In Vitro Evaluation of the Effects of 7-Ketocholesterol and 7 β-Hydroxycholesterol on the Peroxisomal Status: Prevention of Peroxisomal Damages and Concept of Pexotherapy
Adv Exp Med Biol. 2024;1440:437-452. doi: 10.1007/978-3-031-43883-7_21.ABSTRACT7-Ketocholesterol and 7β-hydroxycholesterol are most often derived from the autoxidation of cholesterol. Their quantities are often increased in the body fluids and/or diseased organs of patients with age-related diseases such as cardiovascular diseases, Alzheimer's disease, age-related macular degeneration, and sarcopenia which are frequently associated with a rupture of RedOx homeostasis leading to a high oxidative stress contributing to cell and tissue damages. On murine cells from the central nervous system (158N oligodendrocytes, microglia...
Source: Advances in Experimental Medicine and Biology - November 30, 2023 Category: Research Authors: Imen Ghzaiel Samah Maaloul Mohamed Ksila Amira Namsi Aline Yammine Meriam Debbabi Asma Badreddine Wiem Meddeb Vivien Pires Thomas Nury Franck M énétrier Laure Avoscan Amira Zarrouk Mauhamad Baarine Olfa Masmoudi-Kouki Taoufik Ghrairi Raoudha Abdellaoui Source Type: research
Chemical and Biochemical Features of Spinasterol and Schottenol
Adv Exp Med Biol. 2024;1440:45-55. doi: 10.1007/978-3-031-43883-7_3.ABSTRACTPhytosterols, which are produced in plants, are structurally similar to cholesterol. Their basic structures consist of a cyclo pentano-perhydrophenanthrene nucleus composed of 3 hexane rings and of a pentane ring with an alkyl side chain. There are around more than 250 phytosterols and related compounds that have been identified in natural resources. Among them, spinasterol and schottenol, its dihydro analog, are often found in seeds, and consequently in seed oils, and in other botanical parts of some plant families such as Sapotaceae, Cactaceae, a...
Source: Advances in Experimental Medicine and Biology - November 30, 2023 Category: Research Authors: Farid Khallouki Mohamed Ksila Imen Ghzaiel Soukaina Essadek Mounia Tahri Joutey Samah Maaloul Wafa Zennouhi Laila Benbacer Mohamed Bourhia Lhoussain Hajji Amira Zarrouk Leila Rezig Sandrine Rup-Jacques Raoudha Abdellaoui Taoufik Ghrairi Olfa Masmoudi-Kouk Source Type: research
In Vitro Evaluation of the Effects of 7-Ketocholesterol and 7 β-Hydroxycholesterol on the Peroxisomal Status: Prevention of Peroxisomal Damages and Concept of Pexotherapy
Adv Exp Med Biol. 2024;1440:437-452. doi: 10.1007/978-3-031-43883-7_21.ABSTRACT7-Ketocholesterol and 7β-hydroxycholesterol are most often derived from the autoxidation of cholesterol. Their quantities are often increased in the body fluids and/or diseased organs of patients with age-related diseases such as cardiovascular diseases, Alzheimer's disease, age-related macular degeneration, and sarcopenia which are frequently associated with a rupture of RedOx homeostasis leading to a high oxidative stress contributing to cell and tissue damages. On murine cells from the central nervous system (158N oligodendrocytes, microglia...
Source: Advances in Experimental Medicine and Biology - November 30, 2023 Category: Research Authors: Imen Ghzaiel Samah Maaloul Mohamed Ksila Amira Namsi Aline Yammine Meriam Debbabi Asma Badreddine Wiem Meddeb Vivien Pires Thomas Nury Franck M énétrier Laure Avoscan Amira Zarrouk Mauhamad Baarine Olfa Masmoudi-Kouki Taoufik Ghrairi Raoudha Abdellaoui Source Type: research
Chemical and Biochemical Features of Spinasterol and Schottenol
Adv Exp Med Biol. 2024;1440:45-55. doi: 10.1007/978-3-031-43883-7_3.ABSTRACTPhytosterols, which are produced in plants, are structurally similar to cholesterol. Their basic structures consist of a cyclo pentano-perhydrophenanthrene nucleus composed of 3 hexane rings and of a pentane ring with an alkyl side chain. There are around more than 250 phytosterols and related compounds that have been identified in natural resources. Among them, spinasterol and schottenol, its dihydro analog, are often found in seeds, and consequently in seed oils, and in other botanical parts of some plant families such as Sapotaceae, Cactaceae, a...
Source: Advances in Experimental Medicine and Biology - November 30, 2023 Category: Research Authors: Farid Khallouki Mohamed Ksila Imen Ghzaiel Soukaina Essadek Mounia Tahri Joutey Samah Maaloul Wafa Zennouhi Laila Benbacer Mohamed Bourhia Lhoussain Hajji Amira Zarrouk Leila Rezig Sandrine Rup-Jacques Raoudha Abdellaoui Taoufik Ghrairi Olfa Masmoudi-Kouk Source Type: research
Application of SNAP-tag-EGFR cell membrane chromatography model in screening antitumor active components of Silybum marianum (L.) Gaertn
This study identified silydianin, silychristin, silybin, and isosilybin from Silybum marianum (L.) Gaertn. and verified their potential antitumor effects on EGFR.PMID:37976988 | DOI:10.1016/j.jpba.2023.115816 (Source: Cancer Control)
Source: Cancer Control - November 17, 2023 Category: Cancer & Oncology Authors: Xin Zhang Yuhan Jiang Na Guo Yifan Ding Jingting Feng Chenyang Miao Yanni Lv Source Type: research
Inhibition of Phagocytosis by Silibinin in Mouse Macrophages
This study investigated the effects of silibinin, derived from milk thistle (Silybum marianum), on lipopolysaccharide (LPS)-induced morphological changes in mouse macrophages. Silibinin was treated at various doses and time points to assess its effects on macrophage activation, including morphological changes and phagocytosis. Silibinin effectively inhibited LPS-induced pseudopodia formation and size increase, while unstimulated cells remained round. Silibinin's impact on phagocytosis was dose- and time-dependent, showing a decrease. We explored its mechanism of action on kinases using a MAPK array. Among the three MAPK fa...
Source: Current Issues in Molecular Biology - October 27, 2023 Category: Molecular Biology Authors: Kyung-Hoon Sun Min-Young Lee Young-Jin Jeon Source Type: research
Inhibition of Phagocytosis by Silibinin in Mouse Macrophages
This study investigated the effects of silibinin, derived from milk thistle (Silybum marianum), on lipopolysaccharide (LPS)-induced morphological changes in mouse macrophages. Silibinin was treated at various doses and time points to assess its effects on macrophage activation, including morphological changes and phagocytosis. Silibinin effectively inhibited LPS-induced pseudopodia formation and size increase, while unstimulated cells remained round. Silibinin's impact on phagocytosis was dose- and time-dependent, showing a decrease. We explored its mechanism of action on kinases using a MAPK array. Among the three MAPK fa...
Source: Current Issues in Molecular Biology - October 27, 2023 Category: Molecular Biology Authors: Kyung-Hoon Sun Min-Young Lee Young-Jin Jeon Source Type: research
Inhibition of Phagocytosis by Silibinin in Mouse Macrophages
This study investigated the effects of silibinin, derived from milk thistle (Silybum marianum), on lipopolysaccharide (LPS)-induced morphological changes in mouse macrophages. Silibinin was treated at various doses and time points to assess its effects on macrophage activation, including morphological changes and phagocytosis. Silibinin effectively inhibited LPS-induced pseudopodia formation and size increase, while unstimulated cells remained round. Silibinin's impact on phagocytosis was dose- and time-dependent, showing a decrease. We explored its mechanism of action on kinases using a MAPK array. Among the three MAPK fa...
Source: Current Issues in Molecular Biology - October 27, 2023 Category: Molecular Biology Authors: Kyung-Hoon Sun Min-Young Lee Young-Jin Jeon Source Type: research
Inhibition of Phagocytosis by Silibinin in Mouse Macrophages
This study investigated the effects of silibinin, derived from milk thistle (Silybum marianum), on lipopolysaccharide (LPS)-induced morphological changes in mouse macrophages. Silibinin was treated at various doses and time points to assess its effects on macrophage activation, including morphological changes and phagocytosis. Silibinin effectively inhibited LPS-induced pseudopodia formation and size increase, while unstimulated cells remained round. Silibinin's impact on phagocytosis was dose- and time-dependent, showing a decrease. We explored its mechanism of action on kinases using a MAPK array. Among the three MAPK fa...
Source: Current Issues in Molecular Biology - October 27, 2023 Category: Molecular Biology Authors: Kyung-Hoon Sun Min-Young Lee Young-Jin Jeon Source Type: research
Inhibition of Phagocytosis by Silibinin in Mouse Macrophages
This study investigated the effects of silibinin, derived from milk thistle (Silybum marianum), on lipopolysaccharide (LPS)-induced morphological changes in mouse macrophages. Silibinin was treated at various doses and time points to assess its effects on macrophage activation, including morphological changes and phagocytosis. Silibinin effectively inhibited LPS-induced pseudopodia formation and size increase, while unstimulated cells remained round. Silibinin's impact on phagocytosis was dose- and time-dependent, showing a decrease. We explored its mechanism of action on kinases using a MAPK array. Among the three MAPK fa...
Source: Current Issues in Molecular Biology - October 27, 2023 Category: Molecular Biology Authors: Kyung-Hoon Sun Min-Young Lee Young-Jin Jeon Source Type: research
Inhibition of Phagocytosis by Silibinin in Mouse Macrophages
This study investigated the effects of silibinin, derived from milk thistle (Silybum marianum), on lipopolysaccharide (LPS)-induced morphological changes in mouse macrophages. Silibinin was treated at various doses and time points to assess its effects on macrophage activation, including morphological changes and phagocytosis. Silibinin effectively inhibited LPS-induced pseudopodia formation and size increase, while unstimulated cells remained round. Silibinin's impact on phagocytosis was dose- and time-dependent, showing a decrease. We explored its mechanism of action on kinases using a MAPK array. Among the three MAPK fa...
Source: Current Issues in Molecular Biology - October 27, 2023 Category: Molecular Biology Authors: Kyung-Hoon Sun Min-Young Lee Young-Jin Jeon Source Type: research
Inhibition of Phagocytosis by Silibinin in Mouse Macrophages
This study investigated the effects of silibinin, derived from milk thistle (Silybum marianum), on lipopolysaccharide (LPS)-induced morphological changes in mouse macrophages. Silibinin was treated at various doses and time points to assess its effects on macrophage activation, including morphological changes and phagocytosis. Silibinin effectively inhibited LPS-induced pseudopodia formation and size increase, while unstimulated cells remained round. Silibinin's impact on phagocytosis was dose- and time-dependent, showing a decrease. We explored its mechanism of action on kinases using a MAPK array. Among the three MAPK fa...
Source: Current Issues in Molecular Biology - October 27, 2023 Category: Molecular Biology Authors: Kyung-Hoon Sun Min-Young Lee Young-Jin Jeon Source Type: research
Inhibition of Phagocytosis by Silibinin in Mouse Macrophages
This study investigated the effects of silibinin, derived from milk thistle (Silybum marianum), on lipopolysaccharide (LPS)-induced morphological changes in mouse macrophages. Silibinin was treated at various doses and time points to assess its effects on macrophage activation, including morphological changes and phagocytosis. Silibinin effectively inhibited LPS-induced pseudopodia formation and size increase, while unstimulated cells remained round. Silibinin's impact on phagocytosis was dose- and time-dependent, showing a decrease. We explored its mechanism of action on kinases using a MAPK array. Among the three MAPK fa...
Source: Current Issues in Molecular Biology - October 27, 2023 Category: Molecular Biology Authors: Kyung-Hoon Sun Min-Young Lee Young-Jin Jeon Source Type: research
Inhibition of Phagocytosis by Silibinin in Mouse Macrophages
This study investigated the effects of silibinin, derived from milk thistle (Silybum marianum), on lipopolysaccharide (LPS)-induced morphological changes in mouse macrophages. Silibinin was treated at various doses and time points to assess its effects on macrophage activation, including morphological changes and phagocytosis. Silibinin effectively inhibited LPS-induced pseudopodia formation and size increase, while unstimulated cells remained round. Silibinin's impact on phagocytosis was dose- and time-dependent, showing a decrease. We explored its mechanism of action on kinases using a MAPK array. Among the three MAPK fa...
Source: Current Issues in Molecular Biology - October 27, 2023 Category: Molecular Biology Authors: Kyung-Hoon Sun Min-Young Lee Young-Jin Jeon Source Type: research
Inhibition of Phagocytosis by Silibinin in Mouse Macrophages
This study investigated the effects of silibinin, derived from milk thistle (Silybum marianum), on lipopolysaccharide (LPS)-induced morphological changes in mouse macrophages. Silibinin was treated at various doses and time points to assess its effects on macrophage activation, including morphological changes and phagocytosis. Silibinin effectively inhibited LPS-induced pseudopodia formation and size increase, while unstimulated cells remained round. Silibinin's impact on phagocytosis was dose- and time-dependent, showing a decrease. We explored its mechanism of action on kinases using a MAPK array. Among the three MAPK fa...
Source: Current Issues in Molecular Biology - October 27, 2023 Category: Molecular Biology Authors: Kyung-Hoon Sun Min-Young Lee Young-Jin Jeon Source Type: research
