Clinical characteristics and prognostic analysis of primary extranodal non-Hodgkin lymphoma of the head and neck
CONCLUSIONS: The most common site of PE-NHL in these Chinese patients was the Waldeyer's ring, but the incidence in the nasal cavity was higher than that reported in Western countries. Radiotherapy combined with chemotherapy had better efficacy than chemotherapy alone, and the prognosis depended on the ECOG score and clinical stage. IPI had a better prognostic value in patients in the high-risk group of head and neck PE-NHL.PMID:38604163 | DOI:10.18632/aging.205726 (Source: Aging)
Source: Aging - April 11, 2024 Category: Biomedical Science Authors: Jiamu Lv Yining Jiang Tingting Yu Shengrui Gao Wanzhong Yin Source Type: research
Should paediatric tonsillar asymmetry be an indication for tonsillectomy? A single centre experience
CONCLUSION: Clinical size difference is a poor predictor for true tonsil volume difference. We advise that assessment of tonsil size should be performed in conjunction with the examination of gross visual abnormalities and lymphadenopathy to guide clinical decision making.PMID:38603788 | DOI:10.26635/6965.6386 (Source: New Zealand Medical Journal)
Source: New Zealand Medical Journal - April 11, 2024 Category: General Medicine Authors: Georgia Mackay Alina Rankin Sheneen Meghji Craig McCaffer Source Type: research
Letter to editor: C ‑reactive protein levels, the prognostic nutritional index, and the lactate dehydrogenase‑to‑lymphocyte ratio are important prognostic factors in primary central nervous system lymphoma: a single‑center study of 223 patients
AbstractThis critique evaluates a letter to the editor discussing prognostic factors in primary central nervous system lymphoma (PCNSL), focusing on C-reactive protein (CRP) levels, prognostic nutritional index (PNI), and lactate dehydrogenase (LDH)-to-lymphocyte ratio. While the letter provides valuable insights, limitations including reliance on a single-center dataset, lack of consideration for potential confounders, insufficient contextualization within existing literature, and limited discussion of clinical implications are identified. Addressing these limitations is crucial for enhancing the relevance and applicabili...
Source: Neurosurgical Review - April 11, 2024 Category: Neurosurgery Source Type: research
Cancers, Vol. 16, Pages 1475: Second Neoplasms in Italian Patients with Hairy Cell Leukemia after Treatment with Cladribine: A Multicenter Investigation and Literature Review
Volpetti
Ombretta Annibali
Sergio Storti
Caterina Stelitano
Francesco Marchesi
Sonia Morè
Luana Fianchi
Brunangelo Falini
Alessandro Pulsoni
Enrico Tiacci
Pier Luigi Zinzani
Livio Pagano
Concern has emerged about the prevalence of second cancers among patients with hairy cell leukemia (HCL) treated with purine analogs. We investigated 513 patients with HCL treated with cladribine over the last 30 years at 18 Italian centers and calculated their standardized incidence ratios (SIRs). We identified 24 patients with a second cancer diagnosed at a median time from treatment with cladribine of 59.9 mon...
Source: Cancers - April 11, 2024 Category: Cancer & Oncology Authors: Marianna Criscuolo Maria Elena Tosti Alessandro Broccoli Marzia Varettoni Alessio Maria Edoardo Maraglino Antonella Anastasia Maria Cantonetti Livio Trentin Sofia Kovalchuk Lorella Orsucci Marina Deodato Angelica Spolzino Stefano Volpetti Ombretta Annibal Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1464: The Gut Connection: Exploring the Possibility of Implementing Gut Microbial Metabolites in Lymphoma Treatment
Bhuyan
Recent research has implicated the gut microbiota in the development of lymphoma. Dysbiosis of the gut microbial community can disrupt the production of gut microbial metabolites, thereby impacting host physiology and potentially contributing to lymphoma. Dysbiosis-driven release of gut microbial metabolites such as lipopolysaccharides can promote chronic inflammation, potentially elevating the risk of lymphoma. In contrast, gut microbial metabolites, such as short-chain fatty acids, have shown promise in preclinical studies by promoting regulatory T-cell function, suppressing inflammation, and potentially preve...
Source: Cancers - April 11, 2024 Category: Cancer & Oncology Authors: Ahmad K. Al-Khazaleh Dennis Chang Gerald W. M ünch Deep Jyoti Bhuyan Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1459: Predictors of Survival, Treatment Modalities, and Clinical Outcomes of Diffuse Large B-Cell Lymphoma in Patients Older Than 70 Years Still an Unmet Medical Need in 2024 Based on Real-World Evidence
Conclusions: In this large and real-life Latin American cohort, we demonstrated that patients with DLBCL, NOS older than 70 years still do not have satisfactory clinical outcomes in 2024, with half of cases not reaching 5 years of life expectancy after diagnosis. Although the conventional R-CHOP offers response and survival advantages over attenuated regimens, its myelotoxicity is not negligible. Therefore, the outcomes reported and the prognostic factors here identified may assist clinicians in the appropriate selection of therapeutic strategies adapted to the risk for old and very old DLBCL patients. (Source: Cancers)
Source: Cancers - April 11, 2024 Category: Cancer & Oncology Authors: Lu ís Alberto de Pádua Covas Lage Rita Novello De Vita Lucas Bassolli de Oliveira Alves Mayara D ’Auria Jacomassi Hebert Fabr ício Culler Cadiele Oliana Reichert F ábio Alessandro de Freitas Vanderson Rocha Sheila Aparecida Coelho Siqueira Renata de Tags: Article Source Type: research
Interstitial Pneumonia Associated with Nodal T-follicular Helper Cell Lymphoma: A Case Report
Intern Med. 2024 Apr 9. doi: 10.2169/internalmedicine.3601-24. Online ahead of print.ABSTRACTNodal T-follicular helper cell lymphoma (nTFHL), a hematologic neoplasm originating from T-follicular helper (TFH) cells, occasionally presents with pulmonary radiographic abnormalities, without neoplastic cellular infiltration. However, the precise mechanisms underlying non-neoplastic pulmonary opacities in patients with nTFHL remain unclear. Previous reports have shown that TFH cell abnormalities are associated with collagen disease and interstitial pneumonia with autoimmune features (IPAF). We herein report a patient with nTFHL ...
Source: Internal Medicine - April 10, 2024 Category: Internal Medicine Authors: Satoshi Nakamura Tomotsugu Takano Kousei Nakatsuru Kazuya Tsubouchi Takuji Yamauchi Mikiko Hashisako Takeshi Iwasaki Isamu Okamoto Source Type: research
The transcription factor bmi1 increases hypoxic signaling in oral cavity epithelia
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 8:167161. doi: 10.1016/j.bbadis.2024.167161. Online ahead of print.ABSTRACTThe tongue epithelium is maintained by a proliferative basal layer. This layer contains long-lived stem cells (SCs), which produce progeny cells that move up to the surface as they differentiate. B-lymphoma Mo-MLV insertion region 1 (Bmi1), a protein in mammalian Polycomb Repressive Complex 1 (PRC1) and a biomarker of oral squamous cell carcinoma, is expressed in almost all basal epithelial SCs of the tongue, and single, Bmi1-labelled SCs give rise to cells in all epithelial layers. We previously develope...
Source: Biochimica et Biophysica Acta - April 10, 2024 Category: Biochemistry Authors: Jorge Baquero Xiao-Han Tang Annalisa Ferrotta Tuo Zhang Krysta M DiKun Lorraine J Gudas Source Type: research
Anti-CD20 therapy for older patients with B-cell non-Hodgkin lymphoma in the context of epidemic normalization
Asian J Surg. 2024 Apr 10:S1015-9584(24)00581-5. doi: 10.1016/j.asjsur.2024.03.154. Online ahead of print.NO ABSTRACTPMID:38599972 | DOI:10.1016/j.asjsur.2024.03.154 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 10, 2024 Category: Surgery Authors: Dongdong Zhang Shuangnian Xu Source Type: research
Interstitial Pneumonia Associated with Nodal T-follicular Helper Cell Lymphoma: A Case Report
Intern Med. 2024 Apr 9. doi: 10.2169/internalmedicine.3601-24. Online ahead of print.ABSTRACTNodal T-follicular helper cell lymphoma (nTFHL), a hematologic neoplasm originating from T-follicular helper (TFH) cells, occasionally presents with pulmonary radiographic abnormalities, without neoplastic cellular infiltration. However, the precise mechanisms underlying non-neoplastic pulmonary opacities in patients with nTFHL remain unclear. Previous reports have shown that TFH cell abnormalities are associated with collagen disease and interstitial pneumonia with autoimmune features (IPAF). We herein report a patient with nTFHL ...
Source: Internal Medicine - April 10, 2024 Category: Internal Medicine Authors: Satoshi Nakamura Tomotsugu Takano Kousei Nakatsuru Kazuya Tsubouchi Takuji Yamauchi Mikiko Hashisako Takeshi Iwasaki Isamu Okamoto Source Type: research
Paediatric onset lymphomatoid papulosis: results of a multicentre retrospective cohort study, on behalf of the EORTC Cutaneous Lymphoma Tumours Group (CLTG)
CONCLUSIONS: We report epidemiological data from a large international cohort of children and adolescents with LyP. Overall the prognosis of the disease is good, with excellent survival rates for all patients. Due to increased risk of associated HM, a long-term follow-up should be recommended for LyP patients.PMID:38595050 | DOI:10.1093/bjd/ljae150 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 10, 2024 Category: Dermatology Authors: Ma ël Blanchard Marie-Anne Morren Anne-Marie Busschots Esther Hauben Silvia Alberti-Violetti Emilio Berti Gianluca Avallone Gianluca Tavoletti Michele Panzone Pietro Quaglino Cristiana Colonna Rutger C Melchers Maarten H Vermeer Robert Gniadecki Christin Source Type: research
The transcription factor bmi1 increases hypoxic signaling in oral cavity epithelia
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 8:167161. doi: 10.1016/j.bbadis.2024.167161. Online ahead of print.ABSTRACTThe tongue epithelium is maintained by a proliferative basal layer. This layer contains long-lived stem cells (SCs), which produce progeny cells that move up to the surface as they differentiate. B-lymphoma Mo-MLV insertion region 1 (Bmi1), a protein in mammalian Polycomb Repressive Complex 1 (PRC1) and a biomarker of oral squamous cell carcinoma, is expressed in almost all basal epithelial SCs of the tongue, and single, Bmi1-labelled SCs give rise to cells in all epithelial layers. We previously develope...
Source: Molecular Medicine - April 10, 2024 Category: Molecular Biology Authors: Jorge Baquero Xiao-Han Tang Annalisa Ferrotta Tuo Zhang Krysta M DiKun Lorraine J Gudas Source Type: research
Anti-CD20 therapy for older patients with B-cell non-Hodgkin lymphoma in the context of epidemic normalization
Asian J Surg. 2024 Apr 10:S1015-9584(24)00581-5. doi: 10.1016/j.asjsur.2024.03.154. Online ahead of print.NO ABSTRACTPMID:38599972 | DOI:10.1016/j.asjsur.2024.03.154 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 10, 2024 Category: Surgery Authors: Dongdong Zhang Shuangnian Xu Source Type: research
Interstitial Pneumonia Associated with Nodal T-follicular Helper Cell Lymphoma: A Case Report
Intern Med. 2024 Apr 9. doi: 10.2169/internalmedicine.3601-24. Online ahead of print.ABSTRACTNodal T-follicular helper cell lymphoma (nTFHL), a hematologic neoplasm originating from T-follicular helper (TFH) cells, occasionally presents with pulmonary radiographic abnormalities, without neoplastic cellular infiltration. However, the precise mechanisms underlying non-neoplastic pulmonary opacities in patients with nTFHL remain unclear. Previous reports have shown that TFH cell abnormalities are associated with collagen disease and interstitial pneumonia with autoimmune features (IPAF). We herein report a patient with nTFHL ...
Source: Internal Medicine - April 10, 2024 Category: Internal Medicine Authors: Satoshi Nakamura Tomotsugu Takano Kousei Nakatsuru Kazuya Tsubouchi Takuji Yamauchi Mikiko Hashisako Takeshi Iwasaki Isamu Okamoto Source Type: research
An indirect comparison of acalabrutinib with and without obinutuzumab versus zanubrutinib in treatment-naive CLL
Blood Adv. 2024 Apr 10:bloodadvances.2023012142. doi: 10.1182/bloodadvances.2023012142. Online ahead of print.ABSTRACTThe efficacy and safety of acalabrutinib plus obinutuzumab and acalabrutinib monotherapy versus zanubrutinib in patients with treatment-naive chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) without del(17p) were compared using an unanchored matching-adjusted indirect comparison. Individual patient-level data (IPD) from ELEVATE-TN (acalabrutinib plus obinutuzumab, n = 162; acalabrutinib monotherapy, n = 163) were weighted to match published aggregate baseline data from SEQUOIA cohort 1, w...
Source: Adv Data - April 10, 2024 Category: Epidemiology Authors: Adam S Kittai John N Allan Dan James Helen Bridge Miguel Miranda Alan Sm Yong Fady Fam Jack Roos Vikram Shetty Alan P Skarbnik Matthew S Davids Source Type: research
