Systematic review and meta-analysis of prognostic characteristics for breast cancers in populations with digital versus film mammography indicate the transition may have increased both early detection and overdiagnosis
Film mammography has replaced digital mammography in breast screening programs globally. This led to a small increase in the rate of detection, but whether the detection of clinically important cancers increased is uncertain. We aimed to assess the impact on tumour characteristics of screen-detected and interval breast cancers. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - April 1, 2024 Category: Epidemiology Authors: Rachel Farber, Michael L. Marinovich, Audrey Pinna, Nehmat Houssami, Kevin McGeechan, Alexandra Barratt, Katy JL. Bell Tags: Original Article Source Type: research
Locoregional staging of breast cancer: contrast-enhanced mammography versus breast magnetic resonance imaging
ConclusionsCEM showed results comparable to MRI in the staging of breast cancer in our study population, with a high rate of patient acceptability. (Source: La Radiologia Medica)
Source: La Radiologia Medica - April 1, 2024 Category: Radiology Source Type: research
Mammographic density changes after neoadjuvant chemotherapy in triple-negative breast cancer: Association with treatment and survival outcome
CONCLUSION: In premenopausal women, a contralateral breast density reduction of ≥10 % after NAC was independently associated with pCR, although it did not translate into improved outcomes.PMID:38552382 | DOI:10.1016/j.clinimag.2024.110136 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - March 29, 2024 Category: Cancer & Oncology Authors: Yelim Choi Soo-Yeon Kim Nariya Cho Woo Kyung Moon Source Type: research
Mammographic density changes after neoadjuvant chemotherapy in triple-negative breast cancer: Association with treatment and survival outcome
CONCLUSION: In premenopausal women, a contralateral breast density reduction of ≥10 % after NAC was independently associated with pCR, although it did not translate into improved outcomes.PMID:38552382 | DOI:10.1016/j.clinimag.2024.110136 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 29, 2024 Category: Cancer & Oncology Authors: Yelim Choi Soo-Yeon Kim Nariya Cho Woo Kyung Moon Source Type: research
Mammographic density changes after neoadjuvant chemotherapy in triple-negative breast cancer: Association with treatment and survival outcome
CONCLUSION: In premenopausal women, a contralateral breast density reduction of ≥10 % after NAC was independently associated with pCR, although it did not translate into improved outcomes.PMID:38552382 | DOI:10.1016/j.clinimag.2024.110136 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - March 29, 2024 Category: Cancer & Oncology Authors: Yelim Choi Soo-Yeon Kim Nariya Cho Woo Kyung Moon Source Type: research
Mammographic density changes after neoadjuvant chemotherapy in triple-negative breast cancer: Association with treatment and survival outcome
CONCLUSION: In premenopausal women, a contralateral breast density reduction of ≥10 % after NAC was independently associated with pCR, although it did not translate into improved outcomes.PMID:38552382 | DOI:10.1016/j.clinimag.2024.110136 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 29, 2024 Category: Cancer & Oncology Authors: Yelim Choi Soo-Yeon Kim Nariya Cho Woo Kyung Moon Source Type: research
Cancers, Vol. 16, Pages 1326: Lead-Time Corrected Effect on Breast Cancer Survival in Germany by Mode of Detection
Conclusions: Survival for symptomatic BC was only one quarter of screen-detected tumors, which is obviously biased. After adjustment for lead-time bias and prognostic variables, including UICC stage, survival was 27% to 10% better for screen-detected BC, which might be attributed to BC screening. Although this result fits quite well with published results for other countries with BC screening, further sources for residual confounding (e.g., self-selection) cannot be ruled out. (Source: Cancers)
Source: Cancers - March 28, 2024 Category: Cancer & Oncology Authors: Laura Schumann Moritz Hadwiger Nora Eisemann Alexander Katalinic Tags: Article Source Type: research
Interplay between hormonal and mechanical signals in mammary morphodynamics
Trends Cell Biol. 2024 Mar 26:S0962-8924(24)00053-9. doi: 10.1016/j.tcb.2024.03.004. Online ahead of print.ABSTRACTMammographic density is a well-established risk factor for breast cancer. In a recent study, Northey et al. reveal that the associated increase in tissue stiffness elevates extracellular signal-regulated kinase (ERK) activity, promoting progesterone receptor-dependent receptor activator of nuclear factor κβ (RANK) signaling. Thus, stiffness alters the context of hormonal signaling and increases mammary stem cells. This mechanism suggests potential treatments for breast cancer.PMID:38538440 | DOI:10.1016/j.tc...
Source: Trends in Cell Biology - March 27, 2024 Category: Cytology Authors: Ali şya A Anlaş Celeste M Nelson Source Type: research
Interplay between hormonal and mechanical signals in mammary morphodynamics
Trends Cell Biol. 2024 Mar 26:S0962-8924(24)00053-9. doi: 10.1016/j.tcb.2024.03.004. Online ahead of print.ABSTRACTMammographic density is a well-established risk factor for breast cancer. In a recent study, Northey et al. reveal that the associated increase in tissue stiffness elevates extracellular signal-regulated kinase (ERK) activity, promoting progesterone receptor-dependent receptor activator of nuclear factor κβ (RANK) signaling. Thus, stiffness alters the context of hormonal signaling and increases mammary stem cells. This mechanism suggests potential treatments for breast cancer.PMID:38538440 | DOI:10.1016/j.tc...
Source: Trends in Cell Biology - March 27, 2024 Category: Cytology Authors: Ali şya A Anlaş Celeste M Nelson Source Type: research
Interplay between hormonal and mechanical signals in mammary morphodynamics
Trends Cell Biol. 2024 Mar 26:S0962-8924(24)00053-9. doi: 10.1016/j.tcb.2024.03.004. Online ahead of print.ABSTRACTMammographic density is a well-established risk factor for breast cancer. In a recent study, Northey et al. reveal that the associated increase in tissue stiffness elevates extracellular signal-regulated kinase (ERK) activity, promoting progesterone receptor-dependent receptor activator of nuclear factor κβ (RANK) signaling. Thus, stiffness alters the context of hormonal signaling and increases mammary stem cells. This mechanism suggests potential treatments for breast cancer.PMID:38538440 | DOI:10.1016/j.tc...
Source: Trends in Cell Biology - March 27, 2024 Category: Cytology Authors: Ali şya A Anlaş Celeste M Nelson Source Type: research
Interplay between hormonal and mechanical signals in mammary morphodynamics
Trends Cell Biol. 2024 Mar 26:S0962-8924(24)00053-9. doi: 10.1016/j.tcb.2024.03.004. Online ahead of print.ABSTRACTMammographic density is a well-established risk factor for breast cancer. In a recent study, Northey et al. reveal that the associated increase in tissue stiffness elevates extracellular signal-regulated kinase (ERK) activity, promoting progesterone receptor-dependent receptor activator of nuclear factor κβ (RANK) signaling. Thus, stiffness alters the context of hormonal signaling and increases mammary stem cells. This mechanism suggests potential treatments for breast cancer.PMID:38538440 | DOI:10.1016/j.tc...
Source: Trends in Cell Biology - March 27, 2024 Category: Cytology Authors: Ali şya A Anlaş Celeste M Nelson Source Type: research
Interplay between hormonal and mechanical signals in mammary morphodynamics
Trends Cell Biol. 2024 Mar 26:S0962-8924(24)00053-9. doi: 10.1016/j.tcb.2024.03.004. Online ahead of print.ABSTRACTMammographic density is a well-established risk factor for breast cancer. In a recent study, Northey et al. reveal that the associated increase in tissue stiffness elevates extracellular signal-regulated kinase (ERK) activity, promoting progesterone receptor-dependent receptor activator of nuclear factor κβ (RANK) signaling. Thus, stiffness alters the context of hormonal signaling and increases mammary stem cells. This mechanism suggests potential treatments for breast cancer.PMID:38538440 | DOI:10.1016/j.tc...
Source: Trends in Cell Biology - March 27, 2024 Category: Cytology Authors: Ali şya A Anlaş Celeste M Nelson Source Type: research
Interplay between hormonal and mechanical signals in mammary morphodynamics
Trends Cell Biol. 2024 Mar 26:S0962-8924(24)00053-9. doi: 10.1016/j.tcb.2024.03.004. Online ahead of print.ABSTRACTMammographic density is a well-established risk factor for breast cancer. In a recent study, Northey et al. reveal that the associated increase in tissue stiffness elevates extracellular signal-regulated kinase (ERK) activity, promoting progesterone receptor-dependent receptor activator of nuclear factor κβ (RANK) signaling. Thus, stiffness alters the context of hormonal signaling and increases mammary stem cells. This mechanism suggests potential treatments for breast cancer.PMID:38538440 | DOI:10.1016/j.tc...
Source: Trends in Cell Biology - March 27, 2024 Category: Cytology Authors: Ali şya A Anlaş Celeste M Nelson Source Type: research
Interplay between hormonal and mechanical signals in mammary morphodynamics
Trends Cell Biol. 2024 Mar 26:S0962-8924(24)00053-9. doi: 10.1016/j.tcb.2024.03.004. Online ahead of print.ABSTRACTMammographic density is a well-established risk factor for breast cancer. In a recent study, Northey et al. reveal that the associated increase in tissue stiffness elevates extracellular signal-regulated kinase (ERK) activity, promoting progesterone receptor-dependent receptor activator of nuclear factor κβ (RANK) signaling. Thus, stiffness alters the context of hormonal signaling and increases mammary stem cells. This mechanism suggests potential treatments for breast cancer.PMID:38538440 | DOI:10.1016/j.tc...
Source: Trends in Cell Biology - March 27, 2024 Category: Cytology Authors: Ali şya A Anlaş Celeste M Nelson Source Type: research
Interplay between hormonal and mechanical signals in mammary morphodynamics
Trends Cell Biol. 2024 Mar 26:S0962-8924(24)00053-9. doi: 10.1016/j.tcb.2024.03.004. Online ahead of print.ABSTRACTMammographic density is a well-established risk factor for breast cancer. In a recent study, Northey et al. reveal that the associated increase in tissue stiffness elevates extracellular signal-regulated kinase (ERK) activity, promoting progesterone receptor-dependent receptor activator of nuclear factor κβ (RANK) signaling. Thus, stiffness alters the context of hormonal signaling and increases mammary stem cells. This mechanism suggests potential treatments for breast cancer.PMID:38538440 | DOI:10.1016/j.tc...
Source: Trends in Cell Biology - March 27, 2024 Category: Cytology Authors: Ali şya A Anlaş Celeste M Nelson Source Type: research
