Jianpi Decoction Combined with Medroxyprogesterone Acetate Alleviates Cancer Cachexia and Prevents Muscle Atrophy by Directly Inhibiting E3 Ubiquitin Ligase
ConclusionsAdministration of JP combined with MPA restores tumor-induced cachexia conditions. In addition, the profound effect of JP combined with MPA on tumor-induced cachexia may be due to its inhibition of muscle proteolysis (E3 ubiquitinase system). (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - August 24, 2023 Category: Internal Medicine Source Type: research
Jianpi Decoction Combined with Medroxyprogesterone Acetate Alleviates Cancer Cachexia and Prevents Muscle Atrophy by Directly Inhibiting E3 Ubiquitin Ligase
CONCLUSIONS: Administration of JP combined with MPA restores tumor-induced cachexia conditions. In addition, the profound effect of JP combined with MPA on tumor-induced cachexia may be due to its inhibition of muscle proteolysis (E3 ubiquitinase system).PMID:37612478 | DOI:10.1007/s11655-023-3702-4 (Source: Cancer Control)
Source: Cancer Control - August 23, 2023 Category: Cancer & Oncology Authors: Qi Li Zhao-di Kong Huan Wang Hong-Hui Gu Zhong Chen Shi-Guang Li Yi-Qi Chen Yu Cai Zhen-Jiang Yang Source Type: research
Comparison of Thromboembolism Outcomes in Patients with Sickle Cell Disease Prescribed Hormonal Contraception
This study aims to assess patterns of hormonal contraceptive use and compare risk of contraception-related TE between combined hormonal contraceptives (CHC) and progestin-only contraceptives (POC). Patients with SCD between 12-44 years with a new prescription of a hormonal contraceptive in the CMS MAX database (2006-2018) were followed for one year. Cox regression analysis was used to calculate the hazard ratio (HR) of TE. We identified 7,173 new users: 44.6% initiated CHC and 55.4% initiated POC. Combined oral contraceptive pills (OCP) (36.5%) and progestin-only depot medroxyprogesterone acetate (33.9%) were the most freq...
Source: Adv Data - August 16, 2023 Category: Epidemiology Authors: Natasha S Bala Joseph R Stanek Sara K Vesely Robert M Cronin Susan E Creary Andrea H Roe Wendy Xu Sarah H O'Brien Source Type: research
Characteristics of Menstrual Suppression and Its Association With Mental Health in Transgender Adolescents
CONCLUSION: Effectiveness of and satisfaction with menstrual suppression were high in TGD adolescents receiving this treatment. These findings support the routine exploration and management of menstrual health in TGD adolescents. However, menstrual suppression was not associated with any difference in gender dysphoria, depression, or anxiety symptoms in this cross-sectional study, and longitudinal studies are required to better investigate this.PMID:37562053 | DOI:10.1097/AOG.0000000000005317 (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - August 10, 2023 Category: OBGYN Authors: Dehlia Moussaoui Michele A O'Connell Charlotte V Elder Sonia R Grover Ken C Pang Source Type: research
Characteristics of Menstrual Suppression and Its Association With Mental Health in Transgender Adolescents
CONCLUSION: Effectiveness of and satisfaction with menstrual suppression were high in TGD adolescents receiving this treatment. These findings support the routine exploration and management of menstrual health in TGD adolescents. However, menstrual suppression was not associated with any difference in gender dysphoria, depression, or anxiety symptoms in this cross-sectional study, and longitudinal studies are required to better investigate this.PMID:37562053 | DOI:10.1097/AOG.0000000000005317 (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - August 10, 2023 Category: OBGYN Authors: Dehlia Moussaoui Michele A O'Connell Charlotte V Elder Sonia R Grover Ken C Pang Source Type: research
Characteristics of Menstrual Suppression and Its Association With Mental Health in Transgender Adolescents
CONCLUSION: Effectiveness of and satisfaction with menstrual suppression were high in TGD adolescents receiving this treatment. These findings support the routine exploration and management of menstrual health in TGD adolescents. However, menstrual suppression was not associated with any difference in gender dysphoria, depression, or anxiety symptoms in this cross-sectional study, and longitudinal studies are required to better investigate this.PMID:37562053 | DOI:10.1097/AOG.0000000000005317 (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - August 10, 2023 Category: OBGYN Authors: Dehlia Moussaoui Michele A O'Connell Charlotte V Elder Sonia R Grover Ken C Pang Source Type: research
Characteristics of Menstrual Suppression and Its Association With Mental Health in Transgender Adolescents
CONCLUSION: Effectiveness of and satisfaction with menstrual suppression were high in TGD adolescents receiving this treatment. These findings support the routine exploration and management of menstrual health in TGD adolescents. However, menstrual suppression was not associated with any difference in gender dysphoria, depression, or anxiety symptoms in this cross-sectional study, and longitudinal studies are required to better investigate this.PMID:37562053 | DOI:10.1097/AOG.0000000000005317 (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - August 10, 2023 Category: OBGYN Authors: Dehlia Moussaoui Michele A O'Connell Charlotte V Elder Sonia R Grover Ken C Pang Source Type: research
Characteristics of Menstrual Suppression and Its Association With Mental Health in Transgender Adolescents
CONCLUSION: Effectiveness of and satisfaction with menstrual suppression were high in TGD adolescents receiving this treatment. These findings support the routine exploration and management of menstrual health in TGD adolescents. However, menstrual suppression was not associated with any difference in gender dysphoria, depression, or anxiety symptoms in this cross-sectional study, and longitudinal studies are required to better investigate this.PMID:37562053 | DOI:10.1097/AOG.0000000000005317 (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - August 10, 2023 Category: OBGYN Authors: Dehlia Moussaoui Michele A O'Connell Charlotte V Elder Sonia R Grover Ken C Pang Source Type: research
Characteristics of Menstrual Suppression and Its Association With Mental Health in Transgender Adolescents
CONCLUSION: Effectiveness of and satisfaction with menstrual suppression were high in TGD adolescents receiving this treatment. These findings support the routine exploration and management of menstrual health in TGD adolescents. However, menstrual suppression was not associated with any difference in gender dysphoria, depression, or anxiety symptoms in this cross-sectional study, and longitudinal studies are required to better investigate this.PMID:37562053 | DOI:10.1097/AOG.0000000000005317 (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - August 10, 2023 Category: OBGYN Authors: Dehlia Moussaoui Michele A O'Connell Charlotte V Elder Sonia R Grover Ken C Pang Source Type: research
Selection, Initiation, Continuation, and Efficacy of Reversible Contraception Among Enlisted U.S. Service Women in Their First Term of Service From 2012 to 2020
This study examines rates of contraceptive selection, initiation, continuation, and efficacy among junior enlisted service women in their first 4-year enlistment period, and the service branch specific variability in these outcomes.METHODS: This study is a secondary analysis of Military Healthcare Data Repository records from women who began basic training between 2012 and 2020 and remained on active duty for at least 12 months. We used Kaplan-Meier analyses to examine the effect of age and military branch on contraceptive continuation and efficacy. We used binomial regression for interval censored data, to assess the asso...
Source: Military Medicine - August 5, 2023 Category: International Medicine & Public Health Authors: Christina M Roberts Joshua M Smalley William P Adelman Larissa F Weir Elisabeth Hisle-Gorman Source Type: research
Retrospective study on long-term effects of hormone replacement therapy (HRT) and iron chelation therapy on glucose homeostasis and insulin secretion in female ß- thalassemia major (β-TM) patients with acquired hypogonadotropic- hypogonadism (AHH)
CONCLUSION: Deterioration of glycemia (dysglycemia) occurred in 45.4% (5/11) of thalassemic females on long-term HRT. Additional studies are needed to elucidate the validity of our preliminary observations.PMID:37539597 | DOI:10.23750/abm.v94i4.14631 (Source: Acta Bio-Medica : Atenei Parmensis)
Source: Acta Bio-Medica : Atenei Parmensis - August 4, 2023 Category: General Medicine Authors: Vincenzo De Sanctis Shahina Daar Ashraf Soliman Ploutarchos Tzoulis Salvatore Di Maio Christos Kattamis Source Type: research
Retrospective study on long-term effects of hormone replacement therapy (HRT) and iron chelation therapy on glucose homeostasis and insulin secretion in female ß- thalassemia major (β-TM) patients with acquired hypogonadotropic- hypogonadism (AHH)
CONCLUSION: Deterioration of glycemia (dysglycemia) occurred in 45.4% (5/11) of thalassemic females on long-term HRT. Additional studies are needed to elucidate the validity of our preliminary observations.PMID:37539597 | DOI:10.23750/abm.v94i4.14631 (Source: Acta Bio-Medica : Atenei Parmensis)
Source: Acta Bio-Medica : Atenei Parmensis - August 4, 2023 Category: General Medicine Authors: Vincenzo De Sanctis Shahina Daar Ashraf Soliman Ploutarchos Tzoulis Salvatore Di Maio Christos Kattamis Source Type: research
Retrospective study on long-term effects of hormone replacement therapy (HRT) and iron chelation therapy on glucose homeostasis and insulin secretion in female ß- thalassemia major (β-TM) patients with acquired hypogonadotropic- hypogonadism (AHH)
CONCLUSION: Deterioration of glycemia (dysglycemia) occurred in 45.4% (5/11) of thalassemic females on long-term HRT. Additional studies are needed to elucidate the validity of our preliminary observations.PMID:37539597 | DOI:10.23750/abm.v94i4.14631 (Source: Acta Bio-Medica : Atenei Parmensis)
Source: Acta Bio-Medica : Atenei Parmensis - August 4, 2023 Category: General Medicine Authors: Vincenzo De Sanctis Shahina Daar Ashraf Soliman Ploutarchos Tzoulis Salvatore Di Maio Christos Kattamis Source Type: research
