Estimating HIV incidence in the Akwa Ibom AIDS indicator survey (AKAIS), Nigeria using the limiting antigen avidity recency assay
CONCLUSIONS: The finding of the high HIV incidence among the 15 to 49-year age group calls for renewed and innovative efforts to prevent HIV infection among young adults in Akwa Ibom state.PMID:33619853 | DOI:10.1002/jia2.25669 (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - February 23, 2021 Category: Infectious Diseases Authors: Olubunmi R Negedu-Momoh Oluseyi Balogun Ibrahim Dafa Akan Etuk Edward Adekola Oladele Oluwasanmi Adedokun Ezekiel James Satish R Pandey Hadiza Khamofu Titi Badru Janet Robinson Timothy D Mastro Kwasi Torpey Source Type: research

Examining healthcare transition experiences among youth living with HIV in Atlanta, Georgia, USA: a longitudinal qualitative study
CONCLUSIONS: This study's longitudinal perspective on the healthcare transition experience yields insights that can be incorporated into programming targeting this critically important population. Although our study was conducted in a USA-based clinic with co-located paediatric and adult care services, many of our findings are likely to have relevance in other settings as well. Interventions aiming to improve HIV care engagement through transition should seek to enhance patient-provider communication in both paediatric and adult clinics, improve preparation of patients in paediatric clinics and ease patients gradually into...
Source: Journal of the International AIDS Society - February 23, 2021 Category: Infectious Diseases Authors: Alexis S Halyard Kamini Doraivelu Andr és F Camacho-González Carlos Del R ío Sophia A Hussen Source Type: research

High rates of long-term progression in HIV-1-positive elite controllers
CONCLUSIONS: The rate of long-term progression in EC was very high. Only a minority of patients did not show clinical progression after a median of 17 years of follow-up. These results should be taken in account when considering EC as a model of HIV-1 remission.PMID:33619912 | DOI:10.1002/jia2.25675 (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - February 23, 2021 Category: Infectious Diseases Authors: Maria Borrell Irene Fern ández Flor Etcheverrry Ainoa Ugarte Montserrat Plana Lorna Leal Felipe Garc ía Source Type: research

Estimating HIV incidence in the Akwa Ibom AIDS indicator survey (AKAIS), Nigeria using the limiting antigen avidity recency assay
CONCLUSIONS: The finding of the high HIV incidence among the 15 to 49-year age group calls for renewed and innovative efforts to prevent HIV infection among young adults in Akwa Ibom state.PMID:33619853 | DOI:10.1002/jia2.25669 (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - February 23, 2021 Category: Infectious Diseases Authors: Olubunmi R Negedu-Momoh Oluseyi Balogun Ibrahim Dafa Akan Etuk Edward Adekola Oladele Oluwasanmi Adedokun Ezekiel James Satish R Pandey Hadiza Khamofu Titi Badru Janet Robinson Timothy D Mastro Kwasi Torpey Source Type: research

Examining healthcare transition experiences among youth living with HIV in Atlanta, Georgia, USA: a longitudinal qualitative study
CONCLUSIONS: This study's longitudinal perspective on the healthcare transition experience yields insights that can be incorporated into programming targeting this critically important population. Although our study was conducted in a USA-based clinic with co-located paediatric and adult care services, many of our findings are likely to have relevance in other settings as well. Interventions aiming to improve HIV care engagement through transition should seek to enhance patient-provider communication in both paediatric and adult clinics, improve preparation of patients in paediatric clinics and ease patients gradually into...
Source: Journal of the International AIDS Society - February 23, 2021 Category: Infectious Diseases Authors: Alexis S Halyard Kamini Doraivelu Andr és F Camacho-González Carlos Del R ío Sophia A Hussen Source Type: research

High rates of long-term progression in HIV-1-positive elite controllers
CONCLUSIONS: The rate of long-term progression in EC was very high. Only a minority of patients did not show clinical progression after a median of 17 years of follow-up. These results should be taken in account when considering EC as a model of HIV-1 remission.PMID:33619912 | DOI:10.1002/jia2.25675 (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - February 23, 2021 Category: Infectious Diseases Authors: Maria Borrell Irene Fern ández Flor Etcheverrry Ainoa Ugarte Montserrat Plana Lorna Leal Felipe Garc ía Source Type: research

Attrition in HIV care following HIV diagnosis: a comparison of the pre-UTT and UTT eras in South Africa.
CONCLUSIONS: Overall, nearly two-fifths of HIV positive patients are likely to disengage from care by 12 months after HIV diagnosis under the new SDI policy. Furthermore, the increase in on-ART patient attrition after the introduction of the SDI policy is cause for concern. Further research is needed to determine the best way for rapidly initiating patients on ART and also reducing long-term attrition from care. PMID: 33605061 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - February 20, 2021 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Missed opportunities for sexual transmitted infections testing for HIV pre-exposure prophylaxis users: a systematic review.
Authors: Ong JJ, Fu H, Baggaley RC, Wi TE, Tucker JD, Smith MK, Rafael S, Falconer J, Terris-Prestholt F, Mameletzis I, Mayaud P Abstract INTRODUCTION: Given the synergistic relationship between HIV and sexually transmitted infections (STI), the integration of services has the potential to reduce the incidence of both HIV and STIs. We explored the extent to which STI testing has been offered within HIV pre-exposure prophylaxis (PrEP) programmes worldwide. METHODS: We conducted a systematic review of PrEP programmes implementing STI testing services in nine databases. We approached PrEP implementers for addition...
Source: Journal of the International AIDS Society - February 20, 2021 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

4th HIV Research for Prevention conference (HIVR4P // Virtual), 27 & 28 January | 3 & 4 February 2021.
4th HIV Research for Prevention conference (HIVR4P // Virtual), 27 & 28 January | 3 & 4 February 2021. J Int AIDS Soc. 2021 Feb;24 Suppl 1:e25659 Authors: PMID: 33605533 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - February 20, 2021 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Preference for daily versus on-demand pre-exposure prophylaxis for HIV and correlates among men who have sex with men: the China Real-world Oral PrEP Demonstration study.
CONCLUSIONS: MSM in China prefer both daily and on-demand PrEP when both regimens are provided free. Social structural factors and subjective risk of HIV infection have significant impacts on PrEP preference and use. The upcoming national PrEP guideline should consider incorporating both regimens and the correlates to help implement PrEP in China. PMID: 33586841 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - February 17, 2021 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Home-Based Intervention to Test and Start (HITS): a community-randomized controlled trial to increase HIV testing uptake among men in rural South Africa.
Authors: Tanser FC, Kim HY, Mathenjwa T, Shahmanesh M, Seeley J, Matthews P, Wyke S, McGrath N, Adeagbo O, Sartorius B, Yapa HM, Zuma T, Zeitlin A, Blandford A, Dobra A, Bärnighausen T Abstract INTRODUCTION: The uptake of HIV testing and linkage to care remains low among men, contributing to high HIV incidence in women in South Africa. We conducted the "Home-Based Intervention to Test and Start" (HITS) in a 2x2 factorial cluster randomized controlled trial in one of the World's largest ongoing HIV cohorts in rural South Africa aimed at enhancing both intrinsic and extrinsic motivations for HIV testin...
Source: Journal of the International AIDS Society - February 17, 2021 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Integration of mental health services into HIV healthcare facilities among Thai adolescents and young adults living with HIV.
Authors: Sudjaritruk T, Aurpibul L, Songtaweesin WN, Narkpongphun A, Thisayakorn P, Chotecharoentanan T, Nadsasarn R, Janjing P, Saisaengjan C, Puthanakit T, Mental Health Study Group Abstract INTRODUCTION: To assess the burden of depression, anxiety and suicidality; and to determine the impact of integrated mental health and HIV services on treatment outcomes among Thai adolescents and young adults living with HIV (AYHIV). METHODS: A multicentre prospective cohort study was conducted among AYHIV (15 to 25 years), and age- and sex-matched HIV-uninfected adolescents and young adults (HUAY). The Patient Heal...
Source: Journal of the International AIDS Society - February 13, 2021 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Youth engagement in HIV prevention intervention research in sub-Saharan Africa: a scoping review.
CONCLUSIONS: We found limited youth engagement in youth HIV prevention intervention studies in sub-Saharan Africa. However, several activities resulted in substantial youth engagement and could be relevant in many low-and-middle-income-country (LMIC) settings. PMID: 33569913 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - February 13, 2021 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Estimating the contribution of key populations towards HIV transmission in South Africa.
CONCLUSIONS: Clients of FSWs play a fundamental role in HIV transmission in SA. Addressing the HIV prevention and treatment needs of KPs in generalized HIV epidemics is central to a comprehensive HIV response. PMID: 33533115 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - February 4, 2021 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

The promise of paediatric dolutegravir.
Authors: Golin R, Samuel JM, Phelps BR, Persaud U, Malati CY, Siberry GK PMID: 33522081 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - February 3, 2021 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Response to: "Inclusion as Illusion: Erasing Transgender Women in Research with MSM".
Response to: "Inclusion as Illusion: Erasing Transgender Women in Research with MSM". J Int AIDS Soc. 2021 Jan;24(1):e25662 Authors: Crowell TA, Fast PE, Bekker LG, Sanders EJ PMID: 33496371 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - January 28, 2021 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Inclusion as illusion: erasing transgender women in research with MSM.
Authors: Poteat TC, van der Merwe LLA, Sevelius J, Keatley J PMID: 33496381 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - January 28, 2021 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Preference for using a variety of future HIV pre-exposure prophylaxis products among men who have sex with men in three US cities.
CONCLUSIONS: Most MSM were interested in using various potential future HIV prevention products, especially LAI. However, two typologies of potential users emerged: men who prefer sexual event-based methods (condoms, event-based pill, sexual gels and suppositories) and men who prefer non-sexual event-based methods (daily pill, LAI). Men who reported recent unprotected anal sex preferred a penile gel product most, followed closely by sexual event-based pills and LAI. Racial/ethnic differences were noted as well. These findings on product preferences can help in formulation development and messaging. PMID: 33481359 [PubM...
Source: Journal of the International AIDS Society - January 24, 2021 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Optimizing infant HIV diagnosis with additional screening at immunization clinics in three sub-Saharan African settings: a cost-effectiveness analysis.
CONCLUSIONS: Universal maternal HIV screening at immunization visits with referral to EID and maternal ART initiation may reduce MTCT, improve paediatric LE, and be of comparable value to current HIV-related interventions in high maternal HIV prevalence settings like SA and Zimbabwe. PMID: 33474817 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - January 23, 2021 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Subtype-specific differences in transmission cluster dynamics of HIV-1 B and CRF01_AE in New South Wales, Australia.
Authors: Di Giallonardo F, Pinto AN, Keen P, Shaik A, Carrera A, Salem H, Selvey C, Nigro SJ, Fraser N, Price K, Holden J, Lee FJ, Dwyer DE, Bavinton BR, Geoghegan JL, Grulich AE, Kelleher AD, NSW HIV Prevention Partnership Project Abstract INTRODUCTION: The human immunodeficiency virus 1 (HIV-1) pandemic is characterized by numerous distinct sub-epidemics (clusters) that continually fuel local transmission. The aims of this study were to identify active growing clusters, to understand which factors most influence the transmission dynamics, how these vary between different subtypes and how this information might co...
Source: Journal of the International AIDS Society - January 23, 2021 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Evaluation of near point-of-care viral load implementation in public health facilities across seven countries in sub-Saharan Africa.
CONCLUSIONS: Near-POC VL testing enabled rapid test result delivery for high-risk populations and led to significant improvements in the timeliness of patient result receipt compared to centralized testing. While there was some improvement in time-to-clinical action with near-POC VL testing, major gaps remained. Strengthening of systems supporting the utilization of results for patient management are needed to truly capitalize on the benefits of decentralized testing. PMID: 33455081 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - January 21, 2021 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Antiretroviral therapy and Kaposi's sarcoma trends and outcomes among adults with HIV in Latin America.
CONCLUSIONS: KS incidence in Latin America has remained stable in recent years and risk is highest before and shortly after ART initiation. Early diagnosis of HIV and ART initiation remain critical priorities in the region. PMID: 33405281 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - January 8, 2021 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Approaches to transitioning women into and out of prevention of mother-to-child transmission of HIV services for continued ART: a systematic review.
CONCLUSIONS: This review highlights that, despite the need for women to transition into and out of PMTCT services for continued ART in many settings, there is very limited evidence on optimal transition approaches. Ongoing operational research is required to identify sustainable and acceptable transition approaches and service delivery models that support continuity of HIV care during and after pregnancy. PMID: 33372730 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - December 31, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Prevalence of pretreatment HIV drug resistance in key populations: a systematic review and meta-analysis.
CONCLUSIONS: High prevalence of PDR found in key populations highlights the need to increase access to effective first-line HIV treatment. The low prevalence of nucleotide reverse transcriptase inhibitor (NRTI) PDR suggests that current WHO recommendations for pre-exposure prophylaxis (PrEP) regimens will remain effective and can be scaled up to prevent new HIV infections in high-risk groups. PMID: 33369131 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - December 29, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

High variability in the measurement of HIV primary prevention activities and outcomes.
CONCLUSIONS: These analyses reveal a lack of consensus both between and within countries' and global stakeholders' measurement of HIV prevention. Though some variability is expected, these findings point to a need to refocus attention on achieving greater consensus on a global measurement framework for HIV prevention. PMID: 33345450 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - December 22, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Assessing the performance of international pre-exposure prophylaxis (PrEP) eligibility guidelines in a cohort of Chinese MSM, Beijing, China 2009 to 2016.
CONCLUSIONS: The performance of international indication guidelines in this sample was only slightly better than random allocation. Using such guidelines to screen out MSM self-identifying as interested in PrEP could lead to misallocation of resources and to good candidates for PrEP being denied access. For settings in which international guidelines perform poorly, alternative indication approaches should be considered. PMID: 33345453 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - December 22, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Examining the relationship between physical and sexual violence and psychosocial health in young people living with HIV in rural South Africa.
CONCLUSIONS: In this setting, the prevalence of meaningful depressive symptoms was significantly higher among YLWH with a history of physical or sexual violence as compared to those without a history of violence. However, higher levels of self-esteem or social support appeared to mitigate this association. Programmes to improve self-esteem and social support for youth have the potential to minimize depressive symptoms in YLWH who have experienced physical or sexual violence. PMID: 33340267 [PubMed - as supplied by publisher] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - December 21, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Twenty-four-month outcomes from a cluster-randomized controlled trial of extending antiretroviral therapy refills in ART adherence clubs.
We report retention in care, viral load completion and viral suppression (
Source: Journal of the International AIDS Society - December 21, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

24-Month HIV-free survival among HIV-exposed Infants in Lesotho: the PEAWIL cohort study.
CONCLUSIONS: The implementation of lifelong ART for PMTCT in the Lesotho public health system resulted in low HIV transmission, but survival of HEI remains lower than their HIV uninfected counterparts. PMID: 33314744 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - December 15, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Effectiveness of a psychological intervention delivered by general nurses for alcohol use disorders in people living with HIV in Zimbabwe: a cluster randomized controlled trial.
CONCLUSIONS: Interventions for hazardous drinking and AUD comprising brief, multiple alcohol treatment sessions delivered by nurses in public HIV facilities in low-income African countries can reduce problematic drinking among PLWH. Such interventions should be integrated into the primary care management of AUD and HIV and delivered by non-specialist providers. Research is needed on cost-effectiveness and implementation of such interventions, and on validation of cut-points for alcohol use scales in low resource settings, in partnership with those with lived experience of HIV and AUD. PMID: 33314786 [PubMed - in proces...
Source: Journal of the International AIDS Society - December 15, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Mental health, substance use and viral suppression in adolescents receiving ART at a paediatric HIV clinic in South Africa.
CONCLUSIONS: ALHIV affected by mental health problems have increased rates of unsuppressed viral load and need specific clinical attention. The integration of routine mental health screening in paediatric ART programmes is a feasible approach for identifying and referring adolescents with mental health and adherence problems to counselling and psychosocial support services and if needed to psychiatric care. PMID: 33283916 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - December 8, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Pathways for reduction of HIV-related stigma: a model derived from longitudinal qualitative research in Kenya and Uganda.
CONCLUSIONS: Declines in HIV-related stigma appear to underway and explained by social processes accelerated by UTT efforts. Widespread implementation of UTT shows promise for reducing multiple dimensions of stigma, which is critical for improving health outcomes among PLHIV. PMID: 33283986 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - December 8, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Retention in care and viral suppression in differentiated service delivery models for HIV treatment delivery in sub-Saharan Africa: a rapid systematic review.
CONCLUSIONS: Existing evidence on the clinical outcomes of DSD models for HIV treatment in sub-Saharan Africa is limited in both quantity and quality but suggests that retention in care and viral suppression are roughly equivalent to those in conventional models of care. PMID: 33247517 [PubMed - as supplied by publisher] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - November 29, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Antiretroviral treatment interruption among people living with HIV during COVID-19 outbreak in China: a nationwide cross-sectional study.
CONCLUSIONS: A significant proportion of PLHIV in China are at risk of ATI during the COVID-19 outbreak and some have already experienced ATI. Correlates of ATI and self-reported barriers to ART suggest that social disruptions from COVID-19 have contributed to ATI. Our findings demonstrate an urgent need for policies and interventions to maintain access to HIV care during public health emergencies. PMID: 33247541 [PubMed - as supplied by publisher] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - November 29, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Incentives conditioned on tenofovir levels to support PrEP adherence among young South African women: a randomized trial.
CONCLUSIONS: Among South African AGYW initiating PrEP, drug levels indicated high PrEP adherence in almost half of women at Month 3, with a non-statistically significant higher proportion with high adherence among those in the incentive group. Over half persisted with the 12-month PrEP programme although high adherence declined after Month 3. Strategies to support PrEP adherence and persistence and longer-acting PrEP formulations are needed. PMID: 33247553 [PubMed - as supplied by publisher] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - November 29, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Prevalence of nonsuppressed viral load and associated factors among HIV-positive adults receiving antiretroviral therapy in Eswatini, Lesotho, Malawi, Zambia and Zimbabwe (2015 to 2017): results from population-based nationally representative surveys.
We examined VLS and its determinants among adults receiving ART for at least four months. METHODS: We analysed data from the population-based HIV impact assessment (PHIA) surveys in Eswatini, Lesotho, Malawi, Zambia and Zimbabwe (2015 to 2017). PHIA surveys are nationally representative, cross-sectional household surveys. Data collection included structured interviews, home-based HIV testing and laboratory testing. Blood samples from PLHIV were analysed for HIV RNA, CD4 counts and recent exposure to antiretroviral drugs (ARVs). We calculated representative estimates for the prevalence of VLS (viral load
Source: Journal of the International AIDS Society - November 25, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Prevalence of and factors associated with advanced HIV disease among newly diagnosed people living with HIV in Guangdong Province, China.
This study aimed to explore the prevalence of and factors related to AHD among newly diagnosed PLHIV in Guangdong Province, China. METHODS: Newly diagnosed PLHIV were recruited from six cities in Guangdong Province from May 2018 to June 2019. AHD was defined as an initial CD4 count
Source: Journal of the International AIDS Society - November 25, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

New pathogen, same disparities: why COVID-19 and HIV remain prevalent in U.S. communities of colour and implications for ending the HIV epidemic.
CONCLUSIONS: Racism and discrimination place communities of colour at greater risk for COVID-19 as well as HIV. Achieving and sustaining an end to the U.S. HIV epidemic will require structural change to eliminate conditions that give rise to and maintain disparities. PMID: 33222424 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - November 24, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Paediatric HIV: we are not done yet!
Authors: Penazzato M PMID: 33215880 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - November 22, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Greater dapivirine release from the dapivirine vaginal ring is correlated with lower risk of HIV-1 acquisition: a secondary analysis from a randomized, placebo-controlled trial.
Authors: Brown ER, Hendrix CW, van der Straten A, Kiweewa FM, Mgodi NM, Palanee-Philips T, Marzinke MA, Bekker LG, Soto-Torres L, Hillier SL, Baeten JM, MTN-020/ASPIRE Study Team Abstract INTRODUCTION: A vaginal ring containing 25 mg of the antiretroviral dapivirine has demonstrated efficacy in reducing women's risk of sexually acquiring HIV-1; however, imperfect ring use likely diluted efficacy estimates in clinical trials. The amount of dapivirine remaining in returned rings may reflect the extent of product use, permitting estimation of HIV protection in the context of consistent use. METHODS: We measur...
Source: Journal of the International AIDS Society - November 21, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

A retrospective analysis of the care cascades for non-communicable disease and mental health among people living with HIV at a tertiary-care centre in Malaysia: opportunities to identify gaps and optimize care.
CONCLUSIONS: Systematic screening must be introduced to identify NCDs and mental health issues among PLWH followed by proper linkage and referrals for management of screen-positive cases. Assessment of factors associated with attrition at each step of the care cascade is critically needed to improve health outcomes in our aging patients. PMID: 33206473 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - November 21, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

A call to improve understanding of Undetectable equals Untransmittable (U  = U) in Brazil: a web-based survey.
In this study, we documented the perceived accuracy of U = U in Brazil in three different groups: PLHIV, HIV-negative/unknown cisgender gay/bisexual men who have sex with men (GBM) and HIV-negative/unknown other populations (POP). METHODS: Adult (age ≥ 18y) Brazilians were recruited during October 2019 to complete a web-based survey advertised on Grindr, Facebook and WhatsApp. Perceived accuracy of U = U was assessed with the question: "With regards to HIV-positive individuals transmitting HIV through sexual contact, how accurate do you believe the slogan U = U is?" ...
Source: Journal of the International AIDS Society - November 11, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Sexual behaviour change following HIV testing services: a systematic review and meta-analysis.
CONCLUSIONS: Our findings highlight the importance of using limited resources towards HTS strategies that focus on early HIV diagnosis, treatment and prevention services rather than resources dedicated to supplementing or enhancing HTS with additional counselling or other interventions. PMID: 33161636 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - November 11, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

COVID-19, HIV and key populations: cross-cutting issues and the need for population-specific responses.
CONCLUSIONS: Disruptions to both licit and illicit supply chains, loss of income and livelihoods and changes in behaviour as a result of lockdowns and physical distancing have the potential to exacerbate the impacts of the COVID-19 pandemic on key populations. While these impacts will vary significantly, human-rights approaches to COVID-19 emergency laws and public health prevention measures that are population-specific and sensitive, will be key to reducing adverse health outcomes and ensuring that no one is left behind. PMID: 33119183 [PubMed - as supplied by publisher] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - October 30, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Comparison of effectiveness and cost for different HIV screening strategies implemented at large urban medical centre in the United States.
CONCLUSIONS: The SN strategy yielded the highest proportion of new diagnoses, followed closely by the MPS programme. Both the SN strategy and RS programme were comparable in the cost per new diagnosis. A simultaneous approach that consists of RS in combination with SN testing may be most effective for identifying new HIV infections in settings with heterogeneous epidemics with both high rates of HIV prevalence and HIV testing. PMID: 33119195 [PubMed - as supplied by publisher] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - October 30, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Cost-effectiveness of a 12 country-intervention to scale up short course TB preventive therapy among people living with HIV.
CONCLUSIONS: Our findings provide donors with reasonable evidence of value for money to support investment in short-course TB preventive therapy for people initiating ART in high-burden settings. Our study also illustrates the importance of considering long-term secondary ("catalytic") effects when evaluating the cost-effectiveness of large-scale initiatives designed to change a global policy landscape. PMID: 33107219 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - October 29, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Racial justice and HIV in the United States: now is the time.
Authors: Godley BA, Schoenbach VJ, Adimora AA PMID: 33078585 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - October 22, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Cost-effectiveness of one month of daily isoniazid and rifapentine versus three months of weekly isoniazid and rifapentine for prevention of tuberculosis among people receiving antiretroviral therapy in Uganda.
CONCLUSIONS: 1HP has the potential to be cost-effective under many realistic circumstances. Cost-effectiveness depends on rifapentine price, relative completion and efficacy, prevalence of latent TB and local willingness-to-pay. PMID: 33073520 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - October 20, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Efficacy of silk fibroin biomaterial vehicle for in vivo mucosal delivery of Griffithsin and protection against HIV and SHIV infection ex vivo.
CONCLUSIONS: We demonstrated that in vivo delivery of SF-Grft in rhesus macaques fully protects against SHIV challenge ex vivo after two hours of application and is safe to use in both the vaginal and rectal compartments. Our study provides support for the development of silk fibroin as a highly promising, user-friendly HIV prevention modality to address the global disparity in HIV infection. PMID: 33073530 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - October 20, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Implications of COVID-19 for HIV Research: data sources, indicators and longitudinal analyses.
Authors: Rebeiro PF, Duda SN, Wools-Kaloustian KK, Nash D, Althoff KN, International epidemiology Databases to Evaluate AIDS (IeDEA) PMID: 33047483 [PubMed] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - October 15, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research