Implementation strategies to scale up self-administered depot medroxyprogesterone acetate subcutaneous injectable contraception: a scoping review
ConclusionThis scoping review reported a wide range of interventions employed by countries and programs to scale up DMPA-SC self-administration but minimal evidence of the scale-up outcomes. Evidence from this review can help design better programs that improves access to quality family planning services to achieve the Sustainable Development Goals (SDG) targets 3.7. However, efforts should focus on rigorous implementation research that assess scaled up self-administered DMPA-SC interventions and report their outcomes.RegistrationThe protocol for this review was registered in the protocols.io repository (https://www.protoc...
Source: Systematic Reviews - July 4, 2023 Category: International Medicine & Public Health Source Type: research
A Pilot Study of Adolescent and Young Adult Experience with Subcutaneous Depot Medroxyprogesterone Acetate
To describe satisfaction with and preference for subcutaneous depot medroxyprogesterone acetate (DMPA-SC), along with adherence and feasibility, in adolescents and young adults (AYAs). (Source: Journal of Pediatric and Adolescent Gynecology)
Source: Journal of Pediatric and Adolescent Gynecology - June 22, 2023 Category: OBGYN Authors: Hunter J. Wernick, Evelyn Wentzel, Kenneth Jackson, Kelsey Schmuhl, Olivia Valenti, Andrea E. Bonny, Elise Berlan Source Type: research
Update on the Impact of Depot Medroxyprogesterone Acetate on Vaginal Mucosal Endpoints and Relevance to Sexually Transmitted Infections
AbstractPurpose of ReviewThe long-acting reversible intramuscularly-injected contraceptive depot medroxyprogesterone acetate (DMPA-IM) is widely used by cisgender women in Africa. Although DMPA-IM provides reliable contraception, potential effects on the female genital tract (FGT) mucosa have raised concern, including risk of HIV infection. This review summarises and compares evidence from observational cohort studies and the randomised Evidence for Contraceptive Options in HIV Outcomes (ECHO) Trial.Recent FindingsAlthough previous observational studies found women using DMPA-IM had higher abundance of bacterial vaginosis ...
Source: Current HIV/AIDS Reports - June 21, 2023 Category: Infectious Diseases Source Type: research
Treatment compliance and venous thromboembolism risk in women receiving estradiol/micronised progesterone vs conjugated estrogens/medroxyprogesterone
Context: The Women ’s Health Initiative study (WHI) reported the increased risk of venous thromboembolism (VTE) among women treated with conjugated equine estrogens/medroxyprogesterone acetate (CEE/MPA) vs. placebo. (Source: Maturitas)
Source: Maturitas - June 8, 2023 Category: Primary Care Authors: Rossella Nappi, Nick Panay, Santiago Palacios, Tomasz Paszkowski, Julie H éroux, Mitra Boolell Tags: Abstract ID: 49 Source Type: research
Mifepristone: effect on PBMC receptivity in healthy women and women with endometrial hyperplastic processes
In our previous study we found that peripheral blood mononuclear cells (PBMC) at women with endometrial proliferative processes increase their sensitivity to the suppressing action of sex steroid hormones. In order to reduce the receptivity of PBMC, it is possible to prescribe hormonal drugs. However, when studying the relative binding activity of the receptors, it was found that the affinity of medroxyprogesterone acetate, norethisterone acetate, in PBMC was 54% and 48% respectively. And research of selective modulators of progesterone receptors is promising. (Source: Maturitas)
Source: Maturitas - June 8, 2023 Category: Primary Care Authors: Dina Gutorova, Valentina Breusenko, Elena Kareva Tags: Abstract ID: 248 Source Type: research
MET Inhibits the Proliferation of EC Cells by Increasing MPA Sensitivity
CONCLUSIONS: MET inhibited the proliferation of EC cells by increasing MPA-sensitivity, which was dependent on the inhibition of the CD133 expression and the Akt/mTOR pathway. In addition, if MET acts as an effective progestin sensitizer, it certainly offers promising therapeutic prospects for patients with early-stage EC or overgrown endometrium who have fertility requirements.PMID:37171945 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - May 12, 2023 Category: Complementary Medicine Authors: Fang Sun Jiayun Zhou Yongxin Hao Lei Kuang Bei Zhang Source Type: research
MET Inhibits the Proliferation of EC Cells by Increasing MPA Sensitivity
CONCLUSIONS: MET inhibited the proliferation of EC cells by increasing MPA-sensitivity, which was dependent on the inhibition of the CD133 expression and the Akt/mTOR pathway. In addition, if MET acts as an effective progestin sensitizer, it certainly offers promising therapeutic prospects for patients with early-stage EC or overgrown endometrium who have fertility requirements.PMID:37171945 (Source: Cancer Control)
Source: Cancer Control - May 12, 2023 Category: Cancer & Oncology Authors: Fang Sun Jiayun Zhou Yongxin Hao Lei Kuang Bei Zhang Source Type: research
Fertility-sparing hormonal treatment in patients with stage I endometrial cancer of grade 2 without myometrial invasion and grade 1-2 with superficial myometrial invasion: Gynecologic Oncology Research Investigators coLLaborAtion study (GORILLA-2001)
CONCLUSION: The overall response rate to FST was promising, however, the PD rate was significant during the first 12 months of FST. Therefore, performing thorough endometrial biopsy and imaging studies is essential to strictly evaluate the extent of the disease every 3 months from FST initiation.PMID:37172410 | DOI:10.1016/j.ygyno.2023.04.027 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 12, 2023 Category: Cancer & Oncology Authors: A Jin Lee Eun Jung Yang Nam Kyeong Kim Yeorae Kim Dong Hoon Suh Jeeyeon Kim Joo-Hyuk Son Tae-Wook Kong Suk-Joon Chang Dong Won Hwang Soo Jin Park Hee Seung Kim Ji Geun Yoo Sung Jong Lee Yoo-Young Lee Seung-Hyuk Shim Source Type: research
MET Inhibits the Proliferation of EC Cells by Increasing MPA Sensitivity
CONCLUSIONS: MET inhibited the proliferation of EC cells by increasing MPA-sensitivity, which was dependent on the inhibition of the CD133 expression and the Akt/mTOR pathway. In addition, if MET acts as an effective progestin sensitizer, it certainly offers promising therapeutic prospects for patients with early-stage EC or overgrown endometrium who have fertility requirements.PMID:37171945 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - May 12, 2023 Category: Complementary Medicine Authors: Fang Sun Jiayun Zhou Yongxin Hao Lei Kuang Bei Zhang Source Type: research
MET Inhibits the Proliferation of EC Cells by Increasing MPA Sensitivity
CONCLUSIONS: MET inhibited the proliferation of EC cells by increasing MPA-sensitivity, which was dependent on the inhibition of the CD133 expression and the Akt/mTOR pathway. In addition, if MET acts as an effective progestin sensitizer, it certainly offers promising therapeutic prospects for patients with early-stage EC or overgrown endometrium who have fertility requirements.PMID:37171945 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - May 12, 2023 Category: Complementary Medicine Authors: Fang Sun Jiayun Zhou Yongxin Hao Lei Kuang Bei Zhang Source Type: research
MET Inhibits the Proliferation of EC Cells by Increasing MPA Sensitivity
CONCLUSIONS: MET inhibited the proliferation of EC cells by increasing MPA-sensitivity, which was dependent on the inhibition of the CD133 expression and the Akt/mTOR pathway. In addition, if MET acts as an effective progestin sensitizer, it certainly offers promising therapeutic prospects for patients with early-stage EC or overgrown endometrium who have fertility requirements.PMID:37171945 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - May 12, 2023 Category: Complementary Medicine Authors: Fang Sun Jiayun Zhou Yongxin Hao Lei Kuang Bei Zhang Source Type: research
MET Inhibits the Proliferation of EC Cells by Increasing MPA Sensitivity
CONCLUSIONS: MET inhibited the proliferation of EC cells by increasing MPA-sensitivity, which was dependent on the inhibition of the CD133 expression and the Akt/mTOR pathway. In addition, if MET acts as an effective progestin sensitizer, it certainly offers promising therapeutic prospects for patients with early-stage EC or overgrown endometrium who have fertility requirements.PMID:37171945 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - May 12, 2023 Category: Complementary Medicine Authors: Fang Sun Jiayun Zhou Yongxin Hao Lei Kuang Bei Zhang Source Type: research
MET Inhibits the Proliferation of EC Cells by Increasing MPA Sensitivity
CONCLUSIONS: MET inhibited the proliferation of EC cells by increasing MPA-sensitivity, which was dependent on the inhibition of the CD133 expression and the Akt/mTOR pathway. In addition, if MET acts as an effective progestin sensitizer, it certainly offers promising therapeutic prospects for patients with early-stage EC or overgrown endometrium who have fertility requirements.PMID:37171945 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - May 12, 2023 Category: Complementary Medicine Authors: Fang Sun Jiayun Zhou Yongxin Hao Lei Kuang Bei Zhang Source Type: research
MET Inhibits the Proliferation of EC Cells by Increasing MPA Sensitivity
CONCLUSIONS: MET inhibited the proliferation of EC cells by increasing MPA-sensitivity, which was dependent on the inhibition of the CD133 expression and the Akt/mTOR pathway. In addition, if MET acts as an effective progestin sensitizer, it certainly offers promising therapeutic prospects for patients with early-stage EC or overgrown endometrium who have fertility requirements.PMID:37171945 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - May 12, 2023 Category: Complementary Medicine Authors: Fang Sun Jiayun Zhou Yongxin Hao Lei Kuang Bei Zhang Source Type: research
