Application and progress of CRISPR/Cas9 gene editing in B-cell lymphoma: a narrative review
CONCLUSIONS: CRISPR/Cas9 gene editing has great promise in the treatment of B-cell lymphoma. This article reviews some genes, signaling pathways, and cytokines related to the progression and prognosis of B-cell lymphoma to provide a strong theoretical basis.PMID:38617522 | PMC:PMC11009809 | DOI:10.21037/tcr-23-1146 (Source: Cell Research)
Source: Cell Research - April 15, 2024 Category: Cytology Authors: Ying Jin Haiyi Wu Jianzhao Liu William C Cho Guoqi Song Source Type: research
Outcome in patients with HIV-associated Hodgkin lymphoma treated with chemotherapy using Doxorubicin, Bleomycin, Vinblastine, and Dacarbazine in the combination antiretroviral therapy (cART) era: results of a multicenter study from China
Little is known about the outcome for HIV-associated Hodgkin lymphoma (HIV-HL) as this is less common than HIV-negative lymphoma. Therefore, we performed a multi-center study to analyze the clinical characteri... (Source: Infectious Agents and Cancer)
Source: Infectious Agents and Cancer - April 15, 2024 Category: Cancer & Oncology Authors: Lirong Xiao, Chaoyu Wang, Sai Ma, Yifan Wang, Liping Guan, Juyi Wu, Wei Zhang, Yao Liu and Yan Wu Tags: Research Source Type: research
Pulmonary Manifestations of Sj ögren's Disease
Semin Respir Crit Care Med DOI: 10.1055/s-0044-1785675Sjögren's disease (SjD) is a chronic, progressive autoimmune condition of exocrine and extraglandular tissues. It can present with isolated disease characterized by lymphocytic infiltration of salivary or lacrimal glands, but in approximately one-third of the patients, lymphocytic infiltration extends beyond exocrine glands to involve extraglandular organs such as the lungs. Pulmonary complications have been reported to occur between 9 and 27% of patients with SjD across studies. Respiratory manifestations occur on a spectrum of severity and include airways disease, in...
Source: Seminars in Respiratory and Critical Care Medicine - April 15, 2024 Category: Respiratory Medicine Authors: Byrne, Louise McCarthy, Cormac Fabre, Aurelie Gupta, Nishant Tags: Review Article Source Type: research
Identification of a novel form of caspase-independent cell death triggered by BH3-mimetics in diffuse large B-cell lymphoma cell lines
Cell Death & Disease, Published online: 15 April 2024; doi:10.1038/s41419-024-06652-3Identification of a novel form of caspase-independent cell death triggered by BH3-mimetics in diffuse large B-cell lymphoma cell lines (Source: Cell death and disease)
Source: Cell death and disease - April 15, 2024 Category: Internal Medicine Authors: Nahide Yildirim Lakshmi Sarojam Victoria M. Smith Nadja M. Pieper Marius Anders Ross A. Jackson Dominik C. Fuhrmann Vinzenz S ärchen Daniela Br ücher Andreas Weigert Martin J. S. Dyer Meike Vogler Source Type: research
Molecules, Vol. 29, Pages 1789: Artemisinin Confers Cytoprotection toward Hydrogen Peroxide-Induced Cell Apoptosis in Retinal Pigment Epithelial Cells in Correlation with the Increased Acetylation of Histone H4 at Lysine 8
In conclusion, these results confirmed our hypothesis and indicated that Artemisinin attenuated H2O2-induced apoptosis in apparent correlation with the increase in the Acetyl-H4 (Lys 8) level, which is associated with gene transcription and cell survival. By modulating histone acetylation, Artemisinin may restore the balance between acetylation and deacetylation and enhance the resistance and survival of RPE cells under oxidative stress. Our study provides novel mechanistic insights into the effect of Artemisinin on histone acetylation and apoptosis in RPE cells and supports the potential application of Artemisinin in the ...
Source: Molecules - April 15, 2024 Category: Chemistry Authors: Chao Yang Lijun Ge Xiyong Yu Philip Lazarovici Wenhua Zheng Tags: Article Source Type: research
Analysis of the interaction between the ORF42 and ORF55 proteins encoded by Kaposi ’s sarcoma-associated herpesvirus
AbstractKaposi ’s sarcoma-associated herpesvirus (KSHV) causes Kaposi’s sarcoma, primary effusion lymphoma, and multicentric Castleman disease. The tegument is a structure that is unique to herpesviruses that includes host and viral proteins, including the viral ORF42 and ORF55 proteins. Alphaherpesvirus tegum ent proteins have been well studied, but much is unknown regarding KSHV. Here, we report an interaction between the ORF42 and ORF55 proteins. ORF55 interacted with and recruited ORF42 from the nucleus to the cytoplasm. When ORF42 and ORF55 were expressed simultaneously in cultured cells, the express ion level of ...
Source: Archives of Virology - April 15, 2024 Category: Virology Source Type: research
The cost-effectiveness of including liquid biopsy into molecular profiling strategies for newly diagnosed advanced non-squamous non-small cell lung cancer in an Asian population
With an estimated 2.2 million new cases and 1.8 million deaths in 2020, lung cancer accounts for approximately 1 in 10 cancers cases and 1 in 5 cancer deaths worldwide[1]. Precision oncology enables targeted therapies to decrease tumor burden and symptoms, and improve survival outcomes and quality of life for patients with specific oncogenic driver alterations[2 –4]. There is an expanding list of approved targeted therapies for clinically actionable biomarkers, including epidermal growth factor receptor (EGFR) mutations, anaplastic lymphoma kinase (ALK) and Proto-oncogene tyrosine-protein kinase (ROS1) rearrangements, re...
Source: Lung Cancer - April 15, 2024 Category: Cancer & Oncology Authors: Sibo Liu, Nicholas Graves, Aaron C. Tan Tags: Research Paper Source Type: research
Involved-site radiotherapy is equally effective and less toxic than Involved-field radiotherapy in patients receiving combined modality treatment for early-stage unfavorable Hodgkin lymphoma - an analysis of the randomized phase III HD17 trial of the German Hodgkin Study Group
Combined modality treatment (CMT) with chemotherapy followed by consolidation radiotherapy (RT), provides excellent outcomes for patients with early-stage Hodgkin lymphoma (HL). The international standard of care for consolidation RT, involved-site/involved-node radiotherapy (ISRT/INRT), has never been evaluated in a randomized phase III trial against the former standard involved-field radiotherapy (IFRT). (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 15, 2024 Category: Radiology Authors: Johannes Rosenbrock, Helen Kaul, Michael Oertel, Eren Celik, Philipp Linde, Jiaqi Fan, Dennis A. Eichenauer, Paul J. Broeckelmann, Bastian von Tresckow, Carsten Kobe, Markus Dietlein, Michael Fuchs, Peter Borchmann, Hans Theodor Eich, Christian Baues Source Type: research
Urticarial Vasculitis - A Rare Clinical Presentation Of Hodgkin's Lymphoma
Ann Allergy Asthma Immunol. 2024 Apr 12:S1081-1206(24)00217-5. doi: 10.1016/j.anai.2024.04.006. Online ahead of print.NO ABSTRACTPMID:38615739 | DOI:10.1016/j.anai.2024.04.006 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 14, 2024 Category: Allergy & Immunology Authors: Chase P Rupprecht Pranay Maniar Alexandra E Conway Chih- Yu Fang Sarah A Taylor-Black Source Type: research
Urticarial Vasculitis - A Rare Clinical Presentation Of Hodgkin's Lymphoma
Ann Allergy Asthma Immunol. 2024 Apr 12:S1081-1206(24)00217-5. doi: 10.1016/j.anai.2024.04.006. Online ahead of print.NO ABSTRACTPMID:38615739 | DOI:10.1016/j.anai.2024.04.006 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 14, 2024 Category: Allergy & Immunology Authors: Chase P Rupprecht Pranay Maniar Alexandra E Conway Chih- Yu Fang Sarah A Taylor-Black Source Type: research
Combination of chidamide and PD-1 blockade in Refractory/Relapsed aggressive large B-cell lymphomas with high risk of failing CAR-T therapy
CONCLUSION: Our results indicate that the combination of chidamide and PD-1 blockade as maintenance therapy could improve the outcomes of aggressive LBCL patients at high risk of failing CAR-T cell therapy.PMID:38615378 | DOI:10.1016/j.intimp.2024.112014 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 14, 2024 Category: Allergy & Immunology Authors: Zhenhao Wang Hao Xu Yu Mei Min Xiao Yang Cao Liang Huang Zhuming Yang Yicheng Zhang Zhiqiang Han Miao Zheng Zhenya Hong Source Type: research
Urticarial Vasculitis - A Rare Clinical Presentation Of Hodgkin's Lymphoma
Ann Allergy Asthma Immunol. 2024 Apr 12:S1081-1206(24)00217-5. doi: 10.1016/j.anai.2024.04.006. Online ahead of print.NO ABSTRACTPMID:38615739 | DOI:10.1016/j.anai.2024.04.006 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 14, 2024 Category: Allergy & Immunology Authors: Chase P Rupprecht Pranay Maniar Alexandra E Conway Chih- Yu Fang Sarah A Taylor-Black Source Type: research
Combination of chidamide and PD-1 blockade in Refractory/Relapsed aggressive large B-cell lymphomas with high risk of failing CAR-T therapy
CONCLUSION: Our results indicate that the combination of chidamide and PD-1 blockade as maintenance therapy could improve the outcomes of aggressive LBCL patients at high risk of failing CAR-T cell therapy.PMID:38615378 | DOI:10.1016/j.intimp.2024.112014 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 14, 2024 Category: Allergy & Immunology Authors: Zhenhao Wang Hao Xu Yu Mei Min Xiao Yang Cao Liang Huang Zhuming Yang Yicheng Zhang Zhiqiang Han Miao Zheng Zhenya Hong Source Type: research
Diffuse large B-cell lymphoma in Peri-implant tissues following lumbar spinal fusion surgery: A case report and literature review
Asian J Surg. 2024 Apr 12:S1015-9584(24)00629-8. doi: 10.1016/j.asjsur.2024.03.202. Online ahead of print.NO ABSTRACTPMID:38614844 | DOI:10.1016/j.asjsur.2024.03.202 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 13, 2024 Category: Surgery Authors: Zhide Liu Yong Cao Aozhuo Zu Chunyue Duan Source Type: research
Monoclonal gammopathies of renal significance
Clin Med (Lond). 2023 May;23(3):250-253. doi: 10.7861/clinmed.2023-RM3.ABSTRACTThe term monoclonal gammopathies of renal significance (MGRS) encompasses a group of renal histopathological lesions fulfilling two criteria: (a) they are caused by nephrotoxic monoclonal immunoglobulins and (b) the monoclonal immunoglobulins are produced by small B-cell or plasma cell clones which do not meet the criteria for multiple myeloma or malignant lymphoma. Here, we provide a review of the MGRS definition and related terminology and elaborate on the diagnostic approach and treatment principles from the general physician perspective.PMID...
Source: Clinical Lymphoma and Myeloma - April 13, 2024 Category: Cancer & Oncology Authors: Sahana Gnanasampanthan Andreas Kousios Source Type: research
