Primary extranodal marginal zone mucosa-associated lymphoid tissue-type B-cell lymphoma involving the dura: A case report
CONCLUSION: EMZMBCL is a rare disease that should be considered in the differential diagnosis of subdural lesions, especially when there is no history of trauma or abnormalities in the coagulation system. The patient had a favorable outcome after selecting radiotherapy as the adjuvant therapy.PMID:38628522 | PMC:PMC11021089 | DOI:10.25259/SNI_792_2023 (Source: Surgical Neurology International)
Source: Surgical Neurology International - April 17, 2024 Category: Neurosurgery Authors: Ryo Hamamoto Toshinari Kawasaki Masashi Oda Sosuke Sumiyoshi Kosuke Hayashi Tamaki Kobayashi Yoshihiko Ioroi Tatsuki Uchiyama Motohiro Takayama Masaaki Saiki Source Type: research
Epcoritamab - relapsed or refractory large diffuse B cells lymphoma after two or more lines of systemic therapy
Bull Cancer. 2024 Apr 16:S0007-4551(24)00117-6. doi: 10.1016/j.bulcan.2024.02.011. Online ahead of print.NO ABSTRACTPMID:38631985 | DOI:10.1016/j.bulcan.2024.02.011 (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - April 17, 2024 Category: Cancer & Oncology Authors: Hedi Bensaber Victoria Cacheux Source Type: research
Early evaluation of CAR-T cell therapy response in R/R DLBCL patients using < sup > 18 < /sup > F-FDG PET/CT
CONCLUSION: Fluorine-18-FDG PET/CT findings obtained one month after CAR-T cell therapy showed accuracy for early response evaluation and prediction of progression in patients with R/R DLBCL.PMID:38629814 | DOI:10.1967/s002449912701 (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - April 17, 2024 Category: Nuclear Medicine Authors: Kazuhiro Kitajima Hiroyuki Yokoyama Reona Wada Yukihisa Tamaki Kyoko Yoshihara Katsuji Kaida Satoshi Yoshihara Koichiro Yamakado Source Type: research
Epcoritamab - relapsed or refractory large diffuse B cells lymphoma after two or more lines of systemic therapy
Bull Cancer. 2024 Apr 16:S0007-4551(24)00117-6. doi: 10.1016/j.bulcan.2024.02.011. Online ahead of print.NO ABSTRACTPMID:38631985 | DOI:10.1016/j.bulcan.2024.02.011 (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - April 17, 2024 Category: Cancer & Oncology Authors: Hedi Bensaber Victoria Cacheux Source Type: research
Complete response to front-line therapies is associated with long-term survival in HIV-related lymphomas in Taiwan
CONCLUSIONS: PLWH with DLBCL or BL had OS rates compatible to patients without HIV infection. Better outcomes for patients achieving CR to front-line therapy and those with shorter cART duration before lymphoma diagnosis suggest an underlying biological distinction in the lymphomas and the involvement of immunity, which warrants further studies.PMID:38632022 | DOI:10.1016/j.jmii.2024.04.001 (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - April 17, 2024 Category: Microbiology Authors: Wei-Li Ma Wang-Da Liu Hsin-Yun Sun Wang-Huei Sheng Szu-Min Hsieh Shang-Ju Wu Chien-Ching Hung Source Type: research
Navigating resistance to ALK inhibitors in the Lorlatinib Era: a comprehensive perspective on NSCLC
Expert Rev Anticancer Ther. 2024 Apr 17. doi: 10.1080/14737140.2024.2344648. Online ahead of print.ABSTRACTINTRODUCTION: The emergence of anaplastic lymphoma kinase (ALK) rearrangements in non-small cell lung cancer (NSCLC) has revolutionized targeted therapy. This dynamic landscape, featuring novel ALK inhibitors and combination therapies, necessitates a profound understanding of resistance mechanisms for effective treatment strategies. Recognizing two primary categories - on-target and off-target resistance - underscores the need for comprehensive assessment.AREAS COVERED: This review delves into the intricacies of resis...
Source: Expert Review of Anticancer Therapy - April 17, 2024 Category: Cancer & Oncology Authors: Maria Gemelli Adriana Albini Gianpiero Catalano Matteo Incarbone Maria Cannone Emanuela Balladore Riccardo Ricotta Giuseppe Pelosi Source Type: research
Zinc ameliorates acrylamide-induced oxidative stress and apoptosis in testicular cells via Nrf2/HO-1/NfkB and Bax/Bcl2 signaling pathway
CONCLUSION: In conclusion, zinc may protect against acrylamide-induced testicular toxicity, mediated by its antioxidant, anti-inflammatory, and antiapoptotic effects.PMID:38629506 | DOI:10.1080/13510002.2024.2341537 (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - April 17, 2024 Category: Biochemistry Authors: Ayodeji Johnson Ajibare Adeyemi Fatai Odetayo Olabode Oluwadare Akintoye Luqman Aribidesi Olayaki Source Type: research
Gene expression profiling of vitamin D metabolism enzymes in leukemia and lymphoma patients: molecular aspect interplay of VDR, CYP2R1, and CYP24A1
CONCLUSION: The study revealed a noteworthy difference in VDR protein levels between men and women. The highest mean CYP24A1 protein levels were observed in the age group > 60 years. This study found a significant, moderately positive correlation between VDR protein levels and CYP24A1 protein levels in the male and vitamin D sufficiency groups. In addition, a significant positive correlation was found between VDR mRNA levels and CYP2R1 mRNA levels, VDR mRNA levels and CYP2R1 mRNA levels, and CYP2R1 mRNA levels and CYP24A1 mRNA levels. However, the expression of these genes does not correlate with the protein levels of i...
Source: Molecular Biology Reports - April 17, 2024 Category: Molecular Biology Authors: Anggraini Iriani Andhika Rachman Marsya Kaila Fatina Rizka Kurnia Gemilang Andi Trisnandi Media Fitri Isma Nugraha Source Type: research
Obinutuzumab interference with immunoelectrophoresis in a case of follicular lymphoma
Int J Lab Hematol. 2024 Apr 16. doi: 10.1111/ijlh.14284. Online ahead of print.NO ABSTRACTPMID:38627894 | DOI:10.1111/ijlh.14284 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - April 17, 2024 Category: Hematology Authors: Unal Atas Volkan Karakus Imge Bortay Tekin Ozgur Aydin Omur Gokmen Sevindik Levent Undar Source Type: research
Primary extranodal marginal zone mucosa-associated lymphoid tissue-type B-cell lymphoma involving the dura: A case report
CONCLUSION: EMZMBCL is a rare disease that should be considered in the differential diagnosis of subdural lesions, especially when there is no history of trauma or abnormalities in the coagulation system. The patient had a favorable outcome after selecting radiotherapy as the adjuvant therapy.PMID:38628522 | PMC:PMC11021089 | DOI:10.25259/SNI_792_2023 (Source: Surgical Neurology International)
Source: Surgical Neurology International - April 17, 2024 Category: Neurosurgery Authors: Ryo Hamamoto Toshinari Kawasaki Masashi Oda Sosuke Sumiyoshi Kosuke Hayashi Tamaki Kobayashi Yoshihiko Ioroi Tatsuki Uchiyama Motohiro Takayama Masaaki Saiki Source Type: research
Epcoritamab - relapsed or refractory large diffuse B cells lymphoma after two or more lines of systemic therapy
Bull Cancer. 2024 Apr 16:S0007-4551(24)00117-6. doi: 10.1016/j.bulcan.2024.02.011. Online ahead of print.NO ABSTRACTPMID:38631985 | DOI:10.1016/j.bulcan.2024.02.011 (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - April 17, 2024 Category: Cancer & Oncology Authors: Hedi Bensaber Victoria Cacheux Source Type: research
Early evaluation of CAR-T cell therapy response in R/R DLBCL patients using < sup > 18 < /sup > F-FDG PET/CT
CONCLUSION: Fluorine-18-FDG PET/CT findings obtained one month after CAR-T cell therapy showed accuracy for early response evaluation and prediction of progression in patients with R/R DLBCL.PMID:38629814 | DOI:10.1967/s002449912701 (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - April 17, 2024 Category: Nuclear Medicine Authors: Kazuhiro Kitajima Hiroyuki Yokoyama Reona Wada Yukihisa Tamaki Kyoko Yoshihara Katsuji Kaida Satoshi Yoshihara Koichiro Yamakado Source Type: research
Late-onset Familial Hemophagocytic Lymphohistiocytosis in a survivor of Hodgkin's Lymphoma
Leuk Res Rep. 2023 Nov 7;21:100394. doi: 10.1016/j.lrr.2023.100394. eCollection 2024.ABSTRACTHemophagocytic Lymphohistiocytosis is an inflammatory condition which results in over activation of the immune system. It could be either sporadic or familial. The familial subtype is linked with various genetic mutations and is commonly a disease of the young. Here we report a case of HLH in an adult, occurring in the background of a successfully treated hematological malignancy. Upon workup, he was also found to have pathogenic STXBP2 mutation, suggesting HLH of familial origin. To date, only few cases of adult-onset familial HLH...
Source: Cell Research - April 17, 2024 Category: Cytology Authors: Mirza Rameez Samar Daania Shoaib Nida E Zehra Munira Moosajee Source Type: research
Outcomes of the transformation of follicular lymphoma to diffuse large B ‐cell lymphoma in the rituximab era: A population‐based study
ConclusionThe outcome of t-DLBCL in the rituximab era was better than historical series before the rituximab era. Due to the good prognosis, we did not recommend autologous stem cell transplantation for t-DLBCL receiving watch-and-wait or radiation as initial therapy before HT. (Source: Cancer Medicine)
Source: Cancer Medicine - April 17, 2024 Category: Cancer & Oncology Authors: Wenshuai Zheng,
Mingjuan Liu,
Lixun Guan,
Shenyu Wang Tags: RESEARCH ARTICLE Source Type: research
GSE260998 Germinal Center Dark Zone harbors ATR-dependent determinants of T-cell exclusion that are also identified in aggressive lymphoma – Visium_FFPE_Spatial_Trasciptomics_project
This study provides novel insights into signals controlling asymmetric T-cell distribution between DZ and LZ regions. We identify spatially-resolved DNA damage response and chromatin compaction molecular features precluding DZ T-cell infiltration. The DZ spatial transcriptional signature linked to T-cell immune evasion clustered aggressive Diffuse Large B-cell Lymphomas (DLBCL) for differential T cell infiltration. We reveal the dependence of the DZ transcriptional core signature on the ATR kinase and dissect its role in restraining inflammatory responses contributing to estabslish an immune-repulsive imprint in DLBCL. The...
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
