Journal of Gastroenterology - May 15, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Clinicopathological Features, Treatment Strategy, and Prognosis of Primary Non-Hodgkin's Lymphoma of the Duodenum: A SEER Database Analysis.
In this study, we sought to describe clinical features and identify factors affecting survival in patients with PDL using a large population cohort. Methods: The Surveillance, Epidemiology, and End Results (SEER) database was queried from 1998 to 2015. Results: A total of 1060 cases of PDLs were identified. Clinicopathological features as well as survival data of PDLs were analyzed and compared with 10573 primary gastric lymphomas (PGLs) and 3239 primary small intestinal lymphomas (PSILs) from the SEER database. PDL patients were younger in age (60.96 ± 15.205), and the proportion of stage I (5...
Source: Canadian Journal of Gastroenterology - May 15, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Clinical Significance of Hepatocyte Growth Factor and Transforming Growth Factor-Beta-1 Levels in Assessing Disease Activity in Inflammatory Bowel Disease.
Conclusion. Serum levels of TGF-β and HGF were significantly higher in IBD patients compared with the control group. In the UC group, the levels of HGF and TGF-β were significantly higher than in the CD group. Levels of TGF-β and HGF correlate with the activity of IBD. PMID: 32377513 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - May 8, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Prevalence of Hepatitis C Virus Infection in a Surgical Population of Southeast China: A Large-Scale Multicenter Study.
Authors: Chen P, Zheng Y, Cai Y, Zou P, Li N, Peng C, Gao H, Liu J, Chen Y, Tong Z, Li L Abstract Background: Chronic HCV infection affects 80 million people globally and may progress to advanced liver disease. The present study aims to investigate the present epidemiology of HCV infection in a southeastern Chinese surgical patient cohort. Methods: Blood samples obtained from 78,484 surgical patients from 18 different city and county hospitals were enrolled. The incidence of serum HCV antibody positivity, HCV RNA load, and HCV genotyping, as well as demographics and relevant clinical history, were investigated....
Source: Canadian Journal of Gastroenterology - May 8, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Role of Albumin as a Nutritional and Prognostic Marker in Elective Intestinal Surgery.
Authors: Galata C, Busse L, Birgin E, Weiß C, Hardt J, Reißfelder C, Otto M Abstract Background: The aim of this study was to investigate albumin, nutritional status, and inflammation in the perioperative course of patients undergoing elective intestinal surgery. Methods: A retrospective analysis of patients with preoperative measurements of nutritional parameters who underwent intestinal surgery between April 2017 and August 2018 at our institution was performed. Preoperatively, the correlation of albumin levels with markers for inflammation and nutritional status was investigated. Postoperatively,...
Source: Canadian Journal of Gastroenterology - May 1, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Hepatitis C Virus Screening of High-Risk Patients in a Canadian Emergency Department.
This study shows that ED HCV screening is feasible and that a small number of previously undiagnosed patients can be identified and linked to potentially life-changing care. PMID: 32211349 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - March 28, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Electroacupuncture Relieves Suppression of Autophagy in Interstitial Cells of Cajal of Diabetic Gastroparesis Rats.
In this study, we aimed to figure out the relationship between DGP and autophagy of ICCs. Methods: Sixty Sprague-Dawley (SD) rats were randomly divided into normal control group (NC, 10) and modeling group (50). Rats in the modeling group were injected 2% streptozotocin (STZ) and fed with high-glucose and high-fat diet for 8 weeks in order to establish DGP rat model. After modeling, 30 successfully modeled rats were randomly selected and separated into diabetic gastroparesis group (DGP, 10), GDP rats with electroacupuncture group (EA, 10), and GDP rats with metoclopramide group (MP, 10). When the intervention was compl...
Source: Canadian Journal of Gastroenterology - March 28, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Adherence to Azathioprine/6-Mercaptopurine in Children and Adolescents with Inflammatory Bowel Diseases: A Multimethod Study.
Conclusion: Results provide evidence for ongoing adherence challenges in the paediatric population with IBD. It is recommended that parents/guardians (particularly of older children) and older children themselves, should receive enhanced counselling and education about their prescribed medicines. PMID: 32185153 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - March 19, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Bredemolic Acid Ameliorates Selected Liver Function Biomarkers in a Diet-Induced Prediabetic Rat Model.
Conclusion: BA administration improved liver function in diet-induced prediabetic rats in the presence or absence of dietary intervention. PMID: 32149046 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - March 11, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

A Potential Linking between Vitamin D and Adipose Metabolic Disorders.
Authors: Miao Z, Wang S, Wang Y, Guo L, Zhang J, Liu Y, Yang Q Abstract Vitamin D has been discovered centuries ago, and current studies have focused on the biological effects of vitamin D on adipogenesis. Besides its role in calcium homeostasis and energy metabolism, vitamin D is also involved in the regulation of development and process of metabolic disorders. Adipose tissue is a major storage depot of vitamin D. This review summarized studies on the relationship between vitamin D and adipogenesis and furthermore focuses on adipose metabolic disorders. We reviewed the biological roles and functionalities of vitam...
Source: Canadian Journal of Gastroenterology - March 11, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Gastric Xanthoma Associated with Gastric Cancer Development: An Updated Review.
Authors: Moumin FA, Mohamed AA, Osman AA, Cai J Abstract Gastric xanthelasma (GX) is a rare tumor-like lesion customarily found as an incidental finding due to its asymptomatic appearance. Grossly, it is a well-marked yellow-white plaque created in the lamina propria by microscopic clusters of foamy macrophages. Xanthelasma is rarely correlated with gastric hyperplastic polyps; gastric xanthomas are rare benign lesions that appear to be associated with inflammation of the gastric mucosa. Etiopathogenesis is also unclear, but it has been suggested to be involved in chronic gastritis, infection with Helicobacter pylo...
Source: Canadian Journal of Gastroenterology - March 11, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research