Inhibition of Phagocytosis by Silibinin in Mouse Macrophages
This study investigated the effects of silibinin, derived from milk thistle (Silybum marianum), on lipopolysaccharide (LPS)-induced morphological changes in mouse macrophages. Silibinin was treated at various doses and time points to assess its effects on macrophage activation, including morphological changes and phagocytosis. Silibinin effectively inhibited LPS-induced pseudopodia formation and size increase, while unstimulated cells remained round. Silibinin's impact on phagocytosis was dose- and time-dependent, showing a decrease. We explored its mechanism of action on kinases using a MAPK array. Among the three MAPK fa...
Source: Current Issues in Molecular Biology - October 27, 2023 Category: Molecular Biology Authors: Kyung-Hoon Sun Min-Young Lee Young-Jin Jeon Source Type: research
Inhibition of Phagocytosis by Silibinin in Mouse Macrophages
This study investigated the effects of silibinin, derived from milk thistle (Silybum marianum), on lipopolysaccharide (LPS)-induced morphological changes in mouse macrophages. Silibinin was treated at various doses and time points to assess its effects on macrophage activation, including morphological changes and phagocytosis. Silibinin effectively inhibited LPS-induced pseudopodia formation and size increase, while unstimulated cells remained round. Silibinin's impact on phagocytosis was dose- and time-dependent, showing a decrease. We explored its mechanism of action on kinases using a MAPK array. Among the three MAPK fa...
Source: Current Issues in Molecular Biology - October 27, 2023 Category: Molecular Biology Authors: Kyung-Hoon Sun Min-Young Lee Young-Jin Jeon Source Type: research
Inhibition of Phagocytosis by Silibinin in Mouse Macrophages
This study investigated the effects of silibinin, derived from milk thistle (Silybum marianum), on lipopolysaccharide (LPS)-induced morphological changes in mouse macrophages. Silibinin was treated at various doses and time points to assess its effects on macrophage activation, including morphological changes and phagocytosis. Silibinin effectively inhibited LPS-induced pseudopodia formation and size increase, while unstimulated cells remained round. Silibinin's impact on phagocytosis was dose- and time-dependent, showing a decrease. We explored its mechanism of action on kinases using a MAPK array. Among the three MAPK fa...
Source: Current Issues in Molecular Biology - October 27, 2023 Category: Molecular Biology Authors: Kyung-Hoon Sun Min-Young Lee Young-Jin Jeon Source Type: research
Inhibition of Phagocytosis by Silibinin in Mouse Macrophages
This study investigated the effects of silibinin, derived from milk thistle (Silybum marianum), on lipopolysaccharide (LPS)-induced morphological changes in mouse macrophages. Silibinin was treated at various doses and time points to assess its effects on macrophage activation, including morphological changes and phagocytosis. Silibinin effectively inhibited LPS-induced pseudopodia formation and size increase, while unstimulated cells remained round. Silibinin's impact on phagocytosis was dose- and time-dependent, showing a decrease. We explored its mechanism of action on kinases using a MAPK array. Among the three MAPK fa...
Source: Current Issues in Molecular Biology - October 27, 2023 Category: Molecular Biology Authors: Kyung-Hoon Sun Min-Young Lee Young-Jin Jeon Source Type: research
Inhibition of Phagocytosis by Silibinin in Mouse Macrophages
This study investigated the effects of silibinin, derived from milk thistle (Silybum marianum), on lipopolysaccharide (LPS)-induced morphological changes in mouse macrophages. Silibinin was treated at various doses and time points to assess its effects on macrophage activation, including morphological changes and phagocytosis. Silibinin effectively inhibited LPS-induced pseudopodia formation and size increase, while unstimulated cells remained round. Silibinin's impact on phagocytosis was dose- and time-dependent, showing a decrease. We explored its mechanism of action on kinases using a MAPK array. Among the three MAPK fa...
Source: Current Issues in Molecular Biology - October 27, 2023 Category: Molecular Biology Authors: Kyung-Hoon Sun Min-Young Lee Young-Jin Jeon Source Type: research
Inhibition of Phagocytosis by Silibinin in Mouse Macrophages
This study investigated the effects of silibinin, derived from milk thistle (Silybum marianum), on lipopolysaccharide (LPS)-induced morphological changes in mouse macrophages. Silibinin was treated at various doses and time points to assess its effects on macrophage activation, including morphological changes and phagocytosis. Silibinin effectively inhibited LPS-induced pseudopodia formation and size increase, while unstimulated cells remained round. Silibinin's impact on phagocytosis was dose- and time-dependent, showing a decrease. We explored its mechanism of action on kinases using a MAPK array. Among the three MAPK fa...
Source: Current Issues in Molecular Biology - October 27, 2023 Category: Molecular Biology Authors: Kyung-Hoon Sun Min-Young Lee Young-Jin Jeon Source Type: research
Inhibition of Phagocytosis by Silibinin in Mouse Macrophages
This study investigated the effects of silibinin, derived from milk thistle (Silybum marianum), on lipopolysaccharide (LPS)-induced morphological changes in mouse macrophages. Silibinin was treated at various doses and time points to assess its effects on macrophage activation, including morphological changes and phagocytosis. Silibinin effectively inhibited LPS-induced pseudopodia formation and size increase, while unstimulated cells remained round. Silibinin's impact on phagocytosis was dose- and time-dependent, showing a decrease. We explored its mechanism of action on kinases using a MAPK array. Among the three MAPK fa...
Source: Current Issues in Molecular Biology - October 27, 2023 Category: Molecular Biology Authors: Kyung-Hoon Sun Min-Young Lee Young-Jin Jeon Source Type: research
Inhibition of Phagocytosis by Silibinin in Mouse Macrophages
This study investigated the effects of silibinin, derived from milk thistle (Silybum marianum), on lipopolysaccharide (LPS)-induced morphological changes in mouse macrophages. Silibinin was treated at various doses and time points to assess its effects on macrophage activation, including morphological changes and phagocytosis. Silibinin effectively inhibited LPS-induced pseudopodia formation and size increase, while unstimulated cells remained round. Silibinin's impact on phagocytosis was dose- and time-dependent, showing a decrease. We explored its mechanism of action on kinases using a MAPK array. Among the three MAPK fa...
Source: Current Issues in Molecular Biology - October 27, 2023 Category: Molecular Biology Authors: Kyung-Hoon Sun Min-Young Lee Young-Jin Jeon Source Type: research
Inhibition of Phagocytosis by Silibinin in Mouse Macrophages
This study investigated the effects of silibinin, derived from milk thistle (Silybum marianum), on lipopolysaccharide (LPS)-induced morphological changes in mouse macrophages. Silibinin was treated at various doses and time points to assess its effects on macrophage activation, including morphological changes and phagocytosis. Silibinin effectively inhibited LPS-induced pseudopodia formation and size increase, while unstimulated cells remained round. Silibinin's impact on phagocytosis was dose- and time-dependent, showing a decrease. We explored its mechanism of action on kinases using a MAPK array. Among the three MAPK fa...
Source: Current Issues in Molecular Biology - October 27, 2023 Category: Molecular Biology Authors: Kyung-Hoon Sun Min-Young Lee Young-Jin Jeon Source Type: research
Milk thistle nano-micelle formulation promotes cell cycle arrest and apoptosis in hepatocellular carcinoma cells through modulating miR-155-3p /SOCS2 /PHLDA1 signaling axis
This study compared the effects of milk thistle (MT) and nano-milk thistl... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - September 26, 2023 Category: Complementary Medicine Authors: Saghar Rahnama, Zahra Moazezi Tehrankhah, Fatemeh Mohajerani, Faezeh Shah Mohammadi, Zahra Yousefi Yeganeh, Farhood Najafi, Sadegh Babashah and Majid Sadeghizadeh Tags: Research Source Type: research
Pathophysiology of diabetic hepatopathy and molecular mechanisms underlying the hepatoprotective effects of phytochemicals
Biomed Pharmacother. 2023 Sep 19;167:115502. doi: 10.1016/j.biopha.2023.115502. Online ahead of print.ABSTRACTPatients with diabetes are at risk for liver disorders including glycogen hepatopathy, non-alcoholic fatty liver disease, cirrhosis, and hepatic fibrosis. The pathophysiological mechanisms behind diabetic hepatopathy are complex, some of them include fatty acid accumulation, increased reactive oxygen species, increased advanced glycation end-products, hyperactivity of polyol pathways, increased apoptosis and necrosis, and promotion of fibrosis. A growing number of studies have shown that herbal extracts and their a...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 21, 2023 Category: Drugs & Pharmacology Authors: Leila Mobasheri Mitra Ahadi Ali Beheshti Namdar Mohaddeseh Sadat Alavi Abolfazl Bemidinezhad Seyed Mostafa Moshirian Farahi Mahdi Esmaeilizadeh Niloofar Nikpasand Elham Einafshar Ahmad Ghorbani Source Type: research
Pathophysiology of diabetic hepatopathy and molecular mechanisms underlying the hepatoprotective effects of phytochemicals
Biomed Pharmacother. 2023 Sep 19;167:115502. doi: 10.1016/j.biopha.2023.115502. Online ahead of print.ABSTRACTPatients with diabetes are at risk for liver disorders including glycogen hepatopathy, non-alcoholic fatty liver disease, cirrhosis, and hepatic fibrosis. The pathophysiological mechanisms behind diabetic hepatopathy are complex, some of them include fatty acid accumulation, increased reactive oxygen species, increased advanced glycation end-products, hyperactivity of polyol pathways, increased apoptosis and necrosis, and promotion of fibrosis. A growing number of studies have shown that herbal extracts and their a...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 21, 2023 Category: Drugs & Pharmacology Authors: Leila Mobasheri Mitra Ahadi Ali Beheshti Namdar Mohaddeseh Sadat Alavi Abolfazl Bemidinezhad Seyed Mostafa Moshirian Farahi Mahdi Esmaeilizadeh Niloofar Nikpasand Elham Einafshar Ahmad Ghorbani Source Type: research
Molecules, Vol. 28, Pages 6639: Adsorption of Basic Yellow 28 and Basic Blue 3 Dyes from Aqueous Solution Using Silybum Marianum Stem as a Low-Cost Adsorbent
In the present study, the ability of an adsorbent (SLM Stem) obtained from the stem of the Silybum Marianum plant to treat wastewater containing the cationic dyes basic blue 3 (BB3) and basic yellow 28 (BY28) from aqueous solutions was investigated using a batch method. Then, the SLM Stem (SLM Stem-Natural) adsorbent was carbonized at different temperatures (200–900 °C) and the removal capacity of the products obtained for both dyes was examined again. The investigation continued with the product carbonized at 800 °C (SLM Stem-800 °C), the adsorbent with the highest re...
Source: Molecules - September 15, 2023 Category: Chemistry Authors: T ürkan Börklü Budak Tags: Article Source Type: research
Silibinin alleviates intestinal inflammation via inhibiting JNK signaling in Drosophila
In this study, using Drosophila melanogaster as a model organism, we found that SIL can effectively relieve intestinal inflammation caused by dextran sulfate sodium (DSS). Our results suggested that SIL supplementation can inhibit the overproliferation of intestinal stem cells (ISCs) induced by DSS, protect intestinal barrier function, acid-base balance, and intestinal excretion function, reduce intestinal reactive oxygen species (ROS) levels and inflammatory stress, and extend the lifespan of Drosophila. Furthermore, our study demonstrated that SIL ameliorates intestinal inflammation via modulating the c-Jun N-terminal ki...
Source: Frontiers in Pharmacology - September 14, 2023 Category: Drugs & Pharmacology Source Type: research
Medicinal Plant-Derived Phytochemicals in Detoxification
Curr Pharm Des. 2023 Aug 9. doi: 10.2174/1381612829666230809094242. Online ahead of print.ABSTRACTThe average worldwide human life expectancy is 70 years, with a significantly higher value in Western societies. Many modern diseases are not associated with premature mortality but with a decreased quality of life in aged patients and an excessive accumulation of various toxic compounds in the human body during life. Today, scientists are especially interested in finding compounds that can help increase a healthy lifespan by detoxifying the body. Phytotherapy with specific approaches is used in alternative medicine to remove ...
Source: Current Pharmaceutical Design - August 10, 2023 Category: Drugs & Pharmacology Authors: Geir Bj ørklund Nat ália Cruz-Martins Bey Hing Goh Olha Mykhailenko Roman Lysiuk Mariia Shanaida Larysa Lenchyk Taras Upyr Marius Emil Rusu Antonina Pryshlyak Volodymyr Shanaida Salvatore Chirumbolo Source Type: research
