Future aspects of plant derived bioactive metabolites as therapeutics to combat benign prostatic hyperplasia
CONCLUSION: The review proposes and endorses careful utilization of conventional medications that may be investigated further to discover possible PDE-5, 5 alpha-reductase, an alpha-blocker inhibitor for managing BPH. Even though most conventional formulations, such as 5 alpha-reductase, are readily available, systemic assessment of the effectiveness and mechanism of action of the herbal constituents is still necessary to identify novel chemical moieties that can be further developed for maximum efficacy. However, there exist abundant botanicals and medicinal plants across several regions of Africa, Asia, and the Americas,...
Source: Cell Research - April 18, 2024 Category: Cytology Authors: Raman Krishnamoorthi Anand Ganapathy A Hari Priya V M Alaganandam Kumaran Source Type: research
Multi-modular metabolic engineering and efflux engineering for enhanced lycopene production in recombinant Saccharomyces cerevisiae
J Ind Microbiol Biotechnol. 2024 Apr 15:kuae015. doi: 10.1093/jimb/kuae015. Online ahead of print.ABSTRACTLycopene has been widely used in the food industry and medical field due to its antioxidant, anti-cancer, and anti-inflammatory properties. However, achieving efficient manufacture of lycopene using chassis cells on an industrial scale remains a major challenge. Herein, we attempted to integrate multiple metabolic engineering strategies to establish an efficient and balanced lycopene biosynthetic system in Saccharomyces cerevisiae. First, the lycopene synthesis pathway was modularized to sequentially enhance the metabo...
Source: Journal of Industrial Microbiology and Biotechnology - April 15, 2024 Category: Microbiology Authors: Guangxi Huang Jiarong Li Jingyuan Lin Changqing Duan Guoliang Yan Source Type: research
Multi-modular metabolic engineering and efflux engineering for enhanced lycopene production in recombinant Saccharomyces cerevisiae
J Ind Microbiol Biotechnol. 2024 Apr 15:kuae015. doi: 10.1093/jimb/kuae015. Online ahead of print.ABSTRACTLycopene has been widely used in the food industry and medical field due to its antioxidant, anti-cancer, and anti-inflammatory properties. However, achieving efficient manufacture of lycopene using chassis cells on an industrial scale remains a major challenge. Herein, we attempted to integrate multiple metabolic engineering strategies to establish an efficient and balanced lycopene biosynthetic system in Saccharomyces cerevisiae. First, the lycopene synthesis pathway was modularized to sequentially enhance the metabo...
Source: Cancer Control - April 15, 2024 Category: Cancer & Oncology Authors: Guangxi Huang Jiarong Li Jingyuan Lin Changqing Duan Guoliang Yan Source Type: research
Multi-modular metabolic engineering and efflux engineering for enhanced lycopene production in recombinant Saccharomyces cerevisiae
J Ind Microbiol Biotechnol. 2024 Apr 15:kuae015. doi: 10.1093/jimb/kuae015. Online ahead of print.ABSTRACTLycopene has been widely used in the food industry and medical field due to its antioxidant, anti-cancer, and anti-inflammatory properties. However, achieving efficient manufacture of lycopene using chassis cells on an industrial scale remains a major challenge. Herein, we attempted to integrate multiple metabolic engineering strategies to establish an efficient and balanced lycopene biosynthetic system in Saccharomyces cerevisiae. First, the lycopene synthesis pathway was modularized to sequentially enhance the metabo...
Source: Journal of Industrial Microbiology and Biotechnology - April 15, 2024 Category: Microbiology Authors: Guangxi Huang Jiarong Li Jingyuan Lin Changqing Duan Guoliang Yan Source Type: research
Multi-modular metabolic engineering and efflux engineering for enhanced lycopene production in recombinant Saccharomyces cerevisiae
J Ind Microbiol Biotechnol. 2024 Apr 15:kuae015. doi: 10.1093/jimb/kuae015. Online ahead of print.ABSTRACTLycopene has been widely used in the food industry and medical field due to its antioxidant, anti-cancer, and anti-inflammatory properties. However, achieving efficient manufacture of lycopene using chassis cells on an industrial scale remains a major challenge. Herein, we attempted to integrate multiple metabolic engineering strategies to establish an efficient and balanced lycopene biosynthetic system in Saccharomyces cerevisiae. First, the lycopene synthesis pathway was modularized to sequentially enhance the metabo...
Source: Journal of Industrial Microbiology and Biotechnology - April 15, 2024 Category: Microbiology Authors: Guangxi Huang Jiarong Li Jingyuan Lin Changqing Duan Guoliang Yan Source Type: research
Optimization of ultrasonic conditions for improving the characteristics of corn starch-glycyrrhiza polysaccharide composite to prepare enhanced quality lycopene inclusion complex
In this study, based on response surface optimization of ultrasound pre-treatment conditions for encapsulating lycopene, the corn starch-glycyrrhiza polysaccharide composite (US-CS-GP) was used to prepare a novel lycopene inclusion complex (US-CS-GP-Lyc). Ultrasound treatment (575 W, 25 kHz) at 35 °C for 25 min significantly enhanced the rheological and starch properties of US-CS-GP, facilitating the preparation of US-CS-GP-Lyc with an encapsulation efficiency of 76.12 ± 1.76 %. In addition, the crystalline structure, thermal properties, and microstructure of the obtained lycopene inclusion complex were significantly imp...
Source: International Journal of Biological Macromolecules - April 11, 2024 Category: Biochemistry Authors: Zirun Cheng Qiao Zheng Yuqing Duan Kai Hu Meihong Cai Haihui Zhang Source Type: research
A transcriptional cascade mediated by two APETALA2 family members orchestrates carotenoid biosynthesis in tomato
In this study, we determined that SlAP2c, an APETALA2 (AP2) family member, acts as a transcriptional repressor to regulate carotenoid biosynthesis in tomato (Solanum lycopersicum). Knockout of SlAP2c in both the "MicroTom" and "Ailsa Craig" backgrounds resulted in greater lycopene accumulation, whereas overexpression of this gene led to orange-ripe fruit with significantly lower lycopene contents than the wild type. We established that SlAP2c represses the expression of genes involved in lycopene biosynthesis by directly binding to the cis-elements in their promoters. Moreover, SlAP2c relies on its EAR motif to recruit the...
Source: Journal of Integrative Plant Biology - March 28, 2024 Category: Biology Authors: Xiaoqing He Kaidong Liu Yi Wu Weijie Xu Ruochen Wang Julien Pirrello Mondher Bouzayen Mengbo Wu Mingchun Liu Source Type: research
A transcriptional cascade mediated by two APETALA2 family members orchestrates carotenoid biosynthesis in tomato
In this study, we determined that SlAP2c, an APETALA2 (AP2) family member, acts as a transcriptional repressor to regulate carotenoid biosynthesis in tomato (Solanum lycopersicum). Knockout of SlAP2c in both the "MicroTom" and "Ailsa Craig" backgrounds resulted in greater lycopene accumulation, whereas overexpression of this gene led to orange-ripe fruit with significantly lower lycopene contents than the wild type. We established that SlAP2c represses the expression of genes involved in lycopene biosynthesis by directly binding to the cis-elements in their promoters. Moreover, SlAP2c relies on its EAR motif to recruit the...
Source: Journal of Integrative Plant Biology - March 28, 2024 Category: Biology Authors: Xiaoqing He Kaidong Liu Yi Wu Weijie Xu Ruochen Wang Julien Pirrello Mondher Bouzayen Mengbo Wu Mingchun Liu Source Type: research
A transcriptional cascade mediated by two APETALA2 family members orchestrates carotenoid biosynthesis in tomato
In this study, we determined that SlAP2c, an APETALA2 (AP2) family member, acts as a transcriptional repressor to regulate carotenoid biosynthesis in tomato (Solanum lycopersicum). Knockout of SlAP2c in both the "MicroTom" and "Ailsa Craig" backgrounds resulted in greater lycopene accumulation, whereas overexpression of this gene led to orange-ripe fruit with significantly lower lycopene contents than the wild type. We established that SlAP2c represses the expression of genes involved in lycopene biosynthesis by directly binding to the cis-elements in their promoters. Moreover, SlAP2c relies on its EAR motif to recruit the...
Source: Journal of Integrative Plant Biology - March 28, 2024 Category: Biology Authors: Xiaoqing He Kaidong Liu Yi Wu Weijie Xu Ruochen Wang Julien Pirrello Mondher Bouzayen Mengbo Wu Mingchun Liu Source Type: research
Phytocompounds targeting epigenetic modulations: an assessment in cancer
For centuries, plants have been serving as sources of potential therapeutic agents. In recent years, there has been a growing interest in investigating the effects of plant-derived compounds on epigenetic processes, a novel and captivating Frontier in the field of epigenetics research. Epigenetic changes encompass modifications to DNA, histones, and microRNAs that can influence gene expression. Aberrant epigenetic changes can perturb key cellular processes, including cell cycle control, intercellular communication, DNA repair, inflammation, stress response, and apoptosis. Such disruptions can contribute to cancer developme...
Source: Frontiers in Pharmacology - March 26, 2024 Category: Drugs & Pharmacology Source Type: research
A phase I study of docetaxel plus synthetic lycopene in metastatic prostate cancer patients
CONCLUSIONS: The combination of docetaxel/ADT and synthetic lycopene has low toxicity and favourable pharmacokinetics. The effects of lycopene on biomarkers provide additional support for the toxicity-dependent MTD definition.HIGHLIGHTS: The maximum tolerated dose was identified as 150 mg/day of lycopene in combination with docetaxel/ADT for the treatment of metastatic prostate cancer patients. Small increases in plasma exposure to docetaxel were observed with lycopene co-administration. Mechanistically significant effects were seen on angiogenesis and insulin-like growth factor 1 signalling by lycopene co-administration w...
Source: Methods of Information in Medicine - March 22, 2024 Category: Information Technology Authors: Michael B Lilly Chunli Wu Yu Ke Wen-Pin Chen Adam C Soloff Kent Armeson Noriko N Yokoyama Xiaotian Li Liankun Song Ying Yuan Christine E McLaren Xiaolin Zi Source Type: research
A phase I study of docetaxel plus synthetic lycopene in metastatic prostate cancer patients
CONCLUSIONS: The combination of docetaxel/ADT and synthetic lycopene has low toxicity and favourable pharmacokinetics. The effects of lycopene on biomarkers provide additional support for the toxicity-dependent MTD definition.HIGHLIGHTS: The maximum tolerated dose was identified as 150 mg/day of lycopene in combination with docetaxel/ADT for the treatment of metastatic prostate cancer patients. Small increases in plasma exposure to docetaxel were observed with lycopene co-administration. Mechanistically significant effects were seen on angiogenesis and insulin-like growth factor 1 signalling by lycopene co-administration w...
Source: Clinical Prostate Cancer - March 22, 2024 Category: Cancer & Oncology Authors: Michael B Lilly Chunli Wu Yu Ke Wen-Pin Chen Adam C Soloff Kent Armeson Noriko N Yokoyama Xiaotian Li Liankun Song Ying Yuan Christine E McLaren Xiaolin Zi Source Type: research
A phase I study of docetaxel plus synthetic lycopene in metastatic prostate cancer patients
CONCLUSIONS: The combination of docetaxel/ADT and synthetic lycopene has low toxicity and favourable pharmacokinetics. The effects of lycopene on biomarkers provide additional support for the toxicity-dependent MTD definition.HIGHLIGHTS: The maximum tolerated dose was identified as 150 mg/day of lycopene in combination with docetaxel/ADT for the treatment of metastatic prostate cancer patients. Small increases in plasma exposure to docetaxel were observed with lycopene co-administration. Mechanistically significant effects were seen on angiogenesis and insulin-like growth factor 1 signalling by lycopene co-administration w...
Source: Methods of Information in Medicine - March 22, 2024 Category: Information Technology Authors: Michael B Lilly Chunli Wu Yu Ke Wen-Pin Chen Adam C Soloff Kent Armeson Noriko N Yokoyama Xiaotian Li Liankun Song Ying Yuan Christine E McLaren Xiaolin Zi Source Type: research
A phase I study of docetaxel plus synthetic lycopene in metastatic prostate cancer patients
CONCLUSIONS: The combination of docetaxel/ADT and synthetic lycopene has low toxicity and favourable pharmacokinetics. The effects of lycopene on biomarkers provide additional support for the toxicity-dependent MTD definition.HIGHLIGHTS: The maximum tolerated dose was identified as 150 mg/day of lycopene in combination with docetaxel/ADT for the treatment of metastatic prostate cancer patients. Small increases in plasma exposure to docetaxel were observed with lycopene co-administration. Mechanistically significant effects were seen on angiogenesis and insulin-like growth factor 1 signalling by lycopene co-administration w...
Source: Clinical Prostate Cancer - March 22, 2024 Category: Cancer & Oncology Authors: Michael B Lilly Chunli Wu Yu Ke Wen-Pin Chen Adam C Soloff Kent Armeson Noriko N Yokoyama Xiaotian Li Liankun Song Ying Yuan Christine E McLaren Xiaolin Zi Source Type: research
A phase I study of docetaxel plus synthetic lycopene in metastatic prostate cancer patients
CONCLUSIONS: The combination of docetaxel/ADT and synthetic lycopene has low toxicity and favourable pharmacokinetics. The effects of lycopene on biomarkers provide additional support for the toxicity-dependent MTD definition.HIGHLIGHTS: The maximum tolerated dose was identified as 150 mg/day of lycopene in combination with docetaxel/ADT for the treatment of metastatic prostate cancer patients. Small increases in plasma exposure to docetaxel were observed with lycopene co-administration. Mechanistically significant effects were seen on angiogenesis and insulin-like growth factor 1 signalling by lycopene co-administration w...
Source: Methods of Information in Medicine - March 22, 2024 Category: Information Technology Authors: Michael B Lilly Chunli Wu Yu Ke Wen-Pin Chen Adam C Soloff Kent Armeson Noriko N Yokoyama Xiaotian Li Liankun Song Ying Yuan Christine E McLaren Xiaolin Zi Source Type: research
