Polyethylene glycol hypersensitivity, patient outcomes in a seven year retrospective study
CONCLUSION: PEG hypersensitivity is an uncommon cause of drug-induced anaphylaxis. Four index drugs accounted for two-thirds of cases and reactions to these drugs should prompt PEG hypersensitivity investigations. PEG IDT increases diagnostic yield. The role of SPT with higher MW PEGs requires further attention. Further studies are required to understand PEG thresholds and PEG equivalent doses of various administration routes. COVID-19 vaccines were tolerated by all exposed.PMID:38561050 | DOI:10.1016/j.anai.2024.03.022 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 1, 2024 Category: Allergy & Immunology Authors: Oyindamola Stephanie Kayode Alla Nakonechna Leonard Quok Chean Siew Magdalena Dziadzio Lucinda Kennard Krzysztof Rutkowski Rita Mirakian Annette Wagner Source Type: research
Polyethylene glycol hypersensitivity, patient outcomes in a seven year retrospective study
CONCLUSION: PEG hypersensitivity is an uncommon cause of drug-induced anaphylaxis. Four index drugs accounted for two-thirds of cases and reactions to these drugs should prompt PEG hypersensitivity investigations. PEG IDT increases diagnostic yield. The role of SPT with higher MW PEGs requires further attention. Further studies are required to understand PEG thresholds and PEG equivalent doses of various administration routes. COVID-19 vaccines were tolerated by all exposed.PMID:38561050 | DOI:10.1016/j.anai.2024.03.022 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 1, 2024 Category: Allergy & Immunology Authors: Oyindamola Stephanie Kayode Alla Nakonechna Leonard Quok Chean Siew Magdalena Dziadzio Lucinda Kennard Krzysztof Rutkowski Rita Mirakian Annette Wagner Source Type: research
Polyethylene glycol hypersensitivity, patient outcomes in a seven year retrospective study
CONCLUSION: PEG hypersensitivity is an uncommon cause of drug-induced anaphylaxis. Four index drugs accounted for two-thirds of cases and reactions to these drugs should prompt PEG hypersensitivity investigations. PEG IDT increases diagnostic yield. The role of SPT with higher MW PEGs requires further attention. Further studies are required to understand PEG thresholds and PEG equivalent doses of various administration routes. COVID-19 vaccines were tolerated by all exposed.PMID:38561050 | DOI:10.1016/j.anai.2024.03.022 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 1, 2024 Category: Allergy & Immunology Authors: Oyindamola Stephanie Kayode Alla Nakonechna Leonard Quok Chean Siew Magdalena Dziadzio Lucinda Kennard Krzysztof Rutkowski Rita Mirakian Annette Wagner Source Type: research
Effects of injectable contraception with depot medroxyprogesterone acetate or norethisterone enanthate on estradiol levels and menstrual, psychological and behavioral measures relevant to HIV risk: The WHICH randomized trial
by Mandisa Singata-Madliki, Jenni Smit, Mags Beksinska, Yusentha Balakrishna, Chanel Avenant, Ivana Beesham, Ishen Seocharan, Joanne Batting, Janet P. Hapgood, G. Justus Hofmeyr
BackgroundObservational data suggest lower HIV risk with norethisterone enanthate (NET-EN) than with depo-medroxyprogesterone acetate intramuscular (DMPA-IM) injectable contraceptives. If confirmed, a switch between these similar injectable methods would be programmatically feasible and could impact the trajectory of the HIV epidemic. We aimed in this paper to investigate the effects of DMPA-IM and NET-EN on estradiol levels, measures of depression...
Source: PLoS One - March 26, 2024 Category: Biomedical Science Authors: Mandisa Singata-Madliki Source Type: research
Endometriosis-associated massive ascites in a young Nigerian lady
We report a 31-year-old nulligravida with progressive abdominal swelling, worsening dysmenorrhea, weight loss and a family history of ovarian tumour. Pelvic ultrasonography and Computed Tomography scans suggested an ovarian mass suspected to be an ovarian malignancy. Exploratory laparotomy revealed massive haemorrhagic ascites (8.6 litre) and multiple nodular masses on the anterior abdominal wall, omentum, bowel and pelvic organs, which were biopsied and confirmed on histopathology to be endometriosis. She had drainage of ascites and hormonal suppression using progestogen (Medroxyprogesterone acetate) with no recurrence in...
Source: Ghana Medical Journal - March 20, 2024 Category: African Health Authors: Abiodun S Adeniran Munirdeen A Ijaiya Kazeem O O Ibrahim Saidu Ibrahim Olaleke O Folaranmi Source Type: research
