Potent carotenoid astaxanthin expands the anti-cancer activity of cisplatin in human prostate cancer cells
AbstractProstate cancer (PCa) is the second most common type of cancer and the sixth cause of death in men worldwide. Radiotherapy and immunotherapy are commonly used in treating PCa, but understanding the crosstalk mechanisms of carcinogenesis and new therapeutic approaches is essential for supporting poor diagnosis and existing therapies. Astaxanthin (ASX) is a member of the xanthophyll family that is an oxygenated derivative of carotenoids whose synthesis is in plant extracts from lycopene. ASX has protective effects on various diseases, such as Parkinson ’s disease and cancer by showing potent antioxidant and anti-in...
Source: Journal of Natural Medicines - May 2, 2023 Category: Drugs & Pharmacology Source Type: research
The possible ameliorative role of Lycopene on Tributyltin induced thyroid damage in adult male albino rats (histological, immunohistochemical and biochemical study)
Ultrastruct Pathol. 2023 May 1:1-15. doi: 10.1080/01913123.2023.2205922. Online ahead of print.ABSTRACTTributyltin is used in industrial applications. This current research aimed to study the effect of Tributyltin on the thyroid gland structure and function of adult male albino rats and the protective effect of Lycopene. Twenty-one male adult albino rats were classified into three groups: Control, treated that received Tributyltin, and protective that received Lycopene with Tributyltin. At the end of the experiment, blood samples were collected and T4, T3, and (TSH) were measured. Tissue superoxide dismutase (SOD) and malo...
Source: Ultrastructural Pathology - May 1, 2023 Category: Pathology Authors: Ghada A Elsammak Aliaa Talaat Samar Reda Source Type: research
The possible ameliorative role of Lycopene on Tributyltin induced thyroid damage in adult male albino rats (histological, immunohistochemical and biochemical study)
Ultrastruct Pathol. 2023 May 1:1-15. doi: 10.1080/01913123.2023.2205922. Online ahead of print.ABSTRACTTributyltin is used in industrial applications. This current research aimed to study the effect of Tributyltin on the thyroid gland structure and function of adult male albino rats and the protective effect of Lycopene. Twenty-one male adult albino rats were classified into three groups: Control, treated that received Tributyltin, and protective that received Lycopene with Tributyltin. At the end of the experiment, blood samples were collected and T4, T3, and (TSH) were measured. Tissue superoxide dismutase (SOD) and malo...
Source: Ultrastructural Pathology - May 1, 2023 Category: Pathology Authors: Ghada A Elsammak Aliaa Talaat Samar Reda Source Type: research
Lycopene alleviates oxidative stress-induced cell injury in human vascular endothelial cells by encouraging the SIRT1/Nrf2/HO-1 pathway
CONCLUSION: Lycopene alleviates H2O2-induced oxidative damage in human VECs by reducing intracellular ROS levels, inflammatory factor production, cell adhesiveness, and apoptosis rate under oxidative stress conditions through activation of the SIRT1/Nrf2/HO-1 pathway.PMID:37120838 | DOI:10.1080/10641963.2023.2205051 (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - April 30, 2023 Category: Cardiology Authors: Wenhai Guo Danping Huang Shaodong Li Source Type: research
Lycopene alleviates oxidative stress-induced cell injury in human vascular endothelial cells by encouraging the SIRT1/Nrf2/HO-1 pathway
CONCLUSION: Lycopene alleviates H2O2-induced oxidative damage in human VECs by reducing intracellular ROS levels, inflammatory factor production, cell adhesiveness, and apoptosis rate under oxidative stress conditions through activation of the SIRT1/Nrf2/HO-1 pathway.PMID:37120838 | DOI:10.1080/10641963.2023.2205051 (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - April 30, 2023 Category: Cardiology Authors: Wenhai Guo Danping Huang Shaodong Li Source Type: research
Lycopene alleviates oxidative stress-induced cell injury in human vascular endothelial cells by encouraging the SIRT1/Nrf2/HO-1 pathway
CONCLUSION: Lycopene alleviates H2O2-induced oxidative damage in human VECs by reducing intracellular ROS levels, inflammatory factor production, cell adhesiveness, and apoptosis rate under oxidative stress conditions through activation of the SIRT1/Nrf2/HO-1 pathway.PMID:37120838 | DOI:10.1080/10641963.2023.2205051 (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - April 30, 2023 Category: Cardiology Authors: Wenhai Guo Danping Huang Shaodong Li Source Type: research
