Medroxyprogesterone Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

MET Inhibits the Proliferation of EC Cells by Increasing MPA Sensitivity
CONCLUSIONS: MET inhibited the proliferation of EC cells by increasing MPA-sensitivity, which was dependent on the inhibition of the CD133 expression and the Akt/mTOR pathway. In addition, if MET acts as an effective progestin sensitizer, it certainly offers promising therapeutic prospects for patients with early-stage EC or overgrown endometrium who have fertility requirements.PMID:37171945 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - May 12, 2023 Category: Complementary Medicine Authors: Fang Sun Jiayun Zhou Yongxin Hao Lei Kuang Bei Zhang Source Type: research

Role of steroid receptor-associated and regulated protein in tumor progression and progesterone receptor signaling in endometrial cancer
CONCLUSIONS: This study illustrates that SRARP exerts a tumor-suppressive effect by inhibiting the epithelial-mesenchymal transition via Wnt signaling in EC. In addition, SRARP positively modulates PR expression and interacts with PR to regulate PR downstream target genes.PMID:37144734 | DOI:10.1097/CM9.0000000000002537 (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - May 5, 2023 Category: General Medicine Authors: Jie Liu Zhiqi Wang Jingyi Zhou Jiaqi Wang Xiangjun He Jianliu Wang Source Type: research

Evaluations of memory, anxiety, and the growth factor IGF-1R after post-surgical menopause treatment with a highly selective progestin
Behav Brain Res. 2023 Apr 19:114442. doi: 10.1016/j.bbr.2023.114442. Online ahead of print.ABSTRACTProgestogens are a key component of menopausal hormone therapies. While some progestogens can be detrimental to cognition, there is preclinical evidence that progestogens with a strong progesterone-receptor affinity benefit some molecular mechanisms believed to underlie cognitive function. Thus, a progestin that maximizes progesterone-receptor affinity and minimizes affinities to other receptors may be cognitively beneficial. We evaluated segesterone-acetate (SGA), a 19-norprogesterone derivative with a strong progesterone-re...
Source: Behavioural Brain Research - April 19, 2023 Category: Neurology Authors: Victoria E Bernaud Stephanie V Koebele Steven N Northup-Smith Mari N Willeman Charlotte Barker Alex Schatzki-Lumpkin Maria Valenzuela Sanchez Heather A Bimonte-Nelson Source Type: research

Oral estradiol/micronized progesterone may be associated with lower risk of venous thromboembolism compared with conjugated equine estrogens/medroxyprogesterone acetate in real-world practice
Menopause, a natural phase in the life cycle of women that usually occurs between ages 40 and 58  years, is often associated with bothersome vasomotor, urogenital, and sleep disturbances [1]. Hot flashes and night sweats affect up to 80 % of women [2] and can significantly impair the women's quality of life. Hot flashes represent the most common menopause-related reason for which women seek medical care in the perimenopausal and menopausal period [3,4]. (Source: Maturitas)
Source: Maturitas - April 12, 2023 Category: Primary Care Authors: Nick Panay, Rossella E. Nappi, Petra Stute, Santiago Palacios, Tomasz Paszkowski, Risa Kagan, David F. Archer, Julie H éroux, Mitra Boolell Tags: Original article Source Type: research

Is self-administered DMPA an answer to contraception access in the post-Roe era?
J Fam Pract. 2023 Mar;72(2):84-86. doi: 10.12788/jfp.0558.ABSTRACTCompared with provider-administered depot medroxyprogesterone acetate, a prefilled formulation may offer patients improved access to effective contraception.PMID:36947783 | DOI:10.12788/jfp.0558 (Source: The Journal of Family Practice)
Source: The Journal of Family Practice - March 22, 2023 Category: Practice Management Authors: Lindsay Nakaishi Gregory Castelli Source Type: research

Is self-administered DMPA an answer to contraception access in the post-Roe era?
J Fam Pract. 2023 Mar;72(2):84-86. doi: 10.12788/jfp.0558.ABSTRACTCompared with provider-administered depot medroxyprogesterone acetate, a prefilled formulation may offer patients improved access to effective contraception.PMID:36947783 | PMC:PMC10032666 | DOI:10.12788/jfp.0558 (Source: The Journal of Family Practice)
Source: The Journal of Family Practice - March 22, 2023 Category: Practice Management Authors: Lindsay Nakaishi Gregory Castelli Source Type: research