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Neurodevelopment of children who are HIV-exposed and uninfected in Kenya
CONCLUSIONS: Biologic and social factors were associated with child neurodevelopment. Despite socio-demographic differences between CHEU and CHUU, 1-year neurodevelopment was similar. Addressing IPV and food insecurity may provide benefits regardless of maternal HIV status. DTG use was associated with higher neurodevelopmental scores in CHEU, compared to EFV regimens, potentially contributing to a lack of neurodevelopmental difference between CHEU and CHUU.PMID:37909174 | PMC:PMC10618871 | DOI:10.1002/jia2.26149 (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - November 1, 2023 Category: Infectious Diseases Authors: Michelle A Bulterys Irene Njuguna Maureen King'e Daisy Chebet Hellen Moraa Laur én Gomez Alvin Onyango Kenneth Malavi Gladys Nzia Martin Chege Jillian Neary Anjuli D Wagner Kendall A Lawley Dalton Wamalwa Sarah Benki-Nugent Grace John-Stewart Source Type: research

Better Together: acceptability, feasibility and preliminary impact of chronic illness peer support groups for South African adolescents and young adults
CONCLUSIONS: Recurring, clinic-based peer support groups that integrate youth living with HIV and other chronic diseases are novel. Group sustainability will depend on the commitment of experienced peer leaders and providers, routine scheduling and transportation support. A fully powered randomised trial is needed to test the optimal implementation and causal mental health effects of the Better Together model.PMID:37909178 | PMC:PMC10618872 | DOI:10.1002/jia2.26148 (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - November 1, 2023 Category: Infectious Diseases Authors: Abigail Harrison Bulelwa Mtukushe Caroline Kuo Marta Wilson-Barthes Bianca Davidson Rebecca Sher Omar Gal árraga Jacqueline Hoare Source Type: research

A trial of nurturing care among children who are HIV-exposed and uninfected in eSwatini
CONCLUSIONS: Nurturing care interventions can be integrated into ANC/PVT clinic-home-community programmes. The intervention, mediated through interactive caregiving activities, increased language development scores among CHEU. Partnering with a local team, m2m, to design and implement a culturally relevant intervention illustrates the ability to impact parent-child play and learning activities that are associated with children's neurodevelopment.PMID:37909213 | PMC:PMC10618895 | DOI:10.1002/jia2.26158 (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - November 1, 2023 Category: Infectious Diseases Authors: Andrea Ruff Xolisile Dlamini Bareng As Nonyane Nicole Simmons Duncan Kochelani Fiona Burtt Fakazi Mlotshwa Ncamsile Gama Esca Scheepers Kathrin Schmitz Lethokuhle Simelane Lynn M Van Lith Maureen M Black Source Type: research

Setting the research agenda: involving parents in research on children who are HIV-free
CONCLUSIONS: Mothers and parents living with HIV should be involved in research about their children born HIV-free and are key in identifying research priorities so that findings may translate into an impact on their children's health and wellbeing. Meaningful involvement of women living with HIV through trusted community partners is an effective mechanism by which to elicit views on research about their children.PMID:37909217 | PMC:PMC10618900 | DOI:10.1002/jia2.26150 (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - November 1, 2023 Category: Infectious Diseases Authors: Laurette L Bukasa Angelina Namiba Matilda Brown Estelle Ndu'ngu Mercy Nangwale Gillian Letting Patricia Chirwa Claire Thorne Shema Tariq Source Type: research

Strengthening the evidence to improve health outcomes of children with perinatal HIV exposure
CONCLUSIONS: A growing population of children who are HEU are maturing into adolescence and young adulthood. Research to advance understanding of the possible negative long-term effects of HIV and/or ART exposure in these youth is supported by the US National Institutes of Health. Both large epidemiological studies and smaller more comprehensive cohort studies may be required to address the complexity of the issue. Integrating both types of studies could allow the establishment of more reliable and validated predictions of which youth who are HEU are at the highest risk for specific negative health outcomes, such as mental...
Source: Journal of the International AIDS Society - November 1, 2023 Category: Infectious Diseases Authors: Sonia Lee Susannah Allison Pim Brouwers Source Type: research

When and how to intervene to improve the health of children born HIV-free
J Int AIDS Soc. 2023 Oct;26 Suppl 4(Suppl 4):e26157. doi: 10.1002/jia2.26157.NO ABSTRACTPMID:37909224 | PMC:PMC10618881 | DOI:10.1002/jia2.26157 (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - November 1, 2023 Category: Infectious Diseases Authors: Ceri Evans Andrew J Prendergast Source Type: research

Neurodevelopment among children exposed to HIV and uninfected in sub-Saharan Africa
CONCLUSIONS: CHEU in sub-Saharan Africa have biologic and socio-behavioural factors that may influence their neurodevelopment, brain maturation, immune system and overall health and wellbeing. Multidisciplinary research is needed to disentangle complex interactions between contributing factors. Common environmental and social risk factors for suboptimal neurodevelopment in the general population are disproportionately magnified within the CHEU population, and it is, therefore, important to draw on existing knowledge when considering the socio-behavioural pathways through which HIV exposure could impact CHEU neurodevelopmen...
Source: Journal of the International AIDS Society - November 1, 2023 Category: Infectious Diseases Authors: Michelle A Bulterys Irene Njuguna Mary Mahy Laurie A Gulaid Katheen M Powis Catherine J Wedderburn Grace John-Stewart Source Type: research

Lower academic performance among children with perinatal HIV exposure in Botswana
CONCLUSIONS: In this Botswana-based cohort, primary school academic performance was lower among children HEU compared to children HUU. Biological and socio-demographic factors, including child sex, appear to contribute to this difference. Further research is needed to identify modifiable contributors, develop screening tools to identify the risk of poor academic performance and design interventions to mitigate risk.PMID:37909233 | PMC:PMC10618869 | DOI:10.1002/jia2.26165 (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - November 1, 2023 Category: Infectious Diseases Authors: Kathleen M Powis Lesedi Lebanna Sara Schenkel Gosego Masasa Samuel W Kgole Martha Ngwaca Coulson Kgathi Paige L Williams Amy L Slogrove Roger L Shapiro Shahin Lockman Mompati O Mmalane Joseph M Makhema Jennifer Jao Adam R Cassidy Source Type: research

The role of internalised HIV stigma in disclosure of maternal HIV serostatus to children perinatally HIV-exposed but uninfected: a prospective study in the United States
CONCLUSIONS: Providing support to women as they make decisions about serostatus disclosure to their children may entail addressing internalised HIV stigma and consideration of community-level factors, particularly for non-U.S.-born mothers.PMID:37909234 | PMC:PMC10618870 | DOI:10.1002/jia2.26167 (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - November 1, 2023 Category: Infectious Diseases Authors: Mariam Davtyan Deborah Kacanek Jessica Lee Claire Berman Ellen G Chadwick Renee Smith Liz Salomon Toinette Frederick Pediatric HIV/AIDS Cohort Study Source Type: research

Achieving equity for children and adolescents with perinatal HIV exposure: an urgent need for a paradigm shift
J Int AIDS Soc. 2023 Oct;26 Suppl 4(Suppl 4):e26171. doi: 10.1002/jia2.26171.NO ABSTRACTPMID:37909238 | PMC:PMC10618885 | DOI:10.1002/jia2.26171 (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - November 1, 2023 Category: Infectious Diseases Authors: Jane Namangolwa Mutanga Agnes Ronan Kathleen M Powis Source Type: research

Change in HIV-related characteristics of children hospitalised with infectious diseases in Western Cape, South Africa, 2008-2021: a time trend analysis
CONCLUSIONS: In recent years, among children hospitalised with infectious diseases, there were fewer children with perinatally acquired HIV, while an increased proportion of those without HIV acquisition are exposed to maternal HIV and ART. There is a need to look beyond paediatric HIV prevalence and consider child exposure to HIV and ART among children without HIV, when assessing the HIV epidemic's impact on child health services.PMID:37909168 | PMC:PMC10618898 | DOI:10.1002/jia2.26151 (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - November 1, 2023 Category: Infectious Diseases Authors: Shani T de Beer Amy L Slogrove Brian Eley Suzanne M Ingle Hayley E Jones Florence Phelanyane Kim Anderson Emma Kalk Andrew Boulle Mary-Ann Davies Source Type: research

Children of a syndemic: co-occurring and mutually reinforcing adverse child health exposures in a prospective cohort of HIV-affected mother-infant dyads in Cape Town, South Africa
CONCLUSIONS: These data suggest that maternal HIV-related syndemics may partly drive excess CHEU health risks, highlighting an urgent need for holistic maternal and family care and support alongside ART to optimise the health of CHEU.PMID:37909170 | PMC:PMC10618899 | DOI:10.1002/jia2.26152 (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - November 1, 2023 Category: Infectious Diseases Authors: Stanzi M le Roux Elaine J Abrams Allison Zerbe Tamsin K Phillips Landon Myer Source Type: research