Editorial Board
(Source: Clinical Lymphoma, Myeloma and Leukemia)
Source: Clinical Lymphoma, Myeloma and Leukemia - March 28, 2024 Category: Hematology Source Type: research

Table of Contents
(Source: Clinical Lymphoma, Myeloma and Leukemia)
Source: Clinical Lymphoma, Myeloma and Leukemia - March 28, 2024 Category: Hematology Source Type: research

Targeting TGF-beta activation in cutaneous T-cell lymphomas
Cutaneous T-cell lymphomas (CTCL) are T-cell malignancies of the skin. In advanced-stage CTCL, the remissions are generally rare and short, and overall survival (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - March 28, 2024 Category: Dermatology Authors: J érôme GIUSTINIANI, Van Anh TA, Sadjia Belkhelouat, Maxime BATTISTELLA, Dina OUAHBI, Caroline RAM-WOLFF, Baptiste LOUVEAU, Samia MOURAH, Martine BAGOT, Hélène MOINS-TEISSERENC, Nicolas Ortonne, Armand BENSUSSAN, Adèle DE. MASSON Tags: Letters to the Editor Source Type: research

Allogeneic hematopoietic stem cell transplantation after mogamulizumab in T-cell lymphoma patients: a retrospective analysis
Int J Hematol. 2024 Mar 27. doi: 10.1007/s12185-024-03753-9. Online ahead of print.ABSTRACTAllogeneic hematopoietic stem cell transplantation (allo-HSCT) is an important therapy for patients with T-cell lymphomas, including cutaneous T-cell lymphoma (CTCL), adult T-cell lymphoma (ATL), and peripheral T-cell lymphoma (PTCL). Mogamulizumab is an anti-CCR4 antibody that has been associated with an increased risk of transplant-related complications in retrospective analyses of ATL, particularly when administered within 50 days before transplantation. This post hoc analysis of 3 clinical trials examined safety and outcome data ...
Source: International Journal of Hematology - March 27, 2024 Category: Hematology Authors: Mary Jo Lechowicz Christy Smith Robert Ristuccia Karen Dwyer Source Type: research

Recent advances in understanding the biology of follicular lymphoma
Int J Hematol. 2024 Mar 27. doi: 10.1007/s12185-024-03764-6. Online ahead of print.ABSTRACTFollicular lymphoma (FL), the most common indolent B-cell lymphoma, develops over decades before manifesting as overt disease. BCL2 overexpression by t(14;18) confers a survival advantage to B cells during the germinal center reaction, and abnormalities in epigenetic modifier genes lead to desynchronization of gene expression changes in germinal center B cells. Studies in mouse models have shown that BCL2 overexpression and epigenetic deregulation in B cells cooperatively promote lymphomagenesis. The immune microenvironment also play...
Source: International Journal of Hematology - March 27, 2024 Category: Hematology Authors: Momoko Nishikori Source Type: research

Neuro-protective Effect of Acetyl-11-keto- β-boswellic Acid in a Rat Model of Scopolamine-induced Cholinergic Dysfunction
CONCLUSION: The results suggested the effectiveness of AKBA in preventing learning and memory dysfunction induced by scopolamine. Accordingly, these protective effects might be produced by modulating BDNF, cholinergic system function, oxidative stress, and apoptotic markers.PMID:38532323 | DOI:10.2174/0113816128269289231226115446 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 27, 2024 Category: Drugs & Pharmacology Authors: Amir Hossein Assaran Mahmoud Hosseini Matin Shirazinia Mohammad Hosein Eshaghi Ghalibaf Farimah Beheshti Leila Mobasheri Farshad Mirzavi Arezoo Rajabian Source Type: research

Stigma, risks, and benefits of medicinal cannabis use among Australians with cancer
ConclusionFindings highlight the need for robust data regarding the harms and efficacy of medicinal cannabis and dissemination of such information among healthcare professionals and to patients who choose to use the substance. Ensuring healthcare professionals are equipped to provide non-judgmental and evidence-based guidance may mitigate potential safety and legal risks. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - March 27, 2024 Category: Cancer & Oncology Source Type: research

Mantle Cell Lymphoma under the scope of personalized medicine: perspective and directions
Mantle Cell Lymphoma (MCL) is a rare, incurable non-Hodgkin's lymphoma characterized by naive B cells infiltrating the lymphoid follicle's mantle zone. A key feature of MCL is the cytogenetic abnormality t(11;14) (q13:q14), found in 95% of cases, leading to Cyclin D1 overexpression resulting in uncontrolled cell cycle progression and genetic instability. Occasionally, Cyclin D2 or D3 overexpression can substitute for Cyclin D1, causing similar effects. The transcription factor SOX11 is a hallmark of classical Cyclin D1-positive MCL and also in cases without the typical t(11;14) abnormality, making it an important diagnosti...
Source: Clinical Lymphoma, Myeloma and Leukemia - March 27, 2024 Category: Hematology Authors: Lara Gallucci Figorelle, Peterson Tiago Galv ão, Felipe Matheus Ribeiro de Lima, Patricia Marimon, Nathalia Pentagna, Cristiane Milito, Rony Schaffel, Katia Carneiro Tags: Review Article Source Type: research

Cancers, Vol. 16, Pages 1298: Copy Number Analysis of 9p24.1 in Classic Hodgkin Lymphoma Arising in Immune Deficiency/Dysregulation
In this study, we examined PD-L1 expression levels and 9p24.1 copy number alterations in 27 patients with classic Hodgkin lymphoma arising from immune deficiency/dysregulation. All patients demonstrated PD-L1 protein expression and harbored 9p24.1 copy number alterations on the tumor cells. When comparing clinicopathological data and associations with 9p24.1 copy number features, the copy gain group showed a significantly higher incidence of extranodal lesions and clinical stages than the amplification group. Notably, all cases in the amplification group had latency type II, while 6/8 (75%) in the copy gain group had laten...
Source: Cancers - March 27, 2024 Category: Cancer & Oncology Authors: Kumiko Ohsawa Shuji Momose Asami Nishikori Midori Filiz Nishimura Yuka Gion Keisuke Sawada Morihiro Higashi Michihide Tokuhira Jun-ichi Tamaru Yasuharu Sato Tags: Article Source Type: research

Effect of long-term inorganic nitrate administration on myocardial ischemia-reperfusion injury in ovariectomized rats
Conclusion: The favorable effects of nitrate against IR injury were associated with higher eNOS and Bcl-2 expression, CAT activity, TAC, and lower iNOS, Bax, caspase-3, caspase-8, caspase-9 and TNF-α expression, and MDA in the heart tissue. Nitrate preconditioning alleviated IR-induced myocardial injury in OVX rats; this effect was associated with eNOS upregulation before IR and the blunting of OVX-induced eNOS downregulation, iNOS upregulation, apoptosis, and oxidative stress in heart tissue after IR. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 27, 2024 Category: Drugs & Pharmacology Source Type: research

Clinicopathologic analysis of nodal T-follicular helper cell lymphomas, a multicenter retrospective study from China
ConclusionThere are significant differences in the clinical manifestations, pathology, and survival outcomes among the three subtypes of nTFHLs. However, further research with a larger sample size, and involving clinical pathology and molecular genetics is needed to determine the distinctive biological characteristics of these tumors. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - March 27, 2024 Category: Allergy & Immunology Source Type: research

Acute kidney injury in children with lymphoma
CONCLUSION: TLS, lung infection, and lymphoma clinical stage were identified as independent risk factors for AKI in children with lymphoma during the first 30 days of hospitalization. Clinicians should increase their awareness of AKI in hospitalized patients with lymphoma.PMID:38529931 | DOI:10.5414/CN111157 (Source: Clinical Nephrology)
Source: Clinical Nephrology - March 26, 2024 Category: Urology & Nephrology Authors: Hejia Zhang Yanlong Duan Xiaoxue Li Zhi Chen Xiaorong Liu Source Type: research

Are the GLIM Criteria Guiding in the Course of Hematological Malignancies?
CONCLUSION: Early nutritional support can increase the immunological status of patients with malignant disorders as well as their tolerability to treatment. Minimizing the risk of malnutrition and providing timely calorie and vitamin support are factors that may directly affect febrile neutropenia, duration of fever, and antifungal use, which will consequently lead to a decrease in the length of hospitalization.PMID:38528354 | DOI:10.4103/njcp.njcp_572_23 (Source: Clinical Lymphoma and Myeloma)
Source: Clinical Lymphoma and Myeloma - March 26, 2024 Category: Cancer & Oncology Authors: F Yilmaz M R Aras Hba Ozturk H N Sahin A K Gunes M Albayrak Source Type: research

Chemotherapy-initiated cysteine-rich protein 61 decreases acute B-lymphoblastic leukemia chemosensitivity
CONCLUSION: DNR induces Cyr61 production in B-ALL cells, and increased Cyr61 levels reduce the chemosensitivity of B-ALL cells. Consequently, targeting Cyr61 or related ATM signaling pathway may present a promising treatment strategy to enhance the chemosensitivity of patients with B-ALL.PMID:38530432 | DOI:10.1007/s00432-024-05692-8 (Source: Cell Research)
Source: Cell Research - March 26, 2024 Category: Cytology Authors: Pengchong Shi Zhen Lin Yanfang Song Zhaozhong Li Menglu Zeng Li Luo Yingping Cao Xianjin Zhu Source Type: research

Analysis and Investigation of Bioinformatics and Epigenetics Reveal the Underlying Mechanisms by which FLOT2 Modulates the Progression of Diffuse Large B-cell Lymphoma
CONCLUSIONS: In summary, FLOT2 functions as an oncogene and is linked to DLBCL prognosis and the tumor microenvironment. Targeting FLOT2 deletion emerges as a novel strategy to impede DLBCL aggressiveness by inhibiting cell proliferation and invasion, ultimately inducing apoptotic cell death.PMID:38531803 | DOI:10.24976/Discov.Med.202436182.59 (Source: Discovery Medicine)
Source: Discovery Medicine - March 26, 2024 Category: Research Authors: Yujing Zhang Yao Chen Qiang Guo Ying Zhang Aichun Liu Source Type: research