Hepatitis C elimination in people living with HIV - the importance of biomedical and behavioural interventions.
Authors: van Santen DK, Sacks-Davis R, Hellard M PMID: 32722877 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - July 31, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Raltegravir use and outcomes among children and adolescents living with HIV in the IeDEA global consortium.
Authors: Patten G, Puthanakit T, McGowan CC, Wools-Kaloustian K, Hazra R, Pinto JA, Machado D, Succi R, Sohn AH, Rabie H, Musick B, Davies MA, IeDEA Abstract INTRODUCTION: As integrase inhibitors become available in low- and middle-income countries (LMICs), they offer the potential to expand extremely limited treatment options available to children and adolescents. In LMICs, only small numbers have used raltegravir, primarily as part of third-line regimens. Using data from the IeDEA global consortium, we aimed to describe the characteristics of children on raltegravir-containing regimens and their outcomes. MET...
Source: Journal of the International AIDS Society - July 31, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Challenges posed by COVID-19 to people who inject drugs and lessons from other outbreaks.
CONCLUSIONS: The COVID-19 crisis might increase risks of homelessnes, overdoses and unsafe injecting and sexual practices for PWID. In order to address existing inequalities, consultations with PWID advocacy groups are vital when designing inclusive health response to the COVID-19 pandemic. PMID: 32697423 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - July 24, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Patterns of HIV and SARS-CoV-2 co-infection in Wuhan, China.
Authors: Guo W, Ming F, Feng Y, Zhang Q, Mo P, Liu L, Gao M, Tang W, Liang K PMID: 32697865 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - July 24, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Stigma impedes HIV prevention by stifling patient-provider communication about U  = U.
Stigma impedes HIV prevention by stifling patient-provider communication about U = U. J Int AIDS Soc. 2020 Jul;23(7):e25559 Authors: Calabrese SK, Mayer KH PMID: 32686324 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - July 21, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Will differentiated care for stable HIV patients reduce healthcare systems costs?
CONCLUSIONS: The standard of care for stable patients has already been "differentiated" for years in South Africa, prior to the roll out of the new adherence guidelines. AC and DMD models of care, when implemented as envisioned in the guidelines, are unlikely to generate substantive reductions or increases in provider costs of care. PMID: 32686911 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - July 21, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

SARS-CoV-2 and HIV coinfection: clinical experience from Rhode Island, United States.
We describe outpatient and inpatient preparedness for the COVID-19 pandemic, and present a case series of all known patients with HIV/SARS-CoV-2 coinfection at The Miriam Hospital and Rhode Island Hospital, and The Miriam Hospital Infectious Diseases and Immunology Center, in Providence, Rhode Island, US. RESULTS AND DISCUSSION: The Infectious Diseases and Immunology Center rapidly prepared for outpatient and inpatient care of persons with HIV and SARS-CoV-2. Between 30 March and 20 May 2020, 27 patients with HIV were diagnosed with SARS-CoV-2. Twenty were male, six female and one transgender female; average age was 49...
Source: Journal of the International AIDS Society - July 15, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Abstract Supplement Oral Abstracts from the 23rd International AIDS Conference, 6-10 July 2020.
Authors: PMID: 32649039 [PubMed - as supplied by publisher] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - July 11, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

COVID-19 vulnerability among people who use drugs: recommendations for global public health programmes and policies.
Authors: Holloway IW, C Spaulding A, Miyashita Ochoa A, A Randall L, R King A, HBOU Study Team, Frew PM PMID: 32640098 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - July 10, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Delays in repeat HIV viral load testing for those with elevated viral loads: a national perspective from South Africa.
Authors: Fox MP, Brennan AT, Nattey C, MacLeod WB, Harlow A, Mlisana K, Maskew M, Carmona S, Bor J Abstract INTRODUCTION: In South Africa, HIV patients with an elevated viral load (VL) should receive repeat VL testing after adherence counselling. We set out to use a national HIV Cohort to describe time to repeat viral load testing across South Africa and identify predictors of time to repeat testing. METHODS: We conducted a cohort study of prospectively collected laboratory data. HIV treatment guidelines have changed over time in South Africa, but call for repeat VL testing within six months if 400 to 1000 ...
Source: Journal of the International AIDS Society - July 10, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Trends in CD4 and viral load testing 2005 to 2018: multi-cohort study of people living with HIV in Southern Africa.
CONCLUSIONS: CD4 cell counting declined over time, including testing at the start of ART, despite the fact that many patients still initiated ART with advanced HIV disease. Without CD4 testing and expanded VL testing many patients with advanced HIV disease and treatment failure may go undetected, threatening the effectiveness of ART in sub-Saharan Africa. PMID: 32640106 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - July 10, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Impact of low-level viraemia on virological failure among Asian children with perinatally acquired HIV on first-line combination antiretroviral treatment: a multicentre, retrospective cohort study.
This study aimed to determine the impact of LLV on virological failure (VF) among Asian CLHIV on first-line combination antiretroviral therapy (cART). METHODS: CLHIV aged 50 copies/mL were excluded. LLV was defined as a pVL 50 to 1000 copies/mL, and VF as a single pVL>1000 copies/mL. Baseline was the time of the second pVL 
Source: Journal of the International AIDS Society - July 8, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Know your epidemic, know your response: understanding and responding to the heterogeneity of the COVID-19 epidemics across Southeast Asia.
Authors: Sohn AH, Phanuphak N, Baral S, Kamarulzaman A PMID: 32623817 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - July 7, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

A mobile health-facilitated behavioural intervention for community health workers improves exclusive breastfeeding and early infant HIV diagnosis in India: a cluster randomized trial.
CONCLUSIONS: The COMBIND intervention was easily integrated into India's existing PMTCT programme and improved early uptake of two PMTCT components that require self-motivated health-seeking behaviour, thus providing preliminary evidence to support COMBIND as a potentially scalable PMTCT strategy. Further study would identify modifications needed to optimize other PMTCT outcomes. PMID: 32618115 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - July 5, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Patient-reported reasons for declining same-day antiretroviral therapy initiation in routine HIV care settings in Lusaka, Zambia: results from a mixed-effects regression analysis.
CONCLUSIONS: Given differences observed in barriers to same-day ART initiation reported across sex, age, testing point, and facility type, new, tailored counselling and linkage to care approaches are needed, which should be rigorously evaluated in routine programme settings. PMID: 32618137 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - July 5, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Condom use among young women who sell sex in Zimbabwe: a prevention cascade analysis to identify gaps in HIV prevention programming.
Authors: Chabata ST, Hensen B, Chiyaka T, Mushati P, Busza J, Floyd S, Birdthistle I, Hargreaves JR, Cowan FM Abstract INTRODUCTION: Adolescent girls and young women (AGYW), including those who sell sex in sub-Saharan Africa, are especially vulnerable to HIV. Reaching them with effective prevention is a programmatic priority. The HIV prevention cascade can be used to track intervention coverage, and identify gaps and opportunities for programme strengthening. The aim of this study was to characterise gaps in condom use and identify reasons underlying these gaps among young women who sell sex (YWSS) in Zimbabwe usin...
Source: Journal of the International AIDS Society - July 1, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Cost-effectiveness of couples' voluntary HIV counselling and testing in six African countries: a modelling study guided by an HIV prevention cascade framework.
CONCLUSIONS: Our model indicates that nationalized CVCT could prevent over half of adult HIV infections for 7% to 21% of the modelled countries' five-year PEPFAR budgets. While other studies have indicated that CVCT motivation is high given locally relevant promotional and educational efforts, without required indicators, targets and dedicated budgets, access remains low. PMID: 32602618 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - July 1, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Can HIV recent infection surveillance help us better understand where primary prevention efforts should be targeted? Results of three pilots integrating a recent infection testing algorithm into routine programme activities in Kenya and Zimbabwe.
CONCLUSIONS: We successfully identified recently acquired infections among persons testing HIV-positive in routine testing settings and highlight the importance of incorporating additional information to accurately classify recent infection. We identified a number of groups with a significantly higher proportion of recent infection, suggesting recent infection surveillance, when rolled-out nationally, may help in further targeting primary prevention efforts. PMID: 32602625 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - July 1, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Access to HIV prevention services in East African cross-border areas: a 2016-2017 cross-sectional bio-behavioural study.
CONCLUSIONS: Individuals visiting venues in cross-border areas report poor access to and low effective use of condoms and other prevention services. Availability of HIV prevention services differed by venue and population type and cross-border area, suggesting opportunities for more granular targeting of HIV prevention interventions and transnational coordination of HIV programming. PMID: 32602638 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - July 1, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Disparities in the PrEP continuum for trans women compared to MSM in San Francisco, California: results from population-based cross-sectional behavioural surveillance studies.
CONCLUSIONS: We found PrEP disparities for trans women compared to MSM and the need for differentiated implementation strategies to meet the specific PrEP barriers trans women face. Inclusion of trans women's HIV risks is needed in CDC guidance for PrEP. Interventions to increase trans women's awareness of PrEP including at the provider and community level are also needed. Finally, programming that addresses trans women's barriers to housing and income is also needed to reduce PrEP disparities. PMID: 32602642 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - July 1, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Use of data from various sources to evaluate and improve the prevention of mother-to-child transmission of HIV programme in Zimbabwe: a data integration exercise.
CONCLUSIONS: Data integration was feasible and identified gaps in programme implementation/documentation leading to corrective interventions. Incident infections among mothers are the largest contributors to MTCT: there is need to strengthen the prevention cascade among HIV-negative women. PMID: 32602644 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - July 1, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

HIV risk, risk perception, and PrEP interest among adolescent girls and young women in Lilongwe, Malawi: operationalizing the PrEP cascade.
CONCLUSIONS: These results highlight key relationships between epidemiologic HIV risk, risk perception and interest in PrEP. While risk perception did partially explain the relationship between epidemiologic risk and PrEP interest, there may be other important motivational mechanisms that are not captured in many HIV prevention cascades. The high number of participants with risk scores below the high-risk cutoff who both expressed high perceived risk and interest in PrEP suggests that demand for PrEP among AGYW may not be well aligned with epidemiologic risk. PMID: 32602649 [PubMed - in process] (Source: Journal of the...
Source: Journal of the International AIDS Society - July 1, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

A tale of two cascades: promoting a standardized tool for monitoring progress in HIV prevention.
CONCLUSIONS: The HIV prevention field has been grappling for years with the idea of developing a standardised way to regularly assess progress and to monitor and improve programmes accordingly. The cascade provides the potential to do this, but it is complicated and highly nuanced. We believe the two models proposed here reflect emerging consensus among the range of stakeholders who have been engaging in this discussion and who are dedicated to achieving global HIV prevention goals by ensuring the most appropriate and effective programmes and methods are supported. PMID: 32602653 [PubMed - in process] (Source: Journal ...
Source: Journal of the International AIDS Society - July 1, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Strengthening primary HIV prevention: better use of data to improve programmes, develop strategies and evaluate progress.
Authors: Hargreaves JR, Auerbach JD, Hensen B, Johnson S, Gregson S PMID: 32602656 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - July 1, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Using a HIV prevention cascade for identifying missed opportunities in PrEP delivery in Kenya: results from a programmatic surveillance study.
Authors: Were D, Musau A, Mutegi J, Ongwen P, Manguro G, Kamau M, Marwa T, Gwaro H, Mukui I, Plotkin M, Reed J Abstract INTRODUCTION: HIV prevention cascades have been systematically evaluated in high-income countries, but steps in the pre-exposure prophylaxis (PrEP) service delivery cascade have not been systematically quantified in sub-Saharan Africa. We analysed missed opportunities in the PrEP cascade in a large-scale project serving female sex workers (FSW), men who have sex with men (MSM) and adolescent girls and young women (AGYW) in Kenya. METHODS: Programmatic surveillance was conducted using routine p...
Source: Journal of the International AIDS Society - July 1, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Operationalizing the HIV prevention cascade for PWID using the integrated bio-behavioural survey data from Ukraine.
CONCLUSIONS: Overall, the cascade framework was useful to describe the status of HIV prevention among PWID in Ukraine and to identify areas for improvement in the programming and evaluation of HIV prevention. Access to needle/syringe and condom programmes was substantially below the recommended levels. Effective use of clean syringes was reported by a vast majority of PWID, although likely affected by self-report bias; whereas consistent condom use was infrequent. Socio-demographic and behavioural variables showed significant associations in NSP and CP cascade analyses, with little consistency between the access and effect...
Source: Journal of the International AIDS Society - July 1, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Evaluation of a pre-exposure prophylaxis programme for men who have sex with men and transgender women in Thailand: learning through the HIV prevention cascade lens.
CONCLUSIONS: PrEP service cascades from the Princess PrEP programme identified no or low-risk perception as key barrier to PrEP acceptance among MSM and TGW who met PrEP eligibility criteria. More implementation research studies are needed to explore PrEP motivation and access in larger communities outside of clinical services. This is to identify gaps and strategies to address them within motivation, access and effective use domains of the HIV prevention cascade. PMID: 32602660 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - July 1, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Impact along the HIV pre-exposure prophylaxis "cascade of prevention" in western Kenya: a mathematical modelling study.
CONCLUSIONS: Implementation challenges along the prevention cascade compound to diminish the population-level impact of oral PrEP. Long-acting PrEP is expected to be less impacted by user uptake and adherence, but it is instead dependent on product availability in the short term and retention in the long term. To maximize the impact of long-acting PrEP, ensuring timely product approval and rollout is critical. Research is needed on strategies to improve retention and patterns of PrEP re-initiation. PMID: 32602669 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - July 1, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Qualitative characterizations of relationships among South African adolescent girls and young women and male partners: implications for engagement across HIV self-testing and pre-exposure prophylaxis prevention cascades.
CONCLUSIONS: Screening to identify AGYW relationship dynamics can support tailoring prevention services to relationship-driven barriers and facilitators. HIV prevention counseling for AGYW should address relationship goals or partner's influence, and engage with MP around female-controlled prevention interventions. PMID: 32603025 [PubMed - as supplied by publisher] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - July 1, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

A review of HIV pre-exposure prophylaxis (PrEP) programmes by delivery models in the Asia-Pacific through the healthcare accessibility framework.
CONCLUSION: PrEP programmes could be classified by delivery models through the five constructs of healthcare accessibility. While the coverage of PrEP remains limited in the Asia-Pacific, an evaluation of these models could benchmark best practices, which would in turn allow effective models to be designed. PMID: 32603517 [PubMed - as supplied by publisher] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - July 1, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

"Khotla Bophelong Bo Botle": a gathering of men for health.
"Khotla Bophelong Bo Botle": a gathering of men for health. J Int AIDS Soc. 2020 Jun;23 Suppl 2:e25511 Authors: Stender SC, Rozario A PMID: 32589315 [PubMed - as supplied by publisher] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - June 28, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Shifting the narrative: from "the missing men" to "we are missing the men".
Shifting the narrative: from "the missing men" to "we are missing the men". J Int AIDS Soc. 2020 Jun;23 Suppl 2:e25526 Authors: Grimsrud A, Ameyan W, Ayieko J, Shewchuk T PMID: 32589325 [PubMed - as supplied by publisher] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - June 28, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

An implementation study of oral and blood-based HIV self-testing and linkage to care among men in rural and peri-urban KwaZulu-Natal, South Africa.
CONCLUSIONS: HIVST is acceptable to men and rapid distribution with optional testing support is feasible in rural and peri-urban settings. HIVST kits successfully reached younger men and identified undetected infections. Both oral and blood-based HIVST were selected. Scaling up HIVST distribution and guidance may increase the number of first-time testers among men and help achieve the first UNAIDS "90" for men in South Africa. PMID: 32589337 [PubMed - as supplied by publisher] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - June 28, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Creating HIV risk profiles for men in South Africa: a latent class approach using cross-sectional survey data.
In this study we generated multi-factor profiles of HIV acquisition/transmission risk for men in Durban, South Africa, to help inform targeted programming and service delivery. METHODS: Data come from surveys with 947 men ages 20 to 40 conducted in two informal settlements from May to September 2017. Using latent class analysis (LCA), which detects a small set of underlying groups based on multiple dimensions, we identified classes based on nine HIV risk factors and socio-demographic characteristics. We then compared HIV service use between the classes. RESULTS: We identified four latent classes, with good model fi...
Source: Journal of the International AIDS Society - June 28, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

HIV prevalence, testing and treatment among men who have sex with men through engagement in virtual sexual networks in Kenya: a cross-sectional bio-behavioural study.
We examined HIV testing, HIV prevalence, awareness of HIV-positive status and linkage to antiretroviral therapy (ART), for HIV-positive MSM who solely met partners via physical sites (PMSM), compared with those who did so in virtual sites (either solely via virtual sites (VMSM), or via both virtual and physical sites (DMSM)). METHODS: We conducted a cross-sectional bio-behavioural survey of 1200 MSM, 15 years and above, in three counties in Kenya between May and July 2019, using random sampling of physical and virtual sites. We classified participants as PMSM, DMSM and VMSM, based on where they met sex partners, a...
Source: Journal of the International AIDS Society - June 28, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Lottery incentives have short-term impact on ART initiation among men: results from a randomized pilot study.
CONCLUSIONS: Conditional lottery incentives shortened the time to ART initiation among South African men. Behavioural economics strategies strengthen linkage to ART, but the study power was limited to see an impact on viral suppression. CLINICAL TRIAL NUMBER: NCT03808194. PMID: 32589342 [PubMed - as supplied by publisher] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - June 28, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Gendered health institutions: examining the organization of health services and men's use of HIV testing in Malawi.
CONCLUSIONS: Health institutions in Malawi were organized in ways that created substantial, multilevel barriers to men's HIV testing and reinforced perceptions of absent, difficult men. Future research should prioritize a gendered organization framework to understand and address the complex realities of men's constrained access to HIV services. PMID: 32589346 [PubMed - as supplied by publisher] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - June 28, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Reframing the approach to heterosexual men in the HIV epidemic in sub-Saharan Africa.
Authors: Makusha T, van Rooyen H, Cornell M PMID: 32589347 [PubMed - as supplied by publisher] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - June 28, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Male partner testing and sexual behaviour following provision of multiple HIV self-tests to Kenyan women at higher risk of HIV infection in a cluster randomized trial.
We examined data from women at higher risk of HIV participating in the intervention arm of an ongoing pair-matched cluster randomized trial in Kenya. HIV-negative women ≥18 years who self-reported ≥2 partners in the past month were eligible. Participants received self-tests at enrolment and three-monthly intervals. They were encouraged to offer tests to sexual partners with whom they anticipated condomless sex. At six months, we collected data on self-test distribution, male partner and couples testing, and testing and sexual behaviour in the three most recent transactional sex encounters. We used descriptive an...
Source: Journal of the International AIDS Society - June 28, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Index and targeted community-based testing to optimize HIV case finding and ART linkage among men in Zambia.
CONCLUSIONS: Index testing and targeted community-based HTS are effective strategies to identify men living with HIV in Zambia. Index testing results in higher yield, but lower linkage and fewer absolute men identified compared to targeted community-based HTS. PMID: 32589360 [PubMed - as supplied by publisher] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - June 28, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Population-wide differentials in HIV service access and outcomes in the Western Cape for men as compared to women, South Africa: 2008 to 2018: a cohort analysis.
This study quantifies differentials in HIV care, treatment and mortality outcomes for men and women over time in South Africa. METHODS: We analysed population-wide linked anonymized data, including vital registration linkage, for the Western Cape Province, from the time of first CD4 count. Three antiretroviral therapy guideline eligibility periods were defined: 1 January 2008 to 31 July 2011 (CD4 cell count
Source: Journal of the International AIDS Society - June 28, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

"Patients are not the same, so we cannot treat them the same" - A qualitative content analysis of provider, patient and implementer perspectives on differentiated service delivery models for HIV treatment in South Africa.
CONCLUSIONS: Implementation of DSD models at scale is complex but this evaluation identified several positive aspects of AGL implementation. The positive perception of RPCS interventions and challenges managing patients not stable on treatment aligned with results from the larger evaluation. While some implementation challenges may resolve with experience, ensuring providers and implementers have the necessary training, tools and resources to operationalize AGL effectively is critical to the overall success of South Africa's HIV control strategy. PMID: 32585077 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - June 27, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Associations between schistosomiasis and HIV-1 acquisition risk in four prospective cohorts: a nested case-control analysis.
CONCLUSIONS: Schistosomiasis was not a strong risk factor for HIV-1 acquisition in these four prospective studies. S. mansoni was responsible for the majority of schistosomiasis in these cohorts, and our results do not support the hypothesis that S. mansoni infection is associated with increased HIV-1 acquisition risk. S. haematobium infection was associated with a point estimate of elevated HIV-1 risk in the FSW cohort that was not statistically significant, and there was no trend towards a positive association in the serodiscordant couples cohorts. PMID: 32585078 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - June 27, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Measuring linkage to HIV treatment services following HIV self-testing in low-income settings.
Authors: Choko AT, Jamil MS, MacPherson P, Corbett E, Chitembo L, Ingold H, Bermudez Aza E, d'Elbee M, DiCarlo M, Majam M, Schewchuk T, Wong V, Baggaley R, Johnson C, World Health Organization HIV self-testing technical working group PMID: 32579759 [PubMed - as supplied by publisher] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - June 25, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

It's not all about COVID-19: pneumocystis pneumonia in the era of a respiratory outbreak.
Authors: Choy CY, Wong CS PMID: 32558276 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - June 21, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Impact of male circumcision on risk of HIV infection in men in a changing epidemic context - systematic review and meta-analysis.
CONCLUSIONS: Efficacy of medical male circumcision on HIV incidence from randomized controlled trials was supported by effectiveness from observational studies in populations with diverse HIV risk and changing epidemic contexts. Voluntary Medical Male Circumcision remains an important evidence-based intervention for control of generalized HIV epidemics. PMID: 32558344 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - June 21, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

A call to action: strengthening the capacity for data capture and computational modelling of HIV integrated care in low- and middle-income countries.
Authors: Kupfer LE, Beecroft B, Viboud C, Wang X, Brouwers P PMID: 32562312 [PubMed - as supplied by publisher] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - June 21, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Recommendations for the use of mathematical modelling to support decision-making on integration of non-communicable diseases into HIV care.
CONCLUSIONS: Modelling can and should play an integral part in the decision-making processes for health in general and NCD-HIV integration specifically. It is especially useful where little data is available. The successful use of modelling to inform decision-making will depend on several factors including policy makers' comfort with and understanding of models and their uncertainties, modellers understanding of national priorities, funding opportunities and building local modelling capacity to ensure sustainability. PMID: 32562338 [PubMed - as supplied by publisher] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - June 21, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Integrated screening and treatment services for HIV, hypertension and diabetes in Kenya: assessing the epidemiological impact and cost-effectiveness from a national and regional perspective.
CONCLUSIONS: Integrated screening and treatment of HIV and NCDs can be a cost-effective and impactful approach to save lives of people with HIV in Kenya, although important variation exists at the regional level. Containing the substantial costs required for scale-up will be critical for management of HIV and NCDs on a national scale. PMID: 32562353 [PubMed - as supplied by publisher] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - June 21, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Layering and scaling up chronic non-communicable disease care on existing HIV care systems and acute care settings in Kenya: a cost and budget impact analysis.
Authors: Osetinsky B, Mwangi A, Pastakia S, Wilson-Barthes M, Kimetto J, Rono K, Laktabai J, Galárraga O Abstract INTRODUCTION: Like many countries in sub-Saharan Africa, Kenya is experiencing a rapid rise in the burden of non-communicable diseases (NCDs): NCDs now contribute to over 50% of inpatient admissions and 40% of hospital deaths in the country. The Academic Model Providing Access to Healthcare (AMPATH) Chronic Disease Management (CDM) programme builds on lessons and capacity of HIV care to deliver chronic NCD care layered into both HIV and primary care platforms to over 24,000 patients across 69 hea...
Source: Journal of the International AIDS Society - June 21, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research