A phase I study of docetaxel plus synthetic lycopene in metastatic prostate cancer patients
CONCLUSIONS: The combination of docetaxel/ADT and synthetic lycopene has low toxicity and favourable pharmacokinetics. The effects of lycopene on biomarkers provide additional support for the toxicity-dependent MTD definition.HIGHLIGHTS: The maximum tolerated dose was identified as 150 mg/day of lycopene in combination with docetaxel/ADT for the treatment of metastatic prostate cancer patients. Small increases in plasma exposure to docetaxel were observed with lycopene co-administration. Mechanistically significant effects were seen on angiogenesis and insulin-like growth factor 1 signalling by lycopene co-administration w...
Source: Methods of Information in Medicine - March 22, 2024 Category: Information Technology Authors: Michael B Lilly Chunli Wu Yu Ke Wen-Pin Chen Adam C Soloff Kent Armeson Noriko N Yokoyama Xiaotian Li Liankun Song Ying Yuan Christine E McLaren Xiaolin Zi Source Type: research
A phase I study of docetaxel plus synthetic lycopene in metastatic prostate cancer patients
CONCLUSIONS: The combination of docetaxel/ADT and synthetic lycopene has low toxicity and favourable pharmacokinetics. The effects of lycopene on biomarkers provide additional support for the toxicity-dependent MTD definition.HIGHLIGHTS: The maximum tolerated dose was identified as 150 mg/day of lycopene in combination with docetaxel/ADT for the treatment of metastatic prostate cancer patients. Small increases in plasma exposure to docetaxel were observed with lycopene co-administration. Mechanistically significant effects were seen on angiogenesis and insulin-like growth factor 1 signalling by lycopene co-administration w...
Source: Clinical Prostate Cancer - March 22, 2024 Category: Cancer & Oncology Authors: Michael B Lilly Chunli Wu Yu Ke Wen-Pin Chen Adam C Soloff Kent Armeson Noriko N Yokoyama Xiaotian Li Liankun Song Ying Yuan Christine E McLaren Xiaolin Zi Source Type: research
A phase I study of docetaxel plus synthetic lycopene in metastatic prostate cancer patients
CONCLUSIONS: The combination of docetaxel/ADT and synthetic lycopene has low toxicity and favourable pharmacokinetics. The effects of lycopene on biomarkers provide additional support for the toxicity-dependent MTD definition.HIGHLIGHTS: The maximum tolerated dose was identified as 150 mg/day of lycopene in combination with docetaxel/ADT for the treatment of metastatic prostate cancer patients. Small increases in plasma exposure to docetaxel were observed with lycopene co-administration. Mechanistically significant effects were seen on angiogenesis and insulin-like growth factor 1 signalling by lycopene co-administration w...
Source: Methods of Information in Medicine - March 22, 2024 Category: Information Technology Authors: Michael B Lilly Chunli Wu Yu Ke Wen-Pin Chen Adam C Soloff Kent Armeson Noriko N Yokoyama Xiaotian Li Liankun Song Ying Yuan Christine E McLaren Xiaolin Zi Source Type: research
A phase I study of docetaxel plus synthetic lycopene in metastatic prostate cancer patients
CONCLUSIONS: The combination of docetaxel/ADT and synthetic lycopene has low toxicity and favourable pharmacokinetics. The effects of lycopene on biomarkers provide additional support for the toxicity-dependent MTD definition.HIGHLIGHTS: The maximum tolerated dose was identified as 150 mg/day of lycopene in combination with docetaxel/ADT for the treatment of metastatic prostate cancer patients. Small increases in plasma exposure to docetaxel were observed with lycopene co-administration. Mechanistically significant effects were seen on angiogenesis and insulin-like growth factor 1 signalling by lycopene co-administration w...
Source: Methods of Information in Medicine - March 22, 2024 Category: Information Technology Authors: Michael B Lilly Chunli Wu Yu Ke Wen-Pin Chen Adam C Soloff Kent Armeson Noriko N Yokoyama Xiaotian Li Liankun Song Ying Yuan Christine E McLaren Xiaolin Zi Source Type: research
A phase I study of docetaxel plus synthetic lycopene in metastatic prostate cancer patients
CONCLUSIONS: The combination of docetaxel/ADT and synthetic lycopene has low toxicity and favourable pharmacokinetics. The effects of lycopene on biomarkers provide additional support for the toxicity-dependent MTD definition.HIGHLIGHTS: The maximum tolerated dose was identified as 150 mg/day of lycopene in combination with docetaxel/ADT for the treatment of metastatic prostate cancer patients. Small increases in plasma exposure to docetaxel were observed with lycopene co-administration. Mechanistically significant effects were seen on angiogenesis and insulin-like growth factor 1 signalling by lycopene co-administration w...
Source: Methods of Information in Medicine - March 22, 2024 Category: Information Technology Authors: Michael B Lilly Chunli Wu Yu Ke Wen-Pin Chen Adam C Soloff Kent Armeson Noriko N Yokoyama Xiaotian Li Liankun Song Ying Yuan Christine E McLaren Xiaolin Zi Source Type: research
A phase I study of docetaxel plus synthetic lycopene in metastatic prostate cancer patients
CONCLUSIONS: The combination of docetaxel/ADT and synthetic lycopene has low toxicity and favourable pharmacokinetics. The effects of lycopene on biomarkers provide additional support for the toxicity-dependent MTD definition.HIGHLIGHTS: The maximum tolerated dose was identified as 150 mg/day of lycopene in combination with docetaxel/ADT for the treatment of metastatic prostate cancer patients. Small increases in plasma exposure to docetaxel were observed with lycopene co-administration. Mechanistically significant effects were seen on angiogenesis and insulin-like growth factor 1 signalling by lycopene co-administration w...
Source: Methods of Information in Medicine - March 22, 2024 Category: Information Technology Authors: Michael B Lilly Chunli Wu Yu Ke Wen-Pin Chen Adam C Soloff Kent Armeson Noriko N Yokoyama Xiaotian Li Liankun Song Ying Yuan Christine E McLaren Xiaolin Zi Source Type: research
Longitudinal analysis of carotenoid content in preterm human milk
Conclusion Carotenoid content of HM was dynamic and varied between mothers and as lactation progressed. Infant plasma displayed a distinct distribution of carotenoids from HM. (Source: European Journal of Pediatrics)
Source: European Journal of Pediatrics - March 21, 2024 Category: Pediatrics Source Type: research
Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants
Arch Toxicol. 2024 Mar 14. doi: 10.1007/s00204-024-03696-4. Online ahead of print.ABSTRACTReactive oxygen species (ROS) and reactive nitrogen species (RNS) are well recognized for playing a dual role, since they can be either deleterious or beneficial to biological systems. An imbalance between ROS production and elimination is termed oxidative stress, a critical factor and common denominator of many chronic diseases such as cancer, cardiovascular diseases, metabolic diseases, neurological disorders (Alzheimer's and Parkinson's diseases), and other disorders. To counteract the harmful effects of ROS, organisms have evolved...
Source: Archives of Toxicology - March 14, 2024 Category: Toxicology Authors: Klaudia Jomova Suliman Y Alomar Saleh H Alwasel Eugenie Nepovimova Kamil Kuca Marian Valko Source Type: research
A comparative study of secondary metabolites profiling and biological activity of < em > Smyrnium olusatrum < /em > L. leaf, flower and fruit
Nat Prod Res. 2024 Feb 28:1-15. doi: 10.1080/14786419.2024.2321484. Online ahead of print.ABSTRACTEssential oil (EO) composition of Smyrnium olusatrum was characterised by high proportion of furanosesquiterpenes (51.66-69.35%). The leaf methanolic extract composition was found to be rich with Quercetin-O-hexoside (39.78%). Apigenin 6,8-di-Chexoside represent the major component of flower (18.2%) and fruits (18.82%). Flower extract exhibited the highest contents of total phenolic (48.97 mg GAE/g) and flavonoid (52.63 mg RE/g). The β-carotene and lycopene contents were in the order of 4.55-26.14 mg/100g, and 8.00-49.45 mg/1...
Source: Natural Product Research - February 28, 2024 Category: Biochemistry Authors: Dhouha Hamdi Aziz Hafidi Jean Jacques Lemaire Chokri Messaoud Source Type: research
A comparative study of secondary metabolites profiling and biological activity of < em > Smyrnium olusatrum < /em > L. leaf, flower and fruit
Nat Prod Res. 2024 Feb 28:1-15. doi: 10.1080/14786419.2024.2321484. Online ahead of print.ABSTRACTEssential oil (EO) composition of Smyrnium olusatrum was characterised by high proportion of furanosesquiterpenes (51.66-69.35%). The leaf methanolic extract composition was found to be rich with Quercetin-O-hexoside (39.78%). Apigenin 6,8-di-Chexoside represent the major component of flower (18.2%) and fruits (18.82%). Flower extract exhibited the highest contents of total phenolic (48.97 mg GAE/g) and flavonoid (52.63 mg RE/g). The β-carotene and lycopene contents were in the order of 4.55-26.14 mg/100g, and 8.00-49.45 mg/1...
Source: Natural Product Research - February 28, 2024 Category: Biochemistry Authors: Dhouha Hamdi Aziz Hafidi Jean Jacques Lemaire Chokri Messaoud Source Type: research
Structural insights into the unusual core photocomplex from a triply extremophilic purple bacterium, Halorhodospira halochloris
J Integr Plant Biol. 2024 Feb 27. doi: 10.1111/jipb.13628. Online ahead of print.ABSTRACTHalorhodospira (Hlr.) halochloris is a triply extremophilic phototrophic purple sulfur bacterium, as it is thermophilic, alkaliphilic, and extremely halophilic. The light-harvesting-reaction center (LH1-RC) core complex of this bacterium displays an LH1-Qy transition at 1,016 nm, which is the lowest-energy wavelength absorption among all known phototrophs. Here we report the cryo-EM structure of the LH1-RC at 2.42 Å resolution. The LH1 complex forms a tricyclic ring structure composed of 16 αβγ-polypeptides and one αβ-heterodimer...
Source: Journal of Integrative Plant Biology - February 27, 2024 Category: Biology Authors: Chen-Hui Qi Guang-Lei Wang Fang-Fang Wang Jie Wang Xiang-Ping Wang Mei-Juan Zou Fei Ma Michael T Madigan Yukihiro Kimura Zheng-Yu Wang-Otomo Long-Jiang Yu Source Type: research
Global rewiring of lipid metabolism to produce carotenoid by deleting the transcription factor genes ino2/ino4 in Saccharomyces cerevisiae
Int J Biol Macromol. 2024 Feb 25:130400. doi: 10.1016/j.ijbiomac.2024.130400. Online ahead of print.ABSTRACTThe transcription factor complex INO2 and INO4 in Saccharomyces cerevisiae plays a vital role in lipid biosynthesis by activating multiple genes in the biosynthetic pathways of phospholipid, fatty acid, and sterol. Previous studies have reported conflicting results regarding the effects of ino2 and ino4 gene expression levels on target chemicals. Therefore, this study aimed to examine the influence of different ino2 and ino4 expression levels on carotenoid production (e.g., lycopene), which shares a common precursor,...
Source: International Journal of Biological Macromolecules - February 27, 2024 Category: Biochemistry Authors: Buli Su Peixuan Lai Ming-Rong Deng Honghui Zhu Source Type: research
Structural insights into the unusual core photocomplex from a triply extremophilic purple bacterium, Halorhodospira halochloris
J Integr Plant Biol. 2024 Feb 27. doi: 10.1111/jipb.13628. Online ahead of print.ABSTRACTHalorhodospira (Hlr.) halochloris is a triply extremophilic phototrophic purple sulfur bacterium, as it is thermophilic, alkaliphilic, and extremely halophilic. The light-harvesting-reaction center (LH1-RC) core complex of this bacterium displays an LH1-Qy transition at 1,016 nm, which is the lowest-energy wavelength absorption among all known phototrophs. Here we report the cryo-EM structure of the LH1-RC at 2.42 Å resolution. The LH1 complex forms a tricyclic ring structure composed of 16 αβγ-polypeptides and one αβ-heterodimer...
Source: Journal of Integrative Plant Biology - February 27, 2024 Category: Biology Authors: Chen-Hui Qi Guang-Lei Wang Fang-Fang Wang Jie Wang Xiang-Ping Wang Mei-Juan Zou Fei Ma Michael T Madigan Yukihiro Kimura Zheng-Yu Wang-Otomo Long-Jiang Yu Source Type: research
Structural insights into the unusual core photocomplex from a triply extremophilic purple bacterium, Halorhodospira halochloris
J Integr Plant Biol. 2024 Feb 27. doi: 10.1111/jipb.13628. Online ahead of print.ABSTRACTHalorhodospira (Hlr.) halochloris is a triply extremophilic phototrophic purple sulfur bacterium, as it is thermophilic, alkaliphilic, and extremely halophilic. The light-harvesting-reaction center (LH1-RC) core complex of this bacterium displays an LH1-Qy transition at 1,016 nm, which is the lowest-energy wavelength absorption among all known phototrophs. Here we report the cryo-EM structure of the LH1-RC at 2.42 Å resolution. The LH1 complex forms a tricyclic ring structure composed of 16 αβγ-polypeptides and one αβ-heterodimer...
Source: Journal of Integrative Plant Biology - February 27, 2024 Category: Biology Authors: Chen-Hui Qi Guang-Lei Wang Fang-Fang Wang Jie Wang Xiang-Ping Wang Mei-Juan Zou Fei Ma Michael T Madigan Yukihiro Kimura Zheng-Yu Wang-Otomo Long-Jiang Yu Source Type: research
Dietary Plant Metabolites Induced Epigenetic Modification as a Novel Strategy for the Management of Prostate Cancer
Mini Rev Med Chem. 2024 Feb 21. doi: 10.2174/0113895575283895240207065454. Online ahead of print.ABSTRACTProstate cancer is a widespread malignancy among men, with a substantial global impact on morbidity and mortality. Despite advances in conventional therapies, the need for innovative and less toxic treatments remains a priority. Emerging evidence suggests that dietary plant metabolites possess epigenetic-modifying properties, making them attractive candidates for prostate cancer treatment. The present work reviews the epigenetic effects of dietary plant metabolites in the context of prostate cancer therapy. We first out...
Source: Mini Reviews in Medicinal Chemistry - February 22, 2024 Category: Chemistry Authors: Vaibhav Singh Ekta Shirbhate Rakesh Kore Aditya Mishra Varsha Johariya Ravichandran Veerasamy Amit K Tiwari Harish Rajak Source Type: research
