Effects of a fertility-sparing re-treatment for recurrent atypical endometrial hyperplasia and endometrial cancer: a systematic literature review
J Gynecol Oncol. 2023 Mar 6. doi: 10.3802/jgo.2023.34.e49. Online ahead of print.ABSTRACTTo examine the effectiveness of progestin re-treatment for recurrent endometrial intraepithelial neoplasia (EIN), atypical endometrial hyperplasia (AH) and endometrial cancer (EC) following initial fertility-sparing treatment. A comprehensive systematic review and meta-analysis were conducted by an Expert Panel of the Japan Society of Gynecologic Oncology Endometrial Cancer Committee. Multiple search engines, including PubMed/MEDLINE and the Cochrane Database, were searched in December 2021 using the keywords "Endometrial neoplasms," "...
Source: Journal of Gynecologic Oncology - March 17, 2023 Category: OBGYN Authors: Isao Murakami Hiroko Machida Tohru Morisada Yasuhisa Terao Tsutomu Tabata Mikio Mikami Yasuyuki Hirashima Yoichi Kobayashi Tsukasa Baba Satoru Nagase Source Type: research
Cancers, Vol. 15, Pages 1799: Do Not Forget about Hormonal Therapy for Recurrent Endometrial Cancer: A Review of Options, Updates, and New Combinations
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Hormonal therapy has long been a treatment modality for recurrent endometrial cancer. It is appealing for patients with low-grade, slow-growing tumors or in patients for which other treatment types may be too toxic. Hormonal therapy is well tolerated and has response rates ranging from 9 to 33%. Hormonal treatment options take advantage of the estrogen-dependent molecular pathways in endometrial cancers. Current options for hormonal therapies include progesterone therapy (medroxyprogesterone acetate and megestrol acetate) as a single agent or in combination and agents that target the estrogen pathway. Aromatase inh...
Source: Cancers - March 16, 2023 Category: Cancer & Oncology Authors: Vincent M. Wagner Floor J. Backes Tags: Review Source Type: research
Endometrial stromal cell miR-19b-3p release is reduced during decidualization implying a role in decidual-trophoblast cross-talk
DiscussionOur data demonstrates that decidualization represses miR release by hESFs and overexpression of miR-19b-3p was found in endometrial tissue from patients with a history of early pregnancy loss. miR-19b-3p impaired HTR8/Svneo proliferation implying a role in trophoblast function. Overall we speculate that miR release by hESF may regulate other cell types within the decidua and that appropriate release of miRs by decidualized hESF is essential for healthy implantation and placentation. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 16, 2023 Category: Endocrinology Source Type: research
Patient ’s experience and satisfaction with self-administered subcutaneous depot medroxyprogesterone acetate use during the first year of COVID-19
Self-administered subcutaneous (SC) depot medroxyprogesterone acetate (DMPA) can improve contraception access by eliminating the visit at a health center for administration.For the patients at our New York City health centers who were offered a switch to self-administered DMPA-SC at the onset of the coronavirus disease 2019 (COVID-19) pandemic, we sought to understand their experience of choosing to switch, their experience accessing and using the method, and their method satisfaction. (Source: Contraception)
Source: Contraception - March 15, 2023 Category: OBGYN Authors: Tiffany Joyce Smith, Talia K Urdanigo, Nandini Shroff, Susan E Rubin Tags: Original Research Article Source Type: research
16. Validation of a New Instructional Video for Adolescent Self-Administration of Subcutaneous Depot-medroxyprogesterone
Approximately 15% of adolescents have used depot-medroxyprogesterone. Although traditionally administered in the clinical space, it is effective and well tolerated when subcutaneously self-administered; however, the technique must be taught, and office visits may be a barrier to care. There are no currently available online instructional videos specific to both this age group and medication. We hypothesize that our peer-to peer video lesson is easy to understand, effective as a stand-alone method for accurately teaching safe technique, and well received by adolescents, who will continue to self-administer the medication. (...
Source: Journal of Pediatric and Adolescent Gynecology - March 11, 2023 Category: OBGYN Authors: Caitlin McCarthy, Amanda French, Erin K. Fee Jarem Source Type: research
