Circulating miRNAs as Novel Diagnostic Biomarkers in Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis.
Conclusion: Circulating miRNAs, especially miR-122, might be promising diagnostic biomarkers for NAFLD with high-accuracy, and more large-sample studies are required to support the above findings in the future. PMID: 31531307 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - September 20, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Telbivudine Treatment during Late Pregnancy Prevents Mother-to-Child Transmission of Hepatitis B Virus: A Retrospective Study.
Authors: Cai M, Hao Y, Zhong J, Yao W, Cao X, Gu G, Qin G Abstract Purpose: To investigate the efficacy of telbivudine (LdT) in blocking mother-to-child transmission (MTCT) of hepatitis B virus (HBV) during late pregnancy. Methods: A total of 651 pregnant women aged 18-40 in Nantong Third People's Hospital and Hospital affiliated to Nantong University with positive hepatitis B surface antigen (HBsAg) and HBV DNA were enrolled between January 2011 and December 2015. Patients with HBV DNA≥106 copies/mL (n=251) received LdT during late pregnancy according to the patients' will, while 136 high viral patients wit...
Source: Canadian Journal of Gastroenterology - August 7, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Analysis of Mortality and Survival Rate of Liver Cancer in Zhejiang Province in China: A General Population-Based Study.
Authors: Fei FR, Hu RY, Gong WW, Pan J, Wang M Abstract Background: Few accurate up-to-date studies provide liver cancer mortality and survival information in Zhejiang province. This research aimed to depict the mortality and survival of liver cancer in Zhejiang province in China during 2005-2010. Methods: The data were collected from the Zhejiang Chronic Disease Surveillance Information and Management System, and the mortality rates of liver cancer were calculated by gender, age, and areas. Chinese population census in 2000 and Segi's world population were used for age-standardized mortality rate. The observed...
Source: Canadian Journal of Gastroenterology - August 1, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

An Update on Clinicopathological and Molecular Features of Plexiform Fibromyxoma.
Authors: Su HA, Yen HH, Chen CJ Abstract Plexiform fibromyxoma is a rare and newly described gastric mesenchymal tumor with only 121 reported cases in the literature. Our understanding of plexiform fibromyxoma requires updating since the first case has been reported by Takahashi et al. 12 years ago. The present review summarized reported cases in the literature, and both clinical and pathological aspects of plexiform fibromyxoma were comprehensively discussed. Plexiform fibromyxoma usually causes nonspecific or bleeding signs or symptoms, and therefore clinical recognition of the disease is challenging. Plexiform f...
Source: Canadian Journal of Gastroenterology - August 1, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Causes and Clinical Profiles of Ascites at University of Gondar Hospital, Northwest Ethiopia: Institution-Based Cross-Sectional Study.
Conclusion: In conclusion, liver cirrhosis is the major cause of ascites in Gondar, Ethiopia, while chronic viral hepatitis infections (hepatitis B (HBV) and C (HCV) viruses) are the main causes of liver cirrhosis. The other major causes included heart failure, tuberculosis, and hepatosplenic schistosomiasis. It is wise to consider and give priority to these diseases whenever one is evaluating a patient with ascites. PMID: 31360695 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - August 1, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Clinical Significance of Prothrombin Time in Cholangiocarcinoma Patients with Surgeries.
This study aims to investigate the predictive values of PT levels in patients with cholangiocarcinoma (CCA). Methods: We retrospectively analyzed the PT from 86 CCA patients who underwent curative resection in our hospital from December 2008 to August 2017. The relationship between PT and survival times was analyzed through univariate and multivariate analyses (Cox proportional hazards model). Kaplan-Meier curves and log-rank test were used to assess the effects of PT on overall survival (OS) and tumor recurrence-free survival (RFS). Results: Increased PT level was an effective predictor for OS (P = 0.021; hazard r...
Source: Canadian Journal of Gastroenterology - July 31, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Potential Role of HMGCS2 in Tumor Angiogenesis in Colorectal Cancer and Its Potential Use as a Diagnostic Marker.
Conclusion: These findings implying HMGCS2 may have a negative regulation of tumor angiogenesis and provide an approach to inhibit tumor angiogenesis. PMID: 31355161 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - July 31, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Helicobacter pylori Mutations Conferring Resistance to Fluoroquinolones and Clarithromycin among Dyspeptic Patients Attending a Tertiary Hospital, Tanzania.
Conclusion. A significant proportion of dyspeptic patients attending tertiary hospital in Tanzania are infected with H. pylori strains harbouring clarithromycin or fluoroquinolones resistance mutations. Detection of more than 50% of strains with fluoroquinolones resistance mutations makes the H. pylori second line treatment questionable in our setting. There is a need of surveillance of H. pylori resistance patterns in Tanzania to provide data that can guide empirical treatment to reduce associated morbidity of H. pylori infections. The correlation between A92T fluoroquinolone mutation and phenotypic resistance requires fu...
Source: Canadian Journal of Gastroenterology - July 31, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Laparoscopic Spleen-Preserving Distal Pancreatectomy (LSPDP) versus Open Spleen-Preserving Distal Pancreatectomy (OSPDP): A Comparative Study.
Conclusion: This study confirms that LSPDP is safe, feasible, and superior to OSPDP in terms of operative time, intraoperative blood loss, hospital stay, and postoperative recovery. Hence, it is worth popularizing LSPDP for benign and low-grade malignant tumors of the pancreas. PMID: 31355163 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - July 31, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

The Prevalence of Helicobacter Pylori babA, homB, aspA, and sabA Genes and Its Relationship with Clinical Outcomes in Turkey.
Conclusion: This study managed to determine babA, homB, aspA, and sabA genes of H. pylori by PCR. However, the frequency of these factors was not different in patients with PU and NUD. There is no role of babA, homB, aspA, and sabA genes for the development of peptic ulcer in Turkish population. PMID: 31312620 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - July 19, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Direct Oral Anticoagulant Use and Risk of Diverticular Hemorrhage: A Systematic Review of the Literature.
Conclusion: The evidence suggests the risk of diverticular bleed among DOAC users is equivocal to those not taking DOACs, and the overall incidence of diverticular bleed in the DOAC population is low. As it stands, the risk of thrombotic events from not starting DOACs apparently outweighs the risk of diverticular bleed. PMID: 31316948 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - July 19, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Diagnostic Radiation Exposure in Patients with Inflammatory Bowel Disease.
Conclusion: While potentially harmful levels of radiation exposure are of concern in only a small number of patients, strategies to limit such exposure are encouraged when clinically appropriate. PMID: 31281802 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - July 11, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

The Association of HOTAIR with the Diagnosis and Prognosis of Gastric Cancer and Its Effect on the Proliferation of Gastric Cancer Cells.
Authors: Xu Z, Chen H, Yang B, Liu X, Zhou X, Kong H Abstract Background: Long noncoding RNAs (lncRNAs) are a group of noncoding RNA with the length of more than 200nt. They have been identified as important diagnostic and prognostic molecules for many cancers and play an important role in the development of cancers. However, their clinical value and roles in gastric cancer (GC) remain unclear. Methods: The expression levels of HOTAIR in 54 GC tissues and their matched adjacent nontumor tissues from GC patients and 24 normal mucosa or those with minimal gastritis as healthy controls were determined by qRT-PCR. ...
Source: Canadian Journal of Gastroenterology - July 11, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Ischemic Postconditioning (IPostC) Protects Fibrotic and Cirrhotic Rat Livers after Warm Ischemia.
Conclusion: IPostC following warm ischemia protects healthy, fibrotic, and cirrhotic livers against IRI. Reduced efflux of TXB2 is one possible mechanism for this effect of IPostC and increases sinusoidal microcirculation. These findings may help to improve organ function and recovery of patients after liver resection. PMID: 31281804 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - July 11, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Management of Complications of Portal Hypertension.
Authors: Vilela EG, Thabut D, Rudler M, Bittencourt PL PMID: 31275900 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - July 7, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Concomitant Sj ögren's Syndrome Was Not Associated with a Poorer Response or Outcomes in Ursodeoxycholic Acid-Treated Patients with Primary Biliary Cholangitis.
Concomitant Sjögren's Syndrome Was Not Associated with a Poorer Response or Outcomes in Ursodeoxycholic Acid-Treated Patients with Primary Biliary Cholangitis. Can J Gastroenterol Hepatol. 2019;2019:7396870 Authors: Ni P, Men R, Shen M, Wang T, Huang C, Fan X, Yang L Abstract Aim: Patients with primary biliary cholangitis (PBC) have at least 60% probability of having an autoimmune extrahepatic condition, with the most common being Sjögren's syndrome (SS). The impacts of SS on the response and outcomes in ursodeoxycholic acid (UDCA)-treated patients with PBC, however, remain unclear. The aim o...
Source: Canadian Journal of Gastroenterology - July 7, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Risk-Based Prenatal Hepatitis C Testing Practices and Results, Alaska 2013-2016.
In conclusion, approximately 2% of pregnant women in the study population were known to have been exposed to HCV by the time of their delivery. One-third of women with documented drug abuse did not have an HCV test during pregnancy, revealing gaps in HCV testing of pregnant women. Further studies are needed to understand the full costs and benefits of risk-based screening versus universal screening in this and other populations. PMID: 31275902 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - July 7, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Pooled Analysis of the Efficacy and Safety of Video Capsule Endoscopy in Patients with Implantable Cardiac Devices.
Conclusion: VCE is safe and remains efficient in patients with cardiac devices. If cardiac monitoring is required, wired systems are preferable. PMID: 31236386 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - June 28, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

High Prevalence of Multidrug Resistant Bacteria in Cirrhotic Patients with Spontaneous Bacterial Peritonitis: Is It Time to Change the Standard Antimicrobial Approach?
Conclusion: SBP due to multidrug resistant bacteria is a growing problem, and one should consider reported resistance profiles for the decision-making process of empirical first-line treatment prescription. PMID: 31214551 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - June 21, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Predictive Risk Factors of Intestinal Necrosis in Patients with Mesenteric Venous Thrombosis: Retrospective Study from a Single Center.
Conclusion: Predictive risk factors for IN with MVT were organ failure, elevated serum lactate level, bowel loop dilation on CT, and the time between onset of symptoms and operation. However, this result is from a retrospective study and further long-term, large-sample prospective studies are required to confirm this finding. PMID: 31205904 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - June 18, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Endoscopic Resection of Gastric Submucosal Masses by a Dental Floss Traction Method.
Conclusions: The DFT method efficiently and safely facilitated the ESE procedure during the resection of gastric submucosal tumors. This study was registered with Chinese Clinical Trial Registry under Registration number ChiCTR-OOC-15005833). PMID: 31187025 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - June 14, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Systematic Review and Meta-Analysis of the Utility of Circular RNAs as Biomarkers of Hepatocellular Carcinoma.
In conclusion, this study reveals that circRNAs may serve as promising diagnostic and prognostic biomarkers for HCC. However, further investigations are still required to explore the clinical value of circRNAs. PMID: 31187026 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - June 14, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Response to: Comment on "48-Week Outcome after Cessation of Nucleos(t)ide Analogue Treatment in Chronic Hepatitis B Patient and the Associated Factors with Relapse".
Response to: Comment on "48-Week Outcome after Cessation of Nucleos(t)ide Analogue Treatment in Chronic Hepatitis B Patient and the Associated Factors with Relapse". Can J Gastroenterol Hepatol. 2019;2019:2970510 Authors: Xu WX, Peng L PMID: 31187027 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - June 14, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Donor Small-Droplet Macrovesicular Steatosis Affects Liver Transplant Outcome in HCV-Negative Recipients.
Conclusions: In HCV-negative recipients, allografts with>15% Sd-MaS have significantly reduced graft survival and show low ATP and higher AST peaks in the immediate posttransplant period. Donors with>15% Sd-MaS have significantly higher BMI, longer ICU stays, and lower PaO2. PMID: 31187028 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - June 14, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Brunner's Gland Hyperplasias and Hamartomas in Association with Helicobacter pylori.
Conclusion: Our study demonstrated that H. pylori may play an important role in the development of BG hyperplasia and hamartomas in association with chronic gastritis and duodenitis. This is probably due to chronic irritation. PMID: 31187029 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - June 14, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Elective Splenectomy Combined with Modified Hassab's or Sugiura Procedure for Portal Hypertension in Decompensated Cirrhosis.
Conclusion: Elective splenectomy combined with modified Sugiura procedure seemed to be associated with a reduced trend of no deadly variceal bleeding compared with Hassab's procedure. As statistical significance was not found, further large scale and prospective study was warranted. PMID: 31183338 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - June 12, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

L-Ornithine L-Aspartate for the Treatment of Sarcopenia in Chronic Liver Disease: The Taming of a Vicious Cycle.
Authors: Butterworth RF Abstract Sarcopenia is a common complication of cirrhosis with a negative impact on posttransplant outcome, health-related quality of life (HRQOL), and patient survival. Studies in experimental animals and in patients demonstrate that ammonia is directly implicated in the pathogenesis of sarcopenia in cirrhosis via mechanisms involving increased expression of myostatin and of autophagy markers such as LC3 lipidation and p62 leading to muscle dysmetabolism and sarcopenia. Paradoxically, skeletal muscle replaces liver as the primary ammonia-detoxifying site as a result of the modification of g...
Source: Canadian Journal of Gastroenterology - June 12, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Loss of LLGL1 Expression Correlates with Diffuse Gastric Cancer and Distant Peritoneal Metastases.
Conclusion: LLGL1 is coexpressed with E-cadherin. Loss of expression of either protein is associated with diffuse gastric cancer and peritoneal metastases. LLGL1 does not impact on proliferation or epithelial-mesenchymal transition (EMT) rather increasing cellular adhesion. PMID: 31058107 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - May 8, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Noninvasive Assessment of Liver Fibrosis in Patients with Chronic Hepatitis B or C by Contrast-Enhanced Magnetic Resonance Imaging.
Authors: Hako R, Kristian P, Jarčuška P, Haková I, Hockicková I, Schréter I, Janičko M Abstract Background and Aim. To develop a noninvasive magnetic resonance imaging (MRI) method for evaluation of liver fibrosis. We evaluate the utility of hepatocyte-phase Gadoxetate disodium-enhanced magnetic resonance (MR) imaging in staging hepatic fibrosis and compare it with histological analysis as the reference standard (liver biopsy). Methods. Prospective cohort of 78 patients, who received Gadoxetate disodium dynamic contrast-enhanced MRI (DCE-MRI), were divided into three groups. The first ...
Source: Canadian Journal of Gastroenterology - May 8, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Roles of Steroids in Preventing Esophageal Stricture after Endoscopic Resection.
Conclusions: Therefore, steroids play an irreplaceable role in preventing esophageal stricture after endoscopic resection. Oral and local injections of steroids are the two most acceptable methods and more prospective studies are needed to compare the effectiveness and safety of these two methods. PMID: 31058109 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - May 8, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Applicability of Oral Fluid and Dried Blood Spot for Hepatitis B Virus Diagnosis.
Authors: Villar LM, Bezerra CS, Cruz HM, Portilho MM, Flores GL Abstract Hepatitis B virus (HBV) is one of the major causes of chronic liver disease worldwide; however most of individuals are not aware about the infection. Oral fluid and dried blood spot (DBS) samples may be an alternative to serum to HBV diagnosis to increase the access to diagnosis in remote areas or high-risk groups. The main objective of this review is to give an insight about the usefulness of oral fluid and DBS for detecting HBV markers. Several groups have evaluated the detection of HBsAg, anti-HBc, and anti-HBs markers in oral fluid and DBS...
Source: Canadian Journal of Gastroenterology - May 8, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Unsolved Questions in Salvage TIPSS: Practical Modalities for Placement, Alternative Therapeutics, and Long-Term Outcomes.
Authors: Bouzbib C, Sultanik P, Thabut D, Rudler M Abstract Salvage transjugular intrahepatic portosystemic shunt (TIPSS) has proven its efficacy to treat refractory variceal bleeding for patients with cirrhosis. However, this procedure is associated with very poor outcomes. As it is used as a last resort to treat a severe complication of cirrhosis, it seems essential to improve our practice, with the aim of optimizing management of those patients. Somehow, many questions are still unsolved: which stents should be used? Should a concomitant embolization be systematically considered? Is there any alternative therape...
Source: Canadian Journal of Gastroenterology - May 8, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Safety and Efficacy of a Small J-Tipped Guidewire for Pancreatic Duct Endoscopic Intervention.
Authors: Hirose S, Fukasawa M, Takano S, Kadokura M, Shindo H, Takahashi E, Yokota Y, Fukasawa Y, Kawakami S, Hayakawa H, Sato T, Enomoto N Abstract Background and Aims: The insertion of the guidewires (GWs) into the pancreatic duct is technically difficult, and there is a risk of post-ERCP pancreatitis (PEP). The aim of this study was to evaluate the safety and efficacy of a small J-tipped guidewire for pancreatic duct endoscopic intervention. Methods: This single-site retrospective study was conducted to assess the procedural success rate and adverse events of endoscopic transpapillary interventions to the pa...
Source: Canadian Journal of Gastroenterology - May 8, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Real-Life State of Anti-Hepatitis B Virus Drug Choice in Child-Bearing Age Male Patients and Effect on Fertility and Fetal Safety.
Authors: Hu ZX, Ye YN, Wu WG, Liang XJ, Wu QW, Zhang A, Zheng XR, Gao ZL, Peng L, Xie C Abstract Research on effects of anti-hepatitis B virus (HBV) nucleoside analogs on male fertility and birth defects is limited and safety of nucleoside analogs in pregnancy is still a concern. Chronic hepatitis B (CHB) patients in Guangdong province were surveyed using a structured questionnaire. We collected data including medication type, fertility, and birth defects. Moreover, a survey of the knowledge of antiviral nucleoside analogs safety in fertility of male patients was conducted among physicians nationwide. Semen samples...
Source: Canadian Journal of Gastroenterology - May 8, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Dermatological Disorders following Liver Transplantation: An Update.
Authors: Yadav DK, Bai XL, Liang T Abstract Patients undergoing liver transplantation (LT) are at a high risk of dermatological complications compared to the general population as a result of long-term use of immunosuppressant. However, the risk is not as high as other solid organ transplantations (SOT), particularly for skin cancer. The liver is considered as an immune privileged organ since it has a low prevalence of humoral rejection in contrast to other SOT, and thus, LT requires a minimal amount of immunosuppressants compared to other SOT recipients. However, because of the large volume of the liver, patients ...
Source: Canadian Journal of Gastroenterology - May 8, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Emerging Trends and New Developments in Transient Elastography: A Bibliometric and Cocitation Analysis from 1999 to 2017.
Conclusions: We undertook efforts to provide an insight into the features and evolvement of the most-cited articles in the field of transient elastography. For transient elastography, as a noninvasive assessment of liver fibrosis, its use in the evaluation of liver fibrosis is gradually mature and shows great advantages. Moreover, the field of transient elastography is in a stage of rapid development. PMID: 30949458 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - April 6, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Accuracy of Pretransplant Imaging Diagnostic for Hepatocellular Carcinoma: A Retrospective German Multicenter Study.
Conclusion. There was a relevant percentage (15-40%) of patients misclassified by imaging diagnosis at a time prior to LI-RADS and guidelines to improve imaging of HCC. Outcome analysis showed a good correlation to histological, in contrast poor correlation to imaging diagnosis, suggesting an adjustment of the LT selection and prioritization criteria. PMID: 30949459 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - April 6, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Gastrointestinal Cancers: Molecular Genetics and Biomarkers.
Authors: Sharma KL, Bhatia V, Agarwal P, Kumar A PMID: 30941325 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - April 5, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Real World Experience of Chronic Hepatitis C Retreatment with Genotype Specific Regimens in Nonresponders to Previous Interferon-Free Therapy.
Conclusions: We demonstrated moderate effectiveness of genotype specific rescue therapy in failures due to virologic reason and high in those who discontinued primary therapy. Therefore rescue therapy with genotype specific regimens should be considered always if more potent regimens are not available. PMID: 30941326 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - April 5, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Hepatocellular Carcinoma: From Molecular Basis to Novel Treatment Approaches.
Authors: Akkız H PMID: 30941327 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - April 5, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Jackhammer Esophagus: From Manometric Diagnosis to Clinical Presentation.
Conclusions and Inferences: Jackhammer esophagus represents 3% of the HRM diagnoses in this study, with a significant female preponderance. In more than two-thirds of cases, the clinical presentation of Jackhammer esophagus is dysphagia. PMID: 30941328 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - April 5, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Parameters Suggesting Spontaneous Passage of Stones from Common Bile Duct: A Retrospective Study.
Authors: Khoury T, Adileh M, Imam A, Azraq Y, Bilitzky-Kopit A, Massarwa M, Benson A, Bahouth Z, Abu-Gazaleh S, Sbeit W, Safadi R, Khalaileh A Abstract Background: Common bile duct (CBD) stones are common. However, they are known to pass spontaneously, which obviates the need for ERCP. Aim: The aim of this study is to identify specific predictors for spontaneous passage of CBD stones. Methods: Data was retrospectively collected for all patients who were hospitalized with clinical, laboratory, or ultrasonographic evidence of choledocholithiasis and who underwent magnetic resonance cholangiopancreatography (M...
Source: Canadian Journal of Gastroenterology - April 5, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Clinical Aspects and Prognosis Evaluation of Cirrhotic Patients Hospitalized with Acute Kidney Injury.
Authors: Gomes CGO, de Andrade MVM, Resende Guedes L, Carvalho Rocha H, Gardone Guimarães R, Castro Carvalho FA, Vilela EG Abstract Background: Acute kidney injury occurs in approximately 20% of hospitalized cirrhotic patients. Mortality is estimated at 60% within a month and 65% within a year. Aims: To evaluate survival in 30 days and in 3 months of cirrhotic patients hospitalized with acute kidney injury, identifying factors associated with mortality. Methods: 52 patients with cirrhosis admitted to an academic tertiary center who presented acute kidney injury according to the International Club of ...
Source: Canadian Journal of Gastroenterology - April 5, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Copper Mediates Anti-Inflammatory and Antifibrotic Activity of Gleevec in Hepatocellular Carcinoma-Induced Male Rats.
Authors: Hassan I, Ebaid H, Alhazza IM, Al-Tamimi J, Aman S, Abdel-Mageed AM Abstract The elevated level of copper is one of the hallmark features of cancer cells in most of the types of cancer. In the present study, this feature has been targeted to investigate if coadministration of exogenous copper (Cu+) and its chelating agent like disulfiram (DSF+) influence the antineoplastic activity of the anticancer drug, Gleevec (GLV+), in hepatocellular carcinoma (HCC)-induced rats via immunomodulation. After the treatment, the level of proinflammatory interleukins (IL-1, 2, 6, and 7), anti-inflammatory interleukin (IL-1...
Source: Canadian Journal of Gastroenterology - April 5, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Noninvasive Predictors of High-Risk Varices in Patients with Non-Cirrhotic Portal Hypertension.
Conclusions. In NCPH patients, spleen size may predict risk of HRV at gastroscopy within 12 months. LSM and platelet count are not useful to assess risk of HRV in NCPH. PMID: 30881946 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - March 20, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Phosphorylation of p53 Serine 15 Is a Predictor of Survival for Patients with Hepatocellular Carcinoma.
Conclusions: P53 Ser15-P is associated with poor outcomes in patients with HCC, and this prognostic marker is useful for predicting the survival of patients with PCNA-positive HCC. PMID: 30881947 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - March 20, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Ilececum: A Comprehensive Review.
Authors: Tang SJ, Wu R Abstract For gastrointestinal endoscopists, the ileocecum is the finishing line during colonoscopy and it is identified by three endoscopic landmarks: terminal ileum, ileocecal valve, and the appendiceal orifice. Although ileal intubation is recommended during routine screening colonoscopy, it is not required in most cases of screening colonoscopy. Ileal intubation is indicated in certain circumstances such as suspected inflammatory bowel disease and GI bleeding. There is much pathology that can be observed within the ileocecum. Careful and systematic examination should be stressed during GI ...
Source: Canadian Journal of Gastroenterology - March 13, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Myenteric Denervation of the Gut with Benzalkonium Chloride: A Review of Forty Years of an Experimental Model.
Authors: Garcia SB, Minto SB, Marques IS, Kannen V Abstract Experimental denervation of organs plays a key role in understanding the functional aspects of the normal innervation as well as the diseases related to them. In 1978 the experimental model of myenteric denervation of the rat gut by serosal application of benzalkonium chloride (BAC) was proposed. BAC is a positively charged surface-active alkylamine and is a powerful cationic detergent, which destroys bacteria after ionic attraction and for this reason is largely used as a surgical antiseptic. Since its initial report, the BAC-induced myenteric denervation...
Source: Canadian Journal of Gastroenterology - March 13, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Animal Models of Steatosis (NAFLD) and Steatohepatitis (NASH) Exhibit Hepatic Lobe-Specific Gelatinases Activity and Oxidative Stress.
This study evaluates this heterogeneity in nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) rat models. Twelve-week-old Obese and Lean male Zucker rats were used for NAFLD. Eight-week-old male Wistar rats fed with 8-week methionine-choline-deficient (MCD) diet and relative control diet were used for NASH. Gelatinase (MMP-2; MMP-9) activity and protein levels, tissue inhibitors of metalloproteinase (TIMPs), reactive oxygen species (ROS), and thiobarbituric acid-reactive substances (TBARS) were evaluated in the left (LL), median (ML), and right liver (RL) lobes. Serum hepatic enzymes and TNF-a...
Source: Canadian Journal of Gastroenterology - March 13, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Impact of Chronic Statins Use on the Development of Esophagitis in Patients with Gastroesophageal Reflux Disease.
Authors: Khoury T, Mari A, Amara H, Jabaren M, Watad A, Nseir W, Sbeit W, Mahamid M Abstract Background and Aims: We aimed to assess whether chronic statins used (> 6 months) were protective of the development of esophagitis in patients with gastroesophageal reflux disease. In the presence of esophagitis, complications such as strictures, Barrett's esophagus, and adenocarcinoma were the most common. Statins, lipid lowering drugs with a pleiotropic effect, are recently implicated in various pathologies. Nevertheless, the possible impact of statins in esophagitis development has never been assessed. Methods: W...
Source: Canadian Journal of Gastroenterology - March 13, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research