Abstract No. 193 Protective Factors in Developing Symptoms of Pelvic Venous Disorders): Evaluation of Asymptomatic Patients with Pelvic Varices
This study aimed to explore whether specific pharmacologic exposure, namely neurokinin-1 (NK1) receptor antagonists, calcitonin gene-related peptide (CGRP) receptor antagonists, and the nitric oxide (NO) release antagonist medroxyprogesterone, could serve as protective factors against PeVD symptom development. (Source: Journal of Vascular and Interventional Radiology : JVIR)
Source: Journal of Vascular and Interventional Radiology : JVIR - February 21, 2024 Category: Radiology Authors: E. Gonzales, V. Risner, J. Du Pisanie, N. Keefe, P. Mody, G. Salazar Source Type: research
My Way: development and preliminary evaluation of a novel delivery system for PrEP and other sexual health needs of young women in Western Kenya
CONCLUSIONS: My Way is a promising delivery system for PrEP and other sexual health services among young women in Western Kenya. We found high feasibility and acceptability. PrEP use was modest, but higher with My Way compared to SoC. Long-acting PrEP formulations may overcome important barriers to PrEP use and should be explored in combination with the My Way delivery model.PMID:38379132 | DOI:10.1002/jia2.26217 (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - February 21, 2024 Category: Infectious Diseases Authors: Jessica E Haberer Kevin Oware Lawrence Juma Bernard Nyerere Vincent Momanyi Josephine Odoyo Lindsey Garrison Julita Bhagat Nicholas Musinguzi Jared M Baeten Aaron Siegler Elizabeth A Bukusi Source Type: research
My Way: development and preliminary evaluation of a novel delivery system for PrEP and other sexual health needs of young women in Western Kenya
CONCLUSIONS: My Way is a promising delivery system for PrEP and other sexual health services among young women in Western Kenya. We found high feasibility and acceptability. PrEP use was modest, but higher with My Way compared to SoC. Long-acting PrEP formulations may overcome important barriers to PrEP use and should be explored in combination with the My Way delivery model.PMID:38379132 | PMC:PMC10879470 | DOI:10.1002/jia2.26217 (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - February 21, 2024 Category: Infectious Diseases Authors: Jessica E Haberer Kevin Oware Lawrence Juma Bernard Nyerere Vincent Momanyi Josephine Odoyo Lindsey Garrison Julita Bhagat Nicholas Musinguzi Jared M Baeten Aaron Siegler Elizabeth A Bukusi Source Type: research
GSE241070 gRNA-seq from Ishikawa after medroxyprogesterone treatment
Contributors : Yao Liu ; Shourong Wang ; Jie JiangSeries Type : OtherOrganism : Homo sapiensHormone therapy serves as a primary choice for fertility preservation and is also considered for advanced and recurrent cases with endometrial cancer. While a number of patients fail to respond favorably to hormone treatments. In order to explore the mechanisms underpinning hormone resistance, Here we constructed a whole-genome library for EAC cell lines using the CRISPR-Cas9 system and performed high-throughput sequencing after medroxyprogesterone treatment in this study. For CRISPR screening, ishikawa cells were infected pooled...
Source: GEO: Gene Expression Omnibus - February 12, 2024 Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
Progesterone-induced progesterone receptor membrane component 1 rise-to-decline changes are essential for decidualization
CONCLUSIONS: According to our findings, PGRMC1 expression followed a progestin-induced rise-to-decline expression pattern during human endometrial decidualization process; and the correct execution of this expression program was crucial for successful decidualization. Thereby, the results of our in vitro model explained how PGRMC1 dysregulation during decidualization may present a new perspective on infertility-related diseases.PMID:38308254 | PMC:PMC10837943 | DOI:10.1186/s12958-024-01188-9 (Source: Reproductive Biology)
Source: Reproductive Biology - February 2, 2024 Category: Reproduction Medicine Authors: Hailun Liu Andr é Franken Alexandra P Bielfeld Tanja Fehm Dieter Niederacher Zhongping Cheng Hans Neubauer Nadia Stamm Source Type: research
Comparison of resumption of ovulation after cessation of oral contraceptives and medroxyprogesterone acetate in women with polycystic ovary syndrome
Volume 40, Issue 1, December 2024 . (Source: Gynecological Endocrinology)
Source: Gynecological Endocrinology - February 2, 2024 Category: Endocrinology Authors: Soo Jin HanHoon KimSeung-Yup KuChang Suk Suha Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Koreab Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, Korea Source Type: research
Dihydrotestosterone induces arterial stiffening in female mice
ConclusionsThese findings indicate that androgen promotes arterial stiffening and cardiovascular damage in female mice and is associated with decreased estrogen receptor expression. These data are important for transgender men, women using testosterone for fitness or reduced libido, as well as patients with polycystic ovarian syndrome. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - January 23, 2024 Category: Biology Source Type: research
Oral medroxyprogesterone acetate for the use of ovulation suppression in in-vitro fertilization: A cohort trial
To broadly assess the efficacy of medroxyprogesterone acetate (MPA) for ovulatory suppression during in vitro stimulation (IVF) when compared to gonadotropin releasing hormone (GnRH) antagonist cycles (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 20, 2024 Category: Reproduction Medicine Authors: Annalyn M. Welp, Chris D. Williams, Laura P. Smith, Scott Purcell, Linnea R. Goodman Tags: Assisted reproduction Source Type: research
Oral medroxyprogesterone acetate for the use of ovulation suppression in in vitro fertilization: a cohort trial
To broadly assess the efficacy of medroxyprogesterone acetate (MPA) for ovulatory suppression during in vitro stimulation compared with gonadotropin-releasing hormone (GnRH) antagonist cycles. (Source: Fertility and Sterility)
Source: Fertility and Sterility - January 20, 2024 Category: Reproduction Medicine Authors: Annalyn M. Welp, Chris D. Williams, Laura P. Smith, Scott Purcell, Linnea R. Goodman Tags: Assisted reproduction Source Type: research
Provision of DMPA-SC for self-administration in different practice settings during the COVID-19 pandemic: data from providers across the United States
This study assessed changes in availability of DMPA-SC for self-administration during the pandemic. (Source: Contraception)
Source: Contraception - December 27, 2023 Category: OBGYN Authors: Alison B. Comfort, Alejandra Alvarez, Suzan Goodman, Ushma Upadhyay, Biftu Mengesha, Jennifer Karlin, Mitra Shokat, Maya Blum, Cynthia C. Harper Source Type: research
The impact of medroxyprogesterone acetate on lipid profiles in Women: A time and dose-response meta-analysis of randomized controlled trials
The effect of MPA on the lipid profile and CVD risk is still controversial; hence, this comprehensive dose –response meta-analysis of randomized controlled trials was conducted to assess the effect of MPA on lipid profiles in women. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - December 22, 2023 Category: Endocrinology Authors: Li Feng, Le Wang, Benjamin Hern ández-Wolters, Kousalya Prabahar, Periyannan velu, Hamed Kord-Varkaneh Source Type: research
Effect of tibolone versus hormone replacement therapy on lower urinary tract symptoms and sexual function
CONCLUSIONS: Despite the limited effect, tibolone seems to have more benefit in nocturia than HRT. In addition, tibolone seems to have benefits on overall low urinary tract storage symptoms; and both tibolone and HRT seem to have beneficial effects on female sexual function, despite there were no significant differences between tibolone and HRT.PMID:38092655 | DOI:10.1016/j.jfma.2023.12.007 (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - December 13, 2023 Category: General Medicine Authors: Sheng-Mou Hsiao Shiow-Ru Chang Source Type: research
