Effects of depot medroxyprogesterone acetate, the copper IUD and the levonorgestrel implant on testosterone, sex hormone binding globulin and free testosterone levels: ancillary study of the ECHO randomized clinical trial
Robust information on relative effects of hormonal contraceptives on endogenous androgens is important for understanding beneficial and adverse effects, method choice and development of new methods. (Source: BMC Women's Health)
Source: BMC Women's Health - March 8, 2024 Category: OBGYN Authors: G. Justus Hofmeyr, Mandisa Singata-Madliki, Joanne Batting, Yusentha Balakrishna and Chelsea Morroni Tags: Research Source Type: research
Depot medroxyprogesterone acetate concentrations in patients with and without use of anti-seizure medications
To measure plasma concentrations of medroxyprogesterone acetate (MPA) in users with epilepsy treated with anti-seizure medications and compare these to MPA concentrations in those without epilepsy. (Source: Contraception)
Source: Contraception - March 5, 2024 Category: OBGYN Authors: Caryn Dutton, Sheila K. Mody, Siripanth Nippita, Laura E. Dodge, Trudy Pang, Page B. Pennell, Anne Davis Tags: Brief Research Article Source Type: research
Depot medroxyprogesterone acetate concentrations in patients with and without the use of antiseizure medications
To measure plasma concentrations of medroxyprogesterone acetate (MPA) in users with epilepsy treated with antiseizure medications and compare these to MPA concentrations in those without epilepsy. (Source: Contraception)
Source: Contraception - March 5, 2024 Category: OBGYN Authors: Caryn Dutton, Sheila K. Mody, Siripanth Nippita, Laura E. Dodge, Trudy Pang, Page B. Pennell, Anne Davis Source Type: research
Brain-derived neuerotrophic factor and related mechanisms that mediate and influence progesterone-induced neuroprotection
Historically, progesterone has been studied significantly within the context of reproductive biology. However, there is now an abundance of evidence for its role in regions of the central nervous system (CNS) associated with such non-reproductive functions that include cognition and affect. Here, we describe mechanisms of progesterone action that support its brain-protective effects, and focus particularly on the role of neurotrophins (such as brain-derived neurotrophic factor, BDNF), the receptors that are critical for their regulation, and the role of certain microRNA in influencing the brain-protective effects of proges...
Source: Frontiers in Endocrinology - February 26, 2024 Category: Endocrinology Source Type: research
Best Practices for Hormonal Contraception and Menopause Therapy in Women at Increased Risk for Breast Cancer
AbstractPurpose of ReviewThe present review critically assesses contemporary evidence characterizing the association between hormonal contraception (HC) and/or menopausal hormone replacement therapy (MHT) and breast cancer risk in patients considered “high risk.”Recent FindingsProspective studies of hormonal contraception methods for BRCA 1 mutation carriers do not demonstrate an association between combined oral contraceptives (COC) and hormone receptor-positive breast cancer, findings consistent with those seen from systematic reviews evaluating this risk in patients with a family history of breast cancer. The Center...
Source: Current Breast Cancer Reports - February 26, 2024 Category: Cancer & Oncology Source Type: research
Abnormal Uterine Bleeding Associated With Hormonal Contraception
This article includes algorithms to help clinicians treat abnormal uterine bleeding in people using levonorgestrel intrauterine devices, depo-medroxyprogesterone acetate, progestin implant, progestin-only pills, and combined hormonal contraception. For patients with levonorgestrel intrauterine devices, physicians should first ensure that the device is correctly placed within the uterus, then consider nonsteroidal anti-inflammatory drugs as a first-line treatment for abnormal uterine bleeding; estradiol can be used if nonsteroidal anti-inflammatory drugs are ineffective. For depo-medroxyprogesterone acetate or progestin imp...
Source: American Family Physician - February 23, 2024 Category: Primary Care Authors: Sarina Schrager Kelita Fox Rachel Lee Source Type: research
Abnormal Uterine Bleeding Associated With Hormonal Contraception
This article includes algorithms to help clinicians treat abnormal uterine bleeding in people using levonorgestrel intrauterine devices, depo-medroxyprogesterone acetate, progestin implant, progestin-only pills, and combined hormonal contraception. For patients with levonorgestrel intrauterine devices, physicians should first ensure that the device is correctly placed within the uterus, then consider nonsteroidal anti-inflammatory drugs as a first-line treatment for abnormal uterine bleeding; estradiol can be used if nonsteroidal anti-inflammatory drugs are ineffective. For depo-medroxyprogesterone acetate or progestin imp...
Source: American Family Physician - February 23, 2024 Category: Primary Care Authors: Sarina Schrager Kelita Fox Rachel Lee Source Type: research
Abnormal Uterine Bleeding Associated With Hormonal Contraception
This article includes algorithms to help clinicians treat abnormal uterine bleeding in people using levonorgestrel intrauterine devices, depo-medroxyprogesterone acetate, progestin implant, progestin-only pills, and combined hormonal contraception. For patients with levonorgestrel intrauterine devices, physicians should first ensure that the device is correctly placed within the uterus, then consider nonsteroidal anti-inflammatory drugs as a first-line treatment for abnormal uterine bleeding; estradiol can be used if nonsteroidal anti-inflammatory drugs are ineffective. For depo-medroxyprogesterone acetate or progestin imp...
Source: American Family Physician - February 23, 2024 Category: Primary Care Authors: Sarina Schrager Kelita Fox Rachel Lee Source Type: research
Abnormal Uterine Bleeding Associated With Hormonal Contraception
This article includes algorithms to help clinicians treat abnormal uterine bleeding in people using levonorgestrel intrauterine devices, depo-medroxyprogesterone acetate, progestin implant, progestin-only pills, and combined hormonal contraception. For patients with levonorgestrel intrauterine devices, physicians should first ensure that the device is correctly placed within the uterus, then consider nonsteroidal anti-inflammatory drugs as a first-line treatment for abnormal uterine bleeding; estradiol can be used if nonsteroidal anti-inflammatory drugs are ineffective. For depo-medroxyprogesterone acetate or progestin imp...
Source: American Family Physician - February 23, 2024 Category: Primary Care Authors: Sarina Schrager Kelita Fox Rachel Lee Source Type: research
Abnormal Uterine Bleeding Associated With Hormonal Contraception
This article includes algorithms to help clinicians treat abnormal uterine bleeding in people using levonorgestrel intrauterine devices, depo-medroxyprogesterone acetate, progestin implant, progestin-only pills, and combined hormonal contraception. For patients with levonorgestrel intrauterine devices, physicians should first ensure that the device is correctly placed within the uterus, then consider nonsteroidal anti-inflammatory drugs as a first-line treatment for abnormal uterine bleeding; estradiol can be used if nonsteroidal anti-inflammatory drugs are ineffective. For depo-medroxyprogesterone acetate or progestin imp...
Source: American Family Physician - February 23, 2024 Category: Primary Care Authors: Sarina Schrager Kelita Fox Rachel Lee Source Type: research
Abnormal Uterine Bleeding Associated With Hormonal Contraception
This article includes algorithms to help clinicians treat abnormal uterine bleeding in people using levonorgestrel intrauterine devices, depo-medroxyprogesterone acetate, progestin implant, progestin-only pills, and combined hormonal contraception. For patients with levonorgestrel intrauterine devices, physicians should first ensure that the device is correctly placed within the uterus, then consider nonsteroidal anti-inflammatory drugs as a first-line treatment for abnormal uterine bleeding; estradiol can be used if nonsteroidal anti-inflammatory drugs are ineffective. For depo-medroxyprogesterone acetate or progestin imp...
Source: American Family Physician - February 23, 2024 Category: Primary Care Authors: Sarina Schrager Kelita Fox Rachel Lee Source Type: research
Abnormal Uterine Bleeding Associated With Hormonal Contraception
This article includes algorithms to help clinicians treat abnormal uterine bleeding in people using levonorgestrel intrauterine devices, depo-medroxyprogesterone acetate, progestin implant, progestin-only pills, and combined hormonal contraception. For patients with levonorgestrel intrauterine devices, physicians should first ensure that the device is correctly placed within the uterus, then consider nonsteroidal anti-inflammatory drugs as a first-line treatment for abnormal uterine bleeding; estradiol can be used if nonsteroidal anti-inflammatory drugs are ineffective. For depo-medroxyprogesterone acetate or progestin imp...
Source: American Family Physician - February 23, 2024 Category: Primary Care Authors: Sarina Schrager Kelita Fox Rachel Lee Source Type: research
