Clinical evidence for effectiveness of herbal medicines in treatment of obsessive- compulsive disorder, a review study
CONCLUSION: Overall, herbal medicines can be used as stand-alone therapies for OCD or in conjunction with other methods.PMID:35713134 | DOI:10.2174/1570163819666220616122543 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - June 17, 2022 Category: Drugs & Pharmacology Authors: Maryam Hosseini Abrishami Mohamad Reza Noras Atefeh Soltanifar Roshanak Salari Lida Jarahi Hamideh Khorram Pazhouh Source Type: research
Clinical evidence for effectiveness of herbal medicines in treatment of obsessive- compulsive disorder, a review study
CONCLUSION: Overall, herbal medicines can be used as stand-alone therapies for OCD or in conjunction with other methods.PMID:35713134 | DOI:10.2174/1570163819666220616122543 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - June 17, 2022 Category: Drugs & Pharmacology Authors: Maryam Hosseini Abrishami Mohamad Reza Noras Atefeh Soltanifar Roshanak Salari Lida Jarahi Hamideh Khorram Pazhouh Source Type: research
Clinical evidence for effectiveness of herbal medicines in treatment of obsessive- compulsive disorder, a review study
CONCLUSION: Overall, herbal medicines can be used as stand-alone therapies for OCD or in conjunction with other methods.PMID:35713134 | DOI:10.2174/1570163819666220616122543 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - June 17, 2022 Category: Drugs & Pharmacology Authors: Maryam Hosseini Abrishami Mohamad Reza Noras Atefeh Soltanifar Roshanak Salari Lida Jarahi Hamideh Khorram Pazhouh Source Type: research
Clinical evidence for effectiveness of herbal medicines in treatment of obsessive- compulsive disorder, a review study
CONCLUSION: Overall, herbal medicines can be used as stand-alone therapies for OCD or in conjunction with other methods.PMID:35713134 | DOI:10.2174/1570163819666220616122543 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - June 17, 2022 Category: Drugs & Pharmacology Authors: Maryam Hosseini Abrishami Mohamad Reza Noras Atefeh Soltanifar Roshanak Salari Lida Jarahi Hamideh Khorram Pazhouh Source Type: research
Clinical evidence for effectiveness of herbal medicines in treatment of obsessive- compulsive disorder, a review study
CONCLUSION: Overall, herbal medicines can be used as stand-alone therapies for OCD or in conjunction with other methods.PMID:35713134 | DOI:10.2174/1570163819666220616122543 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - June 17, 2022 Category: Drugs & Pharmacology Authors: Maryam Hosseini Abrishami Mohamad Reza Noras Atefeh Soltanifar Roshanak Salari Lida Jarahi Hamideh Khorram Pazhouh Source Type: research
Clinical evidence for effectiveness of herbal medicines in treatment of obsessive- compulsive disorder, a review study
CONCLUSION: Overall, herbal medicines can be used as stand-alone therapies for OCD or in conjunction with other methods.PMID:35713134 | DOI:10.2174/1570163819666220616122543 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - June 17, 2022 Category: Drugs & Pharmacology Authors: Maryam Hosseini Abrishami Mohamad Reza Noras Atefeh Soltanifar Roshanak Salari Lida Jarahi Hamideh Khorram Pazhouh Source Type: research
Silibinin protects against sepsis and septic myocardial injury in an NR1H3-dependent pathway
This study, for the first time, examined the effects and mechanisms of SIL pretreatment, posttreatment and in combination with classical antibiotics in septic myocardial injury. The survival rate, sepsis score, anal temperature, routine blood parameters, blood biochemical parameters, cardiac function indicators, pathological indicators of myocardial tissue injury, NR1H3 signaling pathway, and several sepsis-related signaling pathways were detected 8 h after cecal ligation and puncture (CLP). Our results showed that SIL pretreatment showed a significant protective effect on sepsis and septic myocardial injury, which was exp...
Source: Free Radical Biology and Medicine - May 31, 2022 Category: Biology Authors: Meng Sun Huadong Zhao Zhenxiao Jin Wangrui Lei Chao Deng Wenwen Yang Chenxi Lu Yuxuan Hou Yan Zhang Ran Tang Lin Zhao Shaofei Zhang Yang Yang Source Type: research
Silibinin protects against sepsis and septic myocardial injury in an NR1H3-dependent pathway
This study, for the first time, examined the effects and mechanisms of SIL pretreatment, posttreatment and in combination with classical antibiotics in septic myocardial injury. The survival rate, sepsis score, anal temperature, routine blood parameters, blood biochemical parameters, cardiac function indicators, pathological indicators of myocardial tissue injury, NR1H3 signaling pathway, and several sepsis-related signaling pathways were detected 8 h after cecal ligation and puncture (CLP). Our results showed that SIL pretreatment showed a significant protective effect on sepsis and septic myocardial injury, which was exp...
Source: Free Radical Biology and Medicine - May 31, 2022 Category: Biology Authors: Meng Sun Huadong Zhao Zhenxiao Jin Wangrui Lei Chao Deng Wenwen Yang Chenxi Lu Yuxuan Hou Yan Zhang Ran Tang Lin Zhao Shaofei Zhang Yang Yang Source Type: research
Silibinin protects against sepsis and septic myocardial injury in an NR1H3-dependent pathway
This study, for the first time, examined the effects and mechanisms of SIL pretreatment, posttreatment and in combination with classical antibiotics in septic myocardial injury. The survival rate, sepsis score, anal temperature, routine blood parameters, blood biochemical parameters, cardiac function indicators, pathological indicators of myocardial tissue injury, NR1H3 signaling pathway, and several sepsis-related signaling pathways were detected 8 h after cecal ligation and puncture (CLP). Our results showed that SIL pretreatment showed a significant protective effect on sepsis and septic myocardial injury, which was exp...
Source: Free Radical Biology and Medicine - May 31, 2022 Category: Biology Authors: Meng Sun Huadong Zhao Zhenxiao Jin Wangrui Lei Chao Deng Wenwen Yang Chenxi Lu Yuxuan Hou Yan Zhang Ran Tang Lin Zhao Shaofei Zhang Yang Yang Source Type: research
Silibinin protects against sepsis and septic myocardial injury in an NR1H3-dependent pathway
This study, for the first time, examined the effects and mechanisms of SIL pretreatment, posttreatment and in combination with classical antibiotics in septic myocardial injury. The survival rate, sepsis score, anal temperature, routine blood parameters, blood biochemical parameters, cardiac function indicators, pathological indicators of myocardial tissue injury, NR1H3 signaling pathway, and several sepsis-related signaling pathways were detected 8 h after cecal ligation and puncture (CLP). Our results showed that SIL pretreatment showed a significant protective effect on sepsis and septic myocardial injury, which was exp...
Source: Free Radical Biology and Medicine - May 31, 2022 Category: Biology Authors: Meng Sun Huadong Zhao Zhenxiao Jin Wangrui Lei Chao Deng Wenwen Yang Chenxi Lu Yuxuan Hou Yan Zhang Ran Tang Lin Zhao Shaofei Zhang Yang Yang Source Type: research
Silibinin protects against sepsis and septic myocardial injury in an NR1H3-dependent pathway
This study, for the first time, examined the effects and mechanisms of SIL pretreatment, posttreatment and in combination with classical antibiotics in septic myocardial injury. The survival rate, sepsis score, anal temperature, routine blood parameters, blood biochemical parameters, cardiac function indicators, pathological indicators of myocardial tissue injury, NR1H3 signaling pathway, and several sepsis-related signaling pathways were detected 8 h after cecal ligation and puncture (CLP). Our results showed that SIL pretreatment showed a significant protective effect on sepsis and septic myocardial injury, which was exp...
Source: Free Radical Biology and Medicine - May 31, 2022 Category: Biology Authors: Meng Sun Huadong Zhao Zhenxiao Jin Wangrui Lei Chao Deng Wenwen Yang Chenxi Lu Yuxuan Hou Yan Zhang Ran Tang Lin Zhao Shaofei Zhang Yang Yang Source Type: research
Molecules, Vol. 27, Pages 2641: Comparative Assessment of Phytoconstituents, Antioxidant Activity and Chemical Analysis of Different Parts of Milk Thistle Silybum marianum L.
ngshan Ji
Cong Li
Silybum marianum L. is a therapeutic plant belonging to the family Asteraceae, which has exhibited silymarin, a principal component used to cure various physiochemical disorders. The study appraised the phytochemical analysis, antioxidant activity and chemical analysis of an extract from the seed, stem and leaves. Qualitative and quantitative phytochemical analysis was evaluated by the Folin–Ciocalteu reagent method and aluminum chloride colorimetric method, respectively. While the antioxidant activity was determined by using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and acetate buffer in f...
Source: Molecules - April 20, 2022 Category: Chemistry Authors: Ansar Javeed Maqsood Ahmed Allah Rakha Sajid Aatika Sikandar Muhammad Aslam Talfoor ul Hassan Sami Ullah Dogar Zahid Nazir Mingshan Ji Cong Li Tags: Article Source Type: research
Silibinin promotes melanogenesis through the PKA and p38 MAPK signaling pathways in melanoma cells
This study investigated the effect of silibinin on melanogenesis in melanoma cells and the associated molecular mechanism. Our findings demonstrated that silibinin markedly increased melanin content in murine B16-F1 and human HMV-II melanoma cells. Silibinin activated intracellular tyrosinase activity and expression of tyrosinase, tyrosinase-related protein (TRP)-1, TRP-2, and microphthalmia-associated transcription factor (MITF). Furthermore, silibinin enhanced the phosphorylation of cyclic AMP-responsive element-binding protein (CREB), protein kinase A (PKA), and p38 mitogen-activated protein kinase (MAPK) but not of Akt...
Source: Biomed Res - April 18, 2022 Category: Research Authors: Takuhiro Uto Tomoe Ohta Koki Katayama Yukihiro Shoyama Source Type: research
Silibinin promotes melanogenesis through the PKA and p38 MAPK signaling pathways in melanoma cells
This study investigated the effect of silibinin on melanogenesis in melanoma cells and the associated molecular mechanism. Our findings demonstrated that silibinin markedly increased melanin content in murine B16-F1 and human HMV-II melanoma cells. Silibinin activated intracellular tyrosinase activity and expression of tyrosinase, tyrosinase-related protein (TRP)-1, TRP-2, and microphthalmia-associated transcription factor (MITF). Furthermore, silibinin enhanced the phosphorylation of cyclic AMP-responsive element-binding protein (CREB), protein kinase A (PKA), and p38 mitogen-activated protein kinase (MAPK) but not of Akt...
Source: Biomed Res - April 18, 2022 Category: Research Authors: Takuhiro Uto Tomoe Ohta Koki Katayama Yukihiro Shoyama Source Type: research
Molecules, Vol. 27, Pages 2401: Antiviral Efficacy of Selected Natural Phytochemicals against SARS-CoV-2 Spike Glycoprotein Using Structure-Based Drug Designing
ieman
SARS-CoV-2 is a highly virulent coronavirus that first surfaced in late 2019 and has since created a pandemic of the acute respiratory sickness known as “coronavirus disease 2019” (COVID-19), posing a threat to human health and public safety. S-RBD is a coronaviral protein that is essential for a coronavirus (CoV) to bind and penetrate into host cells. As a result, it has become a popular pharmacological target. The goal of this study was to find potential candidates for anti-coronavirus disease 2019 (COVID-19) drugs by targeting severe acute respiratory syndrome coronavirus 2 (SARS-Co...
Source: Molecules - April 8, 2022 Category: Chemistry Authors: Bandar Hamad Aloufi Mejdi Snoussi Abdel Moneim E. Sulieman Tags: Article Source Type: research
