< em > miR-325-3p < /em > Reduces Proliferation and Promotes Apoptosis of Gastric Cancer Cells by Inhibiting Human Antigen R
Can J Gastroenterol Hepatol. 2023 Sep 19;2023:6882851. doi: 10.1155/2023/6882851. eCollection 2023.ABSTRACTHuman antigen R (HuR), also known as ELAVL1, is a widely expressed RNA-binding protein (RBP) that has a significant impact on the development and advancement of tumors. Our previous study found that 5-fluorouracil (5-FU) may impede the proliferation and increase apoptosis in gastric cancer cells by reducing the nucleocytoplasmic shuttling of HuR. However, how posttranscriptional regulation influences HuR functions in gastric cancer remains to be elucidated. Here, we demonstrated that miR-325-3p has the potential to re...
Source: Canadian Journal of Gastroenterology - September 28, 2023 Category: Gastroenterology Authors: Zhengwei Huang Yacan Luo Congcong Chen Chaoyang Zhou Zhengkang Su Chang Cai Xi Li Wenzhi Wu Source Type: research