Paget ’s disease of the breast: Insights from imaging to guide surgical management
Paget ’s disease (PD) of the breast is a rare condition accounting for only 1–3% of breast cancers, as evident by the paucity of published data and small cohort analyses.1 Due to its multifocal variation and the unreliability of mammography and ultrasound to detect underlying breast cancer in PD, mast ectomy had long been the standard of care for adequate disease control.1,2 However, further studies comparing mastectomy to breast-conserving surgery (BCS) followed by adjuvant radiation have shown no statistical difference in overall survival. (Source: American Journal of Surgery)
Source: American Journal of Surgery - March 18, 2024 Category: Surgery Authors: Juliet C. Dalton, Jennifer K. Plichta Tags: Invited Commentary Source Type: research
Emerging Clinical Applications for Cone Beam Breast CT: Changing the Breast Imaging Paradigm
AbstractPurpose of ReviewSince its approval by the Unites States Food and Drug Administration (FDA) in 2015, cone-beam breast computed tomography (CBBCT) has gained acceptance among radiologists for breast cancer imaging. This review aims to highlight the advancements and benefits of CBBCT in the diagnostic workup of breast disease. It showcases how CBBCT, including both non-contrast (NC-CBBCT) and contrast-enhanced (CE-CBBCT) protocols, complements and often surpasses the performance of more traditional breast imaging modalities such as mammography and magnetic resonance imaging (MRI).Recent FindingsStudies in clinical se...
Source: Current Breast Cancer Reports - March 18, 2024 Category: Cancer & Oncology Source Type: research
MR-contrast enhanced mammography (CEM) for follow-up of breast cancer patients: a “pros and cons” debate
AbstractWomen with a personal history of breast cancer (PHBC) are at an increased risk of either a local recurrence or a new primary breast cancer. Thus, surveillance is essential for the detection of recurrent disease at the earliest possible stage, allowing for prompt treatment, and potentially improving overall survival. Nowadays, mammography follow-up is the only surveillance imaging technique recommended by international guidelines. Nevertheless, sensitivity of mammography is lower after breast cancer treatment, particularly during the first 5 years, due to increased density or post-treatment changes. Contrast-enhance...
Source: European Radiology - March 15, 2024 Category: Radiology Source Type: research
Case-Based Review of Breast Lymphomas
This article will review several cases of histologically-proven primary and secondary breast lymphomas to demonstrate the multimodal radiologic features, as well as to discuss the approach to diagnostic work up of lymphomas encountered during imaging of the breast and axilla.Recent FindingsImaging findings of breast lymphoma can overlap with those of primary breast cancer. When there is any clinical suspicion for lymphoma in indeterminate or suspicious breast or axillary findings, definitive tissue diagnosis should be pursued with flow cytometry in addition to routine histologic analysis.SummaryBreast lymphomas can have va...
Source: Current Radiology Reports - March 15, 2024 Category: Radiology Source Type: research
Stromal Type I Collagen in Breast Cancer: Correlation to Prognostic Biomarkers and Prediction of Chemotherapy Response
CONCLUSION: Low stromal type I collagen mRNA and protein expression are associated with unfavourable tumour characteristics in breast cancer. Stromal type I collagen might predict chemotherapy response.PMID:38485557 | DOI:10.1016/j.clbc.2024.02.015 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - March 14, 2024 Category: Cancer & Oncology Authors: Malin Jansson Jessica Lindberg Gunilla Rask Johan Svensson Ola Billing Anoosheh Nazemroaya Anette Berglund Fredrik W ärnberg Malin Sund Source Type: research
Stromal Type I Collagen in Breast Cancer: Correlation to Prognostic Biomarkers and Prediction of Chemotherapy Response
CONCLUSION: Low stromal type I collagen mRNA and protein expression are associated with unfavourable tumour characteristics in breast cancer. Stromal type I collagen might predict chemotherapy response.PMID:38485557 | DOI:10.1016/j.clbc.2024.02.015 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 14, 2024 Category: Cancer & Oncology Authors: Malin Jansson Jessica Lindberg Gunilla Rask Johan Svensson Ola Billing Anoosheh Nazemroaya Anette Berglund Fredrik W ärnberg Malin Sund Source Type: research
False negative breast cancers on imaging and associated risk factors: a single institution six-year analysis
ConclusionOur findings suggest that supplemental screening may be useful in breast cancer survivors. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - March 14, 2024 Category: Cancer & Oncology Source Type: research
Multilevel contributors to racial and ethnic inequities in the resolution of abnormal mammography results
ConclusionMore work is needed to understand how imaging center and community characteristics impact racial inequities in resolution and resolution in general. (Source: Cancer Causes and Control)
Source: Cancer Causes and Control - March 13, 2024 Category: Cancer & Oncology Source Type: research
In situ tumor model for longitudinal in silico imaging trials
Phys Med Biol. 2024 Mar 12. doi: 10.1088/1361-6560/ad3322. Online ahead of print.ABSTRACTIn this article, we introduce a computational model for simulating the growth of breast cancer
lesions accounting for the stiffness of surrounding anatomical structures.
Approach: In our model, ligaments are classified as the most rigid structures while the softer parts of the
breast are occupied by fat and glandular tissues As a result of these variations in tissue elasticity, the rapidly
proliferating tumor cells are met with differential resistance. It is found that these cells are likely to circumven...
Source: Physics in Medicine and Biology - March 12, 2024 Category: Physics Authors: Aunnasha Sengupta Miguel Lago Aldo Badano Source Type: research
Evaluating trends in screening mammography volumes at a tertiary academic institution during the COVID-19 pandemic
(Source: Journal of the American College of Radiology : JACR)
Source: Journal of the American College of Radiology : JACR - March 12, 2024 Category: Radiology Authors: Emily B. Ambinder, Kathryn A. Carson, Derek L. Nguyen, Eumee Cha, Ani Peshtani, Kelly S. Myers, Eniola T. Oluyemi Source Type: research
Assessing breast arterial calcification in mammograms and its implications for atherosclerotic cardiovascular disease risk
Breast arterial calcifications (BAC) are incidentally observed on mammograms, yet their implications remain unclear. We investigated lifestyle, reproductive, and cardiovascular determinants of BAC in women undergoing mammography screening. Further, we investigated the relationship between BAC, coronary arterial calcifications (CAC) and estimated 10-year atherosclerotic cardiovascular (ASCVD) risk. (Source: Clinical Imaging)
Source: Clinical Imaging - March 12, 2024 Category: Radiology Authors: Shadi Azam, Rulla M. Tamimi, Michele B. Drotman, Kemi Babagbemi, Allison D. Levy, Jessica M. Pe ña Tags: Breast Imaging Source Type: research
Immediate and delayed risk of breast cancer associated with classic lobular carcinoma in situ and its variants
ConclusionLCIS has both an immediate risk (19.3%) and a delayed risk (18.6%) for cancer with 90.9% occurring in the ipsilateral breast (63.6% at and 27.3% away from the site of LCIS) and 9.1% occurring in the contralateral breast. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - March 12, 2024 Category: Cancer & Oncology Source Type: research
The promise of AI in personalized breast cancer screening: are we there yet?
Nature Reviews Clinical Oncology, Published online: 12 March 2024; doi:10.1038/s41571-024-00877-zThe benefits and potential harms of mammography-based screening for breast cancer are often a matter of debate. Here, I discuss the promises and limitations of a recent study that tested an artificial intelligence-based tool for the detection of breast cancer in digital mammograms in a large, prospective screening setting. (Source: Nature Reviews Clinical Oncology)
Source: Nature Reviews Clinical Oncology - March 12, 2024 Category: Cancer & Oncology Authors: Despina Kontos Source Type: research
Numb cheek syndrome in breast cancer: a case report
ConclusionsOur case represents the first reported left numb cheek syndrome in association with breast cancer, due to maxillary neuropathy without any discrete mass or compressive cause. To avoid delays in diagnosing malignancy, physicians and surgeons should be aware that numb cheek syndrome can occur in association with an underlying malignancy, and that breast cancer should be counted amongst the possibilities. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 11, 2024 Category: Cancer & Oncology Source Type: research
Contrast-enhanced Mammography versus MR Imaging of the Breast
Breast MR imaging and contrast-enhanced mammography (CEM) are both techniques that employ intravenously injected contrast agent to assess breast lesions. This approach is associated with a very high sensitivity for malignant lesions that typically exhibit rapid enhancement due to the leakiness of neovasculature. CEM may be readily available at the breast imaging department and can be performed on the spot. Breast MR imaging provides stronger enhancement than the x-ray-based techniques and offers higher sensitivity. From a patient perspective, both modalities have their benefits and downsides; thus, patient preference could...
Source: Radiologic Clinics of North America - March 9, 2024 Category: Radiology Authors: Ritse M. Mann, Valentina Longo Source Type: research
