Expression and prognostic significance of the PD ‐1/PD‐L1 pathway in AIDS‐related non‐Hodgkin lymphoma
ConclusionsThese data emphasize the importance of PD-1-mediated immune evasion in the complex landscape of immune oncology in AR-NHL co-infected with EBV, and contribute to the diagnostic classification and possible definition of immunotherapeutic strategies for this unique subgroup. (Source: Cancer Medicine)
Source: Cancer Medicine - April 13, 2024 Category: Cancer & Oncology Authors: Han Zhao,
Shaohang Cai,
Yanhua Xiao,
Muye Xia,
Hongjie Chen,
Zhiman Xie,
Xiaoping Tang,
Haolan He,
Jie Peng,
Juanjuan Chen Tags: RESEARCH ARTICLE Source Type: research
Succinic Acid Ameliorates Concanavalin A-Induced Hepatitis by Altering the Inflammatory Microenvironment and Expression of BCL-2 Family Proteins
This study provides novel insights into the biological functions and therapeutic potential of succinic acid in the treatment of autoimmune liver injury. (Source: Inflammation)
Source: Inflammation - April 13, 2024 Category: Allergy & Immunology Source Type: research
Mutation landscape in Chinese nodal diffuse large B-cell lymphoma by targeted next generation sequencing and their relationship with clinicopathological characteristics
Diffuse large B-cell lymphoma (DLBCL), an aggressive and heterogenic malignant entity, is still a challenging clinical problem, since around one-third of patients are not cured with primary treatment. Next-gen... (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - April 13, 2024 Category: Genetics & Stem Cells Authors: Bing Cao, Chenbo Sun, Rui Bi, Zebing Liu, Yijun Jia, Wenli Cui, Menghong Sun, Baohua Yu, Xiaoqiu Li and Xiaoyan Zhou Tags: Research Source Type: research
Succinic Acid Ameliorates Concanavalin A-Induced Hepatitis by Altering the Inflammatory Microenvironment and Expression of BCL-2 Family Proteins
This study provides novel insights into the biological functions and therapeutic potential of succinic acid in the treatment of autoimmune liver injury. (Source: Inflammation)
Source: Inflammation - April 13, 2024 Category: Allergy & Immunology Source Type: research
Safety and efficacy of a new academic CD19-directed CAR-T cell for refractory/relapsed non-Hodgkin lymphoma and acute lymphoblastic leukemia in Brazil
Bone Marrow Transplantation, Published online: 13 April 2024; doi:10.1038/s41409-024-02283-6Safety and efficacy of a new academic CD19-directed CAR-T cell for refractory/relapsed non-Hodgkin lymphoma and acute lymphoblastic leukemia in Brazil (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - April 13, 2024 Category: Hematology Authors: Camila D. Donadel Gil C. De Santis Thiago E. Gon çalves Bruno G. Pires Leonardo C. Palma Flavia Gava Renato Luiz Guerino-Cunha Joana T. B. Faria Gabriela V. A. Silva Luiz Guilherme Darrigo-Junior Giancarlo Fatobene Vanderson Rocha Dimas T. Covas Rodrigo Source Type: research
Higher Mortality in Patients With Diffuse Large B-cell Lymphoma Pre-Existing Arterial Hypertension —Real World Data of the Polish Lymphoma Research Group
This study aimed to assess the long-term prognostic value of arterial hypertension (AH) in diffuse large B-cell lymphoma (DLBCL). (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - April 13, 2024 Category: Cardiology Authors: Sebastian Szmit, Monika D ługosz-Danecka, Joanna Drozd-Sokołowska, Monika Joks, Agnieszka Szeremet, Artur Jurczyszyn, Wojciech Jurczak Tags: Original Article Source Type: research
Diagnostic Value of Transabdominal Ultrasonography in Gastrointestinal Malignant Tumors
CONCLUSION: Transabdominal ultrasonography shows promise as a diagnostic tool for gastrointestinal malignant tumors; however, it is recommended to be used in conjunction with other detection methods such as fibrous gastrointestinal tract examination to minimize the risk of missed diagnoses and misdiagnoses. The study highlights the potential of transabdominal ultrasonography as a non-invasive and accessible diagnostic method for gastrointestinal malignancies. Further research and advancements in imaging technologies are crucial for enhancing diagnostic capabilities and improving patient outcomes in the future.PMID:38607211...
Source: Alternative Therapies in Health and Medicine - April 12, 2024 Category: Complementary Medicine Authors: Jing-Yun Dong Yan-Bing Gao Li-Wei Tang Jing Zheng Source Type: research
Diagnostic Value of Transabdominal Ultrasonography in Gastrointestinal Malignant Tumors
CONCLUSION: Transabdominal ultrasonography shows promise as a diagnostic tool for gastrointestinal malignant tumors; however, it is recommended to be used in conjunction with other detection methods such as fibrous gastrointestinal tract examination to minimize the risk of missed diagnoses and misdiagnoses. The study highlights the potential of transabdominal ultrasonography as a non-invasive and accessible diagnostic method for gastrointestinal malignancies. Further research and advancements in imaging technologies are crucial for enhancing diagnostic capabilities and improving patient outcomes in the future.PMID:38607211...
Source: Alternative Therapies in Health and Medicine - April 12, 2024 Category: Complementary Medicine Authors: Jing-Yun Dong Yan-Bing Gao Li-Wei Tang Jing Zheng Source Type: research
Diagnostic Value of Transabdominal Ultrasonography in Gastrointestinal Malignant Tumors
CONCLUSION: Transabdominal ultrasonography shows promise as a diagnostic tool for gastrointestinal malignant tumors; however, it is recommended to be used in conjunction with other detection methods such as fibrous gastrointestinal tract examination to minimize the risk of missed diagnoses and misdiagnoses. The study highlights the potential of transabdominal ultrasonography as a non-invasive and accessible diagnostic method for gastrointestinal malignancies. Further research and advancements in imaging technologies are crucial for enhancing diagnostic capabilities and improving patient outcomes in the future.PMID:38607211...
Source: Alternative Therapies in Health and Medicine - April 12, 2024 Category: Complementary Medicine Authors: Jing-Yun Dong Yan-Bing Gao Li-Wei Tang Jing Zheng Source Type: research
Diagnostic Value of Transabdominal Ultrasonography in Gastrointestinal Malignant Tumors
CONCLUSION: Transabdominal ultrasonography shows promise as a diagnostic tool for gastrointestinal malignant tumors; however, it is recommended to be used in conjunction with other detection methods such as fibrous gastrointestinal tract examination to minimize the risk of missed diagnoses and misdiagnoses. The study highlights the potential of transabdominal ultrasonography as a non-invasive and accessible diagnostic method for gastrointestinal malignancies. Further research and advancements in imaging technologies are crucial for enhancing diagnostic capabilities and improving patient outcomes in the future.PMID:38607211...
Source: Alternative Therapies in Health and Medicine - April 12, 2024 Category: Complementary Medicine Authors: Jing-Yun Dong Yan-Bing Gao Li-Wei Tang Jing Zheng Source Type: research
Protracted Anaphylaxis and Cytokine Release Syndrome Six Days Following Rituximab Desensitization
Rapid desensitization to monoclonal antibodies is a well-described method for readministering medications after certain types of hypersensitivity reactions in cases where no therapeutic alternatives are available1. Our institution follows a standardized, 12-step protocol developed and described by Castells when these medications must be given2. Although reactions may occur during desensitization to monoclonal antibodies such as rituximab, many can be safely managed3. Here, we describe a case of a patient with non-Hodgkin's B-cell lymphoma who developed a protracted, mixed reaction to rituximab desensitization. (Source: Ann...
Source: Annals of Allergy, Asthma and Immunology - April 12, 2024 Category: Allergy & Immunology Authors: Kelsey A. Finkel, Heejin Jung, Haejin Kim, David T. Coleman Tags: Letters Source Type: research
Urticarial Vasculitis - A Rare Clinical Presentation Of Hodgkin's Lymphoma
A 49-year-old male was admitted to the intensive care unit in June 2023 for symptoms of severe refractory idiopathic anaphylaxis. His symptoms began with acute diffuse urticaria, which progressed to lip angioedema, wheezing, dyspnea, dizziness, and pre-syncope. At initial evaluation in the emergency department he was hypotensive to 72/52 mm Hg requiring two rounds of intramuscular epinephrine and ultimately an epinephrine drip. These measures resolved his symptoms except for urticaria, for which he received a five day course of 40mg prednisone and 20mg cetirizine twice daily with improvement of his hives. (Source: Annals o...
Source: Annals of Allergy, Asthma and Immunology - April 12, 2024 Category: Allergy & Immunology Authors: Chase P. Rupprecht, Pranay Maniar, Alexandra E. Conway, Chih- Yu Fang, Sarah A. Taylor-Black Tags: Letters Source Type: research
Prognostic Utility of a Novel Prognostic Model Consisting of Age, CRP, Ki67, and POD24 in Patients with Angioimmunoblastic T-Cell Lymphoma
AbstractTo find the independent factors affecting the prognosis of AITL patients, establish a novel predictive model, and stratify the prognosis of AITL patients. We retrospectively analyzed the clinical data of 86 patients diagnosed with AITL in the First Affiliated Hospital of Wenzhou Medical University from December 2010 to March 2022. The clinical features, recurrence time, and death time of patients were collected and analyzed statistically. The median age of our patients was 68 years old, and the male-to-female ratio was 2.2: 1. There are differences between males and females in ECOG PS score (p = 0.037), β2 m...
Source: Indian Journal of Hematology and Blood Transfusion - April 12, 2024 Category: Hematology Source Type: research
Prognostic Significance of T-Cells and Macrophages in the Tumour Microenvironment of Nodal DLBCL
AbstractRevised International Prognostic (R-IPI) score is used widely for risk stratification of DLBCL cases, yet some patients belonging to same risk category tend to exhibit different outcomes. The role of T-cells and macrophages in prognostication of lymphomas has been a point of interest of late. We aimed to study the association of FOXP3 positive T-regulatory cells, cytotoxic T-cells and macrophages with the immunophenotypic subtypes, clinicopathological characteristics, treatment response and survival in nodal diffuse large B-cell lymphoma (DLBCL) patients. The clinicopathological and treatment data of 83 DLBCL patie...
Source: Indian Journal of Hematology and Blood Transfusion - April 12, 2024 Category: Hematology Source Type: research
Understanding hemoglobin contribution to high-dose methotrexate disposition —population pharmacokinetics in pediatric patients with hematological malignancies
ConclusionThe developed population pharmacokinetic model can contribute to the therapy optimization during HDMTX in pediatric patients with ALL and NHL. In addition to renal function and body weight, it describes the influence of hemoglobin on CL, allowing better understanding of its contribution to the disposition of HDMTX. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - April 11, 2024 Category: Drugs & Pharmacology Source Type: research
