Dietary Plant Metabolites Induced Epigenetic Modification as a Novel Strategy for the Management of Prostate Cancer
Mini Rev Med Chem. 2024 Feb 21. doi: 10.2174/0113895575283895240207065454. Online ahead of print.ABSTRACTProstate cancer is a widespread malignancy among men, with a substantial global impact on morbidity and mortality. Despite advances in conventional therapies, the need for innovative and less toxic treatments remains a priority. Emerging evidence suggests that dietary plant metabolites possess epigenetic-modifying properties, making them attractive candidates for prostate cancer treatment. The present work reviews the epigenetic effects of dietary plant metabolites in the context of prostate cancer therapy. We first out...
Source: Mini Reviews in Medicinal Chemistry - February 22, 2024 Category: Chemistry Authors: Vaibhav Singh Ekta Shirbhate Rakesh Kore Aditya Mishra Varsha Johariya Ravichandran Veerasamy Amit K Tiwari Harish Rajak Source Type: research
Dietary Plant Metabolites Induced Epigenetic Modification as a Novel Strategy for the Management of Prostate Cancer
Mini Rev Med Chem. 2024 Feb 21. doi: 10.2174/0113895575283895240207065454. Online ahead of print.ABSTRACTProstate cancer is a widespread malignancy among men, with a substantial global impact on morbidity and mortality. Despite advances in conventional therapies, the need for innovative and less toxic treatments remains a priority. Emerging evidence suggests that dietary plant metabolites possess epigenetic-modifying properties, making them attractive candidates for prostate cancer treatment. The present work reviews the epigenetic effects of dietary plant metabolites in the context of prostate cancer therapy. We first out...
Source: Mini Reviews in Medicinal Chemistry - February 22, 2024 Category: Chemistry Authors: Vaibhav Singh Ekta Shirbhate Rakesh Kore Aditya Mishra Varsha Johariya Ravichandran Veerasamy Amit K Tiwari Harish Rajak Source Type: research
Dietary Plant Metabolites Induced Epigenetic Modification as a Novel Strategy for the Management of Prostate Cancer
Mini Rev Med Chem. 2024 Feb 21. doi: 10.2174/0113895575283895240207065454. Online ahead of print.ABSTRACTProstate cancer is a widespread malignancy among men, with a substantial global impact on morbidity and mortality. Despite advances in conventional therapies, the need for innovative and less toxic treatments remains a priority. Emerging evidence suggests that dietary plant metabolites possess epigenetic-modifying properties, making them attractive candidates for prostate cancer treatment. The present work reviews the epigenetic effects of dietary plant metabolites in the context of prostate cancer therapy. We first out...
Source: Mini Reviews in Medicinal Chemistry - February 22, 2024 Category: Chemistry Authors: Vaibhav Singh Ekta Shirbhate Rakesh Kore Aditya Mishra Varsha Johariya Ravichandran Veerasamy Amit K Tiwari Harish Rajak Source Type: research
Diet-derived circulating antioxidants and risk of inflammatory bowel disease: a Mendelian randomization study and meta-analysis
ConclusionOur results provide strong evidence that the absolute circulating level of retinol is associated with a reduction in the risk of UC. Further MR studies with more instrumental variables on circulating antioxidants, especially absolute circulating antioxidants, are needed to confirm our results. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - February 21, 2024 Category: Allergy & Immunology Source Type: research
Cancers, Vol. 16, Pages 714: Role of Nutraceuticals in Counteracting Inflammation in In Vitro Macrophages Obtained from Childhood Cancer Survivors
ossi
Maura Argenziano
The advancement of anti-cancer therapies has markedly improved the survival rate of children with cancer, making them long-term childhood cancer survivors (CCS). Nevertheless, these treatments cause a low-grade inflammatory state, determining inflamm-aging and, thus, favoring the early onset of chronic diseases normally associated with old age. Identification of novel and safer therapeutic strategies is needed to counteract and prevent inflamm-aging. Macrophages are cells involved in immune and inflammatory responses, with a pivotal role in iron metabolism, which is related to inflammation. We o...
Source: Cancers - February 8, 2024 Category: Cancer & Oncology Authors: Alessandra Di Paola Maria Maddalena Marrapodi Elvira Pota Rosa Colucci Cante Deeksha Rana Giulia Giliberti Giuseppe Di Feo Shakeel Ahmed Domenico Roberti Roberto Nigro Francesca Rossi Maura Argenziano Tags: Article Source Type: research
CRISPR/Cas9-based toolkit for rapid marker recycling and combinatorial libraries in Komagataella phaffii
In this study, a redesigned gRNA plasmid carrying red and green fluorescent proteins facilitated plasmid construction and marker recycling, respectively, making marker recycling more convenient and reliable. Subsequently, based on the knockdown of Ku70 and DNA ligase IV, we experimented with integrating multiple DNA fragments at a single locus. A 26.5-kb-long DNA fragment divided into 11 expression cassettes for lycopene synthesis could be successfully integrated into a single locus at one time with a success rate of 57%. A 27-kb-long DNA fragment could also be precisely knocked out with a 50% positive rate in K. phaffii b...
Source: Applied Microbiology and Biotechnology - February 7, 2024 Category: Microbiology Authors: Wei Zhou Yuanyi Li Guosong Liu Weichuang Qin Dongzhi Wei Fengqing Wang Bei Gao Source Type: research
Lycopene mitigates DHT-induced apoptosis and oxidative stress in human granulosa cell line KGN by regulating the Nrf2 pathway
ConclusionIn summary, this work revealed that lycopene alleviates oxidative stress and apoptosis in KGN cells in the presence of DHT, which at least partly by depending on the activation of Nrf2 cascade signal at the molecular level. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - February 5, 2024 Category: Cytology Source Type: research
Association between dietary carotenoid intakes and abdominal aortic calcification in adults: National Health and Nutrition Examination Survey 2013-2014
CONCLUSION: α-carotene, β-carotene, β-cryptoxanthin, lycopene, lutein with zeaxanthin and total carotenoids were inversely associated with the risk of severe AAC in adults.PMID:38303096 | PMC:PMC10835982 | DOI:10.1186/s41043-024-00511-9 (Source: Journal of Health, Population, and Nutrition)
Source: Journal of Health, Population, and Nutrition - February 2, 2024 Category: International Medicine & Public Health Authors: Weidong Chen Yuanqing Li Min Li Hai Li Caifang Chen Yanzhao Lin Source Type: research
Lycopene inhibits apoptosis of mouse spermatocytes in varicocele via miR-23a/b-induced downregulation of PROK2
CONCLUSIONS: Lycopene could attenuate hypoxia-induced spermatocyte injury through the miR-23a/b-PROK2 pathway.IMPLICATIONS: Lycopene may be an effective treatment for varicocele to improve testicular impairment.PMID:38301353 | DOI:10.1071/RD23136 (Source: Reproduction, Fertility, and Development)
Source: Reproduction, Fertility, and Development - February 1, 2024 Category: Reproduction Medicine Authors: Hongqiang Wang Baojuan Zhu Tao Jing Lei Yu Kaishu Zhang Yujie Liu Hanshu Wang Source Type: research
Association of dietary carotenoid intake with the prevalence kidney stones among the general adult population
ConclusionOur findings indicated that higher dietary carotenoid intake levels were associated with decreased prevalence of kidney stones, and increasing the intake of foods rich in β-carotene may prevent the development of kidney stones. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - January 25, 2024 Category: Urology & Nephrology Source Type: research
Is variety more important than quantity of fruits and vegetables in relation to cardiovascular disease incidence and mortality? Results from a prospective cohort study
Int J Food Sci Nutr. 2024 Jan 22:1-11. doi: 10.1080/09637486.2024.2304134. Online ahead of print.ABSTRACTWe aimed to prospectively assess the association between variety and quantity of fruits and vegetables (FV) and cardiovascular diseases (CVD) incidence and mortality due to the limited evidence. Our analysis included 2,918 adults with a follow-up period of 29,559 person-years. An inverse association was detected between fruit intake and the risk of incidence and mortality from CVD. We found no association between diversity scores of fruits, vegetables, and FV with CVD risk. Subjects with high quantity-high variety, high...
Source: International Journal of Food Sciences and Nutrition - January 22, 2024 Category: Nutrition Authors: Asma Kazemi Mahdieh Golzarand Sara Shojaei-Zarghani Siavash Babajafari Parvin Mirmiran Fereidoun Azizi Source Type: research
Molecules, Vol. 29, Pages 487: Effect of Novel Processing Techniques on the Carotenoid Release during the Production of Red Guava Juice
This study systematically evaluates the impact of diverse processing techniques on the efficient release of carotenoids. The primary objective is to facilitate the transfer of carotenoids into the juice fraction, yielding carotenoid-enriched juice seamlessly integrable into aqueous-based food matrices. The untreated guava puree exhibited a modest release of carotenoids, with only 66.26% of β-carotene and 57.08% of lycopene reaching the juice. Contrastly, both high-pressure homogenization (HPH) at 25 Mpa and enzyme (EM) treatment significantly enhanced carotenoid release efficiency (p < 0.05), while ...
Source: Molecules - January 18, 2024 Category: Chemistry Authors: Xiaoxue Zheng Ziting Chen Ziming Guo Mengting Chen Bijun Xie Zhida Sun Kai Hu Tags: Article Source Type: research
Molecules, Vol. 29, Pages 314: Bioprospecting of Selected Species of Polypore Fungi from the Western Balkans
vana Vunduk
Growing mushrooms means meeting challenges while aiming for sustainability and circularity. Wherever the producer is located, commercial strains are the same originating from several producers. Customized strains adapted to local conditions are urgently needed. Before introducing new species to the strain development pipeline, the chemical characterization and biological activity of wild ones need to be assessed. Accordingly, the mycoceutical potential of five polypore mushroom species from Serbia was evaluated including: secondary metabolite composition, oxidative damage prevention, anti-tyrosinase, and an...
Source: Molecules - January 8, 2024 Category: Chemistry Authors: Maja Kozarski Anita Klaus Bojana Špirović-Trifunović Srdjan Mileti ć Vesna Lazi ć Željko Žižak Jovana Vunduk Tags: Article Source Type: research
Chitosan nanoparticles encapsulating curcumin counteract salt-mediated ionic toxicity in wheat seedlings: an ecofriendly and sustainable approach
Environ Sci Pollut Res Int. 2024 Jan 5. doi: 10.1007/s11356-023-31768-y. Online ahead of print.ABSTRACTOver-accumulating salts in soil are hazardous materials that interfere with the biochemical pathways in growing plants drastically affecting their physiological attributes, growth, and productivity. Soil salinization poses severe threats to highly-demanded and important crops directly challenging food security and sustainable productivity. Recently, there has been a great demand to exploit natural sources for the development of nontoxic nanoformulations of growth enhancers and stress emulators. The chitosan (CS) has growt...
Source: Environmental Science and Pollution Research International - January 5, 2024 Category: Environmental Health Authors: Arruje Hameed Waqas Maqsood Amjad Hameed Muhammad Abdul Qayyum Toheed Ahmed Tahir Farooq Source Type: research
Association of Dietary Carotenoids Intakes with Obesity in Adults: NHANES 2007-2018
This study indicated that intakes of total carotenoids, α-carotene, β-carotene, β-cryptoxanthin, and lutein+zeaxanthin were inversely associated with the risk of obesity.PMID:38171812 | DOI:10.3177/jnsv.69.402 (Source: Journal of Nutritional Science and Vitaminology)
Source: Journal of Nutritional Science and Vitaminology - January 3, 2024 Category: Nutrition Authors: Xi Yu Chen Yuan Xueshu Song Haiying Zhang Source Type: research
