Retention in care and viral suppression in differentiated service delivery models for HIV treatment delivery in sub-Saharan Africa: a rapid systematic review.
CONCLUSIONS: Existing evidence on the clinical outcomes of DSD models for HIV treatment in sub-Saharan Africa is limited in both quantity and quality but suggests that retention in care and viral suppression are roughly equivalent to those in conventional models of care. PMID: 33247517 [PubMed - as supplied by publisher] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - November 29, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Antiretroviral treatment interruption among people living with HIV during COVID-19 outbreak in China: a nationwide cross-sectional study.
CONCLUSIONS: A significant proportion of PLHIV in China are at risk of ATI during the COVID-19 outbreak and some have already experienced ATI. Correlates of ATI and self-reported barriers to ART suggest that social disruptions from COVID-19 have contributed to ATI. Our findings demonstrate an urgent need for policies and interventions to maintain access to HIV care during public health emergencies. PMID: 33247541 [PubMed - as supplied by publisher] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - November 29, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Incentives conditioned on tenofovir levels to support PrEP adherence among young South African women: a randomized trial.
CONCLUSIONS: Among South African AGYW initiating PrEP, drug levels indicated high PrEP adherence in almost half of women at Month 3, with a non-statistically significant higher proportion with high adherence among those in the incentive group. Over half persisted with the 12-month PrEP programme although high adherence declined after Month 3. Strategies to support PrEP adherence and persistence and longer-acting PrEP formulations are needed. PMID: 33247553 [PubMed - as supplied by publisher] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - November 29, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Prevalence of nonsuppressed viral load and associated factors among HIV-positive adults receiving antiretroviral therapy in Eswatini, Lesotho, Malawi, Zambia and Zimbabwe (2015 to 2017): results from population-based nationally representative surveys.
We examined VLS and its determinants among adults receiving ART for at least four months. METHODS: We analysed data from the population-based HIV impact assessment (PHIA) surveys in Eswatini, Lesotho, Malawi, Zambia and Zimbabwe (2015 to 2017). PHIA surveys are nationally representative, cross-sectional household surveys. Data collection included structured interviews, home-based HIV testing and laboratory testing. Blood samples from PLHIV were analysed for HIV RNA, CD4 counts and recent exposure to antiretroviral drugs (ARVs). We calculated representative estimates for the prevalence of VLS (viral load
Source: Journal of the International AIDS Society - November 25, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Prevalence of and factors associated with advanced HIV disease among newly diagnosed people living with HIV in Guangdong Province, China.
This study aimed to explore the prevalence of and factors related to AHD among newly diagnosed PLHIV in Guangdong Province, China. METHODS: Newly diagnosed PLHIV were recruited from six cities in Guangdong Province from May 2018 to June 2019. AHD was defined as an initial CD4 count
Source: Journal of the International AIDS Society - November 25, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

New pathogen, same disparities: why COVID-19 and HIV remain prevalent in U.S. communities of colour and implications for ending the HIV epidemic.
CONCLUSIONS: Racism and discrimination place communities of colour at greater risk for COVID-19 as well as HIV. Achieving and sustaining an end to the U.S. HIV epidemic will require structural change to eliminate conditions that give rise to and maintain disparities. PMID: 33222424 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - November 24, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Paediatric HIV: we are not done yet!
Authors: Penazzato M PMID: 33215880 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - November 22, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Greater dapivirine release from the dapivirine vaginal ring is correlated with lower risk of HIV-1 acquisition: a secondary analysis from a randomized, placebo-controlled trial.
Authors: Brown ER, Hendrix CW, van der Straten A, Kiweewa FM, Mgodi NM, Palanee-Philips T, Marzinke MA, Bekker LG, Soto-Torres L, Hillier SL, Baeten JM, MTN-020/ASPIRE Study Team Abstract INTRODUCTION: A vaginal ring containing 25 mg of the antiretroviral dapivirine has demonstrated efficacy in reducing women's risk of sexually acquiring HIV-1; however, imperfect ring use likely diluted efficacy estimates in clinical trials. The amount of dapivirine remaining in returned rings may reflect the extent of product use, permitting estimation of HIV protection in the context of consistent use. METHODS: We measur...
Source: Journal of the International AIDS Society - November 21, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

A retrospective analysis of the care cascades for non-communicable disease and mental health among people living with HIV at a tertiary-care centre in Malaysia: opportunities to identify gaps and optimize care.
CONCLUSIONS: Systematic screening must be introduced to identify NCDs and mental health issues among PLWH followed by proper linkage and referrals for management of screen-positive cases. Assessment of factors associated with attrition at each step of the care cascade is critically needed to improve health outcomes in our aging patients. PMID: 33206473 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - November 21, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

A call to improve understanding of Undetectable equals Untransmittable (U  = U) in Brazil: a web-based survey.
In this study, we documented the perceived accuracy of U = U in Brazil in three different groups: PLHIV, HIV-negative/unknown cisgender gay/bisexual men who have sex with men (GBM) and HIV-negative/unknown other populations (POP). METHODS: Adult (age ≥ 18y) Brazilians were recruited during October 2019 to complete a web-based survey advertised on Grindr, Facebook and WhatsApp. Perceived accuracy of U = U was assessed with the question: "With regards to HIV-positive individuals transmitting HIV through sexual contact, how accurate do you believe the slogan U = U is?" ...
Source: Journal of the International AIDS Society - November 11, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Sexual behaviour change following HIV testing services: a systematic review and meta-analysis.
CONCLUSIONS: Our findings highlight the importance of using limited resources towards HTS strategies that focus on early HIV diagnosis, treatment and prevention services rather than resources dedicated to supplementing or enhancing HTS with additional counselling or other interventions. PMID: 33161636 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - November 11, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

COVID-19, HIV and key populations: cross-cutting issues and the need for population-specific responses.
CONCLUSIONS: Disruptions to both licit and illicit supply chains, loss of income and livelihoods and changes in behaviour as a result of lockdowns and physical distancing have the potential to exacerbate the impacts of the COVID-19 pandemic on key populations. While these impacts will vary significantly, human-rights approaches to COVID-19 emergency laws and public health prevention measures that are population-specific and sensitive, will be key to reducing adverse health outcomes and ensuring that no one is left behind. PMID: 33119183 [PubMed - as supplied by publisher] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - October 30, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Comparison of effectiveness and cost for different HIV screening strategies implemented at large urban medical centre in the United States.
CONCLUSIONS: The SN strategy yielded the highest proportion of new diagnoses, followed closely by the MPS programme. Both the SN strategy and RS programme were comparable in the cost per new diagnosis. A simultaneous approach that consists of RS in combination with SN testing may be most effective for identifying new HIV infections in settings with heterogeneous epidemics with both high rates of HIV prevalence and HIV testing. PMID: 33119195 [PubMed - as supplied by publisher] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - October 30, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Cost-effectiveness of a 12 country-intervention to scale up short course TB preventive therapy among people living with HIV.
CONCLUSIONS: Our findings provide donors with reasonable evidence of value for money to support investment in short-course TB preventive therapy for people initiating ART in high-burden settings. Our study also illustrates the importance of considering long-term secondary ("catalytic") effects when evaluating the cost-effectiveness of large-scale initiatives designed to change a global policy landscape. PMID: 33107219 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - October 29, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Racial justice and HIV in the United States: now is the time.
Authors: Godley BA, Schoenbach VJ, Adimora AA PMID: 33078585 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - October 22, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Cost-effectiveness of one month of daily isoniazid and rifapentine versus three months of weekly isoniazid and rifapentine for prevention of tuberculosis among people receiving antiretroviral therapy in Uganda.
CONCLUSIONS: 1HP has the potential to be cost-effective under many realistic circumstances. Cost-effectiveness depends on rifapentine price, relative completion and efficacy, prevalence of latent TB and local willingness-to-pay. PMID: 33073520 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - October 20, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Efficacy of silk fibroin biomaterial vehicle for in vivo mucosal delivery of Griffithsin and protection against HIV and SHIV infection ex vivo.
CONCLUSIONS: We demonstrated that in vivo delivery of SF-Grft in rhesus macaques fully protects against SHIV challenge ex vivo after two hours of application and is safe to use in both the vaginal and rectal compartments. Our study provides support for the development of silk fibroin as a highly promising, user-friendly HIV prevention modality to address the global disparity in HIV infection. PMID: 33073530 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - October 20, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Implications of COVID-19 for HIV Research: data sources, indicators and longitudinal analyses.
Authors: Rebeiro PF, Duda SN, Wools-Kaloustian KK, Nash D, Althoff KN, International epidemiology Databases to Evaluate AIDS (IeDEA) PMID: 33047483 [PubMed] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - October 15, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Effects of vitamin D and calcium supplementation on bone mineral density among Thai youth using daily HIV pre-exposure prophylaxis.
The objective of this study was to evaluate the effect of vitamin D and calcium supplementation on BMD among Thai youth receiving daily oral PrEP. METHODS: This open-label randomized trial was conducted in male youth aged between 15 and 24 years. Participants were randomized to Arm A who received once-daily TDF/FTC plus vitamin D3 and calcium supplementation with meals twice daily (400 units of vitamin D3 and 1200 mg of elemental calcium/day) or Arm B who received once-daily TDF/FTC only. PrEP users were defined as taking at least two tablets/week (tenofovir-diphosphate level of>350 fmol/punch). Adher...
Source: Journal of the International AIDS Society - October 13, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Retention-in-care in the PMTCT cascade: definitions matter! Analyses from the INSPIRE projects in Malawi, Nigeria and Zimbabwe.
CONCLUSIONS: Our study highlights the variability of definitions in estimating retention-in-care. Some definitions are very stringent which may be required in some instances. A simple indicator such as attendance at a single time point may be sufficient for programme planning and evaluation. PMID: 33030306 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - October 10, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Responding to the ECHO trial results: modelling the potential impact of changing contraceptive method mix on HIV and reproductive health in South Africa.
CONCLUSIONS: If there is any real increased HIV risk for DMPA users that has not been detected by the recent randomized trial, a reduction in DMPA use could reduce the ongoing number of new HIV infections. However, such a change would place more women at risk of adverse reproductive health effects. It is imperative that these effects are minimized by focusing on expanding access to safe, effective and acceptable alternative contraceptive methods for all women. PMID: 33030312 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - October 10, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Time-varying age- and CD4-stratified rates of mortality and WHO stage 3 and stage 4 events in children, adolescents and youth 0 to 24 years living with perinatally acquired HIV, before and after antiretroviral therapy initiation in the paediatric IeDEA Global Cohort Consortium.
Authors: Desmonde S, Neilan AM, Musick B, Patten G, Chokephaibulkit K, Edmonds A, Duda SN, Malateste K, Wools-Kaloustian K, Ciaranello AL, Davies MA, Leroy V, IeDEA Abstract INTRODUCTION: Evaluating outcomes of paediatric patients with HIV provides crucial data for clinicians and policymakers. We analysed mortality and clinical events rates among children, adolescents, and youth with perinatally acquired HIV (PHIV) aged 0 to 24 years stratified by time-varying age and CD4, before and after antiretroviral therapy (ART), in the paediatric IeDEA multiregional collaboration (East, West, Central and Southern Africa...
Source: Journal of the International AIDS Society - October 10, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

An open-label, randomized crossover study to evaluate the acceptability and preference for contraceptive options in female adolescents, 15 to 19 years of age in Cape Town, as a proxy for HIV prevention methods (UChoose).
Authors: Gill K, Happel AU, Pidwell T, Mendelsohn A, Duyver M, Johnson L, Meyer L, Slack C, Strode A, Mendel E, Fynn L, Wallace M, Spiegel H, Jaspan H, Passmore JA, Hosek S, Smit D, Rinehart A, Bekker LG Abstract INTRODUCTION: Young women in Southern Africa have extremely high HIV incidence rates necessitating the availability of female-controlled prevention methods. Understanding adolescent preference for seeking contraception would improve our understanding of acceptability, feasibility and adherence to similar modes of delivery for HIV prevention. METHODS: UChoose was an open-label randomized crossover study...
Source: Journal of the International AIDS Society - October 10, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

HIV Glasgow - Virtual, 5-8 October 2020.
Authors: PMID: 33015953 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - October 7, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Enrolment characteristics associated with retention among HIV negative Kenyan gay, bisexual and other men who have sex with men enrolled in the Anza Mapema cohort study.
DISCUSSION: Among 609 enrolled HIV-negative GBMSM, the median age was 23 years (interquartile range, 21 to 28 years), 19.0% had completed ≤8 years of education and 4.1% had resided in the study area
Source: Journal of the International AIDS Society - October 3, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Sexually transmitted infection screening, prevalence and incidence among South African men and transgender women who have sex with men enrolled in a combination HIV prevention cohort study: the Sibanye Methods for Prevention Packages Programme (MP3) project.
CONCLUSIONS: Prevalence and incidence of urethral and rectal STIs were high among these South African MSM and TGW, and were similar to rates in other settings in the world. Clinical symptoms from these infections were rare, highlighting limitations of syndromic surveillance and suggesting the need for presumptive testing and/or treatment to address the STI epidemic among MSM/TGW in South Africa. PMID: 33000886 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - October 3, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Risk factors for loss to follow-up among at-risk HIV negative men who have sex with men participating in a research cohort with access to pre-exposure prophylaxis in coastal Kenya.
CONCLUSIONS: About one in three participants became LTFU after one year of follow-up, irrespective of PrEP use. Research preparedness involving MSM should be strengthened for HIV prevention intervention evaluations in coastal Kenya. PMID: 33000889 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - October 3, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Online socializing among men who have sex with men and transgender people in Nairobi and Johannesburg and implications for public health-related research and health promotion: an analysis of qualitative and respondent-driven sampling survey data.
CONCLUSIONS: Most MSM and TG in these cities socialize online regularly. Users reported HIV acquisition risk behaviours, yet this space is not fully utilized for sexual health promotion and research engagement. Effective, safe and acceptable means of using online channels to engage with MSM/TG that account for MSM and TG's strategies and concerns for managing online security should now be explored, as complements or alternatives to existing outreach. PMID: 33000904 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - October 3, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

A more responsive, multi-pronged strategy is needed to strengthen HIV healthcare for men who have sex with men in a decentralized health system: qualitative insights of a case study in the Kenyan coast.
CONCLUSIONS: To strengthen HIV healthcare for MSM within a decentralized Kenyan health system, a more responsive, multi-pronged strategy adaptable and relevant to MSM's healthcare needs is required. Continued engagement with policy leadership, collaboration with health facilities, and partnerships with different community stakeholders are critical to improve HIV healthcare services for MSM. PMID: 33000906 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - October 3, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Association of age with healthcare needs and engagement among Nigerian men who have sex with men and transgender women: cross-sectional and longitudinal analyses from an observational cohort.
Authors: Ramadhani HO, Crowell TA, Nowak RG, Ndembi N, Kayode BO, Kokogho A, Ononaku U, Shoyemi E, Ekeh C, Adebajo S, Baral SD, Charurat ME Abstract INTRODUCTION: Young men who have sex with men (MSM) and transgender women (TGW) face stigmas that hinder access to healthcare. The aim of the study was to understand age-related determinants of healthcare needs and engagement among MSM and TGW. METHODS: The TRUST/RV368 cohort provides integrated prevention and treatment services for HIV and other sexually transmitted infections (STIs) tailored to the needs of sexual and gender minorities. MSM and TGW aged ≥16&nb...
Source: Journal of the International AIDS Society - October 3, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Involvement of African men and transgender women who have sex with men in HIV research: progress, but much more must be done.
Authors: Crowell TA, Fast PE, Bekker LG, Sanders EJ PMID: 33000908 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - October 3, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

The feasibility of recruiting and retaining men who have sex with men and transgender women in a multinational prospective HIV prevention research cohort study in sub-Saharan Africa (HPTN 075).
CONCLUSIONS: HPTN 075 successfully enrolled a multinational sample of MSM/TGW in SSA in a prospective HIV prevention research study with a high retention rate and few documented social harms. This supports the feasibility of conducting large-scale research trials in this population to address its urgent, unmet HIV prevention needs. PMID: 33000911 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - October 3, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

HIV infection and engagement in HIV care cascade among men who have sex with men and transgender women in Kigali, Rwanda: a cross-sectional study.
This study aimed to characterize HIV prevalence and care cascade among MSM and TGW in Kigali. METHODS: MSM and TGW ≥ 18 years were recruited using respondent-driven sampling (RDS) from March-August 2018 in Kigali. Participants underwent a structured interview including measures of individual, network and structural determinants. HIV and sexually transmitted infections (STI) including syphilis, Neisseria gonorrhoea (NG) and Chlamydia trachomatis (CT) were tested. Viral load was measured for MSM living with HIV. Robust Poisson regression was used to characterize the determinants of HIV infection and eng...
Source: Journal of the International AIDS Society - October 3, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

From general to specific: moving past the general population in the HIV response across sub-Saharan Africa.
CONCLUSIONS: We recommend that the term general population be retired from the field's lexicon. HIV programmes should strengthen their capacity to describe the heterogeneity of those they serve and plan their interventions accordingly. To increase the efficiency and impact of the HIV response, it is urgent to stratify the category of general population by risk. Sexual networks are a promising basis for this stratification. PMID: 33000913 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - October 3, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Retention of a cohort of men who have sex with men and transgender women at risk for and living with HIV in Abuja and Lagos, Nigeria: a longitudinal analysis.
Authors: Kayode BO, Mitchell A, Ndembi N, Kokogho A, Ramadhani HO, Adebajo S, Robb ML, Baral SD, Ake JA, Charurat ME, Crowell TA, Nowak RG, TRUST/RV368 Study Group Abstract INTRODUCTION: Men who have sex with men (MSM), and transgender women (TGW), face specific obstacles to retention in care, particularly in settings with stigmatization such as sub-Saharan Africa. We evaluated the impacts of HIV status and other factors on loss-to-follow-up (LTFU) and visit adherence among MSM and TGW in Abuja and Lagos, Nigeria. METHODS: TRUST/RV368 is an open cohort that provides comprehensive and integrated prevention and t...
Source: Journal of the International AIDS Society - October 3, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Acute and early HIV infection screening among men who have sex with men, a systematic review and meta-analysis.
CONCLUSIONS: Strategies mobilizing MSM for targeted AEHI testing resulted in substantially higher AEHI yields than universal AEHI testing. Targeted AEHI testing may be optimized using risk and/or symptom scores, especially if scores include symptoms. Studies assessing AEHI yield and validation of risk and/or symptom scores among MSM in SSA are urgently needed. PMID: 33000916 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - October 3, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

HIV prevalence and incidence in a cohort of South African men and transgender women who have sex with men: the Sibanye Methods for Prevention Packages Programme (MP3) project.
CONCLUSIONS: HIV incidence was high among MSM and TGW in the context of receiving a comprehensive package of prevention interventions and offering of PrEP. PrEP uptake was high; the observed incidence of HIV in those who started PrEP was about half the incidence of HIV in those who did not. Future implementation-oriented studies should focus on decisions to start and continue PrEP for those at highest risk, including young MSM. PMID: 33000918 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - October 3, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Adapting HIV services for pregnant and breastfeeding women, infants, children, adolescents and families in resource-constrained settings during the COVID-19 pandemic.
CONCLUSIONS: Protecting pregnant and breastfeeding women, infants, children and adolescents from acquiring SARS-CoV-2 while sustaining essential HIV services is an immense global health challenge. Tailored, family friendly programme adaptations for case-finding, ART delivery and viral load monitoring for these populations have the potential to limit SARS-CoV-2 transmission while ensuring the continuity of life-saving HIV case identification and treatment efforts. PMID: 32996705 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - October 2, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Ageing with HIV: health implications and evolving care needs.
Authors: Ahmad A, Neelamegam M, Rajasuriar R PMID: 32996718 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - October 2, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Pharmacy delivery to expand the reach of PrEP in Africa.
Authors: Ortblad KF, Mogere P, Bukusi E, Ngure K, Baeten JM PMID: 32996721 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - October 2, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Identifying groups of people with similar sociobehavioural characteristics in Malawi to inform HIV interventions: a latent class analysis.
CONCLUSIONS: LCA is an efficient method to find groups of people sharing common HIV risk profiles, identify particularly vulnerable sub-populations, and plan targeted interventions focusing on these groups. Tailored support, prevention and HIV testing programmes should focus particularly on female household heads, adolescent girls living in rural areas, older married men and young men who have never been married. PMID: 32985772 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - September 30, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Review on the molecular epidemiology of sexually acquired hepatitis C virus infection in the Asia-Pacific region.
CONCLUSIONS: The distribution of sexually acquired HCV was sparsely scattered across countries/cities in the Asia-Pacific region. The threat of overlapping risk differed by locations, whereas transnational outbreaks remained uncommon. The paucity of information has hindered progress with comprehensive assessment in the Asia-Pacific region, where seroprevalence of HCV among HIV-positive MSM was relatively high. PMID: 32969173 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - September 26, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Successes and gaps in the HIV cascade of care of a high HIV prevalence setting in Zimbabwe: a population-based survey.
Authors: Conan N, Coulborn RM, Simons E, Mapfumo A, Apollo T, Garone DB, Casas EC, Puren AJ, Chihana ML, Maman D Abstract INTRODUCTION: Gutu, a rural district in Zimbabwe, has been implementing comprehensive HIV care with the support of Médecins Sans Frontières (MSF) since 2011, decentralizing testing and treatment services to all rural healthcare facilities. We evaluated HIV prevalence, incidence and the cascade of care, in Gutu District five years after MSF began its activities. METHODS: A cross-sectional study was implemented between September and December 2016. Using multistage cluster samplin...
Source: Journal of the International AIDS Society - September 26, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

HIV seronegativity in children, adolescents and young adults living with perinatally acquired HIV: A cross-sectional study in Thailand.
This study aimed to determine the frequency and associated factors of seronegativity in Thai children, adolescents and young adults with PHIV. METHODS: A cross-sectional HIV serological study was performed in children, adolescents and young adults two years or older who were receiving ART with undetectable HIV-RNA for at least one year from August 2018 to August 2019. Medical records were extracted for multivariate analysis of independent factors for seronegativity. RESULTS AND DISCUSSION: Of 110 patients, 50 male, median (range) age was 18.4 (4.8 to 26.6) years, 8 (7.3%) were seronegative, and 1 (0.9 %) was inconc...
Source: Journal of the International AIDS Society - September 24, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Early access to antiretroviral therapy versus standard of care among HIV-positive participants in Eswatini in the public health sector: the MaxART stepped-wedge randomized controlled trial.
Authors: Khan S, Spiegelman D, Walsh F, Mazibuko S, Pasipamire M, Chai B, Reis R, Mlambo K, Delva W, Khumalo G, Zwane M, Fleming Y, Mafara E, Hettema A, Lejeune C, Chao A, Bärnighausen T, Okello V Abstract INTRODUCTION: The WHO recommends antiretroviral treatment (ART) for all HIV-positive patients regardless of CD4 count or disease stage, referred to as "Early Access to ART for All" (EAAA). The health systems effects of EAAA implementation are unknown. This trial was implemented in a government-managed public health system with the aim to examine the "real world" impact of EAAA on care ret...
Source: Journal of the International AIDS Society - September 20, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Determinants of suboptimal CD4+ T cell recovery after antiretroviral therapy initiation in a prospective cohort of acute HIV-1 infection.
Authors: Handoko R, Colby DJ, Kroon E, Sacdalan C, de Souza M, Pinyakorn S, Prueksakaew P, Munkong C, Ubolyam S, Akapirat S, Chiarella J, Krebs S, Sereti I, Valcour V, Paul R, Michael NL, Phanuphak N, Ananworanich J, Spudich S, SEARCH 010/RV254 Study Team Abstract INTRODUCTION: Up to 30% of individuals treated with antiretroviral therapy (ART) during chronic HIV fail to recover CD4 counts to>500 cells/mm3 despite plasma viral suppression. We investigated the frequency and associations of suboptimal CD4 recovery after ART started during acute HIV infection (AHI). METHODS: Participants who started ART in ...
Source: Journal of the International AIDS Society - September 20, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

HIV-1 transmitted drug resistance surveillance: shifting trends in study design and prevalence estimates.
CONCLUSIONS: Overall, NNRTI and dual NRTI/NNRTI-associated TDR prevalence was significantly higher in sub-Saharan Africa studies published between 2014 and 2019 compared with those published between 2009 and 2013. The decreasing proportion of studies from the hardest hit LMIC regions and the shift away from sentinel sites for recent infection suggests that global TDR surveillance efforts and publication of findings require renewed emphasis. PMID: 32936523 [PubMed - as supplied by publisher] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - September 17, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Persistent HIV-controllers are more prone to spontaneously clear HCV: a retrospective cohort study.
CONCLUSIONS: This study shows an association between spontaneous persistent HIV-control and HCV spontaneous clearance. The study findings support the idea of preserved immune mechanisms in persistent HIV control implicated in HCV spontaneous clearance. These results highlight persistent HIV-controllers but not transient controllers as a good model of functional HIV cure. PMID: 32909370 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - September 13, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Economic evaluation of facility-based HIV self-testing among adult outpatients in Malawi.
CONCLUSIONS: While the cost per new ART initiation through FB-HIVST was higher than Standard PITC, FB-HIVST could become cost-saving compared to PITC if the cost of kits is reduced or if treatment linkage rate were increased in the FB-HIVST arm. For high volume OPDs, HIVST may increase facility capacity and increase the number of newly diagnosed positives. PMID: 32909387 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - September 13, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Young people are experts and leaders in the HIV response.
Authors: Rufurwadzo TG, Inarukundo A, Noviyanti I, Subero MA PMID: 32869457 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - September 3, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research