Declining HIV incidence in sub-Saharan Africa: a systematic review and meta-analysis of empiric data
The objective of this study was to assess whether modelled trends are supported by empirical evidence.METHODS: We conducted a systematic review and meta-analysis of adult HIV incidence data from sub-Saharan Africa by searching Embase, Scopus, PubMed and OVID databases and technical reports published between 1 January 2010 and 23 July 2019. We included prospective and cross-sectional studies that directly measured incidence from blood samples. Incidence data were abstracted according to population risk group, geographic location, sex, intervention arm and calendar period. Weighted regression models were used to assess incid...
Source: Journal of the International AIDS Society - October 21, 2021 Category: Infectious Diseases Authors: Keya Joshi Justin Lessler Oluwasolape Olawore Gideon Loevinsohn Sophrena Bushey Aaron A R Tobian M Kate Grabowski Source Type: research

Innate and adaptive abnormalities in youth with vertically acquired HIV through a multicentre cohort in Spain
CONCLUSIONS: Immunological changes associated with vertically acquired HIV, characterized by increased activation and exhaustion levels in innate and adaptive immune components, are only partially restored by ART. The CD4/CD8 ratio can be a useful marker of disease progression for routine clinical practice.PMID:34672108 | DOI:10.1002/jia2.25804 (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - October 21, 2021 Category: Infectious Diseases Authors: Itz íar Carrasco Laura Tarancon-Diez Elena V ázquez-Alejo Santiago Jim énez de Ory Tal ía Sainz Miren Apilanez Cristina Epalza Sara Guill én Jos é Tomás Ramos Cristina D íez Jose Ignacio Bernardino Jos é Antonio Iribarren Angielys Zamora Mar ía Source Type: research

Declining HIV incidence in sub-Saharan Africa: a systematic review and meta-analysis of empiric data
The objective of this study was to assess whether modelled trends are supported by empirical evidence.METHODS: We conducted a systematic review and meta-analysis of adult HIV incidence data from sub-Saharan Africa by searching Embase, Scopus, PubMed and OVID databases and technical reports published between 1 January 2010 and 23 July 2019. We included prospective and cross-sectional studies that directly measured incidence from blood samples. Incidence data were abstracted according to population risk group, geographic location, sex, intervention arm and calendar period. Weighted regression models were used to assess incid...
Source: Journal of the International AIDS Society - October 21, 2021 Category: Infectious Diseases Authors: Keya Joshi Justin Lessler Oluwasolape Olawore Gideon Loevinsohn Sophrena Bushey Aaron A R Tobian M Kate Grabowski Source Type: research

Innate and adaptive abnormalities in youth with vertically acquired HIV through a multicentre cohort in Spain
CONCLUSIONS: Immunological changes associated with vertically acquired HIV, characterized by increased activation and exhaustion levels in innate and adaptive immune components, are only partially restored by ART. The CD4/CD8 ratio can be a useful marker of disease progression for routine clinical practice.PMID:34672108 | DOI:10.1002/jia2.25804 (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - October 21, 2021 Category: Infectious Diseases Authors: Itz íar Carrasco Laura Tarancon-Diez Elena V ázquez-Alejo Santiago Jim énez de Ory Tal ía Sainz Miren Apilanez Cristina Epalza Sara Guill én Jos é Tomás Ramos Cristina D íez Jose Ignacio Bernardino Jos é Antonio Iribarren Angielys Zamora Mar ía Source Type: research

Declining HIV incidence in sub-Saharan Africa: a systematic review and meta-analysis of empiric data
The objective of this study was to assess whether modelled trends are supported by empirical evidence.METHODS: We conducted a systematic review and meta-analysis of adult HIV incidence data from sub-Saharan Africa by searching Embase, Scopus, PubMed and OVID databases and technical reports published between 1 January 2010 and 23 July 2019. We included prospective and cross-sectional studies that directly measured incidence from blood samples. Incidence data were abstracted according to population risk group, geographic location, sex, intervention arm and calendar period. Weighted regression models were used to assess incid...
Source: Journal of the International AIDS Society - October 21, 2021 Category: Infectious Diseases Authors: Keya Joshi Justin Lessler Oluwasolape Olawore Gideon Loevinsohn Sophrena Bushey Aaron A R Tobian M Kate Grabowski Source Type: research

Modelling the impact of HIV and HCV prevention and treatment interventions for people who inject drugs in Dar es Salaam, Tanzania
CONCLUSIONS: Combination interventions, including sexual risk reduction and HCV treatment, are needed to eliminate HCV and HIV among PWID in Tanzania.PMID:34661964 | DOI:10.1002/jia2.25817 (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - October 18, 2021 Category: Infectious Diseases Authors: Hannah Fraser Jack Stone Ernst Wisse Veryeh Sambu Peter Mfisi Ivan J Duran Mireia Aguirre Soriano Josephine G Walker Nobelrich Makere Niklas Luhmann William Kafura Maieule Nouvellet Allan Ragi Bernard Mundia Peter Vickerman Source Type: research

HIV PrEP is more than ART-lite: Longitudinal study of real-world PrEP services data identifies missing measures meaningful to HIV prevention programming
CONCLUSIONS: PrEP users frequently cycle on and off PrEP. Early discontinuation and delays in obtaining additional prescriptions were common, with broad predictive variability noted. Time off PrEP decreased with cycle number in all countries, suggesting normalization of use with experience. More nuanced measures of use are needed than exist for HIV treatment if effective use of PrEP is to be meaningfully measured. Providers should be equipped with measures and counselling messages that recognize non-continuous and cyclical use patterns so that clients are supported to align fluctuating risk and use, and can readily restart...
Source: Journal of the International AIDS Society - October 14, 2021 Category: Infectious Diseases Authors: Jason Bailey Reed Prakriti Shrestha Daniel Were Tafadzwa Chakare Jane Mutegi Brian Wakhutu Abednego Musau Nyane Matebello Nonyana Alice Christensen Rupa Patel Jessica Rodrigues Robyn Eakle Kelly Curran Diwakar Mohan Source Type: research

Preferences for transitional HIV care among people living with HIV recently released from prison in Zambia: a discrete choice experiment
J Int AIDS Soc. 2021 Oct;24(10):e25805. doi: 10.1002/jia2.25805.ABSTRACTINTRODUCTION: No studies from sub-Saharan Africa have attempted to assess HIV service delivery preferences among incarcerated people living with HIV as they transition from prisons to the community ("releasees"). We conducted a discrete choice experiment (DCE) to characterize releasee preferences for transitional HIV care services in Zambia to inform the development of a differentiated service delivery model to promote HIV care continuity for releasees.METHODS: Between January and October 2019, we enrolled a consecutive sample of 101 releasee...
Source: Journal of the International AIDS Society - October 14, 2021 Category: Infectious Diseases Authors: Jan Ostermann Valerie Yelverton Helene J Smith Mirriam Nanyangwe Lillian Kashela Peter Chisenga Vivien Mai Chilambwe Mwila Michael E Herce Source Type: research

HIV PrEP is more than ART-lite: Longitudinal study of real-world PrEP services data identifies missing measures meaningful to HIV prevention programming
CONCLUSIONS: PrEP users frequently cycle on and off PrEP. Early discontinuation and delays in obtaining additional prescriptions were common, with broad predictive variability noted. Time off PrEP decreased with cycle number in all countries, suggesting normalization of use with experience. More nuanced measures of use are needed than exist for HIV treatment if effective use of PrEP is to be meaningfully measured. Providers should be equipped with measures and counselling messages that recognize non-continuous and cyclical use patterns so that clients are supported to align fluctuating risk and use, and can readily restart...
Source: Journal of the International AIDS Society - October 14, 2021 Category: Infectious Diseases Authors: Jason Bailey Reed Prakriti Shrestha Daniel Were Tafadzwa Chakare Jane Mutegi Brian Wakhutu Abednego Musau Nyane Matebello Nonyana Alice Christensen Rupa Patel Jessica Rodrigues Robyn Eakle Kelly Curran Diwakar Mohan Source Type: research

Preferences for transitional HIV care among people living with HIV recently released from prison in Zambia: a discrete choice experiment
J Int AIDS Soc. 2021 Oct;24(10):e25805. doi: 10.1002/jia2.25805.ABSTRACTINTRODUCTION: No studies from sub-Saharan Africa have attempted to assess HIV service delivery preferences among incarcerated people living with HIV as they transition from prisons to the community ("releasees"). We conducted a discrete choice experiment (DCE) to characterize releasee preferences for transitional HIV care services in Zambia to inform the development of a differentiated service delivery model to promote HIV care continuity for releasees.METHODS: Between January and October 2019, we enrolled a consecutive sample of 101 releasee...
Source: Journal of the International AIDS Society - October 14, 2021 Category: Infectious Diseases Authors: Jan Ostermann Valerie Yelverton Helene J Smith Mirriam Nanyangwe Lillian Kashela Peter Chisenga Vivien Mai Chilambwe Mwila Michael E Herce Source Type: research

HIV PrEP is more than ART-lite: Longitudinal study of real-world PrEP services data identifies missing measures meaningful to HIV prevention programming
CONCLUSIONS: PrEP users frequently cycle on and off PrEP. Early discontinuation and delays in obtaining additional prescriptions were common, with broad predictive variability noted. Time off PrEP decreased with cycle number in all countries, suggesting normalization of use with experience. More nuanced measures of use are needed than exist for HIV treatment if effective use of PrEP is to be meaningfully measured. Providers should be equipped with measures and counselling messages that recognize non-continuous and cyclical use patterns so that clients are supported to align fluctuating risk and use, and can readily restart...
Source: Journal of the International AIDS Society - October 14, 2021 Category: Infectious Diseases Authors: Jason Bailey Reed Prakriti Shrestha Daniel Were Tafadzwa Chakare Jane Mutegi Brian Wakhutu Abednego Musau Nyane Matebello Nonyana Alice Christensen Rupa Patel Jessica Rodrigues Robyn Eakle Kelly Curran Diwakar Mohan Source Type: research

Preferences for transitional HIV care among people living with HIV recently released from prison in Zambia: a discrete choice experiment
J Int AIDS Soc. 2021 Oct;24(10):e25805. doi: 10.1002/jia2.25805.ABSTRACTINTRODUCTION: No studies from sub-Saharan Africa have attempted to assess HIV service delivery preferences among incarcerated people living with HIV as they transition from prisons to the community ("releasees"). We conducted a discrete choice experiment (DCE) to characterize releasee preferences for transitional HIV care services in Zambia to inform the development of a differentiated service delivery model to promote HIV care continuity for releasees.METHODS: Between January and October 2019, we enrolled a consecutive sample of 101 releasee...
Source: Journal of the International AIDS Society - October 14, 2021 Category: Infectious Diseases Authors: Jan Ostermann Valerie Yelverton Helene J Smith Mirriam Nanyangwe Lillian Kashela Peter Chisenga Vivien Mai Chilambwe Mwila Michael E Herce Source Type: research

HIV PrEP is more than ART-lite: Longitudinal study of real-world PrEP services data identifies missing measures meaningful to HIV prevention programming
CONCLUSIONS: PrEP users frequently cycle on and off PrEP. Early discontinuation and delays in obtaining additional prescriptions were common, with broad predictive variability noted. Time off PrEP decreased with cycle number in all countries, suggesting normalization of use with experience. More nuanced measures of use are needed than exist for HIV treatment if effective use of PrEP is to be meaningfully measured. Providers should be equipped with measures and counselling messages that recognize non-continuous and cyclical use patterns so that clients are supported to align fluctuating risk and use, and can readily restart...
Source: Journal of the International AIDS Society - October 14, 2021 Category: Infectious Diseases Authors: Jason Bailey Reed Prakriti Shrestha Daniel Were Tafadzwa Chakare Jane Mutegi Brian Wakhutu Abednego Musau Nyane Matebello Nonyana Alice Christensen Rupa Patel Jessica Rodrigues Robyn Eakle Kelly Curran Diwakar Mohan Source Type: research

Preferences for transitional HIV care among people living with HIV recently released from prison in Zambia: a discrete choice experiment
J Int AIDS Soc. 2021 Oct;24(10):e25805. doi: 10.1002/jia2.25805.ABSTRACTINTRODUCTION: No studies from sub-Saharan Africa have attempted to assess HIV service delivery preferences among incarcerated people living with HIV as they transition from prisons to the community ("releasees"). We conducted a discrete choice experiment (DCE) to characterize releasee preferences for transitional HIV care services in Zambia to inform the development of a differentiated service delivery model to promote HIV care continuity for releasees.METHODS: Between January and October 2019, we enrolled a consecutive sample of 101 releasee...
Source: Journal of the International AIDS Society - October 14, 2021 Category: Infectious Diseases Authors: Jan Ostermann Valerie Yelverton Helene J Smith Mirriam Nanyangwe Lillian Kashela Peter Chisenga Vivien Mai Chilambwe Mwila Michael E Herce Source Type: research

"It's a burden, it's a nuisance. I wish I didn't have these other ailments": a qualitative exploration of comorbidities management among older people living with HIV who use drugs in Vancouver, British Columbia
CONCLUSIONS: Our findings underscore the need for HIV care to shift from a primary focus on managing HIV to an integrated, patient-centred approach that addresses both HIV and non-HIV-related health needs, as well as an equitable and non-judgemental delivery of such care for an ageing population of PLHIV who use drugs.PMID:34636148 | DOI:10.1002/jia2.25785 (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - October 12, 2021 Category: Infectious Diseases Authors: Koharu Loulou Chayama Cara Ng Will Small Andrew Ivsins Ryan McNeil Source Type: research

How community ART delivery may improve HIV treatment outcomes: Qualitative inquiry into mechanisms of effect in a randomized trial of community-based ART initiation, monitoring and re-supply (DO ART) in South Africa and Uganda
CONCLUSIONS: Understanding the mechanisms through which HIV service delivery innovations produce an effect is key to transferability and potential scale-up. The perspectives and priorities of PLHIV can indicate actionable changes for HIV care programs that may increase engagement in care and improve treatment outcomes.PMID:34624173 | PMC:PMC8500674 | DOI:10.1002/jia2.25821 (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - October 8, 2021 Category: Infectious Diseases Authors: Hannah N Gilbert Monique A Wyatt Emily E Pisarski Stephen Asiimwe Heidi van Rooyen Janet Seeley Maryam Shahmanesh Bosco Turyamureeba Alastair van Heerden Oluwafemi Adeagbo Connie L Celum Ruanne V Barnabas Norma C Ware Delivery Optimization of Antiretrovir Source Type: research

How community ART delivery may improve HIV treatment outcomes: Qualitative inquiry into mechanisms of effect in a randomized trial of community-based ART initiation, monitoring and re-supply (DO ART) in South Africa and Uganda
CONCLUSIONS: Understanding the mechanisms through which HIV service delivery innovations produce an effect is key to transferability and potential scale-up. The perspectives and priorities of PLHIV can indicate actionable changes for HIV care programs that may increase engagement in care and improve treatment outcomes.PMID:34624173 | DOI:10.1002/jia2.25821 (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - October 8, 2021 Category: Infectious Diseases Authors: Hannah N Gilbert Monique A Wyatt Emily E Pisarski Stephen Asiimwe Heidi van Rooyen Janet Seeley Maryam Shahmanesh Bosco Turyamureeba Alastair van Heerden Oluwafemi Adeagbo Connie L Celum Ruanne V Barnabas Norma C Ware Delivery Optimization of Antiretrovir Source Type: research

Retention in care and viral suppression after same-day ART initiation: One-year outcomes of the SLATE I and II individually randomized clinical trials in South Africa
CONCLUSIONS: An offer of SDI of ART, following a carefully designed protocol to identify patients who are eligible and ready to start treatment, is not inherently associated with an overall increase in patient attrition from care and leads to similar rates of viral suppression.TRIAL REGISTRATION: Clinicaltrials.gov NCT02891135, registered 01 September 2016. First participant enrolled 06 March 2017 in South Africa. Clinicaltrials.gov NCT03315013, registered 19 October 2017. First participant enrolled 14 March 2018.PMID:34612601 | DOI:10.1002/jia2.25825 (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - October 6, 2021 Category: Infectious Diseases Authors: Mhairi Maskew Alana T Brennan Willem D F Venter Matthew P Fox Lungisile Vezi Sydney Rosen Source Type: research

Association between HIV PrEP indications and use in a national sexual network study of US men who have sex with men
CONCLUSIONS: Indications for PrEP strongly predicted current PrEP use among US MSM. However, we identified substantial misalignment between indications and use in both directions (indicated MSM who were not benefitting from PrEP, and MSM taking PrEP while not presently being indicated). PrEP underuse by those at greatest risk for HIV acquisition may limit the projected impact of PrEP implementation, despite reported increases in PrEP provision. This calls for further implementation efforts to improve PrEP delivery to those most in need during periods of elevated sexual risk and to close the gap between indications and upta...
Source: Journal of the International AIDS Society - October 4, 2021 Category: Infectious Diseases Authors: Kevin M Weiss Pragati Prasad Travis Sanchez Steven M Goodreau Samuel M Jenness Source Type: research

The wisdom of mistrust: qualitative insights from transgender women who participated in PrEP research in Lima, Peru
CONCLUSIONS: Findings highlight the wisdom inherent in PrEP mistrust as a reflection of trans women's experiences that underscore the broken bonds of trust between communities, researchers and the research enterprise. PrEP mistrust is amplified through perceived paradoxes that suggest to trans women that they are key experimental participants but not target PrEP users outside of research settings. Findings highlight the urgent need to reframe mistrust not as a characteristic of trans women to be addressed through education and outreach, but as a systemic institutional- and industry-level problem replicated, manifested and ...
Source: Journal of the International AIDS Society - September 27, 2021 Category: Infectious Diseases Authors: Amaya Perez-Brumer Sarah Naz-McLean Leyla Huerta Ximena Salazar Javier R Lama Jorge Sanchez Alfonso Silva-Santisteban Sari L Reisner Kenneth H Mayer Jesse L Clark Source Type: research

When healthcare providers are supportive, 'I'd rather not test alone': Exploring uptake and acceptability of HIV self-testing for youth in Zimbabwe - A mixed method study
CONCLUSIONS: In the context of supportive, trusted and youth-friendly providers, youth clients overwhelmingly preferred provider-delivered HIV testing over client-initiated HIVST or HIVST off site. This highlights the importance of listening to youth to improve engagement in testing. While young people want autonomy in choosing when, where and how to test, they do not want to necessarily test on their own. They desire quality in-person counselling, guidance and support, alongside privacy and confidentiality. To increase the appeal of HIVST for youth, greater provision of access to private spaces is required, and accessible...
Source: Journal of the International AIDS Society - September 27, 2021 Category: Infectious Diseases Authors: Constancia V Mavodza Constance R S Mackworth-Young Tsitsi Bandason Ethel Dauya Chido Dziva Chikwari Mandikudza Tembo Tsitsi Apollo Getrude Ncube Katharina Kranzer Rashida Abbas Ferrand Sarah Bernays Source Type: research

The wisdom of mistrust: qualitative insights from transgender women who participated in PrEP research in Lima, Peru
CONCLUSIONS: Findings highlight the wisdom inherent in PrEP mistrust as a reflection of trans women's experiences that underscore the broken bonds of trust between communities, researchers and the research enterprise. PrEP mistrust is amplified through perceived paradoxes that suggest to trans women that they are key experimental participants but not target PrEP users outside of research settings. Findings highlight the urgent need to reframe mistrust not as a characteristic of trans women to be addressed through education and outreach, but as a systemic institutional- and industry-level problem replicated, manifested and ...
Source: Journal of the International AIDS Society - September 27, 2021 Category: Infectious Diseases Authors: Amaya Perez-Brumer Sarah Naz-McLean Leyla Huerta Ximena Salazar Javier R Lama Jorge Sanchez Alfonso Silva-Santisteban Sari L Reisner Kenneth H Mayer Jesse L Clark Source Type: research

When healthcare providers are supportive, 'I'd rather not test alone': Exploring uptake and acceptability of HIV self-testing for youth in Zimbabwe - A mixed method study
CONCLUSIONS: In the context of supportive, trusted and youth-friendly providers, youth clients overwhelmingly preferred provider-delivered HIV testing over client-initiated HIVST or HIVST off site. This highlights the importance of listening to youth to improve engagement in testing. While young people want autonomy in choosing when, where and how to test, they do not want to necessarily test on their own. They desire quality in-person counselling, guidance and support, alongside privacy and confidentiality. To increase the appeal of HIVST for youth, greater provision of access to private spaces is required, and accessible...
Source: Journal of the International AIDS Society - September 27, 2021 Category: Infectious Diseases Authors: Constancia V Mavodza Constance R S Mackworth-Young Tsitsi Bandason Ethel Dauya Chido Dziva Chikwari Mandikudza Tembo Tsitsi Apollo Getrude Ncube Katharina Kranzer Rashida Abbas Ferrand Sarah Bernays Source Type: research

The wisdom of mistrust: qualitative insights from transgender women who participated in PrEP research in Lima, Peru
CONCLUSIONS: Findings highlight the wisdom inherent in PrEP mistrust as a reflection of trans women's experiences that underscore the broken bonds of trust between communities, researchers and the research enterprise. PrEP mistrust is amplified through perceived paradoxes that suggest to trans women that they are key experimental participants but not target PrEP users outside of research settings. Findings highlight the urgent need to reframe mistrust not as a characteristic of trans women to be addressed through education and outreach, but as a systemic institutional- and industry-level problem replicated, manifested and ...
Source: Journal of the International AIDS Society - September 27, 2021 Category: Infectious Diseases Authors: Amaya Perez-Brumer Sarah Naz-McLean Leyla Huerta Ximena Salazar Javier R Lama Jorge Sanchez Alfonso Silva-Santisteban Sari L Reisner Kenneth H Mayer Jesse L Clark Source Type: research

When healthcare providers are supportive, 'I'd rather not test alone': Exploring uptake and acceptability of HIV self-testing for youth in Zimbabwe - A mixed method study
CONCLUSIONS: In the context of supportive, trusted and youth-friendly providers, youth clients overwhelmingly preferred provider-delivered HIV testing over client-initiated HIVST or HIVST off site. This highlights the importance of listening to youth to improve engagement in testing. While young people want autonomy in choosing when, where and how to test, they do not want to necessarily test on their own. They desire quality in-person counselling, guidance and support, alongside privacy and confidentiality. To increase the appeal of HIVST for youth, greater provision of access to private spaces is required, and accessible...
Source: Journal of the International AIDS Society - September 27, 2021 Category: Infectious Diseases Authors: Constancia V Mavodza Constance R S Mackworth-Young Tsitsi Bandason Ethel Dauya Chido Dziva Chikwari Mandikudza Tembo Tsitsi Apollo Getrude Ncube Katharina Kranzer Rashida Abbas Ferrand Sarah Bernays Source Type: research

The wisdom of mistrust: qualitative insights from transgender women who participated in PrEP research in Lima, Peru
CONCLUSIONS: Findings highlight the wisdom inherent in PrEP mistrust as a reflection of trans women's experiences that underscore the broken bonds of trust between communities, researchers and the research enterprise. PrEP mistrust is amplified through perceived paradoxes that suggest to trans women that they are key experimental participants but not target PrEP users outside of research settings. Findings highlight the urgent need to reframe mistrust not as a characteristic of trans women to be addressed through education and outreach, but as a systemic institutional- and industry-level problem replicated, manifested and ...
Source: Journal of the International AIDS Society - September 27, 2021 Category: Infectious Diseases Authors: Amaya Perez-Brumer Sarah Naz-McLean Leyla Huerta Ximena Salazar Javier R Lama Jorge Sanchez Alfonso Silva-Santisteban Sari L Reisner Kenneth H Mayer Jesse L Clark Source Type: research

When healthcare providers are supportive, 'I'd rather not test alone': Exploring uptake and acceptability of HIV self-testing for youth in Zimbabwe - A mixed method study
CONCLUSIONS: In the context of supportive, trusted and youth-friendly providers, youth clients overwhelmingly preferred provider-delivered HIV testing over client-initiated HIVST or HIVST off site. This highlights the importance of listening to youth to improve engagement in testing. While young people want autonomy in choosing when, where and how to test, they do not want to necessarily test on their own. They desire quality in-person counselling, guidance and support, alongside privacy and confidentiality. To increase the appeal of HIVST for youth, greater provision of access to private spaces is required, and accessible...
Source: Journal of the International AIDS Society - September 27, 2021 Category: Infectious Diseases Authors: Constancia V Mavodza Constance R S Mackworth-Young Tsitsi Bandason Ethel Dauya Chido Dziva Chikwari Mandikudza Tembo Tsitsi Apollo Getrude Ncube Katharina Kranzer Rashida Abbas Ferrand Sarah Bernays Source Type: research

The wisdom of mistrust: qualitative insights from transgender women who participated in PrEP research in Lima, Peru
CONCLUSIONS: Findings highlight the wisdom inherent in PrEP mistrust as a reflection of trans women's experiences that underscore the broken bonds of trust between communities, researchers and the research enterprise. PrEP mistrust is amplified through perceived paradoxes that suggest to trans women that they are key experimental participants but not target PrEP users outside of research settings. Findings highlight the urgent need to reframe mistrust not as a characteristic of trans women to be addressed through education and outreach, but as a systemic institutional- and industry-level problem replicated, manifested and ...
Source: Journal of the International AIDS Society - September 27, 2021 Category: Infectious Diseases Authors: Amaya Perez-Brumer Sarah Naz-McLean Leyla Huerta Ximena Salazar Javier R Lama Jorge Sanchez Alfonso Silva-Santisteban Sari L Reisner Kenneth H Mayer Jesse L Clark Source Type: research

When healthcare providers are supportive, 'I'd rather not test alone': Exploring uptake and acceptability of HIV self-testing for youth in Zimbabwe - A mixed method study
CONCLUSIONS: In the context of supportive, trusted and youth-friendly providers, youth clients overwhelmingly preferred provider-delivered HIV testing over client-initiated HIVST or HIVST off site. This highlights the importance of listening to youth to improve engagement in testing. While young people want autonomy in choosing when, where and how to test, they do not want to necessarily test on their own. They desire quality in-person counselling, guidance and support, alongside privacy and confidentiality. To increase the appeal of HIVST for youth, greater provision of access to private spaces is required, and accessible...
Source: Journal of the International AIDS Society - September 27, 2021 Category: Infectious Diseases Authors: Constancia V Mavodza Constance R S Mackworth-Young Tsitsi Bandason Ethel Dauya Chido Dziva Chikwari Mandikudza Tembo Tsitsi Apollo Getrude Ncube Katharina Kranzer Rashida Abbas Ferrand Sarah Bernays Source Type: research

The wisdom of mistrust: qualitative insights from transgender women who participated in PrEP research in Lima, Peru
CONCLUSIONS: Findings highlight the wisdom inherent in PrEP mistrust as a reflection of trans women's experiences that underscore the broken bonds of trust between communities, researchers and the research enterprise. PrEP mistrust is amplified through perceived paradoxes that suggest to trans women that they are key experimental participants but not target PrEP users outside of research settings. Findings highlight the urgent need to reframe mistrust not as a characteristic of trans women to be addressed through education and outreach, but as a systemic institutional- and industry-level problem replicated, manifested and ...
Source: Journal of the International AIDS Society - September 27, 2021 Category: Infectious Diseases Authors: Amaya Perez-Brumer Sarah Naz-McLean Leyla Huerta Ximena Salazar Javier R Lama Jorge Sanchez Alfonso Silva-Santisteban Sari L Reisner Kenneth H Mayer Jesse L Clark Source Type: research

When healthcare providers are supportive, 'I'd rather not test alone': Exploring uptake and acceptability of HIV self-testing for youth in Zimbabwe - A mixed method study
CONCLUSIONS: In the context of supportive, trusted and youth-friendly providers, youth clients overwhelmingly preferred provider-delivered HIV testing over client-initiated HIVST or HIVST off site. This highlights the importance of listening to youth to improve engagement in testing. While young people want autonomy in choosing when, where and how to test, they do not want to necessarily test on their own. They desire quality in-person counselling, guidance and support, alongside privacy and confidentiality. To increase the appeal of HIVST for youth, greater provision of access to private spaces is required, and accessible...
Source: Journal of the International AIDS Society - September 27, 2021 Category: Infectious Diseases Authors: Constancia V Mavodza Constance R S Mackworth-Young Tsitsi Bandason Ethel Dauya Chido Dziva Chikwari Mandikudza Tembo Tsitsi Apollo Getrude Ncube Katharina Kranzer Rashida Abbas Ferrand Sarah Bernays Source Type: research

Achieving consistency in measures of HIV-1 viral suppression across countries: derivation of an adjustment based on international antiretroviral treatment cohort data
J Int AIDS Soc. 2021 Sep;24 Suppl 5(Suppl 5):e25776. doi: 10.1002/jia2.25776.ABSTRACTINTRODUCTION: The third of the Joint United Nations Programme on HIV/AIDS (UNAIDS) 90-90-90 targets is to achieve a 90% rate of viral suppression (HIV viral load
Source: Journal of the International AIDS Society - September 21, 2021 Category: Infectious Diseases Authors: Leigh F Johnson Azar Kariminia Adam Trickey Constantin T Yiannoutsos Didier K Ekouevi Albert K Minga Ana Roberta Pati Pascom Win Min Han Lei Zhang Keri N Althoff Peter F Rebeiro Gad Murenzi Jonathan Ross Nei-Yuan Hsiao Kimberly Marsh Source Type: research

Updates to Spectrum's case surveillance and vital registration tool for HIV estimates and projections
CONCLUSIONS: CSAVR offers an approach to using routine surveillance and vital registration data to estimate and project trends in both HIV incidence and knowledge of HIV status.PMID:34546641 | PMC:PMC8454676 | DOI:10.1002/jia2.25777 (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - September 21, 2021 Category: Infectious Diseases Authors: Severin G Mahiane Jeffrey W Eaton Robert Glaubius Kelsey K Case Keith M Sabin Kimberly Marsh Source Type: research

Estimating male circumcision coverage in 15 priority countries in sub-Saharan Africa
CONCLUSIONS: VMMC programme data from most of the priority countries were successfully reviewed, updated, validated and incorporated into the annual HIV Estimates process in 2020. It is important to ensure that these data continue to be used for programme planning and management. Current and future data issues will need to be addressed, and countries will need ongoing support to do so. The integration of the DMPPT2 Online into the annual HIV Estimates process is a positive step forward in terms of streamlining country-owned planning and analytical practices for the HIV response.PMID:34546643 | PMC:PMC8454680 | DOI:10.1002/...
Source: Journal of the International AIDS Society - September 21, 2021 Category: Infectious Diseases Authors: Peter M Stegman Randy Yee Joshua Davis Michel Tchuenche Rachael Linder Lycias Zembe Luisa Frescura Katharine E Kripke Source Type: research

Disease progression and mortality with untreated HIV infection: evidence synthesis of HIV seroconverter cohorts, antiretroviral treatment clinical cohorts and population-based survey data
CONCLUSIONS: Synthesis of multiple data sources results in similar overall survival as previous Spectrum parameter assumptions but implies more rapid progression and longer survival in lower CD4 categories. New natural history parameter values improve consistency of model estimates with recent cross-sectional CD4 data and trends in CD4 counts at ART initiation.PMID:34546644 | PMC:PMC8454684 | DOI:10.1002/jia2.25784 (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - September 21, 2021 Category: Infectious Diseases Authors: Robert Glaubius Nikhil Kothegal Sehin Birhanu Sasi Jonnalagadda Severin Guy Mahiane Leigh F Johnson Tim Brown John Stover Tara D Mangal Nikos Pantazis Jeffrey W Eaton Source Type: research

Global HIV mortality trends among children on antiretroviral treatment corrected for under-reported deaths: an updated analysis of the International epidemiology Databases to Evaluate AIDS collaboration
J Int AIDS Soc. 2021 Sep;24 Suppl 5(Suppl 5):e25780. doi: 10.1002/jia2.25780.ABSTRACTINTRODUCTION: The Joint United Nations Programme on HIV/AIDS (UNAIDS) projections of paediatric HIV prevalence and deaths rely on the International epidemiology Databases to Evaluate AIDS (IeDEA) consortium for mortality estimates among children living with HIV (CHIV) receiving antiretroviral therapy (ART). Previous estimates, based on data through 2014, may no longer be accurate due to expanded paediatric HIV care and treatment eligibility, and the possibility of unreported deaths in CHIV considered lost to follow-up (LTFU). We therefore ...
Source: Journal of the International AIDS Society - September 21, 2021 Category: Infectious Diseases Authors: Reshma Kassanjee Leigh F Johnson Elizabeth Zaniewski Marie Ballif Benedikt Christ Constantin T Yiannoutsos Patience Nyakato Sophie Desmonde Andrew Edmonds Tavitiya Sudjaritruk Jorge Pinto Rachel Vreeman D ésiré Lucien Dahourou Christelle Twizere Azar Ka Source Type: research

HIV acquisition in pregnancy: implications for mother-to-child transmission at the population level in sub-Saharan Africa
CONCLUSIONS: Estimates of population-level HIV acquisition risk in sub-Saharan Africa should not be taken directly from per-condomless-coital-act studies to estimate vertical transmission. Changes in sexual behaviour and differences in HIV-serodiscordancy during pregnancy/postpartum reduce the impact of increased risk of HIV acquisition per-condomless-coital-act, this will vary by region.PMID:34546647 | PMC:PMC8454677 | DOI:10.1002/jia2.25783 (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - September 21, 2021 Category: Infectious Diseases Authors: Milly Marston Kathryn Risher Mary I Mahy Source Type: research

Updates to the Spectrum/AIM model for the UNAIDS 2020 HIV estimates
CONCLUSIONS: These changes are intended to provide more accurate estimates of HIV burden. The effects of these changes on paediatric indicators are small except in countries with new surveys that might have updated patterns of breastfeeding. Changes to the adult model have little effect on total new infections. AIDS-related deaths will be somewhat lower in countries that have data on ART drop out but might be increased by HIV care disruptions due to COVID-19. The updated model uses newly available data to improve the estimation of paediatric and adult HIV indicators.PMID:34546648 | PMC:PMC8454674 | DOI:10.1002/jia2.25778 (...
Source: Journal of the International AIDS Society - September 21, 2021 Category: Infectious Diseases Authors: John Stover Robert Glaubius Reshma Kassanjee Caitlin M Dugdale Source Type: research

Progress towards 2020 global HIV impact and treatment targets
CONCLUSIONS: The UNAIDS epidemiological estimates provide information that promote accountability and estimate progress towards global targets at the national level. Additional strategic information and analyses are required to identify the populations that are furthest from the targets and the programmes and policies that are keeping countries from meeting their targets.PMID:34546655 | PMC:PMC8454678 | DOI:10.1002/jia2.25779 (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - September 21, 2021 Category: Infectious Diseases Authors: Mary I Mahy Keith M Sabin Ali Feizzadeh Ian Wanyeki Source Type: research

Naomi: a new modelling tool for estimating HIV epidemic indicators at the district level in sub-Saharan Africa
CONCLUSIONS: The Naomi model synthesizes multiple subnational data sources to furnish estimates of key indicators for HIV programme planning, resource allocation, and target setting. Further model development to meet evolving HIV policy priorities and programme need should be accompanied by continued strengthening and understanding of routine health system data.PMID:34546657 | PMC:PMC8454682 | DOI:10.1002/jia2.25788 (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - September 21, 2021 Category: Infectious Diseases Authors: Jeffrey W Eaton Laura Dwyer-Lindgren Steve Gutreuter Megan O'Driscoll Oliver Stevens Sumali Bajaj Rob Ashton Alexandra Hill Emma Russell Rachel Esra Nicolas Dolan Yusuf O Anifowoshe Mark Woodbridge Ian Fellows Robert Glaubius Emily Haeuser Taylor Okonek J Source Type: research

Accounting for misclassified and unknown cause of death data in vital registration systems for estimating trends in HIV mortality
CONCLUSIONS: Correcting for miscoding and misclassification of cause of death data can enhance the utility of the data for analyzing trends in HIV mortality and tracking progress toward the Sustainable Development Goal targets.PMID:34546661 | PMC:PMC8454675 | DOI:10.1002/jia2.25791 (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - September 21, 2021 Category: Infectious Diseases Authors: Hmwe H Kyu Deepa Jahagirdar Matthew Cunningham Magdalene Walters Edmond Brewer Amanda Novotney Eve Wool Ilse Dippennar Fablina Sharara Chieh Han Shelly Balassyano Greg Bertolacci Christopher J L Murray Mohsen Naghavi Source Type: research